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Adverse events and oncotargeted kinase inhibitors / / Giuseppe Tridente
| Adverse events and oncotargeted kinase inhibitors / / Giuseppe Tridente |
| Autore | Tridente G. |
| Pubbl/distr/stampa | London, England : , : Academic Press, , 2017 |
| Descrizione fisica | 1 online resource (717 pages) : illustrations, tables |
| Disciplina | 612.01516 |
| Soggetto topico | Protein-tyrosine kinase - Inhibitors |
| ISBN |
0-12-809445-1
0-12-809400-1 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Introduction -- Kinases -- Kinase inhibitors -- Adverse events -- Imantinib -- Gefitinib -- Erlotinib -- Sorafenib -- Sunitinib -- Dasatinib -- Lapatinib -- Nilotinib -- Pazopanib -- Vandetanib -- Vemurafenib -- Crizotinib -- Ruxolitinib -- Axitinib -- Bosutinib -- Regorafenib -- Cabozantinib -- Ponatinib -- Dabrafenib -- Trametinib -- Afatinib -- Idelaisib -- Ibrutinib -- Overview -- Conclusion and perspectives. |
| Record Nr. | UNINA-9910583341503321 |
Tridente G.
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| London, England : , : Academic Press, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Aspartic acid proteases as therapeutic targets / / edited by Arun K. Ghosh
| Aspartic acid proteases as therapeutic targets / / edited by Arun K. Ghosh |
| Pubbl/distr/stampa | Weinheim, Germany : , : Wiley-VCH, , 2010 |
| Descrizione fisica | 1 online resource (641 p.) |
| Disciplina |
571.9/36
612.01516 |
| Collana | Methods and Principles in Medicinal Chemistry |
| Soggetto topico |
Aspartic proteinases
Aspartic proteinases - Inhibitors - Therapeutic use |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-282-77490-5
9786612774904 3-527-64162-9 3-527-63094-5 3-527-63095-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Aspartic Acid Proteases as Therapeutic Targets; Contents; List of Contributors; Preface; A Personal Foreword; Part: One Overview of Aspartic Acid Proteases; 1 Introduction to the Aspartic Proteinase Family; 2 Aspartic Proteases: Structure, Function, and Inhibition; 3 Human Aspartic Proteinases; 4 Structure-Based Drug Design Strategies for Inhibition of Aspartic Proteinases; Part Two: HIV-1 Protease as Target for the Treatment of HIV/AIDS; 5 HIV-1 Protease: Role in Viral Replication, Protein-Ligand X-Ray Crystal Structures and Inhibitor Design
6 First-Generation HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS7 Second-Generation Approved HIV Protease Inhibitors for the Treatment of HIV/AIDS; 8 Darunavir, a New PI with Dual Mechanism: From a Novel Drug Design Concept to New Hope Against Drug-Resistant HIV; 9 Development of HIV-1 Protease Inhibitors, Antiretroviral Resistance, and Current Challenges of HIV/AIDS Management; Part Three: Renin as Target for the Treatment of Hypertension; 10 Discovery and Development of Aliskiren, the First-in-Class Direct Renin Inhibitor for the Treatment of Hypertension 11 Evolution of Diverse Classes of Renin Inhibitors Through the YearsPart Four: ?-Secretase as Target for the Treatment of Alzheimer""s Disease; 12: ?-Secretase: An Unusual Enzyme with Many Possible Disease Targets, Including Alzheimer""s Disease; 13 ?-Secretase Inhibition: An Overview of Development of Inhibitors for the Treatment of Alzheimer's Disease; Part Five: ß-Secretase as Target for the Treatment of Alzheimer's Disease; 14 BACE: A (Almost) Perfect Target for Staving Off Alzheimer's Disease 15 The Discovery of ß-Secretase and Development Toward a Clinical Inhibitor for AD: An Exciting Academic Collaboration16 Peptidomimetic BACE1 Inhibitors for Treatment of Alzheimer.s Disease: Design and Evolution; 17 Nonpeptide BACE1 Inhibitors: Design and Synthesis; Part Six: Plasmepsins and Other Aspartic Proteases as Drug Targets; 18 The Plasmepsin Family as Antimalarial Drug Targets; 19 Plasmepsins Inhibitors as Potential Drugs Against Malaria: Starving the Parasite; 20 Fungal Aspartic Proteases as Possible Therapeutic Targets; Index |
| Record Nr. | UNINA-9910140801803321 |
| Weinheim, Germany : , : Wiley-VCH, , 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Aspartic acid proteases as therapeutic targets / / edited by Arun K. Ghosh
| Aspartic acid proteases as therapeutic targets / / edited by Arun K. Ghosh |
| Pubbl/distr/stampa | Weinheim, Germany : , : Wiley-VCH, , 2010 |
| Descrizione fisica | 1 online resource (641 p.) |
| Disciplina |
571.9/36
612.01516 |
| Collana | Methods and Principles in Medicinal Chemistry |
| Soggetto topico |
Aspartic proteinases
Aspartic proteinases - Inhibitors - Therapeutic use |
| ISBN |
1-282-77490-5
9786612774904 3-527-64162-9 3-527-63094-5 3-527-63095-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Aspartic Acid Proteases as Therapeutic Targets; Contents; List of Contributors; Preface; A Personal Foreword; Part: One Overview of Aspartic Acid Proteases; 1 Introduction to the Aspartic Proteinase Family; 2 Aspartic Proteases: Structure, Function, and Inhibition; 3 Human Aspartic Proteinases; 4 Structure-Based Drug Design Strategies for Inhibition of Aspartic Proteinases; Part Two: HIV-1 Protease as Target for the Treatment of HIV/AIDS; 5 HIV-1 Protease: Role in Viral Replication, Protein-Ligand X-Ray Crystal Structures and Inhibitor Design
6 First-Generation HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS7 Second-Generation Approved HIV Protease Inhibitors for the Treatment of HIV/AIDS; 8 Darunavir, a New PI with Dual Mechanism: From a Novel Drug Design Concept to New Hope Against Drug-Resistant HIV; 9 Development of HIV-1 Protease Inhibitors, Antiretroviral Resistance, and Current Challenges of HIV/AIDS Management; Part Three: Renin as Target for the Treatment of Hypertension; 10 Discovery and Development of Aliskiren, the First-in-Class Direct Renin Inhibitor for the Treatment of Hypertension 11 Evolution of Diverse Classes of Renin Inhibitors Through the YearsPart Four: ?-Secretase as Target for the Treatment of Alzheimer""s Disease; 12: ?-Secretase: An Unusual Enzyme with Many Possible Disease Targets, Including Alzheimer""s Disease; 13 ?-Secretase Inhibition: An Overview of Development of Inhibitors for the Treatment of Alzheimer's Disease; Part Five: ß-Secretase as Target for the Treatment of Alzheimer's Disease; 14 BACE: A (Almost) Perfect Target for Staving Off Alzheimer's Disease 15 The Discovery of ß-Secretase and Development Toward a Clinical Inhibitor for AD: An Exciting Academic Collaboration16 Peptidomimetic BACE1 Inhibitors for Treatment of Alzheimer.s Disease: Design and Evolution; 17 Nonpeptide BACE1 Inhibitors: Design and Synthesis; Part Six: Plasmepsins and Other Aspartic Proteases as Drug Targets; 18 The Plasmepsin Family as Antimalarial Drug Targets; 19 Plasmepsins Inhibitors as Potential Drugs Against Malaria: Starving the Parasite; 20 Fungal Aspartic Proteases as Possible Therapeutic Targets; Index |
| Record Nr. | UNINA-9910829994603321 |
| Weinheim, Germany : , : Wiley-VCH, , 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Aspartic acid proteases as therapeutic targets / / edited by Arun K. Ghosh
| Aspartic acid proteases as therapeutic targets / / edited by Arun K. Ghosh |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, 2010 |
| Descrizione fisica | 1 online resource (641 p.) |
| Disciplina |
571.9/36
612.01516 |
| Altri autori (Persone) | GhoshArun K., Prof. Dr. |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Aspartic proteinases
Aspartic proteinases - Inhibitors - Therapeutic use |
| ISBN |
9786612774904
9781282774902 1282774905 9783527641628 3527641629 9783527630943 3527630945 9783527630950 3527630953 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Aspartic Acid Proteases as Therapeutic Targets; Contents; List of Contributors; Preface; A Personal Foreword; Part: One Overview of Aspartic Acid Proteases; 1 Introduction to the Aspartic Proteinase Family; 2 Aspartic Proteases: Structure, Function, and Inhibition; 3 Human Aspartic Proteinases; 4 Structure-Based Drug Design Strategies for Inhibition of Aspartic Proteinases; Part Two: HIV-1 Protease as Target for the Treatment of HIV/AIDS; 5 HIV-1 Protease: Role in Viral Replication, Protein-Ligand X-Ray Crystal Structures and Inhibitor Design
6 First-Generation HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS7 Second-Generation Approved HIV Protease Inhibitors for the Treatment of HIV/AIDS; 8 Darunavir, a New PI with Dual Mechanism: From a Novel Drug Design Concept to New Hope Against Drug-Resistant HIV; 9 Development of HIV-1 Protease Inhibitors, Antiretroviral Resistance, and Current Challenges of HIV/AIDS Management; Part Three: Renin as Target for the Treatment of Hypertension; 10 Discovery and Development of Aliskiren, the First-in-Class Direct Renin Inhibitor for the Treatment of Hypertension 11 Evolution of Diverse Classes of Renin Inhibitors Through the YearsPart Four: ?-Secretase as Target for the Treatment of Alzheimer""s Disease; 12: ?-Secretase: An Unusual Enzyme with Many Possible Disease Targets, Including Alzheimer""s Disease; 13 ?-Secretase Inhibition: An Overview of Development of Inhibitors for the Treatment of Alzheimer's Disease; Part Five: ß-Secretase as Target for the Treatment of Alzheimer's Disease; 14 BACE: A (Almost) Perfect Target for Staving Off Alzheimer's Disease 15 The Discovery of ß-Secretase and Development Toward a Clinical Inhibitor for AD: An Exciting Academic Collaboration16 Peptidomimetic BACE1 Inhibitors for Treatment of Alzheimer.s Disease: Design and Evolution; 17 Nonpeptide BACE1 Inhibitors: Design and Synthesis; Part Six: Plasmepsins and Other Aspartic Proteases as Drug Targets; 18 The Plasmepsin Family as Antimalarial Drug Targets; 19 Plasmepsins Inhibitors as Potential Drugs Against Malaria: Starving the Parasite; 20 Fungal Aspartic Proteases as Possible Therapeutic Targets; Index |
| Record Nr. | UNINA-9911018822903321 |
| Weinheim, : Wiley-VCH, 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Protein kinase inhibitors in research and medicine / edited by Kevan M. Shokat
| Protein kinase inhibitors in research and medicine / edited by Kevan M. Shokat |
| Pubbl/distr/stampa | Amsterdam...[etc.], : Elsevier, copyr. 2014 |
| Descrizione fisica | XII, 241 p., [21] c. di tav. : ill. ; 23 cm |
| Disciplina | 612.01516 |
| Collana | Methods in enzymology |
| Soggetto topico | Biomedicina - Ricerca scientifica - Proteina chinasi C - Metodi |
| ISBN | 978-0-12-397918-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-990006038280203316 |
| Amsterdam...[etc.], : Elsevier, copyr. 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
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Role of Tyrosine Kinases in Gastrointestinal Malignancies / / edited by Ganji Purnachandra Nagaraju
| Role of Tyrosine Kinases in Gastrointestinal Malignancies / / edited by Ganji Purnachandra Nagaraju |
| Edizione | [1st ed. 2018.] |
| Pubbl/distr/stampa | Singapore : , : Springer Singapore : , : Imprint : Springer, , 2018 |
| Descrizione fisica | 1 online resource (249 pages) |
| Disciplina | 612.01516 |
| Soggetto topico |
Cancer - Research
Human physiology Cytology Proteins Gene expression Oncology Cancer Research Human Physiology Cell Biology Receptors Gene Expression |
| ISBN | 981-13-1486-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Chapter 1. 1. Overview of tyrosine kinases and their receptors in gastrointestinal malignancies- -- Chapter 2. EGFR and Erb-B2R (HER2): their role in Esophagus cancer -- Chapter 3. HGFR and FGFR2: their role in progression and metastasis of Esophagus cancer -- Chapter 4. Role of Src and VEGF R tyrosine kinases in Esophagus cancer -- Chapter 5. HGF receptor tyrosine kinase in gastric cancer. - Chapter 6. The EGF/ErbB receptor family of tyrosine kinases in gastric cancer -- Chapter 7. Helicobacter pylori CagA protein: its role and interaction tyrosine kinases in gastric cancer -- Chapter 8. RON receptor tyrosine kinase in pancreatic cancer progression -- Chapter 9. EGFR and Cytoplasmic kinases Src targeting in pancreatic cancer -- Chapter 10. VEGF and PDGFR targeting in pancreatic cancer -- Chapter 11. c-KIT, and FLT-3: their role in Hepatocellular carcinoma -- Chapter 12. VEGFR, and PDGFR: their targeting in Liver Cancer -- Chapter 13. EGFR and FGFR in growth and metastasis of colorectal cancer -- Chapter 14. VEGFR, and PDGFR: their targeting in colorectal cancerm -- Chapter 15. Nano materials and their impact on tyrosine kinase on selected gastrointestinal malignancies -- Chapter 16. Tyrosine kinase inhibitors and their clinical prospective in gastrointestinal malignancies -- Chapter 17. Drug resistance against tyrosine kinase inhibitors in gastrointestinal malignancies -- Chapter 18. Tyrosine kinases: their expression, diagnostic, therapeutic and prognostic aspects in gastrointestinal cancers. |
| Record Nr. | UNINA-9910298430703321 |
| Singapore : , : Springer Singapore : , : Imprint : Springer, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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SH Domains : Structure, Mechanisms and Applications / / edited by Natalya Kurochkina
| SH Domains : Structure, Mechanisms and Applications / / edited by Natalya Kurochkina |
| Edizione | [1st ed. 2015.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015 |
| Descrizione fisica | 1 online resource (252 p.) |
| Disciplina | 612.01516 |
| Soggetto topico |
Proteins
Cytology Protein Science Protein Structure Protein-Ligand Interactions Cell Biology |
| ISBN | 3-319-20098-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | SH3 Domains as Suitable Models to Study Amyloid Aggregation -- SH Domain Proteins in Plants: Roles in Signaling Transduction and Membrane Trafficking -- Versatility of SH3 Domains in the Cellular Machinery -- Structure-Function Relationship of Bacterial SH3 Domains -- Activation of PI3K by Thyroid Hormone Nuclear Receptors -- SH Domains’ Interaction with SliMs: Maximizing Adaptivity of Signaling Networks -- SH Domains and Epidermal Growth Factor Receptor -- SH2 Domain Structures and Interactions -- Cytoskeletal Signaling by Src Homology Domain-Containing Adaptor Proteins -- Structure and Function of Jak3- SH2 Domain -- Helical Assemblies and SH Domains. |
| Record Nr. | UNINA-9910298268003321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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