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Cyclic-nucleotide phosphodiesterases in the central nervous system : from biology to drug discovery / / edited by Nicholas J. Brandon, Anthony R. West
| Cyclic-nucleotide phosphodiesterases in the central nervous system : from biology to drug discovery / / edited by Nicholas J. Brandon, Anthony R. West |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , 2014 |
| Descrizione fisica | 1 online resource (402 p.) |
| Disciplina | 612.01513 |
| Collana | Wiley Series in Drug Discovery and Development |
| Soggetto topico |
Cyclic nucleotide phosphodiesterases
Central nervous system - Physiology Nucleotides, Cyclic |
| ISBN |
1-118-83630-8
1-118-83650-2 1-118-83632-4 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Phosphodiesterases and cyclic nucleotide signaling in the CNS / Marco Conti and Wito Richter -- Putting together the pieces of phosphodiesterase distribution patterns in the brain : a jigsaw puzzle of cyclic nucleotide regulation / Michy P. Kelly -- Compartmentalization and regulation of cyclic nucleotide signalling in the CNS / Manuela Zaccolo and Alessandra Stangherlin -- Pharmacological manipulation of cyclic nucleotide phosphodiesterase signaling for the treatment of neurological and psychiatric disorders in the brain / Frank S. Menniti, Niels Plath, Christopher J. Schmidt, and Niels Svenstrup -- Recent results in phosphodiesterase inhibitor development and CNS applications / David P. Rotella -- Crystal structures of phosphodiesterases and implication on discovery of inhibitors / Hengming Ke, Huanchen Wang, Mengchun Ye, and Yingchun Huang -- Inhibition of cyclic nucleotide phosphodiesterases to regulate memory / Han-Ting Zhang, Ying Xu, James O'Donnell -- Emerging role for PDE4 in neuropsychiatric disorders : translating advances from genetic studies into relevant therapeutic strategies / Sandra P. Zoubovsky, Nicholas J. Brandon P, and Akira Sawa -- Beyond erectile dysfunction : understanding PDE5 activity in the central nervous system / Eva P. P. Bollen, Kris Rutten, Olga A. H. Reneerkens, Harry M.W Steinbusch, and Jos Prickaerts -- Molecular and cellular understanding of PDE10A : a dual-substrate phosphodiesterase with therapeutic potential to modulate basal ganglia function / Erik I. Charych and Nicholas J. Brandon -- Role of cyclic nucleotide signaling and phosphodiesterase activation in the modulation of electrophysiological activity of central neurons / Sarah Threlfell and Anthony R. West -- The role of phosphodiesterases in dopamine systems governing motivated behavior / Gretchen L. Snyder, Akinori Nishi, and Joseph P. Hendrick -- Inhibition of phosphodiesterases as a strategy for treatment of spinal cord injury / Elena Nikulina and Marie T. Filbin. |
| Record Nr. | UNINA-9910132237603321 |
| Hoboken, New Jersey : , : Wiley, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cyclic-nucleotide phosphodiesterases in the central nervous system : from biology to drug discovery / / edited by Nicholas J. Brandon, Anthony R. West
| Cyclic-nucleotide phosphodiesterases in the central nervous system : from biology to drug discovery / / edited by Nicholas J. Brandon, Anthony R. West |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , 2014 |
| Descrizione fisica | 1 online resource (402 p.) |
| Disciplina | 612.01513 |
| Collana | Wiley Series in Drug Discovery and Development |
| Soggetto topico |
Cyclic nucleotide phosphodiesterases
Central nervous system - Physiology Nucleotides, Cyclic |
| ISBN |
1-118-83630-8
1-118-83650-2 1-118-83632-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Phosphodiesterases and cyclic nucleotide signaling in the CNS / Marco Conti and Wito Richter -- Putting together the pieces of phosphodiesterase distribution patterns in the brain : a jigsaw puzzle of cyclic nucleotide regulation / Michy P. Kelly -- Compartmentalization and regulation of cyclic nucleotide signalling in the CNS / Manuela Zaccolo and Alessandra Stangherlin -- Pharmacological manipulation of cyclic nucleotide phosphodiesterase signaling for the treatment of neurological and psychiatric disorders in the brain / Frank S. Menniti, Niels Plath, Christopher J. Schmidt, and Niels Svenstrup -- Recent results in phosphodiesterase inhibitor development and CNS applications / David P. Rotella -- Crystal structures of phosphodiesterases and implication on discovery of inhibitors / Hengming Ke, Huanchen Wang, Mengchun Ye, and Yingchun Huang -- Inhibition of cyclic nucleotide phosphodiesterases to regulate memory / Han-Ting Zhang, Ying Xu, James O'Donnell -- Emerging role for PDE4 in neuropsychiatric disorders : translating advances from genetic studies into relevant therapeutic strategies / Sandra P. Zoubovsky, Nicholas J. Brandon P, and Akira Sawa -- Beyond erectile dysfunction : understanding PDE5 activity in the central nervous system / Eva P. P. Bollen, Kris Rutten, Olga A. H. Reneerkens, Harry M.W Steinbusch, and Jos Prickaerts -- Molecular and cellular understanding of PDE10A : a dual-substrate phosphodiesterase with therapeutic potential to modulate basal ganglia function / Erik I. Charych and Nicholas J. Brandon -- Role of cyclic nucleotide signaling and phosphodiesterase activation in the modulation of electrophysiological activity of central neurons / Sarah Threlfell and Anthony R. West -- The role of phosphodiesterases in dopamine systems governing motivated behavior / Gretchen L. Snyder, Akinori Nishi, and Joseph P. Hendrick -- Inhibition of phosphodiesterases as a strategy for treatment of spinal cord injury / Elena Nikulina and Marie T. Filbin. |
| Record Nr. | UNINA-9910807350503321 |
| Hoboken, New Jersey : , : Wiley, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||