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Carbohydrate recognition [[electronic resource] ] : biological problems, methods, and applications / / edited by Binghe Wang, Geert-Jan Boons
| Carbohydrate recognition [[electronic resource] ] : biological problems, methods, and applications / / edited by Binghe Wang, Geert-Jan Boons |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2011 |
| Descrizione fisica | 1 online resource (450 p.) |
| Disciplina | 612/.01578 |
| Altri autori (Persone) |
WangBinghe
BoonsGeert-Jan |
| Collana | Wiley series in drug discovery and development |
| Soggetto topico | Carbohydrates - Therapeutic use |
| ISBN |
1-283-22788-6
9786613227881 1-118-01757-9 1-118-01758-7 1-118-01756-0 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
CARBOHYDRATE RECOGNITION; PREFACE; CONTRIBUTORS; 1 MAMMALIAN GLYCAN BIOSYNTHESIS: BUILDING A TEMPLATE FOR BIOLOGICAL RECOGNITION; 2 THE ROLES OF CARBOHYDRATE BINDING IN CELL ADHESION AND INFLAMMATION; 3 THE ROLE OF CARBOHYDRATES IN VIRAL INFECTIONS; 4 THE ROLE OF CARBOHYDRATES IN BACTERIAL INFECTIONS; 5 THE ROLES OF CARBOHYDRATE BINDING IN FERTILIZATION; 6 CARBOHYDRATE BIOMARKERS; 7 GALECTINS AND THEIR ROLE IN VARIOUS BIOLOGICAL PROCESSES; 8 GLYCOIMMUNOLOGY; 9 TOOLS FOR GLYCOMICS: GLYCAN AND LECTIN MICROARRAYS; 10 COMBINATORIAL BIOSYNTHESIS OF COMPLEX CARBOHYDRATES
11 MASS SPECTROMETRY IN CARBOHYDRATE SEQUENCING AND BINDING ANALYSIS12 SYNTHETIC LECTIN MIMICS ARTIFICIAL CARBOHYDRATE RECEPTORS; 13 LECTIN BINDING AND ITS STRUCTURAL BASIS; 14 MULTIVALENCY IN CARBOHYDRATE BINDING; 15 CARBOHYDRATE BINDING AGENTS: POTENTIAL THERAPEUTICS WITH MULTIPLE INHIBITORY ACTIONS AGAINST ENVELOPED VIRUSES; 16 INFORMATICS FOR GLYCOBIOLOGY AND GLYCOMICS; INDEX |
| Record Nr. | UNINA-9910139614503321 |
| Hoboken, N.J., : Wiley, c2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Carbohydrate recognition : biological problems, methods, and applications / / edited by Binghe Wang, Geert-Jan Boons
| Carbohydrate recognition : biological problems, methods, and applications / / edited by Binghe Wang, Geert-Jan Boons |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2011 |
| Descrizione fisica | 1 online resource (450 p.) |
| Disciplina | 612/.01578 |
| Altri autori (Persone) |
WangBinghe
BoonsGeert-Jan |
| Collana | Wiley series in drug discovery and development |
| Soggetto topico | Carbohydrates - Therapeutic use |
| ISBN |
9786613227881
9781283227889 1283227886 9781118017579 1118017579 9781118017586 1118017587 9781118017562 1118017560 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
CARBOHYDRATE RECOGNITION; PREFACE; CONTRIBUTORS; 1 MAMMALIAN GLYCAN BIOSYNTHESIS: BUILDING A TEMPLATE FOR BIOLOGICAL RECOGNITION; 2 THE ROLES OF CARBOHYDRATE BINDING IN CELL ADHESION AND INFLAMMATION; 3 THE ROLE OF CARBOHYDRATES IN VIRAL INFECTIONS; 4 THE ROLE OF CARBOHYDRATES IN BACTERIAL INFECTIONS; 5 THE ROLES OF CARBOHYDRATE BINDING IN FERTILIZATION; 6 CARBOHYDRATE BIOMARKERS; 7 GALECTINS AND THEIR ROLE IN VARIOUS BIOLOGICAL PROCESSES; 8 GLYCOIMMUNOLOGY; 9 TOOLS FOR GLYCOMICS: GLYCAN AND LECTIN MICROARRAYS; 10 COMBINATORIAL BIOSYNTHESIS OF COMPLEX CARBOHYDRATES
11 MASS SPECTROMETRY IN CARBOHYDRATE SEQUENCING AND BINDING ANALYSIS12 SYNTHETIC LECTIN MIMICS ARTIFICIAL CARBOHYDRATE RECEPTORS; 13 LECTIN BINDING AND ITS STRUCTURAL BASIS; 14 MULTIVALENCY IN CARBOHYDRATE BINDING; 15 CARBOHYDRATE BINDING AGENTS: POTENTIAL THERAPEUTICS WITH MULTIPLE INHIBITORY ACTIONS AGAINST ENVELOPED VIRUSES; 16 INFORMATICS FOR GLYCOBIOLOGY AND GLYCOMICS; INDEX |
| Record Nr. | UNINA-9910815595203321 |
| Hoboken, N.J., : Wiley, c2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Iminosugars [[electronic resource] ] : from synthesis to therapeutic applications / / editors, Philippe Compain and Olivier R. Martin
| Iminosugars [[electronic resource] ] : from synthesis to therapeutic applications / / editors, Philippe Compain and Olivier R. Martin |
| Pubbl/distr/stampa | Chichester, West Sussex, England ; ; Hoboken, NJ, USA, : J. Wiley, c2007 |
| Descrizione fisica | 1 online resource (487 p.) |
| Disciplina |
572.565
612/.01578 |
| Altri autori (Persone) |
CompainPhilippe
MartinOlivier R |
| Soggetto topico |
Imino sugars - Synthesis
Imino sugars - Therapeutic use |
| ISBN |
1-281-13531-3
9786611135317 0-470-51743-3 0-470-51744-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Iminosugars; Contents; Foreword; Preface; List of contributors; 1 Iminosugars: past, present and future; 2 Naturally occurring iminosugars and related alkaloids: structure, activity and applications; 2.1 Introduction; 2.2 -Glucosidase inhibitors; 2.3 -Glucosidase inhibitors; 2.4 - and -Galactosidase inhibitors; 2.5 -Mannosidase inhibitors; 2.6 Concluding remarks and future prospects; References; 3 General strategies for the synthesis of iminosugars and new approaches towards iminosugar libraries; 3.1 Introduction; 3.2 Monocyclic compounds; 3.3 1-N-Iminosugars; 3.4 Bicyclic compounds
3.5 Other bicyclic compounds3.6 Iminosugar conjugates; 3.7 Conclusions; References; 4 Iminosugar C-glycosides: synthesis and biological activity; 4.1 Introduction; 4.2 Synthesis of iminosugar C-glycosides; 4.3 Biological activity of iminosugar C-glycosides; 4.4 Conclusion; References; 5 Imino-C-disaccharides and analogues: synthesis and biological activity; 5.1 Introduction; 5.2 Synthesis of imino-C-disaccharides; 5.3 Conformations of imino-C-disaccharides; 5.4 Glycosidase inhibitory activities of imino-C-disaccharides 5.5 Efficient combinatorial method for the discovery of glycosidase inhibitors5.6 Antitumour activity of new -mannosidase inhibitors; 5.7 Conclusion; References; 6 Isofagomine, noeuromycin and other 1-azasugars, iminosugar-related glycosidase inhibitors; 6.1 Introduction; 6.2 1-Azasugars that are piperidines (isofagomine, noeuromycin, etc.); 6.3 1-Azasugars that are hydrazines; 6.4 1-Azasugars that are oxazines; 6.5 1-Azasugars that are piperidones; 6.6 Sulphur-containing analogues of 1-azasugars; 6.7 Slow inhibition and thermodynamics of binding 6.8 Are 1-azasugars (and iminosugars) transition state analogues?References; 7 Iminosugar-based glycosyltransferase inhibitors; 7.1 Biological role and structural features of glycosyltransferases; 7.2 Development of inhibitors of glycosyltransferases; 7.3 Conclusion; References; 8 Transition state analogue inhibitors of N-ribosyltransferases; 8.1 Introduction; 8.2 Nucleoside hydrolases; 8.3 Purine nucleoside phosphorylases (PNPs); 8.4 5'-Methylthioadenosine (MTA) nucleosidases and phosphorylases; 8.5 Ricin A-chain; References; 9 Iminosugars as antiviral agents; 9.1 Introduction 9.2 The relationship between glucosidase inhibition and antiviral action9.3 Fate of viral glycoproteins in glucosidase-inhibited cells; 9.4 Specificity of glucosidase inhibition; 9.5 N-Alkyl DNJs inhibit virus growth by non-glucosidase inhibitory mechanisms - other potential activities of these compounds; 9.6 New directions for improving glucosidase inhibitors as antiviral agents; References; 10 Iminosugars as active-site-specific chaperones for the treatment of lysosomal storage disorders; 10.1 Introduction; 10.2 Degradation of glycosphingolipids 10.3 Lysosomal enzyme biosynthesis and ER-associated degradation (ERAD) |
| Record Nr. | UNINA-9910145735503321 |
| Chichester, West Sussex, England ; ; Hoboken, NJ, USA, : J. Wiley, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Iminosugars [[electronic resource] ] : from synthesis to therapeutic applications / / editors, Philippe Compain and Olivier R. Martin
| Iminosugars [[electronic resource] ] : from synthesis to therapeutic applications / / editors, Philippe Compain and Olivier R. Martin |
| Pubbl/distr/stampa | Chichester, West Sussex, England ; ; Hoboken, NJ, USA, : J. Wiley, c2007 |
| Descrizione fisica | 1 online resource (487 p.) |
| Disciplina |
572.565
612/.01578 |
| Altri autori (Persone) |
CompainPhilippe
MartinOlivier R |
| Soggetto topico |
Imino sugars - Synthesis
Imino sugars - Therapeutic use |
| ISBN |
1-281-13531-3
9786611135317 0-470-51743-3 0-470-51744-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Iminosugars; Contents; Foreword; Preface; List of contributors; 1 Iminosugars: past, present and future; 2 Naturally occurring iminosugars and related alkaloids: structure, activity and applications; 2.1 Introduction; 2.2 -Glucosidase inhibitors; 2.3 -Glucosidase inhibitors; 2.4 - and -Galactosidase inhibitors; 2.5 -Mannosidase inhibitors; 2.6 Concluding remarks and future prospects; References; 3 General strategies for the synthesis of iminosugars and new approaches towards iminosugar libraries; 3.1 Introduction; 3.2 Monocyclic compounds; 3.3 1-N-Iminosugars; 3.4 Bicyclic compounds
3.5 Other bicyclic compounds3.6 Iminosugar conjugates; 3.7 Conclusions; References; 4 Iminosugar C-glycosides: synthesis and biological activity; 4.1 Introduction; 4.2 Synthesis of iminosugar C-glycosides; 4.3 Biological activity of iminosugar C-glycosides; 4.4 Conclusion; References; 5 Imino-C-disaccharides and analogues: synthesis and biological activity; 5.1 Introduction; 5.2 Synthesis of imino-C-disaccharides; 5.3 Conformations of imino-C-disaccharides; 5.4 Glycosidase inhibitory activities of imino-C-disaccharides 5.5 Efficient combinatorial method for the discovery of glycosidase inhibitors5.6 Antitumour activity of new -mannosidase inhibitors; 5.7 Conclusion; References; 6 Isofagomine, noeuromycin and other 1-azasugars, iminosugar-related glycosidase inhibitors; 6.1 Introduction; 6.2 1-Azasugars that are piperidines (isofagomine, noeuromycin, etc.); 6.3 1-Azasugars that are hydrazines; 6.4 1-Azasugars that are oxazines; 6.5 1-Azasugars that are piperidones; 6.6 Sulphur-containing analogues of 1-azasugars; 6.7 Slow inhibition and thermodynamics of binding 6.8 Are 1-azasugars (and iminosugars) transition state analogues?References; 7 Iminosugar-based glycosyltransferase inhibitors; 7.1 Biological role and structural features of glycosyltransferases; 7.2 Development of inhibitors of glycosyltransferases; 7.3 Conclusion; References; 8 Transition state analogue inhibitors of N-ribosyltransferases; 8.1 Introduction; 8.2 Nucleoside hydrolases; 8.3 Purine nucleoside phosphorylases (PNPs); 8.4 5'-Methylthioadenosine (MTA) nucleosidases and phosphorylases; 8.5 Ricin A-chain; References; 9 Iminosugars as antiviral agents; 9.1 Introduction 9.2 The relationship between glucosidase inhibition and antiviral action9.3 Fate of viral glycoproteins in glucosidase-inhibited cells; 9.4 Specificity of glucosidase inhibition; 9.5 N-Alkyl DNJs inhibit virus growth by non-glucosidase inhibitory mechanisms - other potential activities of these compounds; 9.6 New directions for improving glucosidase inhibitors as antiviral agents; References; 10 Iminosugars as active-site-specific chaperones for the treatment of lysosomal storage disorders; 10.1 Introduction; 10.2 Degradation of glycosphingolipids 10.3 Lysosomal enzyme biosynthesis and ER-associated degradation (ERAD) |
| Record Nr. | UNINA-9910830224103321 |
| Chichester, West Sussex, England ; ; Hoboken, NJ, USA, : J. Wiley, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Iminosugars : from synthesis to therapeutic applications / / editors, Philippe Compain and Olivier R. Martin
| Iminosugars : from synthesis to therapeutic applications / / editors, Philippe Compain and Olivier R. Martin |
| Pubbl/distr/stampa | Chichester, West Sussex, England ; ; Hoboken, NJ, USA, : J. Wiley, c2007 |
| Descrizione fisica | 1 online resource (487 p.) |
| Disciplina | 612/.01578 |
| Altri autori (Persone) |
CompainPhilippe
MartinOlivier R |
| Soggetto topico |
Imino sugars - Synthesis
Imino sugars - Therapeutic use |
| ISBN |
9786611135317
9781281135315 1281135313 9780470517437 0470517433 9780470517444 0470517441 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Iminosugars; Contents; Foreword; Preface; List of contributors; 1 Iminosugars: past, present and future; 2 Naturally occurring iminosugars and related alkaloids: structure, activity and applications; 2.1 Introduction; 2.2 -Glucosidase inhibitors; 2.3 -Glucosidase inhibitors; 2.4 - and -Galactosidase inhibitors; 2.5 -Mannosidase inhibitors; 2.6 Concluding remarks and future prospects; References; 3 General strategies for the synthesis of iminosugars and new approaches towards iminosugar libraries; 3.1 Introduction; 3.2 Monocyclic compounds; 3.3 1-N-Iminosugars; 3.4 Bicyclic compounds
3.5 Other bicyclic compounds3.6 Iminosugar conjugates; 3.7 Conclusions; References; 4 Iminosugar C-glycosides: synthesis and biological activity; 4.1 Introduction; 4.2 Synthesis of iminosugar C-glycosides; 4.3 Biological activity of iminosugar C-glycosides; 4.4 Conclusion; References; 5 Imino-C-disaccharides and analogues: synthesis and biological activity; 5.1 Introduction; 5.2 Synthesis of imino-C-disaccharides; 5.3 Conformations of imino-C-disaccharides; 5.4 Glycosidase inhibitory activities of imino-C-disaccharides 5.5 Efficient combinatorial method for the discovery of glycosidase inhibitors5.6 Antitumour activity of new -mannosidase inhibitors; 5.7 Conclusion; References; 6 Isofagomine, noeuromycin and other 1-azasugars, iminosugar-related glycosidase inhibitors; 6.1 Introduction; 6.2 1-Azasugars that are piperidines (isofagomine, noeuromycin, etc.); 6.3 1-Azasugars that are hydrazines; 6.4 1-Azasugars that are oxazines; 6.5 1-Azasugars that are piperidones; 6.6 Sulphur-containing analogues of 1-azasugars; 6.7 Slow inhibition and thermodynamics of binding 6.8 Are 1-azasugars (and iminosugars) transition state analogues?References; 7 Iminosugar-based glycosyltransferase inhibitors; 7.1 Biological role and structural features of glycosyltransferases; 7.2 Development of inhibitors of glycosyltransferases; 7.3 Conclusion; References; 8 Transition state analogue inhibitors of N-ribosyltransferases; 8.1 Introduction; 8.2 Nucleoside hydrolases; 8.3 Purine nucleoside phosphorylases (PNPs); 8.4 5'-Methylthioadenosine (MTA) nucleosidases and phosphorylases; 8.5 Ricin A-chain; References; 9 Iminosugars as antiviral agents; 9.1 Introduction 9.2 The relationship between glucosidase inhibition and antiviral action9.3 Fate of viral glycoproteins in glucosidase-inhibited cells; 9.4 Specificity of glucosidase inhibition; 9.5 N-Alkyl DNJs inhibit virus growth by non-glucosidase inhibitory mechanisms - other potential activities of these compounds; 9.6 New directions for improving glucosidase inhibitors as antiviral agents; References; 10 Iminosugars as active-site-specific chaperones for the treatment of lysosomal storage disorders; 10.1 Introduction; 10.2 Degradation of glycosphingolipids 10.3 Lysosomal enzyme biosynthesis and ER-associated degradation (ERAD) |
| Record Nr. | UNINA-9911019314703321 |
| Chichester, West Sussex, England ; ; Hoboken, NJ, USA, : J. Wiley, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||