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Amino acids in human nutrition and health [[electronic resource] /] / edited by J.P.F. D'Mello
Amino acids in human nutrition and health [[electronic resource] /] / edited by J.P.F. D'Mello
Pubbl/distr/stampa Wallingford, Oxfordshire ; ; Cambridge, MA, : CABI, c2012
Descrizione fisica 1 online resource (578 p.)
Disciplina 612.015756
612/.015756
Altri autori (Persone) D'MelloJ. P. Felix
Soggetto topico Amino acids in human nutrition
Amino acids - Metabolism
ISBN 1-283-42582-3
9786613425829
1-84593-901-8
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Contents; Contributors; Preface; Glossary; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; R; S; T; U; V; W; PART I: ENZYMES AND METABOLISM; 1 Glutamate Dehydrogenase; 1.1 Abstract; 1.2 Introduction; 1.3 GDH in Animals; 1.4 Active Site; 1.5 Role of GDH in Insulin Homeostasis; 1.6 Evolution of GDH Allostery; 1.7 Conclusions; 1.8 Acknowledgements; 2 Aminotransferases; 2.1 Abstract; 2.2 Introduction; 2.3 The Role of Aminotransferases in Brain Metabolism; 2.4 Alanine Aminotransferases and Glutamate
2.5 Aspartate Aminotransferases and their Role in the Malate-Aspartate Shuttle and Glutamate Metabolism2.6 Pathological Conditions Resulting from Impaired Aminotransferase Metabolism; 2.7 Aminotransferase Proteins as Biomarkers of Disease; 2.8 Conclusions and Future Directions; 3 Arginase; 3.1 Abstract; 3.2 Introduction; 3.3 Isoforms and Distribution; 3.4 Structure and Location of Arginase; 3.5 Involvement of Arginase in Health and Disease; 3.6 Regulation of Activity; 3.7 Arginase Inhibitors; 3.8 Conclusions
4 Bypassing the Endothelial L-Arginine-Nitric Oxide Pathway: Effects of Dietary Nitrite and Nitrate on Cardiovascular Function4.1 Abstract; 4.2 Introduction; 4.3 L-Arginine: A Semi-Essential Amino Acid in Human Physiology; 4.4 L-Arginine is the Substrate of the Nitric Oxide Synthases: The L-Arginine-Nitric Oxide Pathway; 4.5 L-Arginine in Cardiovascular Disease: Perspectives and Limitations; 4.6 Nitric Oxide Generation without NO-Synthase? Bypassing the L-Arginine Pathway; 4.7 The Nitrate-Nitrite-Nitric Oxide Pathway; 4.8 Effects of Nitrite and Nitrate in Human Physiology
4.9 Dietary Nitrate and Nitrite4.10 Conclusions; 4.11 Acknowledgements; 5 Histidine Decarboxylase; 5.1 Abstract; 5.2 Introduction; 5.3 Histidine Decarboxylase Enzyme; 5.4 Histidine Decarboxylase Gene; 5.5 Pharmacological Inhibition; 5.6 mRNA Antisense and Gene Knockout; 5.7 Neurophysiology and Behaviour; 5.8 Summary and Conclusions; 5.9 Acknowledgements; 6 Glutamate Decarboxylase; 6.1 Abstract; 6.2 Introduction; 6.3 Distribution of GABA; 6.4 GAD 65 in Blood Leucocytes; 6.5 Taste Signalling; 6.6 Suggestions for Future Research; 6.7 Conclusions; 6.8 Acknowledgements; 7 Glutaminase; 7.1 Abstract
7.2 Introduction7.3 Mammalian Glutaminase Genes and Transcripts; 7.4 Mammalian Glutaminase Enzymes; 7.5 Glutaminase Expression in Mammalian Brain; 7.6 State of Art and Perspectives; 7.7 Conclusions; 7.8 Acknowledgements; 8 D-Serine and Serine Racemase in the Retina; 8.1 Abstract; 8.2 Introduction; 8.3 NMDA Receptor and D-serine as a Co-agonist; 8.4 D-Serine in the Retina; 8.5 Mechanisms of D-Serine Uptake in the Retina; 8.6 D-Serine and Serine Racemase in Retinal Neurons; 8.7 Role of D-Serine in the Retina; 8.8 Role of D-Serine and Serine Racemase in Neuronal Cell Death; 8.9 Conclusions
8.10 Acknowledgements
Record Nr. UNINA-9910627299803321
Wallingford, Oxfordshire ; ; Cambridge, MA, : CABI, c2012
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Biology of IGF-1 [[electronic resource] ] : its interaction with insulin in health and malignant states / / [edited by Gregory Bock, Jamie Goode]
Biology of IGF-1 [[electronic resource] ] : its interaction with insulin in health and malignant states / / [edited by Gregory Bock, Jamie Goode]
Pubbl/distr/stampa The Atrium, Southern Gate, Chichester, UK ; ; Hoboken, NJ, : John Wiley & Sons, c2004
Descrizione fisica 1 online resource (294 p.)
Disciplina 612.01575
612/.015756
Altri autori (Persone) BockGregory
GoodeJamie
Collana Novartis Foundation symposium
Soggetto topico Somatomedin - Physiological effect
Somatomedin - Pathophysiology
Carcinogenesis
Soggetto genere / forma Electronic books.
ISBN 1-280-27251-1
9786610272518
0-470-66753-2
0-470-86997-6
0-470-86999-2
Classificazione 44.78
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Circulating IGF-I and its role in cancer: lessons from the IGF-1 gene-deletion (LID) mouse -- Physiology of the IGF system -- Molecular basis of insulin action -- IGF-1 and insulin as growth hormones -- Insulin-like growth factors and neoplasia -- Loss of IGF2 imprinting: mechanisms and consequences -- Insulin and IGF-1 receptor trafficking and signalling -- The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb -- Structural biology of insulin and IGF-1 receptors -- Genetic blockade of the insulin-like growth factor-I receptor for human malignancy -- IGF-1 and prostate cancer -- IGF-1 and breast cancer -- IGFBPs and cancer -- The IGF receptor as anticancer treatment target -- Nutrition, insulin, IGF-1 metabolism and cancer risk: a summary of epidemiological evidence.
Record Nr. UNINA-9910143555703321
The Atrium, Southern Gate, Chichester, UK ; ; Hoboken, NJ, : John Wiley & Sons, c2004
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Biology of IGF-1 [[electronic resource] ] : its interaction with insulin in health and malignant states / / [edited by Gregory Bock, Jamie Goode]
Biology of IGF-1 [[electronic resource] ] : its interaction with insulin in health and malignant states / / [edited by Gregory Bock, Jamie Goode]
Pubbl/distr/stampa The Atrium, Southern Gate, Chichester, UK ; ; Hoboken, NJ, : John Wiley & Sons, c2004
Descrizione fisica 1 online resource (294 p.)
Disciplina 612.01575
612/.015756
Altri autori (Persone) BockGregory
GoodeJamie
Collana Novartis Foundation symposium
Soggetto topico Somatomedin - Physiological effect
Somatomedin - Pathophysiology
Carcinogenesis
ISBN 1-280-27251-1
9786610272518
0-470-66753-2
0-470-86997-6
0-470-86999-2
Classificazione 44.78
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Circulating IGF-I and its role in cancer: lessons from the IGF-1 gene-deletion (LID) mouse -- Physiology of the IGF system -- Molecular basis of insulin action -- IGF-1 and insulin as growth hormones -- Insulin-like growth factors and neoplasia -- Loss of IGF2 imprinting: mechanisms and consequences -- Insulin and IGF-1 receptor trafficking and signalling -- The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb -- Structural biology of insulin and IGF-1 receptors -- Genetic blockade of the insulin-like growth factor-I receptor for human malignancy -- IGF-1 and prostate cancer -- IGF-1 and breast cancer -- IGFBPs and cancer -- The IGF receptor as anticancer treatment target -- Nutrition, insulin, IGF-1 metabolism and cancer risk: a summary of epidemiological evidence.
Record Nr. UNINA-9910830531903321
The Atrium, Southern Gate, Chichester, UK ; ; Hoboken, NJ, : John Wiley & Sons, c2004
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Biology of IGF-1 [[electronic resource] ] : its interaction with insulin in health and malignant states / / [edited by Gregory Bock, Jamie Goode]
Biology of IGF-1 [[electronic resource] ] : its interaction with insulin in health and malignant states / / [edited by Gregory Bock, Jamie Goode]
Pubbl/distr/stampa The Atrium, Southern Gate, Chichester, UK ; ; Hoboken, NJ, : John Wiley & Sons, c2004
Descrizione fisica 1 online resource (294 p.)
Disciplina 612.01575
612/.015756
Altri autori (Persone) BockGregory
GoodeJamie
Collana Novartis Foundation symposium
Soggetto topico Somatomedin - Physiological effect
Somatomedin - Pathophysiology
Carcinogenesis
ISBN 1-280-27251-1
9786610272518
0-470-66753-2
0-470-86997-6
0-470-86999-2
Classificazione 44.78
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Circulating IGF-I and its role in cancer: lessons from the IGF-1 gene-deletion (LID) mouse -- Physiology of the IGF system -- Molecular basis of insulin action -- IGF-1 and insulin as growth hormones -- Insulin-like growth factors and neoplasia -- Loss of IGF2 imprinting: mechanisms and consequences -- Insulin and IGF-1 receptor trafficking and signalling -- The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb -- Structural biology of insulin and IGF-1 receptors -- Genetic blockade of the insulin-like growth factor-I receptor for human malignancy -- IGF-1 and prostate cancer -- IGF-1 and breast cancer -- IGFBPs and cancer -- The IGF receptor as anticancer treatment target -- Nutrition, insulin, IGF-1 metabolism and cancer risk: a summary of epidemiological evidence.
Record Nr. UNINA-9910841087903321
The Atrium, Southern Gate, Chichester, UK ; ; Hoboken, NJ, : John Wiley & Sons, c2004
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Chemical ligation : tools for biomolecule synthesis and modification / / edited by Luca D. D'Andrea and Alessandra Romanelli
Chemical ligation : tools for biomolecule synthesis and modification / / edited by Luca D. D'Andrea and Alessandra Romanelli
Pubbl/distr/stampa Hoboken, New Jersey : , : Wiley, , 2017
Descrizione fisica 1 online resource (583 pages) : illustrations (some color)
Disciplina 612/.015756
Soggetto topico Biosynthesis
Peptides - Synthesis
Proteins - Synthesis
Bioorganic chemistry
Chemistry, Organic
ISBN 1-119-04413-8
1-119-04409-X
1-119-04411-1
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910271052903321
Hoboken, New Jersey : , : Wiley, , 2017
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Chemical ligation : tools for biomolecule synthesis and modification / / edited by Luca D. D'Andrea and Alessandra Romanelli
Chemical ligation : tools for biomolecule synthesis and modification / / edited by Luca D. D'Andrea and Alessandra Romanelli
Pubbl/distr/stampa Hoboken, New Jersey : , : Wiley, , 2017
Descrizione fisica 1 online resource (583 pages) : illustrations (some color)
Disciplina 612/.015756
Soggetto topico Biosynthesis
Peptides - Synthesis
Proteins - Synthesis
Bioorganic chemistry
Chemistry, Organic
ISBN 1-119-04413-8
1-119-04409-X
1-119-04411-1
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910807725603321
Hoboken, New Jersey : , : Wiley, , 2017
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Flexible viruses [[electronic resource] ] : structural disorder in viral proteins / / edited by Vladimir Uversky, Sonia Longhi
Flexible viruses [[electronic resource] ] : structural disorder in viral proteins / / edited by Vladimir Uversky, Sonia Longhi
Autore Uversky Vladimir N
Pubbl/distr/stampa Hoboken, N.J., : Wiley, c2012
Descrizione fisica 1 online resource (534 p.)
Disciplina 612/.015756
Altri autori (Persone) LonghiSonia
Collana Wiley series in protein and peptide science
Soggetto topico Viral proteins
ISBN 1-283-31596-3
9786613315960
1-118-13556-3
1-118-13557-1
1-118-13554-7
Classificazione SCI007000
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto FLEXIBLE VIRUSES; CONTENTS; Preface; Introduction to the Wiley Series on Protein and Peptide Science; Contributors; 1 Do Viral Proteins Possess Unique Features?; 2 Functional Role of Structural Disorder in Capsid Proteins; 3 Structural Disorder Within the Nucleoprotein and Phosphoprotein from Measles, Nipah, and Hendra Viruses; 4 Structural Disorder Within Sendai Virus Nucleoprotein and Phosphoprotein; 5 Structural Disorder in Proteins of the Rhabdoviridae Replication Complex; 6 Structural Disorder in Matrix Proteins of HIV-Related Viruses
7 Structural Disorder in Proteins From Influenza Virus8 Making Order in the Intrinsically Disordered Regions of HIV-1 Vif Protein; 9 Order from Disorder: Structure, Function, and Dynamics of the HIV-1 Transactivator of Transcription; 10 Intrinsically Disordered Domains of Sesbania Mosaic Virus Encoded Proteins; 11 Intrinsic Disorder in Genome-Linked Viral Proteins VPgs of Potyviruses; 12 Intrinsic Disorder in the Human Papillomavirus E7 Protein; 13 The Semliki Forest Virus Capsid Protease is Disordered and Yet Displays Catalytic Activity
14 Core-lations Between Intrinsic Disorder and Multifaceted Activities in Hepatitis C Virus and Related Viruses15 The NS5A Domain II of HCV: Conservation of Intrinsic Disorder in Several Genotypes; 16 Bacteriophage l N Protein Disorder-Order Transitions Upon Interactions with RNA or Proteins; 17 N-Terminal Extension Region of Hordeivirus Movement TGB1 Protein Consists of Two Domains with Different Content of Disordered Structure; Index
Record Nr. UNINA-9910141216203321
Uversky Vladimir N  
Hoboken, N.J., : Wiley, c2012
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Flexible viruses [[electronic resource] ] : structural disorder in viral proteins / / edited by Vladimir Uversky, Sonia Longhi
Flexible viruses [[electronic resource] ] : structural disorder in viral proteins / / edited by Vladimir Uversky, Sonia Longhi
Autore Uversky Vladimir N
Pubbl/distr/stampa Hoboken, N.J., : Wiley, c2012
Descrizione fisica 1 online resource (534 p.)
Disciplina 612/.015756
Altri autori (Persone) LonghiSonia
Collana Wiley series in protein and peptide science
Soggetto topico Viral proteins
ISBN 1-283-31596-3
9786613315960
1-118-13556-3
1-118-13557-1
1-118-13554-7
Classificazione SCI007000
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto FLEXIBLE VIRUSES; CONTENTS; Preface; Introduction to the Wiley Series on Protein and Peptide Science; Contributors; 1 Do Viral Proteins Possess Unique Features?; 2 Functional Role of Structural Disorder in Capsid Proteins; 3 Structural Disorder Within the Nucleoprotein and Phosphoprotein from Measles, Nipah, and Hendra Viruses; 4 Structural Disorder Within Sendai Virus Nucleoprotein and Phosphoprotein; 5 Structural Disorder in Proteins of the Rhabdoviridae Replication Complex; 6 Structural Disorder in Matrix Proteins of HIV-Related Viruses
7 Structural Disorder in Proteins From Influenza Virus8 Making Order in the Intrinsically Disordered Regions of HIV-1 Vif Protein; 9 Order from Disorder: Structure, Function, and Dynamics of the HIV-1 Transactivator of Transcription; 10 Intrinsically Disordered Domains of Sesbania Mosaic Virus Encoded Proteins; 11 Intrinsic Disorder in Genome-Linked Viral Proteins VPgs of Potyviruses; 12 Intrinsic Disorder in the Human Papillomavirus E7 Protein; 13 The Semliki Forest Virus Capsid Protease is Disordered and Yet Displays Catalytic Activity
14 Core-lations Between Intrinsic Disorder and Multifaceted Activities in Hepatitis C Virus and Related Viruses15 The NS5A Domain II of HCV: Conservation of Intrinsic Disorder in Several Genotypes; 16 Bacteriophage l N Protein Disorder-Order Transitions Upon Interactions with RNA or Proteins; 17 N-Terminal Extension Region of Hordeivirus Movement TGB1 Protein Consists of Two Domains with Different Content of Disordered Structure; Index
Record Nr. UNINA-9910809692803321
Uversky Vladimir N  
Hoboken, N.J., : Wiley, c2012
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
GPCR molecular pharmacology and drug targeting [[electronic resource] ] : shifting paradigms and new directions / / edited by Annette Gilchrist
GPCR molecular pharmacology and drug targeting [[electronic resource] ] : shifting paradigms and new directions / / edited by Annette Gilchrist
Pubbl/distr/stampa Hoboken, N.J., : Wiley, c2010
Descrizione fisica 1 online resource (544 p.)
Disciplina 612/.015756
Altri autori (Persone) GilchristAnnette
Soggetto topico G proteins
Drug targeting
ISBN 1-118-03517-8
1-282-68599-6
9786612685996
0-470-62732-8
0-470-62731-X
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto GPCR MOLECULAR PHARMACOLOGY AND DRUG TARGETING: SHIFTING PARADIGMS AND NEW DIRECTIONS; CONTENTS; PREFACE; CONTRIBUTORS; CHAPTER 1: The Evolution of Receptors: From On-Off Switches to Microprocessors; CHAPTER 2: The Evolving Pharmacology of GPCRs; CHAPTER 3: The Emergence of Allosteric Modulators for G Protein - Coupled Receptors; CHAPTER 4: Receptor-Mediated G Protein Activation: How, How Many, and Where?; CHAPTER 5: Molecular Pharmacology of Frizzleds-with Implications for Possible Therapy
CHAPTER 6: Secretin Receptor Dimerization: A Possible Functionally Important Paradigm for Family B G Protein-Coupled ReceptorsCHAPTER 7: Past and Future Strategies for GPCR Deorphanization; CHAPTER 8: High-Throughput GPCR Screening Technologies and the Emerging Importance of the Cell Phenotype; CHAPTER 9: Are "Traditional" Biochemical Techniques Out of Fashion in the New Era of GPCR Pharmacology?; CHAPTER 10: Fluorescence and Resonance Energy Transfer Shine New Light on GPCR Function; CHAPTER 11: Integration of Label-Free Detection Methods in GPCR Drug Discovery
CHAPTER 12: Screening for Allosteric Modulators of G Protein-Coupled ReceptorsCHAPTER 13: Ultra-High-Throughput Screening Assays for GPCRs; CHAPTER 14: New Techniques to Express and Crystallize G Protein-Coupled Receptors; CHAPTER 15: Structure and Modeling of GPCRs: Implications for Drug Discovery; CHAPTER 16: X-Ray Structure Developments for GPCR Drug Targets; CHAPTER 17: Pharmacological Chaperones: Potential for the Treatment of Hereditary Diseases Caused by Mutations in G Protein-Coupled Receptors; INDEX
Record Nr. UNINA-9910139201903321
Hoboken, N.J., : Wiley, c2010
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
GPCR molecular pharmacology and drug targeting [[electronic resource] ] : shifting paradigms and new directions / / edited by Annette Gilchrist
GPCR molecular pharmacology and drug targeting [[electronic resource] ] : shifting paradigms and new directions / / edited by Annette Gilchrist
Pubbl/distr/stampa Hoboken, N.J., : Wiley, c2010
Descrizione fisica 1 online resource (544 p.)
Disciplina 612/.015756
Altri autori (Persone) GilchristAnnette
Soggetto topico G proteins
Drug targeting
ISBN 1-118-03517-8
1-282-68599-6
9786612685996
0-470-62732-8
0-470-62731-X
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto GPCR MOLECULAR PHARMACOLOGY AND DRUG TARGETING: SHIFTING PARADIGMS AND NEW DIRECTIONS; CONTENTS; PREFACE; CONTRIBUTORS; CHAPTER 1: The Evolution of Receptors: From On-Off Switches to Microprocessors; CHAPTER 2: The Evolving Pharmacology of GPCRs; CHAPTER 3: The Emergence of Allosteric Modulators for G Protein - Coupled Receptors; CHAPTER 4: Receptor-Mediated G Protein Activation: How, How Many, and Where?; CHAPTER 5: Molecular Pharmacology of Frizzleds-with Implications for Possible Therapy
CHAPTER 6: Secretin Receptor Dimerization: A Possible Functionally Important Paradigm for Family B G Protein-Coupled ReceptorsCHAPTER 7: Past and Future Strategies for GPCR Deorphanization; CHAPTER 8: High-Throughput GPCR Screening Technologies and the Emerging Importance of the Cell Phenotype; CHAPTER 9: Are "Traditional" Biochemical Techniques Out of Fashion in the New Era of GPCR Pharmacology?; CHAPTER 10: Fluorescence and Resonance Energy Transfer Shine New Light on GPCR Function; CHAPTER 11: Integration of Label-Free Detection Methods in GPCR Drug Discovery
CHAPTER 12: Screening for Allosteric Modulators of G Protein-Coupled ReceptorsCHAPTER 13: Ultra-High-Throughput Screening Assays for GPCRs; CHAPTER 14: New Techniques to Express and Crystallize G Protein-Coupled Receptors; CHAPTER 15: Structure and Modeling of GPCRs: Implications for Drug Discovery; CHAPTER 16: X-Ray Structure Developments for GPCR Drug Targets; CHAPTER 17: Pharmacological Chaperones: Potential for the Treatment of Hereditary Diseases Caused by Mutations in G Protein-Coupled Receptors; INDEX
Record Nr. UNINA-9910811243903321
Hoboken, N.J., : Wiley, c2010
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui