Amino acids in human nutrition and health [[electronic resource] /] / edited by J.P.F. D'Mello |
Pubbl/distr/stampa | Wallingford, Oxfordshire ; ; Cambridge, MA, : CABI, c2012 |
Descrizione fisica | 1 online resource (578 p.) |
Disciplina |
612.015756
612/.015756 |
Altri autori (Persone) | D'MelloJ. P. Felix |
Soggetto topico |
Amino acids in human nutrition
Amino acids - Metabolism |
ISBN |
1-283-42582-3
9786613425829 1-84593-901-8 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Contents; Contributors; Preface; Glossary; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; R; S; T; U; V; W; PART I: ENZYMES AND METABOLISM; 1 Glutamate Dehydrogenase; 1.1 Abstract; 1.2 Introduction; 1.3 GDH in Animals; 1.4 Active Site; 1.5 Role of GDH in Insulin Homeostasis; 1.6 Evolution of GDH Allostery; 1.7 Conclusions; 1.8 Acknowledgements; 2 Aminotransferases; 2.1 Abstract; 2.2 Introduction; 2.3 The Role of Aminotransferases in Brain Metabolism; 2.4 Alanine Aminotransferases and Glutamate
2.5 Aspartate Aminotransferases and their Role in the Malate-Aspartate Shuttle and Glutamate Metabolism2.6 Pathological Conditions Resulting from Impaired Aminotransferase Metabolism; 2.7 Aminotransferase Proteins as Biomarkers of Disease; 2.8 Conclusions and Future Directions; 3 Arginase; 3.1 Abstract; 3.2 Introduction; 3.3 Isoforms and Distribution; 3.4 Structure and Location of Arginase; 3.5 Involvement of Arginase in Health and Disease; 3.6 Regulation of Activity; 3.7 Arginase Inhibitors; 3.8 Conclusions 4 Bypassing the Endothelial L-Arginine-Nitric Oxide Pathway: Effects of Dietary Nitrite and Nitrate on Cardiovascular Function4.1 Abstract; 4.2 Introduction; 4.3 L-Arginine: A Semi-Essential Amino Acid in Human Physiology; 4.4 L-Arginine is the Substrate of the Nitric Oxide Synthases: The L-Arginine-Nitric Oxide Pathway; 4.5 L-Arginine in Cardiovascular Disease: Perspectives and Limitations; 4.6 Nitric Oxide Generation without NO-Synthase? Bypassing the L-Arginine Pathway; 4.7 The Nitrate-Nitrite-Nitric Oxide Pathway; 4.8 Effects of Nitrite and Nitrate in Human Physiology 4.9 Dietary Nitrate and Nitrite4.10 Conclusions; 4.11 Acknowledgements; 5 Histidine Decarboxylase; 5.1 Abstract; 5.2 Introduction; 5.3 Histidine Decarboxylase Enzyme; 5.4 Histidine Decarboxylase Gene; 5.5 Pharmacological Inhibition; 5.6 mRNA Antisense and Gene Knockout; 5.7 Neurophysiology and Behaviour; 5.8 Summary and Conclusions; 5.9 Acknowledgements; 6 Glutamate Decarboxylase; 6.1 Abstract; 6.2 Introduction; 6.3 Distribution of GABA; 6.4 GAD 65 in Blood Leucocytes; 6.5 Taste Signalling; 6.6 Suggestions for Future Research; 6.7 Conclusions; 6.8 Acknowledgements; 7 Glutaminase; 7.1 Abstract 7.2 Introduction7.3 Mammalian Glutaminase Genes and Transcripts; 7.4 Mammalian Glutaminase Enzymes; 7.5 Glutaminase Expression in Mammalian Brain; 7.6 State of Art and Perspectives; 7.7 Conclusions; 7.8 Acknowledgements; 8 D-Serine and Serine Racemase in the Retina; 8.1 Abstract; 8.2 Introduction; 8.3 NMDA Receptor and D-serine as a Co-agonist; 8.4 D-Serine in the Retina; 8.5 Mechanisms of D-Serine Uptake in the Retina; 8.6 D-Serine and Serine Racemase in Retinal Neurons; 8.7 Role of D-Serine in the Retina; 8.8 Role of D-Serine and Serine Racemase in Neuronal Cell Death; 8.9 Conclusions 8.10 Acknowledgements |
Record Nr. | UNINA-9910627299803321 |
Wallingford, Oxfordshire ; ; Cambridge, MA, : CABI, c2012 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Biology of IGF-1 [[electronic resource] ] : its interaction with insulin in health and malignant states / / [edited by Gregory Bock, Jamie Goode] |
Pubbl/distr/stampa | The Atrium, Southern Gate, Chichester, UK ; ; Hoboken, NJ, : John Wiley & Sons, c2004 |
Descrizione fisica | 1 online resource (294 p.) |
Disciplina |
612.01575
612/.015756 |
Altri autori (Persone) |
BockGregory
GoodeJamie |
Collana | Novartis Foundation symposium |
Soggetto topico |
Somatomedin - Physiological effect
Somatomedin - Pathophysiology Carcinogenesis |
Soggetto genere / forma | Electronic books. |
ISBN |
1-280-27251-1
9786610272518 0-470-66753-2 0-470-86997-6 0-470-86999-2 |
Classificazione | 44.78 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Circulating IGF-I and its role in cancer: lessons from the IGF-1 gene-deletion (LID) mouse -- Physiology of the IGF system -- Molecular basis of insulin action -- IGF-1 and insulin as growth hormones -- Insulin-like growth factors and neoplasia -- Loss of IGF2 imprinting: mechanisms and consequences -- Insulin and IGF-1 receptor trafficking and signalling -- The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb -- Structural biology of insulin and IGF-1 receptors -- Genetic blockade of the insulin-like growth factor-I receptor for human malignancy -- IGF-1 and prostate cancer -- IGF-1 and breast cancer -- IGFBPs and cancer -- The IGF receptor as anticancer treatment target -- Nutrition, insulin, IGF-1 metabolism and cancer risk: a summary of epidemiological evidence. |
Record Nr. | UNINA-9910143555703321 |
The Atrium, Southern Gate, Chichester, UK ; ; Hoboken, NJ, : John Wiley & Sons, c2004 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Biology of IGF-1 [[electronic resource] ] : its interaction with insulin in health and malignant states / / [edited by Gregory Bock, Jamie Goode] |
Pubbl/distr/stampa | The Atrium, Southern Gate, Chichester, UK ; ; Hoboken, NJ, : John Wiley & Sons, c2004 |
Descrizione fisica | 1 online resource (294 p.) |
Disciplina |
612.01575
612/.015756 |
Altri autori (Persone) |
BockGregory
GoodeJamie |
Collana | Novartis Foundation symposium |
Soggetto topico |
Somatomedin - Physiological effect
Somatomedin - Pathophysiology Carcinogenesis |
ISBN |
1-280-27251-1
9786610272518 0-470-66753-2 0-470-86997-6 0-470-86999-2 |
Classificazione | 44.78 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Circulating IGF-I and its role in cancer: lessons from the IGF-1 gene-deletion (LID) mouse -- Physiology of the IGF system -- Molecular basis of insulin action -- IGF-1 and insulin as growth hormones -- Insulin-like growth factors and neoplasia -- Loss of IGF2 imprinting: mechanisms and consequences -- Insulin and IGF-1 receptor trafficking and signalling -- The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb -- Structural biology of insulin and IGF-1 receptors -- Genetic blockade of the insulin-like growth factor-I receptor for human malignancy -- IGF-1 and prostate cancer -- IGF-1 and breast cancer -- IGFBPs and cancer -- The IGF receptor as anticancer treatment target -- Nutrition, insulin, IGF-1 metabolism and cancer risk: a summary of epidemiological evidence. |
Record Nr. | UNINA-9910830531903321 |
The Atrium, Southern Gate, Chichester, UK ; ; Hoboken, NJ, : John Wiley & Sons, c2004 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Biology of IGF-1 [[electronic resource] ] : its interaction with insulin in health and malignant states / / [edited by Gregory Bock, Jamie Goode] |
Pubbl/distr/stampa | The Atrium, Southern Gate, Chichester, UK ; ; Hoboken, NJ, : John Wiley & Sons, c2004 |
Descrizione fisica | 1 online resource (294 p.) |
Disciplina |
612.01575
612/.015756 |
Altri autori (Persone) |
BockGregory
GoodeJamie |
Collana | Novartis Foundation symposium |
Soggetto topico |
Somatomedin - Physiological effect
Somatomedin - Pathophysiology Carcinogenesis |
ISBN |
1-280-27251-1
9786610272518 0-470-66753-2 0-470-86997-6 0-470-86999-2 |
Classificazione | 44.78 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Circulating IGF-I and its role in cancer: lessons from the IGF-1 gene-deletion (LID) mouse -- Physiology of the IGF system -- Molecular basis of insulin action -- IGF-1 and insulin as growth hormones -- Insulin-like growth factors and neoplasia -- Loss of IGF2 imprinting: mechanisms and consequences -- Insulin and IGF-1 receptor trafficking and signalling -- The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb -- Structural biology of insulin and IGF-1 receptors -- Genetic blockade of the insulin-like growth factor-I receptor for human malignancy -- IGF-1 and prostate cancer -- IGF-1 and breast cancer -- IGFBPs and cancer -- The IGF receptor as anticancer treatment target -- Nutrition, insulin, IGF-1 metabolism and cancer risk: a summary of epidemiological evidence. |
Record Nr. | UNINA-9910841087903321 |
The Atrium, Southern Gate, Chichester, UK ; ; Hoboken, NJ, : John Wiley & Sons, c2004 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Chemical ligation : tools for biomolecule synthesis and modification / / edited by Luca D. D'Andrea and Alessandra Romanelli |
Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , 2017 |
Descrizione fisica | 1 online resource (583 pages) : illustrations (some color) |
Disciplina | 612/.015756 |
Soggetto topico |
Biosynthesis
Peptides - Synthesis Proteins - Synthesis Bioorganic chemistry Chemistry, Organic |
ISBN |
1-119-04413-8
1-119-04409-X 1-119-04411-1 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910271052903321 |
Hoboken, New Jersey : , : Wiley, , 2017 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Chemical ligation : tools for biomolecule synthesis and modification / / edited by Luca D. D'Andrea and Alessandra Romanelli |
Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , 2017 |
Descrizione fisica | 1 online resource (583 pages) : illustrations (some color) |
Disciplina | 612/.015756 |
Soggetto topico |
Biosynthesis
Peptides - Synthesis Proteins - Synthesis Bioorganic chemistry Chemistry, Organic |
ISBN |
1-119-04413-8
1-119-04409-X 1-119-04411-1 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910807725603321 |
Hoboken, New Jersey : , : Wiley, , 2017 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Flexible viruses [[electronic resource] ] : structural disorder in viral proteins / / edited by Vladimir Uversky, Sonia Longhi |
Autore | Uversky Vladimir N |
Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2012 |
Descrizione fisica | 1 online resource (534 p.) |
Disciplina | 612/.015756 |
Altri autori (Persone) | LonghiSonia |
Collana | Wiley series in protein and peptide science |
Soggetto topico | Viral proteins |
ISBN |
1-283-31596-3
9786613315960 1-118-13556-3 1-118-13557-1 1-118-13554-7 |
Classificazione | SCI007000 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
FLEXIBLE VIRUSES; CONTENTS; Preface; Introduction to the Wiley Series on Protein and Peptide Science; Contributors; 1 Do Viral Proteins Possess Unique Features?; 2 Functional Role of Structural Disorder in Capsid Proteins; 3 Structural Disorder Within the Nucleoprotein and Phosphoprotein from Measles, Nipah, and Hendra Viruses; 4 Structural Disorder Within Sendai Virus Nucleoprotein and Phosphoprotein; 5 Structural Disorder in Proteins of the Rhabdoviridae Replication Complex; 6 Structural Disorder in Matrix Proteins of HIV-Related Viruses
7 Structural Disorder in Proteins From Influenza Virus8 Making Order in the Intrinsically Disordered Regions of HIV-1 Vif Protein; 9 Order from Disorder: Structure, Function, and Dynamics of the HIV-1 Transactivator of Transcription; 10 Intrinsically Disordered Domains of Sesbania Mosaic Virus Encoded Proteins; 11 Intrinsic Disorder in Genome-Linked Viral Proteins VPgs of Potyviruses; 12 Intrinsic Disorder in the Human Papillomavirus E7 Protein; 13 The Semliki Forest Virus Capsid Protease is Disordered and Yet Displays Catalytic Activity 14 Core-lations Between Intrinsic Disorder and Multifaceted Activities in Hepatitis C Virus and Related Viruses15 The NS5A Domain II of HCV: Conservation of Intrinsic Disorder in Several Genotypes; 16 Bacteriophage l N Protein Disorder-Order Transitions Upon Interactions with RNA or Proteins; 17 N-Terminal Extension Region of Hordeivirus Movement TGB1 Protein Consists of Two Domains with Different Content of Disordered Structure; Index |
Record Nr. | UNINA-9910141216203321 |
Uversky Vladimir N | ||
Hoboken, N.J., : Wiley, c2012 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Flexible viruses [[electronic resource] ] : structural disorder in viral proteins / / edited by Vladimir Uversky, Sonia Longhi |
Autore | Uversky Vladimir N |
Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2012 |
Descrizione fisica | 1 online resource (534 p.) |
Disciplina | 612/.015756 |
Altri autori (Persone) | LonghiSonia |
Collana | Wiley series in protein and peptide science |
Soggetto topico | Viral proteins |
ISBN |
1-283-31596-3
9786613315960 1-118-13556-3 1-118-13557-1 1-118-13554-7 |
Classificazione | SCI007000 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
FLEXIBLE VIRUSES; CONTENTS; Preface; Introduction to the Wiley Series on Protein and Peptide Science; Contributors; 1 Do Viral Proteins Possess Unique Features?; 2 Functional Role of Structural Disorder in Capsid Proteins; 3 Structural Disorder Within the Nucleoprotein and Phosphoprotein from Measles, Nipah, and Hendra Viruses; 4 Structural Disorder Within Sendai Virus Nucleoprotein and Phosphoprotein; 5 Structural Disorder in Proteins of the Rhabdoviridae Replication Complex; 6 Structural Disorder in Matrix Proteins of HIV-Related Viruses
7 Structural Disorder in Proteins From Influenza Virus8 Making Order in the Intrinsically Disordered Regions of HIV-1 Vif Protein; 9 Order from Disorder: Structure, Function, and Dynamics of the HIV-1 Transactivator of Transcription; 10 Intrinsically Disordered Domains of Sesbania Mosaic Virus Encoded Proteins; 11 Intrinsic Disorder in Genome-Linked Viral Proteins VPgs of Potyviruses; 12 Intrinsic Disorder in the Human Papillomavirus E7 Protein; 13 The Semliki Forest Virus Capsid Protease is Disordered and Yet Displays Catalytic Activity 14 Core-lations Between Intrinsic Disorder and Multifaceted Activities in Hepatitis C Virus and Related Viruses15 The NS5A Domain II of HCV: Conservation of Intrinsic Disorder in Several Genotypes; 16 Bacteriophage l N Protein Disorder-Order Transitions Upon Interactions with RNA or Proteins; 17 N-Terminal Extension Region of Hordeivirus Movement TGB1 Protein Consists of Two Domains with Different Content of Disordered Structure; Index |
Record Nr. | UNINA-9910809692803321 |
Uversky Vladimir N | ||
Hoboken, N.J., : Wiley, c2012 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
GPCR molecular pharmacology and drug targeting [[electronic resource] ] : shifting paradigms and new directions / / edited by Annette Gilchrist |
Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2010 |
Descrizione fisica | 1 online resource (544 p.) |
Disciplina | 612/.015756 |
Altri autori (Persone) | GilchristAnnette |
Soggetto topico |
G proteins
Drug targeting |
ISBN |
1-118-03517-8
1-282-68599-6 9786612685996 0-470-62732-8 0-470-62731-X |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
GPCR MOLECULAR PHARMACOLOGY AND DRUG TARGETING: SHIFTING PARADIGMS AND NEW DIRECTIONS; CONTENTS; PREFACE; CONTRIBUTORS; CHAPTER 1: The Evolution of Receptors: From On-Off Switches to Microprocessors; CHAPTER 2: The Evolving Pharmacology of GPCRs; CHAPTER 3: The Emergence of Allosteric Modulators for G Protein - Coupled Receptors; CHAPTER 4: Receptor-Mediated G Protein Activation: How, How Many, and Where?; CHAPTER 5: Molecular Pharmacology of Frizzleds-with Implications for Possible Therapy
CHAPTER 6: Secretin Receptor Dimerization: A Possible Functionally Important Paradigm for Family B G Protein-Coupled ReceptorsCHAPTER 7: Past and Future Strategies for GPCR Deorphanization; CHAPTER 8: High-Throughput GPCR Screening Technologies and the Emerging Importance of the Cell Phenotype; CHAPTER 9: Are "Traditional" Biochemical Techniques Out of Fashion in the New Era of GPCR Pharmacology?; CHAPTER 10: Fluorescence and Resonance Energy Transfer Shine New Light on GPCR Function; CHAPTER 11: Integration of Label-Free Detection Methods in GPCR Drug Discovery CHAPTER 12: Screening for Allosteric Modulators of G Protein-Coupled ReceptorsCHAPTER 13: Ultra-High-Throughput Screening Assays for GPCRs; CHAPTER 14: New Techniques to Express and Crystallize G Protein-Coupled Receptors; CHAPTER 15: Structure and Modeling of GPCRs: Implications for Drug Discovery; CHAPTER 16: X-Ray Structure Developments for GPCR Drug Targets; CHAPTER 17: Pharmacological Chaperones: Potential for the Treatment of Hereditary Diseases Caused by Mutations in G Protein-Coupled Receptors; INDEX |
Record Nr. | UNINA-9910139201903321 |
Hoboken, N.J., : Wiley, c2010 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
GPCR molecular pharmacology and drug targeting [[electronic resource] ] : shifting paradigms and new directions / / edited by Annette Gilchrist |
Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2010 |
Descrizione fisica | 1 online resource (544 p.) |
Disciplina | 612/.015756 |
Altri autori (Persone) | GilchristAnnette |
Soggetto topico |
G proteins
Drug targeting |
ISBN |
1-118-03517-8
1-282-68599-6 9786612685996 0-470-62732-8 0-470-62731-X |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
GPCR MOLECULAR PHARMACOLOGY AND DRUG TARGETING: SHIFTING PARADIGMS AND NEW DIRECTIONS; CONTENTS; PREFACE; CONTRIBUTORS; CHAPTER 1: The Evolution of Receptors: From On-Off Switches to Microprocessors; CHAPTER 2: The Evolving Pharmacology of GPCRs; CHAPTER 3: The Emergence of Allosteric Modulators for G Protein - Coupled Receptors; CHAPTER 4: Receptor-Mediated G Protein Activation: How, How Many, and Where?; CHAPTER 5: Molecular Pharmacology of Frizzleds-with Implications for Possible Therapy
CHAPTER 6: Secretin Receptor Dimerization: A Possible Functionally Important Paradigm for Family B G Protein-Coupled ReceptorsCHAPTER 7: Past and Future Strategies for GPCR Deorphanization; CHAPTER 8: High-Throughput GPCR Screening Technologies and the Emerging Importance of the Cell Phenotype; CHAPTER 9: Are "Traditional" Biochemical Techniques Out of Fashion in the New Era of GPCR Pharmacology?; CHAPTER 10: Fluorescence and Resonance Energy Transfer Shine New Light on GPCR Function; CHAPTER 11: Integration of Label-Free Detection Methods in GPCR Drug Discovery CHAPTER 12: Screening for Allosteric Modulators of G Protein-Coupled ReceptorsCHAPTER 13: Ultra-High-Throughput Screening Assays for GPCRs; CHAPTER 14: New Techniques to Express and Crystallize G Protein-Coupled Receptors; CHAPTER 15: Structure and Modeling of GPCRs: Implications for Drug Discovery; CHAPTER 16: X-Ray Structure Developments for GPCR Drug Targets; CHAPTER 17: Pharmacological Chaperones: Potential for the Treatment of Hereditary Diseases Caused by Mutations in G Protein-Coupled Receptors; INDEX |
Record Nr. | UNINA-9910811243903321 |
Hoboken, N.J., : Wiley, c2010 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|