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Aluminum in biology and medicine
Aluminum in biology and medicine
Edizione [1st ed.]
Pubbl/distr/stampa Chichester [England] ; ; New York, : Wiley, 1992
Descrizione fisica 1 online resource (336 p.)
Disciplina 612/.01524
Altri autori (Persone) ChadwickDerek
WhelanJulie
Collana Ciba Foundation symposium
Soggetto topico Aluminum - Physiological effect
Aluminum - Pathophysiology
Alzheimer's disease - Pathophysiology
ISBN 1-282-34780-2
9786612347801
0-470-51430-2
0-470-51431-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto ALUMINIUM IN BIOLOGY AND MEDICINE; Contents; Aluminium in biology: an introduction; Aluminium speciation in biology; Dietary and other sources of aluminium intake; The interrelationship between silicon and aluminium in the biological effects of aluminium; The epidemiology of Alzheimer's disease in relation to aluminium; Aluminium and the pathogenesis of Alzheimer's disease: a summary of evidence; Intestinal absorption of aluminium; Aluminium intoxication in renal disease; Aluminium and Alzheimer's disease
Aluminium accumulation, B-amyloid deposition and neurofibrillary changes in the central nervous systemAluminium(III) in experimental cell pathology; Elemental analysis of neurofibrillary tangles in Alzheimer's disease using proton-induced X-ray analysis; Aluminium and the neurofibrillary tangle: results of tissue microprobe studies; Intracellular effects of aluminium on receptor-activated cytoplasmic Ca2+ signals in pancreatic acinar cells; Neurotoxic effects of dietary aluminium
Molecular characterization and measurement of Alzheimer's disease pathology: implications for genetic and environmental aetiologySumming-up; Index of contributors; Subject index
Record Nr. UNINA-9910876910603321
Chichester [England] ; ; New York, : Wiley, 1992
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Biomineralization [[electronic resource] ] : medical aspects of solubility / / [edited by] Erich Königsberger and LanChi Königsberger
Biomineralization [[electronic resource] ] : medical aspects of solubility / / [edited by] Erich Königsberger and LanChi Königsberger
Pubbl/distr/stampa Chichester, England ; ; Hoboken, NJ, : J. Wiley, c2006
Descrizione fisica 1 online resource (312 p.)
Disciplina 572.51
612.01524
612/.01524
Altri autori (Persone) KönigsbergerErich
KönigsbergerLanChi
Soggetto topico Biomineralization
Soggetto genere / forma Electronic books.
ISBN 1-280-51928-2
9786610519286
0-470-09212-2
0-470-09211-4
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Solubility phenomena related to normal and pathological biomineralization processes / Erich Königsberger and LanChi Königsberger -- Mechanisms of renal and salivary calculi formation and development / Félix Grases and Antonia Costa-Bauzá -- Calcium and magnesium phosphates : normal and pathological mineralization / Clara F. Magalhães, Paula A.A.P. Marques, and Rui N. Correia -- Relevance of a polymer-induced liquid-precursor (PILP) mineralization process to normal and pathological biomineralization / Fairland F. Amos ... [et al.] -- Pathological biomineralization of iron / Wanida Chua-anusorn and Timothy G. St. Pierre.
Record Nr. UNINA-9910143705703321
Chichester, England ; ; Hoboken, NJ, : J. Wiley, c2006
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Biomineralization [[electronic resource] ] : medical aspects of solubility / / [edited by] Erich Königsberger and LanChi Königsberger
Biomineralization [[electronic resource] ] : medical aspects of solubility / / [edited by] Erich Königsberger and LanChi Königsberger
Pubbl/distr/stampa Chichester, England ; ; Hoboken, NJ, : J. Wiley, c2006
Descrizione fisica 1 online resource (312 p.)
Disciplina 572.51
612.01524
612/.01524
Altri autori (Persone) KönigsbergerErich
KönigsbergerLanChi
Soggetto topico Biomineralization
ISBN 1-280-51928-2
9786610519286
0-470-09212-2
0-470-09211-4
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Solubility phenomena related to normal and pathological biomineralization processes / Erich Königsberger and LanChi Königsberger -- Mechanisms of renal and salivary calculi formation and development / Félix Grases and Antonia Costa-Bauzá -- Calcium and magnesium phosphates : normal and pathological mineralization / Clara F. Magalhães, Paula A.A.P. Marques, and Rui N. Correia -- Relevance of a polymer-induced liquid-precursor (PILP) mineralization process to normal and pathological biomineralization / Fairland F. Amos ... [et al.] -- Pathological biomineralization of iron / Wanida Chua-anusorn and Timothy G. St. Pierre.
Record Nr. UNINA-9910830163103321
Chichester, England ; ; Hoboken, NJ, : J. Wiley, c2006
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Biomineralization : medical aspects of solubility / / [edited by] Erich Konigsberger and LanChi Konigsberger
Biomineralization : medical aspects of solubility / / [edited by] Erich Konigsberger and LanChi Konigsberger
Pubbl/distr/stampa Chichester, England ; ; Hoboken, NJ, : J. Wiley, c2006
Descrizione fisica 1 online resource (312 p.)
Disciplina 612/.01524
Altri autori (Persone) KonigsbergerErich
KonigsbergerLanChi
Soggetto topico Biomineralization
ISBN 1-280-51928-2
9786610519286
0-470-09212-2
0-470-09211-4
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Solubility phenomena related to normal and pathological biomineralization processes / Erich Konigsberger and LanChi Konigsberger -- Mechanisms of renal and salivary calculi formation and development / Felix Grases and Antonia Costa-Bauza -- Calcium and magnesium phosphates : normal and pathological mineralization / Clara F. Magalhaes, Paula A.A.P. Marques, and Rui N. Correia -- Relevance of a polymer-induced liquid-precursor (PILP) mineralization process to normal and pathological biomineralization / Fairland F. Amos ... [et al.] -- Pathological biomineralization of iron / Wanida Chua-anusorn and Timothy G. St. Pierre.
Record Nr. UNINA-9910876853403321
Chichester, England ; ; Hoboken, NJ, : J. Wiley, c2006
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Ligand design in medicinal inorganic chemistry / / edited by Tim Storr ; contributors Peter J. Barnard [and thirty seven others]
Ligand design in medicinal inorganic chemistry / / edited by Tim Storr ; contributors Peter J. Barnard [and thirty seven others]
Pubbl/distr/stampa Chichester, England : , : Wiley, , 2014
Descrizione fisica 1 online resource (493 p.)
Disciplina 612/.01524
Soggetto topico DNA-drug interactions
Ligand binding (Biochemistry)
Drugs - Design
Pharmaceutical chemistry
ISBN 1-118-69789-8
1-118-69719-7
1-118-69791-X
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Cover; Title Page; Copyright; Contents; About the Editor; List of Contributors; Chapter 1 Introduction to Ligand Design in Medicinal Inorganic Chemistry; References; Chapter 2 Platinum-Based Anticancer Agents; 2.1 Introduction; 2.2 The advent of platinum-based anticancer agents; 2.3 Strategies for overcoming the limitations of cisplatin; 2.4 The influence of ligands on the physicochemical properties of platinum anticancer complexes; 2.4.1 Lipophilicity; 2.4.2 Reactivity; 2.4.3 Rate of reduction; 2.5 Ligands for enhancing the anticancer activity of platinum complexes
2.5.1 Ligands for improving DNA affinity2.5.2 Ligands for inhibiting enzymes; 2.6 Ligands for enhancing the tumour selectivity of platinum complexes; 2.6.1 Ligands for targeting transporters; 2.6.2 Ligands for targeting receptors; 2.6.3 Ligands for targeting the EPR effect; 2.6.4 Ligands for targeting bone cancer; 2.7 Ligands for photoactivatable platinum complexes; 2.8 Conclusions; References; Chapter 3 Coordination Chemistry and Ligand Design in the Development of Metal Based Radiopharmaceuticals; 3.1 Introduction; 3.1.1 Metals in nuclear medicine
3.1.2 The importance of coordination chemistry3.1.3 Overview; 3.2 General metal based radiopharmaceutical design; 3.2.1 Choice of radionuclide; 3.2.2 Production of the radiometal starting materials; 3.2.3 Ligand and chelate design consideration; 3.3 Survey of the coordination chemistry of radiometals applicable to nuclear medicine; 3.3.1 Technetium; 3.3.2 Rhenium; 3.3.3 Gallium; 3.3.4 Indium; 3.3.5 Yttrium and lanthanides; 3.3.6 Copper; 3.3.7 Zirconium; 3.3.8 Scandium; 3.3.9 Cobalt; 3.4 Conclusions; References; Chapter 4 Ligand Design in d-Block Optical Imaging Agents and Sensors
4.1 Summary and scope4.2 Introduction; 4.2.1 Criteria for biological imaging optical probes; 4.3 Overview of transition-metal optical probes in biomedicinal applications; 4.3.1 Common families of transition metal probes; 4.4 Ligand design for controlling photophysics; 4.4.1 Photophysical processes in transition metal optical imaging agents and sensors; 4.4.2 Photophysically active ligand families-tuning electronic levels; 4.4.3 Ligands which control photophysics through indirect effects; 4.4.4 Transition metal optical probes with carbonyl ligands; 4.5 Ligand design for controlling stability
4.6 Ligand design for controlling transport and localisation4.6.1 Passive diffusion; 4.6.2 Active transport; 4.7 Ligand design for controlling distribution; 4.7.1 Mitochondrial-targeting probes; 4.7.2 Nuclear-targeting probes; 4.7.3 Bioconjugation; 4.8 Selected examples of ligand design for important individual probes; 4.8.1 A pH-sensitive ligand to control Ir luminescence; 4.8.2 Dimeric NHC ligands for gold cyclophanes; 4.9 Transition metal probes incorporating or capable of more than one imaging mode; 4.9.1 Bimodal MRI/optical probes; 4.9.2 Bimodal radio/optical probes
4.9.3 Bimodal IR/optical probes
Record Nr. UNINA-9910132205303321
Chichester, England : , : Wiley, , 2014
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Ligand design in medicinal inorganic chemistry / / edited by Tim Storr ; contributors Peter J. Barnard [and thirty seven others]
Ligand design in medicinal inorganic chemistry / / edited by Tim Storr ; contributors Peter J. Barnard [and thirty seven others]
Pubbl/distr/stampa Chichester, England : , : Wiley, , 2014
Descrizione fisica 1 online resource (493 p.)
Disciplina 612/.01524
Soggetto topico DNA-drug interactions
Ligand binding (Biochemistry)
Drugs - Design
Pharmaceutical chemistry
ISBN 1-118-69789-8
1-118-69719-7
1-118-69791-X
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Cover; Title Page; Copyright; Contents; About the Editor; List of Contributors; Chapter 1 Introduction to Ligand Design in Medicinal Inorganic Chemistry; References; Chapter 2 Platinum-Based Anticancer Agents; 2.1 Introduction; 2.2 The advent of platinum-based anticancer agents; 2.3 Strategies for overcoming the limitations of cisplatin; 2.4 The influence of ligands on the physicochemical properties of platinum anticancer complexes; 2.4.1 Lipophilicity; 2.4.2 Reactivity; 2.4.3 Rate of reduction; 2.5 Ligands for enhancing the anticancer activity of platinum complexes
2.5.1 Ligands for improving DNA affinity2.5.2 Ligands for inhibiting enzymes; 2.6 Ligands for enhancing the tumour selectivity of platinum complexes; 2.6.1 Ligands for targeting transporters; 2.6.2 Ligands for targeting receptors; 2.6.3 Ligands for targeting the EPR effect; 2.6.4 Ligands for targeting bone cancer; 2.7 Ligands for photoactivatable platinum complexes; 2.8 Conclusions; References; Chapter 3 Coordination Chemistry and Ligand Design in the Development of Metal Based Radiopharmaceuticals; 3.1 Introduction; 3.1.1 Metals in nuclear medicine
3.1.2 The importance of coordination chemistry3.1.3 Overview; 3.2 General metal based radiopharmaceutical design; 3.2.1 Choice of radionuclide; 3.2.2 Production of the radiometal starting materials; 3.2.3 Ligand and chelate design consideration; 3.3 Survey of the coordination chemistry of radiometals applicable to nuclear medicine; 3.3.1 Technetium; 3.3.2 Rhenium; 3.3.3 Gallium; 3.3.4 Indium; 3.3.5 Yttrium and lanthanides; 3.3.6 Copper; 3.3.7 Zirconium; 3.3.8 Scandium; 3.3.9 Cobalt; 3.4 Conclusions; References; Chapter 4 Ligand Design in d-Block Optical Imaging Agents and Sensors
4.1 Summary and scope4.2 Introduction; 4.2.1 Criteria for biological imaging optical probes; 4.3 Overview of transition-metal optical probes in biomedicinal applications; 4.3.1 Common families of transition metal probes; 4.4 Ligand design for controlling photophysics; 4.4.1 Photophysical processes in transition metal optical imaging agents and sensors; 4.4.2 Photophysically active ligand families-tuning electronic levels; 4.4.3 Ligands which control photophysics through indirect effects; 4.4.4 Transition metal optical probes with carbonyl ligands; 4.5 Ligand design for controlling stability
4.6 Ligand design for controlling transport and localisation4.6.1 Passive diffusion; 4.6.2 Active transport; 4.7 Ligand design for controlling distribution; 4.7.1 Mitochondrial-targeting probes; 4.7.2 Nuclear-targeting probes; 4.7.3 Bioconjugation; 4.8 Selected examples of ligand design for important individual probes; 4.8.1 A pH-sensitive ligand to control Ir luminescence; 4.8.2 Dimeric NHC ligands for gold cyclophanes; 4.9 Transition metal probes incorporating or capable of more than one imaging mode; 4.9.1 Bimodal MRI/optical probes; 4.9.2 Bimodal radio/optical probes
4.9.3 Bimodal IR/optical probes
Record Nr. UNINA-9910816425603321
Chichester, England : , : Wiley, , 2014
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Spin states in biochemistry and inorganic chemistry : influence on structure and reactivity / / edited by Marcel Swart and Miquel Costas
Spin states in biochemistry and inorganic chemistry : influence on structure and reactivity / / edited by Marcel Swart and Miquel Costas
Pubbl/distr/stampa West Sussex, England : , : Wiley, , 2016
Descrizione fisica 1 online resource (684 p.)
Disciplina 612/.01524
Soggetto topico Nuclear spin
Free radicals (Chemistry)
Biochemistry
Chemistry, Inorganic
Spin (Física nuclear)
Radicals lliures (Química)
Bioquímica
Química inorgànica
ISBN 1-118-89828-1
1-118-89827-3
1-118-89830-3
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Title page; Copyright; Dedication; About the Editors; Marcel Swart; Miquel Costas; List of Contributors; Foreword; Acknowledgments; 1 General Introduction to Spin States; 1.1 Introduction; 1.2 Experimental Chemistry: Reactivity, Synthesis and Spectroscopy; 1.3 Computational Chemistry: Quantum Chemistry and Basis Sets; References; 2 Application of Density Functional and Density Functional Based Ligand Field Theory to Spin States; 2.1 Introduction; 2.2 What Is the Problem with Theory?; 2.3 Validation and Application Studies; 2.4 Concluding Remarks; Acknowledgments; References
3 Ab Initio Wavefunction Approaches to Spin States3.1 Introduction and Scope; 3.2 Wavefunction-Based Methods for Spin States; 3.3 Spin Crossover; 3.4 Magnetic Coupling; 3.5 Spin States in Biochemical and Biomimetic Systems; 3.6 Two-State Reactivity; 3.7 Concluding Remarks; References; 4 Experimental Techniques for Determining Spin States; 4.1 Introduction; 4.2 Magnetic Measurements; 4.3 EPR Spectroscopy; 4.4 Mössbauer Spectroscopy; 4.5 X-ray Spectroscopic Techniques; 4.6 NMR Spectroscopy; 4.7 Other Techniques; 4.A Appendix; References; 5 Molecular Discovery in Spin Crossover; 5.1 Introduction
5.2 Theoretical Background5.3 Thermal SCO Systems: Fe(II); 5.4 SCO in Non-d6 Systems; 5.5 Computational Methods; 5.6 Outlook; References; 6 Multiple Spin-State Scenarios in Organometallic Reactivity; 6.1 Introduction; 6.2 "Spin-Forbidden" Reactions and Two-State Reactivity; 6.3 Spin-State Changes in Transition Metal Complexes; 6.4 Spin-State Changes in Catalysis; 6.5 Concluding Remarks; References; 7 Principles and Prospects of Spin-States Reactivity in Chemistry and Bioinorganic Chemistry; 7.1 Introduction; 7.2 Spin-States Reactivity
7.3 Prospects of Two-State Reactivity and Multi-State Reactivity7.4 Concluding Remarks; Acknowledgement; Note Added in Proof; References; 8 Multiple Spin-State Scenarios in Gas-Phase Reactions; 8.1 Introduction; 8.2 Experimental Methods for the Investigation of Metal-Ion Reactions; 8.3 Multiple State Reactivity: Reactions of Metal Cations with Methane; 8.4 Effect of the Oxidation State: Reactions of Metal Hydride Cations with Methane; 8.5 Two-State Reactivity: Reactions of Metal Oxide Cations; 8.6 Effect of Ligands; 8.7 Effect of Noninnocent Ligands; 8.8 Concluding Remarks; References
9 Catalytic Function and Mechanism of Heme and Nonheme Iron(IV)-Oxo Complexes in Nature9.1 Introduction; 9.2 Cytochrome P450 Enzymes; 9.3 Nonheme Iron Dioxygenases; 9.4 Conclusions; 9.5 Acknowledgments; References; 10 Terminal Metal-Oxo Species with Unusual Spin States; 10.1 Introduction; 10.2 Bonding; 10.3 Case Studies; 10.4 Reactivity; 10.5 Summary; Note Added in Proof; References; 11 Multiple Spin Scenarios in Transition-Metal Complexes Involving Redox Non-Innocent Ligands; 11.1 Introduction; 11.2 Survey of Non-Innocent Ligands; 11.3 Identification of Non-Innocent Ligands
11.4 Selected Examples of Biological and Chemical Systems Involving Non-Innocent Ligands
Record Nr. UNINA-9910131469603321
West Sussex, England : , : Wiley, , 2016
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Spin states in biochemistry and inorganic chemistry : influence on structure and reactivity / / edited by Marcel Swart and Miquel Costas
Spin states in biochemistry and inorganic chemistry : influence on structure and reactivity / / edited by Marcel Swart and Miquel Costas
Pubbl/distr/stampa West Sussex, England : , : Wiley, , 2016
Descrizione fisica 1 online resource (684 p.)
Disciplina 612/.01524
Soggetto topico Nuclear spin
Free radicals (Chemistry)
Biochemistry
Chemistry, Inorganic
Spin (Física nuclear)
Radicals lliures (Química)
Bioquímica
Química inorgànica
ISBN 1-118-89828-1
1-118-89827-3
1-118-89830-3
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Title page; Copyright; Dedication; About the Editors; Marcel Swart; Miquel Costas; List of Contributors; Foreword; Acknowledgments; 1 General Introduction to Spin States; 1.1 Introduction; 1.2 Experimental Chemistry: Reactivity, Synthesis and Spectroscopy; 1.3 Computational Chemistry: Quantum Chemistry and Basis Sets; References; 2 Application of Density Functional and Density Functional Based Ligand Field Theory to Spin States; 2.1 Introduction; 2.2 What Is the Problem with Theory?; 2.3 Validation and Application Studies; 2.4 Concluding Remarks; Acknowledgments; References
3 Ab Initio Wavefunction Approaches to Spin States3.1 Introduction and Scope; 3.2 Wavefunction-Based Methods for Spin States; 3.3 Spin Crossover; 3.4 Magnetic Coupling; 3.5 Spin States in Biochemical and Biomimetic Systems; 3.6 Two-State Reactivity; 3.7 Concluding Remarks; References; 4 Experimental Techniques for Determining Spin States; 4.1 Introduction; 4.2 Magnetic Measurements; 4.3 EPR Spectroscopy; 4.4 Mössbauer Spectroscopy; 4.5 X-ray Spectroscopic Techniques; 4.6 NMR Spectroscopy; 4.7 Other Techniques; 4.A Appendix; References; 5 Molecular Discovery in Spin Crossover; 5.1 Introduction
5.2 Theoretical Background5.3 Thermal SCO Systems: Fe(II); 5.4 SCO in Non-d6 Systems; 5.5 Computational Methods; 5.6 Outlook; References; 6 Multiple Spin-State Scenarios in Organometallic Reactivity; 6.1 Introduction; 6.2 "Spin-Forbidden" Reactions and Two-State Reactivity; 6.3 Spin-State Changes in Transition Metal Complexes; 6.4 Spin-State Changes in Catalysis; 6.5 Concluding Remarks; References; 7 Principles and Prospects of Spin-States Reactivity in Chemistry and Bioinorganic Chemistry; 7.1 Introduction; 7.2 Spin-States Reactivity
7.3 Prospects of Two-State Reactivity and Multi-State Reactivity7.4 Concluding Remarks; Acknowledgement; Note Added in Proof; References; 8 Multiple Spin-State Scenarios in Gas-Phase Reactions; 8.1 Introduction; 8.2 Experimental Methods for the Investigation of Metal-Ion Reactions; 8.3 Multiple State Reactivity: Reactions of Metal Cations with Methane; 8.4 Effect of the Oxidation State: Reactions of Metal Hydride Cations with Methane; 8.5 Two-State Reactivity: Reactions of Metal Oxide Cations; 8.6 Effect of Ligands; 8.7 Effect of Noninnocent Ligands; 8.8 Concluding Remarks; References
9 Catalytic Function and Mechanism of Heme and Nonheme Iron(IV)-Oxo Complexes in Nature9.1 Introduction; 9.2 Cytochrome P450 Enzymes; 9.3 Nonheme Iron Dioxygenases; 9.4 Conclusions; 9.5 Acknowledgments; References; 10 Terminal Metal-Oxo Species with Unusual Spin States; 10.1 Introduction; 10.2 Bonding; 10.3 Case Studies; 10.4 Reactivity; 10.5 Summary; Note Added in Proof; References; 11 Multiple Spin Scenarios in Transition-Metal Complexes Involving Redox Non-Innocent Ligands; 11.1 Introduction; 11.2 Survey of Non-Innocent Ligands; 11.3 Identification of Non-Innocent Ligands
11.4 Selected Examples of Biological and Chemical Systems Involving Non-Innocent Ligands
Record Nr. UNINA-9910810404303321
West Sussex, England : , : Wiley, , 2016
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui