Aluminum in biology and medicine |
Edizione | [1st ed.] |
Pubbl/distr/stampa | Chichester [England] ; ; New York, : Wiley, 1992 |
Descrizione fisica | 1 online resource (336 p.) |
Disciplina | 612/.01524 |
Altri autori (Persone) |
ChadwickDerek
WhelanJulie |
Collana | Ciba Foundation symposium |
Soggetto topico |
Aluminum - Physiological effect
Aluminum - Pathophysiology Alzheimer's disease - Pathophysiology |
ISBN |
1-282-34780-2
9786612347801 0-470-51430-2 0-470-51431-0 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
ALUMINIUM IN BIOLOGY AND MEDICINE; Contents; Aluminium in biology: an introduction; Aluminium speciation in biology; Dietary and other sources of aluminium intake; The interrelationship between silicon and aluminium in the biological effects of aluminium; The epidemiology of Alzheimer's disease in relation to aluminium; Aluminium and the pathogenesis of Alzheimer's disease: a summary of evidence; Intestinal absorption of aluminium; Aluminium intoxication in renal disease; Aluminium and Alzheimer's disease
Aluminium accumulation, B-amyloid deposition and neurofibrillary changes in the central nervous systemAluminium(III) in experimental cell pathology; Elemental analysis of neurofibrillary tangles in Alzheimer's disease using proton-induced X-ray analysis; Aluminium and the neurofibrillary tangle: results of tissue microprobe studies; Intracellular effects of aluminium on receptor-activated cytoplasmic Ca2+ signals in pancreatic acinar cells; Neurotoxic effects of dietary aluminium Molecular characterization and measurement of Alzheimer's disease pathology: implications for genetic and environmental aetiologySumming-up; Index of contributors; Subject index |
Record Nr. | UNINA-9910876910603321 |
Chichester [England] ; ; New York, : Wiley, 1992 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Biomineralization [[electronic resource] ] : medical aspects of solubility / / [edited by] Erich Königsberger and LanChi Königsberger |
Pubbl/distr/stampa | Chichester, England ; ; Hoboken, NJ, : J. Wiley, c2006 |
Descrizione fisica | 1 online resource (312 p.) |
Disciplina |
572.51
612.01524 612/.01524 |
Altri autori (Persone) |
KönigsbergerErich
KönigsbergerLanChi |
Soggetto topico | Biomineralization |
Soggetto genere / forma | Electronic books. |
ISBN |
1-280-51928-2
9786610519286 0-470-09212-2 0-470-09211-4 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Solubility phenomena related to normal and pathological biomineralization processes / Erich Königsberger and LanChi Königsberger -- Mechanisms of renal and salivary calculi formation and development / Félix Grases and Antonia Costa-Bauzá -- Calcium and magnesium phosphates : normal and pathological mineralization / Clara F. Magalhães, Paula A.A.P. Marques, and Rui N. Correia -- Relevance of a polymer-induced liquid-precursor (PILP) mineralization process to normal and pathological biomineralization / Fairland F. Amos ... [et al.] -- Pathological biomineralization of iron / Wanida Chua-anusorn and Timothy G. St. Pierre. |
Record Nr. | UNINA-9910143705703321 |
Chichester, England ; ; Hoboken, NJ, : J. Wiley, c2006 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Biomineralization [[electronic resource] ] : medical aspects of solubility / / [edited by] Erich Königsberger and LanChi Königsberger |
Pubbl/distr/stampa | Chichester, England ; ; Hoboken, NJ, : J. Wiley, c2006 |
Descrizione fisica | 1 online resource (312 p.) |
Disciplina |
572.51
612.01524 612/.01524 |
Altri autori (Persone) |
KönigsbergerErich
KönigsbergerLanChi |
Soggetto topico | Biomineralization |
ISBN |
1-280-51928-2
9786610519286 0-470-09212-2 0-470-09211-4 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Solubility phenomena related to normal and pathological biomineralization processes / Erich Königsberger and LanChi Königsberger -- Mechanisms of renal and salivary calculi formation and development / Félix Grases and Antonia Costa-Bauzá -- Calcium and magnesium phosphates : normal and pathological mineralization / Clara F. Magalhães, Paula A.A.P. Marques, and Rui N. Correia -- Relevance of a polymer-induced liquid-precursor (PILP) mineralization process to normal and pathological biomineralization / Fairland F. Amos ... [et al.] -- Pathological biomineralization of iron / Wanida Chua-anusorn and Timothy G. St. Pierre. |
Record Nr. | UNINA-9910830163103321 |
Chichester, England ; ; Hoboken, NJ, : J. Wiley, c2006 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Biomineralization : medical aspects of solubility / / [edited by] Erich Konigsberger and LanChi Konigsberger |
Pubbl/distr/stampa | Chichester, England ; ; Hoboken, NJ, : J. Wiley, c2006 |
Descrizione fisica | 1 online resource (312 p.) |
Disciplina | 612/.01524 |
Altri autori (Persone) |
KonigsbergerErich
KonigsbergerLanChi |
Soggetto topico | Biomineralization |
ISBN |
1-280-51928-2
9786610519286 0-470-09212-2 0-470-09211-4 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Solubility phenomena related to normal and pathological biomineralization processes / Erich Konigsberger and LanChi Konigsberger -- Mechanisms of renal and salivary calculi formation and development / Felix Grases and Antonia Costa-Bauza -- Calcium and magnesium phosphates : normal and pathological mineralization / Clara F. Magalhaes, Paula A.A.P. Marques, and Rui N. Correia -- Relevance of a polymer-induced liquid-precursor (PILP) mineralization process to normal and pathological biomineralization / Fairland F. Amos ... [et al.] -- Pathological biomineralization of iron / Wanida Chua-anusorn and Timothy G. St. Pierre. |
Record Nr. | UNINA-9910876853403321 |
Chichester, England ; ; Hoboken, NJ, : J. Wiley, c2006 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Ligand design in medicinal inorganic chemistry / / edited by Tim Storr ; contributors Peter J. Barnard [and thirty seven others] |
Pubbl/distr/stampa | Chichester, England : , : Wiley, , 2014 |
Descrizione fisica | 1 online resource (493 p.) |
Disciplina | 612/.01524 |
Soggetto topico |
DNA-drug interactions
Ligand binding (Biochemistry) Drugs - Design Pharmaceutical chemistry |
ISBN |
1-118-69789-8
1-118-69719-7 1-118-69791-X |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Cover; Title Page; Copyright; Contents; About the Editor; List of Contributors; Chapter 1 Introduction to Ligand Design in Medicinal Inorganic Chemistry; References; Chapter 2 Platinum-Based Anticancer Agents; 2.1 Introduction; 2.2 The advent of platinum-based anticancer agents; 2.3 Strategies for overcoming the limitations of cisplatin; 2.4 The influence of ligands on the physicochemical properties of platinum anticancer complexes; 2.4.1 Lipophilicity; 2.4.2 Reactivity; 2.4.3 Rate of reduction; 2.5 Ligands for enhancing the anticancer activity of platinum complexes
2.5.1 Ligands for improving DNA affinity2.5.2 Ligands for inhibiting enzymes; 2.6 Ligands for enhancing the tumour selectivity of platinum complexes; 2.6.1 Ligands for targeting transporters; 2.6.2 Ligands for targeting receptors; 2.6.3 Ligands for targeting the EPR effect; 2.6.4 Ligands for targeting bone cancer; 2.7 Ligands for photoactivatable platinum complexes; 2.8 Conclusions; References; Chapter 3 Coordination Chemistry and Ligand Design in the Development of Metal Based Radiopharmaceuticals; 3.1 Introduction; 3.1.1 Metals in nuclear medicine 3.1.2 The importance of coordination chemistry3.1.3 Overview; 3.2 General metal based radiopharmaceutical design; 3.2.1 Choice of radionuclide; 3.2.2 Production of the radiometal starting materials; 3.2.3 Ligand and chelate design consideration; 3.3 Survey of the coordination chemistry of radiometals applicable to nuclear medicine; 3.3.1 Technetium; 3.3.2 Rhenium; 3.3.3 Gallium; 3.3.4 Indium; 3.3.5 Yttrium and lanthanides; 3.3.6 Copper; 3.3.7 Zirconium; 3.3.8 Scandium; 3.3.9 Cobalt; 3.4 Conclusions; References; Chapter 4 Ligand Design in d-Block Optical Imaging Agents and Sensors 4.1 Summary and scope4.2 Introduction; 4.2.1 Criteria for biological imaging optical probes; 4.3 Overview of transition-metal optical probes in biomedicinal applications; 4.3.1 Common families of transition metal probes; 4.4 Ligand design for controlling photophysics; 4.4.1 Photophysical processes in transition metal optical imaging agents and sensors; 4.4.2 Photophysically active ligand families-tuning electronic levels; 4.4.3 Ligands which control photophysics through indirect effects; 4.4.4 Transition metal optical probes with carbonyl ligands; 4.5 Ligand design for controlling stability 4.6 Ligand design for controlling transport and localisation4.6.1 Passive diffusion; 4.6.2 Active transport; 4.7 Ligand design for controlling distribution; 4.7.1 Mitochondrial-targeting probes; 4.7.2 Nuclear-targeting probes; 4.7.3 Bioconjugation; 4.8 Selected examples of ligand design for important individual probes; 4.8.1 A pH-sensitive ligand to control Ir luminescence; 4.8.2 Dimeric NHC ligands for gold cyclophanes; 4.9 Transition metal probes incorporating or capable of more than one imaging mode; 4.9.1 Bimodal MRI/optical probes; 4.9.2 Bimodal radio/optical probes 4.9.3 Bimodal IR/optical probes |
Record Nr. | UNINA-9910132205303321 |
Chichester, England : , : Wiley, , 2014 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Ligand design in medicinal inorganic chemistry / / edited by Tim Storr ; contributors Peter J. Barnard [and thirty seven others] |
Pubbl/distr/stampa | Chichester, England : , : Wiley, , 2014 |
Descrizione fisica | 1 online resource (493 p.) |
Disciplina | 612/.01524 |
Soggetto topico |
DNA-drug interactions
Ligand binding (Biochemistry) Drugs - Design Pharmaceutical chemistry |
ISBN |
1-118-69789-8
1-118-69719-7 1-118-69791-X |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Cover; Title Page; Copyright; Contents; About the Editor; List of Contributors; Chapter 1 Introduction to Ligand Design in Medicinal Inorganic Chemistry; References; Chapter 2 Platinum-Based Anticancer Agents; 2.1 Introduction; 2.2 The advent of platinum-based anticancer agents; 2.3 Strategies for overcoming the limitations of cisplatin; 2.4 The influence of ligands on the physicochemical properties of platinum anticancer complexes; 2.4.1 Lipophilicity; 2.4.2 Reactivity; 2.4.3 Rate of reduction; 2.5 Ligands for enhancing the anticancer activity of platinum complexes
2.5.1 Ligands for improving DNA affinity2.5.2 Ligands for inhibiting enzymes; 2.6 Ligands for enhancing the tumour selectivity of platinum complexes; 2.6.1 Ligands for targeting transporters; 2.6.2 Ligands for targeting receptors; 2.6.3 Ligands for targeting the EPR effect; 2.6.4 Ligands for targeting bone cancer; 2.7 Ligands for photoactivatable platinum complexes; 2.8 Conclusions; References; Chapter 3 Coordination Chemistry and Ligand Design in the Development of Metal Based Radiopharmaceuticals; 3.1 Introduction; 3.1.1 Metals in nuclear medicine 3.1.2 The importance of coordination chemistry3.1.3 Overview; 3.2 General metal based radiopharmaceutical design; 3.2.1 Choice of radionuclide; 3.2.2 Production of the radiometal starting materials; 3.2.3 Ligand and chelate design consideration; 3.3 Survey of the coordination chemistry of radiometals applicable to nuclear medicine; 3.3.1 Technetium; 3.3.2 Rhenium; 3.3.3 Gallium; 3.3.4 Indium; 3.3.5 Yttrium and lanthanides; 3.3.6 Copper; 3.3.7 Zirconium; 3.3.8 Scandium; 3.3.9 Cobalt; 3.4 Conclusions; References; Chapter 4 Ligand Design in d-Block Optical Imaging Agents and Sensors 4.1 Summary and scope4.2 Introduction; 4.2.1 Criteria for biological imaging optical probes; 4.3 Overview of transition-metal optical probes in biomedicinal applications; 4.3.1 Common families of transition metal probes; 4.4 Ligand design for controlling photophysics; 4.4.1 Photophysical processes in transition metal optical imaging agents and sensors; 4.4.2 Photophysically active ligand families-tuning electronic levels; 4.4.3 Ligands which control photophysics through indirect effects; 4.4.4 Transition metal optical probes with carbonyl ligands; 4.5 Ligand design for controlling stability 4.6 Ligand design for controlling transport and localisation4.6.1 Passive diffusion; 4.6.2 Active transport; 4.7 Ligand design for controlling distribution; 4.7.1 Mitochondrial-targeting probes; 4.7.2 Nuclear-targeting probes; 4.7.3 Bioconjugation; 4.8 Selected examples of ligand design for important individual probes; 4.8.1 A pH-sensitive ligand to control Ir luminescence; 4.8.2 Dimeric NHC ligands for gold cyclophanes; 4.9 Transition metal probes incorporating or capable of more than one imaging mode; 4.9.1 Bimodal MRI/optical probes; 4.9.2 Bimodal radio/optical probes 4.9.3 Bimodal IR/optical probes |
Record Nr. | UNINA-9910816425603321 |
Chichester, England : , : Wiley, , 2014 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Spin states in biochemistry and inorganic chemistry : influence on structure and reactivity / / edited by Marcel Swart and Miquel Costas |
Pubbl/distr/stampa | West Sussex, England : , : Wiley, , 2016 |
Descrizione fisica | 1 online resource (684 p.) |
Disciplina | 612/.01524 |
Soggetto topico |
Nuclear spin
Free radicals (Chemistry) Biochemistry Chemistry, Inorganic Spin (Física nuclear) Radicals lliures (Química) Bioquímica Química inorgànica |
ISBN |
1-118-89828-1
1-118-89827-3 1-118-89830-3 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Title page; Copyright; Dedication; About the Editors; Marcel Swart; Miquel Costas; List of Contributors; Foreword; Acknowledgments; 1 General Introduction to Spin States; 1.1 Introduction; 1.2 Experimental Chemistry: Reactivity, Synthesis and Spectroscopy; 1.3 Computational Chemistry: Quantum Chemistry and Basis Sets; References; 2 Application of Density Functional and Density Functional Based Ligand Field Theory to Spin States; 2.1 Introduction; 2.2 What Is the Problem with Theory?; 2.3 Validation and Application Studies; 2.4 Concluding Remarks; Acknowledgments; References
3 Ab Initio Wavefunction Approaches to Spin States3.1 Introduction and Scope; 3.2 Wavefunction-Based Methods for Spin States; 3.3 Spin Crossover; 3.4 Magnetic Coupling; 3.5 Spin States in Biochemical and Biomimetic Systems; 3.6 Two-State Reactivity; 3.7 Concluding Remarks; References; 4 Experimental Techniques for Determining Spin States; 4.1 Introduction; 4.2 Magnetic Measurements; 4.3 EPR Spectroscopy; 4.4 Mössbauer Spectroscopy; 4.5 X-ray Spectroscopic Techniques; 4.6 NMR Spectroscopy; 4.7 Other Techniques; 4.A Appendix; References; 5 Molecular Discovery in Spin Crossover; 5.1 Introduction 5.2 Theoretical Background5.3 Thermal SCO Systems: Fe(II); 5.4 SCO in Non-d6 Systems; 5.5 Computational Methods; 5.6 Outlook; References; 6 Multiple Spin-State Scenarios in Organometallic Reactivity; 6.1 Introduction; 6.2 "Spin-Forbidden" Reactions and Two-State Reactivity; 6.3 Spin-State Changes in Transition Metal Complexes; 6.4 Spin-State Changes in Catalysis; 6.5 Concluding Remarks; References; 7 Principles and Prospects of Spin-States Reactivity in Chemistry and Bioinorganic Chemistry; 7.1 Introduction; 7.2 Spin-States Reactivity 7.3 Prospects of Two-State Reactivity and Multi-State Reactivity7.4 Concluding Remarks; Acknowledgement; Note Added in Proof; References; 8 Multiple Spin-State Scenarios in Gas-Phase Reactions; 8.1 Introduction; 8.2 Experimental Methods for the Investigation of Metal-Ion Reactions; 8.3 Multiple State Reactivity: Reactions of Metal Cations with Methane; 8.4 Effect of the Oxidation State: Reactions of Metal Hydride Cations with Methane; 8.5 Two-State Reactivity: Reactions of Metal Oxide Cations; 8.6 Effect of Ligands; 8.7 Effect of Noninnocent Ligands; 8.8 Concluding Remarks; References 9 Catalytic Function and Mechanism of Heme and Nonheme Iron(IV)-Oxo Complexes in Nature9.1 Introduction; 9.2 Cytochrome P450 Enzymes; 9.3 Nonheme Iron Dioxygenases; 9.4 Conclusions; 9.5 Acknowledgments; References; 10 Terminal Metal-Oxo Species with Unusual Spin States; 10.1 Introduction; 10.2 Bonding; 10.3 Case Studies; 10.4 Reactivity; 10.5 Summary; Note Added in Proof; References; 11 Multiple Spin Scenarios in Transition-Metal Complexes Involving Redox Non-Innocent Ligands; 11.1 Introduction; 11.2 Survey of Non-Innocent Ligands; 11.3 Identification of Non-Innocent Ligands 11.4 Selected Examples of Biological and Chemical Systems Involving Non-Innocent Ligands |
Record Nr. | UNINA-9910131469603321 |
West Sussex, England : , : Wiley, , 2016 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Spin states in biochemistry and inorganic chemistry : influence on structure and reactivity / / edited by Marcel Swart and Miquel Costas |
Pubbl/distr/stampa | West Sussex, England : , : Wiley, , 2016 |
Descrizione fisica | 1 online resource (684 p.) |
Disciplina | 612/.01524 |
Soggetto topico |
Nuclear spin
Free radicals (Chemistry) Biochemistry Chemistry, Inorganic Spin (Física nuclear) Radicals lliures (Química) Bioquímica Química inorgànica |
ISBN |
1-118-89828-1
1-118-89827-3 1-118-89830-3 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Title page; Copyright; Dedication; About the Editors; Marcel Swart; Miquel Costas; List of Contributors; Foreword; Acknowledgments; 1 General Introduction to Spin States; 1.1 Introduction; 1.2 Experimental Chemistry: Reactivity, Synthesis and Spectroscopy; 1.3 Computational Chemistry: Quantum Chemistry and Basis Sets; References; 2 Application of Density Functional and Density Functional Based Ligand Field Theory to Spin States; 2.1 Introduction; 2.2 What Is the Problem with Theory?; 2.3 Validation and Application Studies; 2.4 Concluding Remarks; Acknowledgments; References
3 Ab Initio Wavefunction Approaches to Spin States3.1 Introduction and Scope; 3.2 Wavefunction-Based Methods for Spin States; 3.3 Spin Crossover; 3.4 Magnetic Coupling; 3.5 Spin States in Biochemical and Biomimetic Systems; 3.6 Two-State Reactivity; 3.7 Concluding Remarks; References; 4 Experimental Techniques for Determining Spin States; 4.1 Introduction; 4.2 Magnetic Measurements; 4.3 EPR Spectroscopy; 4.4 Mössbauer Spectroscopy; 4.5 X-ray Spectroscopic Techniques; 4.6 NMR Spectroscopy; 4.7 Other Techniques; 4.A Appendix; References; 5 Molecular Discovery in Spin Crossover; 5.1 Introduction 5.2 Theoretical Background5.3 Thermal SCO Systems: Fe(II); 5.4 SCO in Non-d6 Systems; 5.5 Computational Methods; 5.6 Outlook; References; 6 Multiple Spin-State Scenarios in Organometallic Reactivity; 6.1 Introduction; 6.2 "Spin-Forbidden" Reactions and Two-State Reactivity; 6.3 Spin-State Changes in Transition Metal Complexes; 6.4 Spin-State Changes in Catalysis; 6.5 Concluding Remarks; References; 7 Principles and Prospects of Spin-States Reactivity in Chemistry and Bioinorganic Chemistry; 7.1 Introduction; 7.2 Spin-States Reactivity 7.3 Prospects of Two-State Reactivity and Multi-State Reactivity7.4 Concluding Remarks; Acknowledgement; Note Added in Proof; References; 8 Multiple Spin-State Scenarios in Gas-Phase Reactions; 8.1 Introduction; 8.2 Experimental Methods for the Investigation of Metal-Ion Reactions; 8.3 Multiple State Reactivity: Reactions of Metal Cations with Methane; 8.4 Effect of the Oxidation State: Reactions of Metal Hydride Cations with Methane; 8.5 Two-State Reactivity: Reactions of Metal Oxide Cations; 8.6 Effect of Ligands; 8.7 Effect of Noninnocent Ligands; 8.8 Concluding Remarks; References 9 Catalytic Function and Mechanism of Heme and Nonheme Iron(IV)-Oxo Complexes in Nature9.1 Introduction; 9.2 Cytochrome P450 Enzymes; 9.3 Nonheme Iron Dioxygenases; 9.4 Conclusions; 9.5 Acknowledgments; References; 10 Terminal Metal-Oxo Species with Unusual Spin States; 10.1 Introduction; 10.2 Bonding; 10.3 Case Studies; 10.4 Reactivity; 10.5 Summary; Note Added in Proof; References; 11 Multiple Spin Scenarios in Transition-Metal Complexes Involving Redox Non-Innocent Ligands; 11.1 Introduction; 11.2 Survey of Non-Innocent Ligands; 11.3 Identification of Non-Innocent Ligands 11.4 Selected Examples of Biological and Chemical Systems Involving Non-Innocent Ligands |
Record Nr. | UNINA-9910810404303321 |
West Sussex, England : , : Wiley, , 2016 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|