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Liver regeneration : basic mechanisms, relevant models and clinical applications / / edited by Udayan Apte, PhD Dabt, Associate Professor, Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, KS, USA
| Liver regeneration : basic mechanisms, relevant models and clinical applications / / edited by Udayan Apte, PhD Dabt, Associate Professor, Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, KS, USA |
| Pubbl/distr/stampa | London, UK ; ; San Diego, CA ; ; Waltham, MA : , : Elsevier, , [2015] |
| Descrizione fisica | 1 online resource (326 p.) |
| Disciplina | 611.36 |
| Soggetto topico | Liver - Regeneration |
| ISBN | 0-12-800431-2 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Liver Regeneration: Basic Mechanisms, Relevant Models and Clinical Applications; Copyright; Dedication; Contents; Contributors; Preface; Part I: Introduction; Chapter 1: Liver Regeneration: An Introduction; 1.1. History; 1.2. Models of Liver Regeneration; 1.3. Mechanisms of Liver Regeneration; 1.4. Regeneration Using Progenitor Cells; 1.5. Mitogen-Induced Hepatocyte Proliferation; 1.6. Frontiers; References; Part II: Methods to Assess Liver Regeneration; Chapter 2: Models to Study Liver Regeneration; 2.1. Introduction; 2.2. Main Models; 2.2.1. Partial Hepatectomy
2.2.1.1. PH Procedure2.2.1.2. Establishing Baseline, Time Course, and Proper Controls; 2.2.2. Models of Liver Regeneration After Chemical-Induced Liver Injury; 2.2.2.1. d-Galactosamine: Mechanism of Hepatotoxicity; 2.2.2.1.1. d-Galactosamine: Hepatic Regenerative Response; 2.2.2.2. Carbon Tetrachloride: Mechanism of Hepatotoxicity; 2.2.2.2.1. CCl4: Hepatic Regenerative Response; 2.2.2.3. Thioacetamide; 2.2.2.4. Acetaminophen; 2.2.2.5. Regeneration After Ischemia/Reflow; 2.2.2.5.1. Mechanisms of I/R Injury and Repair; 2.3. Alternate Models of Liver Growth; 2.3.1. Postnatal Liver Growth 2.3.2. Pregnancy-Induced Liver Growth2.4. Models to Study HPCs; 2.4.1. 2-Acetylaminofluorene Combined with Partial Hepatectomy; 2.4.2. The DDC Diet Model; 2.4.3. The CDE Diet Model; 2.5. Assays Used to Assess Liver Regeneration; 2.5.1. PCNA Immunolocalization; 2.5.2. 3H-TdR and BrdU Incorporation; 2.5.3. Ki67 Immunolocalization; 2.6. Additional Methods; References; Chapter 3: Liver Regeneration in Zebrafish; 3.1. Introduction; 3.2. The Therapeutic Impact of Zebrafish Research; 3.3. Adult Liver Anatomy and Physiology; 3.4. Liver Regeneration Following Partial Hepatectomy 3.5. Drug-Induced Hepatotoxicity3.6. Genetic Hepatocyte Ablation; 3.7. Summary; References; Part III: Molecular Mechanisms of Liver Regeneration; Chapter 4: The Priming and Progression Theory of Liver Regeneration; 4.1. Overview of Studies of Liver Regeneration; 4.2. Salient Features of Liver Regeneration Prior to 1970; 4.3. Identifying Hepatomitogens in the 1970s-1980s; 4.4. 1990s: Development of the Priming and Progression Model, with a Focus on Inflammatory Stimuli During Regeneration; 4.5. Priming Alone Versus Priming and Progression: 1/3 Versus 2/3 Hepatectomy 4.6. Controversies Regarding the Importance of Priming in Regeneration4.7. Recent Insight into Cell-Cycle ``Competency;́́ 4.8. The Role of NPCs in Priming and Progression; 4.9. Future Directions; References; Chapter 5: Extracellular Signals Involved in Liver Regeneration: Direct and Auxiliary Mitogens; 5.1. Hepatocyte Growth Assay; 5.2. Complete Versus Auxiliary Mitogens; 5.3. Complete or Direct Mitogens; 5.3.1. Hepatocyte Growth Factor; 5.3.2. Ligands of EGFR; 5.4. Auxiliary Mitogens; 5.5. TNFα; 5.6. IL6; 5.7. Norepinephrine; 5.8. Insulin; 5.9. Summary; References Chapter 6: Developmental Pathways in Liver Regeneration-I |
| Record Nr. | UNINA-9910298039203321 |
| London, UK ; ; San Diego, CA ; ; Waltham, MA : , : Elsevier, , [2015] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Prometheus and the Liver through Art and Medicine / / Merel Gulik, Julia Rosmalen, Belle Rosmalen, Thomas Gulik
| Prometheus and the Liver through Art and Medicine / / Merel Gulik, Julia Rosmalen, Belle Rosmalen, Thomas Gulik |
| Autore | Rosmalen Julia |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Amsterdam : , : Amsterdam University Press, , [2022] |
| Descrizione fisica | 1 online resource (208 p.) |
| Disciplina | 611.36 |
| Soggetto topico | ART / Subjects & Themes / General |
| Soggetto non controllato | Prometheus, myth, art, liver, medicine |
| ISBN | 90-485-5741-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Frontmatter -- CONTENTS -- INTRODUCTION -- 1 THE PROMETHEUS MYTH -- 2 THE DEPICTION OF PROMETHEUS IN CLASSICAL ANTIQUITY -- 3 THE LIVER ACCORDING TO THE ANCIENT GREEKS AND THE ETRUSCANS -- 4 THE HARUSPEX AND HEPATOSCOPY -- 5 PROMETHEUS IN THE MIDDLE AGES -- 6 THE LIVER IN THE THE MIDDLE AGES, ACCORDING TO GALEN -- 7 PROMETHEUS IN THE RENAISSANCE -- 8 THE LIVER IN THE RENAISSANCE AS DESCRIBED BY REISCH, VESALIUS, AND DA VINCI -- 9 PROMETHEUS IN THE BAROQUE -- THE WOUNDS OF CHRIST AND PROMETHEUS – TWO OF A KIND? -- 10 THE LIVER IN THE BAROQUE, ACCORDING TO VAN DEN SPIEGEL, GLISSON, AND BIDLOO -- 11 PROMETHEUS AND MODERNITY -- MARY SHELLEY’S FRANKENSTEIN; OR, THE MODERN PROMETHEUS -- 12 THE LIVER IN THE ENLIGHTENMENT -- 13 THE TWENTIETH-CENTURY PROMETHEUS -- 14 LIVER SURGERY AND LIVER REGENERATION -- REGENERATION OF THE HYDRA POLYP -- ACKNOWLEDGEMENTS -- ON THE AUTHORS -- BIBLIOGRAPHY -- INDEX |
| Record Nr. | UNINA-9910583589903321 |
Rosmalen Julia
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| Amsterdam : , : Amsterdam University Press, , [2022] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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