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Caco-2 cells and their uses [[electronic resource] /] / Megan A. Schulz, editor
| Caco-2 cells and their uses [[electronic resource] /] / Megan A. Schulz, editor |
| Pubbl/distr/stampa | Hauppauge, N.Y., : Nova Science Publishers, Inc., c2011 |
| Descrizione fisica | 1 online resource (219 p.) |
| Disciplina | 611/.0187 |
| Altri autori (Persone) | SchulzMegan A |
| Collana | Cell biology research progress |
| Soggetto topico |
Epithelial cells
Monomolecular films Intestinal absorption |
| Soggetto genere / forma | Electronic books. |
| ISBN | 1-62081-613-X |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910465754103321 |
| Hauppauge, N.Y., : Nova Science Publishers, Inc., c2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Caco-2 cells and their uses [[electronic resource] /] / Megan A. Schulz, editor
| Caco-2 cells and their uses [[electronic resource] /] / Megan A. Schulz, editor |
| Pubbl/distr/stampa | Hauppauge, N.Y., : Nova Science Publishers, Inc., c2011 |
| Descrizione fisica | 1 online resource (219 p.) |
| Disciplina | 611/.0187 |
| Altri autori (Persone) | SchulzMegan A |
| Collana | Cell biology research progress |
| Soggetto topico |
Epithelial cells
Monomolecular films Intestinal absorption |
| ISBN | 1-62081-613-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910791742703321 |
| Hauppauge, N.Y., : Nova Science Publishers, Inc., c2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Caco-2 cells and their uses [[electronic resource] /] / Megan A. Schulz, editor
| Caco-2 cells and their uses [[electronic resource] /] / Megan A. Schulz, editor |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hauppauge, N.Y., : Nova Science Publishers, Inc., c2011 |
| Descrizione fisica | 1 online resource (219 p.) |
| Disciplina | 611/.0187 |
| Altri autori (Persone) | SchulzMegan A |
| Collana | Cell biology research progress |
| Soggetto topico |
Epithelial cells
Monomolecular films Intestinal absorption |
| ISBN | 1-62081-613-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- CACO-2 CELLS AND THEIR USES -- CACO-2 CELLS AND THEIR USES -- Library of Congress Cataloging-in-Publication Data -- CONTENTS -- PREFACE -- Chapter 1 THE INDUSTRIAL AND ACADEMIC RATIONALE OF CACO-2 CELL MODELS TODAY -- ABSTRACT -- ABBREVIATIONS -- 1. INTRODUCTION -- 2. CACO-2 CELL ADVANTAGES, DRAWBACKS AND TRANSPORTER-ENZYME EXPRESSION PATTERNS -- 2.1. Applicability of CACO-2 Models to Predict the Fraction of Drug Absorbed in Humans -- 2.2. CACO-2 Transporters and Enzyme Expression and the Comparison with the In Vivo Human Expression -- 3. CACO-2 CELLS AS AN IN VITRO PROGNOSTIC TOOL FOR ASSESSING PHARMACOKINETIC DRUG-GARLIC INTERACTIONS -- 4. CACO-2 CELLS FOR THE EVALUATION OF SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEMS (SMEDDS) -- 4.1. Self-Microemulsifying Drug Delivery Systems:The Objectives and Advantages -- 4.2. Studies Performed to Evaluate SMEDDS Impact on Intestinal Absorption of Drugs -- 4.3. The Mechanism Responsible for Increased Absorption of Furosemide Incorporated in SMEDDS -- CONCLUSION -- REFERENCES -- Chapter 2 A CRITICAL PERSPECTIVE ON CELL LINES STUDIES IN NUTRITION: THE CASE OF INTESTINAL ABSORPTION -- ABSTRACT -- INTRODUCTION -- RESEARCH WITH CELL LINES -- CELL LINES IN INTESTINAL ABSORPTION STUDIES -- NON-HUMAN CELL LINES IN INTESTINAL ABSORPTION STUDIES -- IN VITRO CELL CULTURES AS AN ALTERNATIVE TO ANIMAL TESTING -- INTESTINAL CELL LINES AS AN IN VITRO MODEL OF CLINICAL VALUE -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 3 CO-CULTURE SYSTEMS WITH CACO-2 CELLS TO EVALUATE THE BIOACTIVITY OF PLANT EXTRACTS -- ABSTRACT -- INTRODUCTION -- CO-CULTURE SYSTEMS USING CACO-2 CELLS: CELL VIABILITY AND FUNCTIONALITY -- WORKING WITH NATURAL EXTRACTS: CACO-2 AS A FILTER TO SIMULATE THE HUMAN INTESTINAL BARRIER -- WORKING WITH NATURAL EXTRACTS: ARE THESE FILTERED EXTRACTS BIOACTIVE? -- CONCLUSION.
ACKNOWLEDGMENTS -- REFERENCES -- Chapter 4 THE USE OF CACO-2 CELLS IN THE STUDY OF INTESTINAL TRANSPORT -- ABSTRACT -- INTRODUCTION -- USES OF CACO-2 CELLS -- Paracellular Pathway -- Transcellular Pathway -- CONCLUSION -- REFERENCES -- Chapter 5 CACO-2 CELLS AS AN EXPERIMENTAL MODEL FOR THE STUDY OF CELL-MATRIX INTERACTIONS AND WOUND HEALING IN INTESTINAL VILLUS CELLS -- ABSTRACT -- INTRODUCTION -- CACO-2 CELLS AND CELL-MATRIX INTERACTIONS -- CACO-2 CELLS AND CELL-MATRIX INTERACTIONS IN CO-CULTURE -- CACO-2 CELLS IN CO-CULTURE: A WOUND HEALING MODEL -- CONCLUSIONS -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 6 EFFECT OF POLYUNSATURATED FATTY ACIDS AND BILE SALTS ON BUTYRATE UPTAKE BY INTESTINAL EPITHELIAL CELLS -- ABSTRACT -- INTRODUCTION -- MATERIALS AND METHODS -- CACO-2 Cell Culture -- IEC-6 Cell Culture -- Determination of 14C-BT uptake by CACO-2 and IEC-6 Cells -- Treatment of the Cells with Compounds -- Determination of Cell Viability -- Protein Determination -- Calculation and Statistics -- Materials -- RESULTS -- Effect of Pufas and Bile Acids on 14C-BT Apical uptake by CACO-2 Cells -- Effect of Pufas and Bile Acids on 14C-BT Apical uptake by IEC-6 Cells -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 7 ANALYSIS OF BOTULINUM TOXIN: INTESTINAL EPITHELIAL BARRIER INTERACTION USING EPITHELIAL MONOLAYER CULTURE SYSTEMS -- ABSTRACT -- INTRODUCTION -- 1. TRANSCYTOSIS OF BONT ACROSS CULTURED INTESTINAL EPITHELIAL MONOLAYERS -- 2. ADHESION OF HA TO INTESTINAL EPITHELIAL CELLS -- 3. DISRUPTION OF THE INTERCELLULAR EPITHELIAL BARRIER BY HA -- 4. POSSIBLE MECHANISMS OF BONT COMPLEX TRANSPORT ACROSS THE INTESTINAL EPITHELIAL MONOLAYER -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 8 CACO-2 CELLS AND GENOTOXICITY STUDIES OF FOOD CONTAMINANTS -- ABSTRACT -- INTRODUCTION ON IN VITRO GENOTOXICITY TESTING. IN VITRO HUMAN INTESTINAL CELLS: PERTINENCE FOR GENOTOXICITY TESTING OF FOOD CONTAMINANTS -- USE OF CACO-2 CELLS IN GENOTOXICITY TESTS -- Comet Assay -- Others -- CYTOKINESIS-BLOCK MICRONUCLEUS ASSAY -- On Undifferentiated Cells -- On Differentiated Cells: Development and Application -- IMPROVEMENT OF THIS CELL MODEL TO PREDICT TOXICITY AND MECHANISTIC ENDPOINTS -- Co-Cultures CACO-2/TK6 -- Metabolism Regulation -- CONCLUSIONS -- ACKNOWLEDGMENT -- REFERENCES -- Chapter 9 CACO-2 CELLS FOR STUDYING INTESTINAL ABSORPTION MECHANISMS: COMPARISON AND CORRELATIONS WITH RAT MODEL -- ABSTRACT -- INTRODUCTION: IN VITRO MODELS OF INTESTINAL PERMEATION -- ABSORPTION IN THE GASTROINTESTINAL TRACT: ROUTES OF PERMEATION ACROSS INTESTINAL CELLS. -- IN VITRO MODELS OF THE INTESTINAL BARRIER: CELL MODELS -- CACO-2 -- Other Cell Lines -- HT29 Cells -- CACO-2 CELLS FOR PREDICTING ORAL FRACTION ABSORBED: COMPARISON WITH HUMAN, RAT AND PAMPA MODELS -- CACO-2 CELLS FOR THE STUDY OF DRUG ABSORPTION MECHANISMS: MODELING APPROACHES FOR PARAMETER ESTIMATION -- Apparent Permeability Estimation (Sink versus Non Sink Conditions) -- Mathematical Modeling of CACO-2 Data for Parameter Estimation -- P versus C -- Amounts versus Time -- CORRELATION BETWEEN CACO-2 CELLS DATA AND IN SITU RAT DATA FOR THE STUDY OF P-GP MEDIATED SECRETION -- CONCLUSIONS -- REFERENCES -- Chapter 10 NANOCARRIER ABSORPTION STUDIES WITH CACO-2 CELLS -- ABSTRACT -- INTRODUCTION -- I. METHOD -- a. Absorption Study -- b. Mechanistic Studies -- II. RESULTS -- a. Absorption Study -- b. Mechanistics Study -- III. DISADVANTAGE/ LIMIT OF CACO-2 TO STUDY DRUG TRANSPORT / OTHER METHOD -- a. Parallel Artificial Membrane Permeation Assay (PAMPA) -- b. Alternative Cell Culture Models -- c. In Vivo or Ex Vivo Studies -- CONCLUSION -- ACKNOWLEDGMENT -- BIBLIOGRAPHY. Chapter 11 CACO-2 CELLS AS A MODEL TO STUDY THE INTESTINAL EFFECTS OF NON-ABSORBABLE PHYTOCHEMICALS -- ABSTRACT -- ABBREVIATIONS -- 1. INTRODUCTION -- 2. PROCYANIDINS:STRUCTURE AND METABOLISM -- 3. PROCYANIDINS AND THE HEALTH OF THE GASTROINTESTINAL TRACT -- 4. INTERACTIONS OF PROCYANIDINS WITH CACO-2 CELL MEMBRANES -- 5. PROCYANIDINS PROTECTCACO-2 CELLSFROM OXIDATION AND PERMEABILIZATION -- 6. PROCYANIDINS PROTECTCACO-2 CELLS FROM INFLAMMATION -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- INDEX. |
| Record Nr. | UNINA-9910822031303321 |
| Hauppauge, N.Y., : Nova Science Publishers, Inc., c2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Culture of epithelial cells [[electronic resource] /] / editors, R. Ian Freshney and Mary G. Freshney
| Culture of epithelial cells [[electronic resource] /] / editors, R. Ian Freshney and Mary G. Freshney |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | New York, : Wiley-Liss, c2002 |
| Descrizione fisica | 1 online resource (479 p.) |
| Disciplina |
611.0187
611/.0187 |
| Altri autori (Persone) |
FreshneyR. Ian
FreshneyMary G |
| Collana | Culture of specialized cells |
| Soggetto topico |
Epithelial cells
Cell culture Epithelium - Cultures and culture media |
| ISBN |
1-280-54172-5
9786610541720 0-471-45912-7 0-471-22120-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
CULTURE OF EPITHELIAL CELLS Second Edition; Contents; Contributors; Preface; Preface to First Edition; List of Abbreviations; Chapter 1. Introduction; Chapter 2. Cell Interaction and Epithelial Differentiation; Chapter 3. The Epidermis; Chapter 4. Culture of Human Mammary Epithelial Cells; Chapter 5. Culture of Human Cervical Epithelial Cells; Chapter 6. Human Prostatic Epithelial Cells; Chapter 7. Human Oral Epithelium; Chapter 8. Normal Human Bronchial Epithelial Cell Culture; Chapter 9. Isolation and Culture of Pulmonary Alveolar Epithelial Type II Cells
Chapter 10. Isolation and Culture of Intestinal Epithelial CellsChapter 11. Isolation and Culture of Animal and Human Hepatocytes; Chapter 12. Culture of Human Urothelium; Chapter 13. Other Epithelial Cells; List of Suppliers; Index |
| Record Nr. | UNINA-9910142500003321 |
| New York, : Wiley-Liss, c2002 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Mechanobiology of the endothelium / / editor, Helim Aranda-Espinoza, Fischell Department of Bioengineering, University of Maryland College Park, MD USA
| Mechanobiology of the endothelium / / editor, Helim Aranda-Espinoza, Fischell Department of Bioengineering, University of Maryland College Park, MD USA |
| Pubbl/distr/stampa | Boca Raton : , : CRC Press, , [2015] |
| Descrizione fisica | 1 online resource (278 p.) |
| Disciplina |
611.0187
611/.0187 |
| Soggetto topico | Endothelium - Physiology |
| ISBN |
0-429-17139-0
1-4822-0724-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Preface; Contents; Chapter 1: The Endothelium as a Mechanosensor; Chapter 2: Mechanobiology of the Endothelial Nucleus; Chapter 3: Cancer Metastasis and Biomechanics of the Endothelium; Chapter 4: Valvular Endothelial Mechanobiology; Chapter 5: Environmental Factors that Influence the Response of the Endothelium to Flow; Chapter 6: Differential Response of the Endothelium to Simultaneous Chemical and Mechanical Stimulation in Inflammation Response; Chapter 7: The Role of Cholesterol and Lipoproteins in Control of Endothelial Biomechanics
Chapter 8: Implications of Fluid Shear Stress in Capillary Sprouting during Adult Microvascular Network RemodelingChapter 9: Endothelial Cell Adhesion Molecules and Drug Delivery Applications; Chapter 10: Leukocyte Transendothelial Migration: A Biophysical Event; Color Plate Section |
| Record Nr. | UNINA-9910787852203321 |
| Boca Raton : , : CRC Press, , [2015] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Mechanobiology of the endothelium / / editor, Helim Aranda-Espinoza, Fischell Department of Bioengineering, University of Maryland College Park, MD USA
| Mechanobiology of the endothelium / / editor, Helim Aranda-Espinoza, Fischell Department of Bioengineering, University of Maryland College Park, MD USA |
| Pubbl/distr/stampa | Boca Raton : , : CRC Press, , [2015] |
| Descrizione fisica | 1 online resource (278 p.) |
| Disciplina |
611.0187
611/.0187 |
| Soggetto topico | Endothelium - Physiology |
| ISBN |
0-429-17139-0
1-4822-0724-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Preface; Contents; Chapter 1: The Endothelium as a Mechanosensor; Chapter 2: Mechanobiology of the Endothelial Nucleus; Chapter 3: Cancer Metastasis and Biomechanics of the Endothelium; Chapter 4: Valvular Endothelial Mechanobiology; Chapter 5: Environmental Factors that Influence the Response of the Endothelium to Flow; Chapter 6: Differential Response of the Endothelium to Simultaneous Chemical and Mechanical Stimulation in Inflammation Response; Chapter 7: The Role of Cholesterol and Lipoproteins in Control of Endothelial Biomechanics
Chapter 8: Implications of Fluid Shear Stress in Capillary Sprouting during Adult Microvascular Network RemodelingChapter 9: Endothelial Cell Adhesion Molecules and Drug Delivery Applications; Chapter 10: Leukocyte Transendothelial Migration: A Biophysical Event; Color Plate Section |
| Record Nr. | UNINA-9910823477203321 |
| Boca Raton : , : CRC Press, , [2015] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Mucus and mucosa [[electronic resource]]
| Mucus and mucosa [[electronic resource]] |
| Pubbl/distr/stampa | London, : Pitman |
| Descrizione fisica | 1 online resource (258 p.) |
| Disciplina | 611/.0187 |
| Collana | Ciba Foundation symposium |
| Soggetto topico |
Mucous membrane
Mucus |
| ISBN |
0-212-79783-2
1-280-78416-4 9786613694553 0-470-72090-5 0-470-71860-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Mucus and mucosa; Contents; Introduction; Regulation of secretion from serous and mucous cells in the trachea; Discussion; Regulation of intestinal goblet cells in situ, in mucosal explants and in the isolated epithelium; Discussion; Airway mucus: composition and regulation of its secretion by neuropeptides in vitro; Discussion; Acute and chronic models for hypersecretion of intestinal mucin; Discussion; Proteinases release mucin from airways goblet cells; Discussion; General Discussion Regulation of mucus secretion; Some characteristics of duodenal epithelium; Discussion
Fluid transport across airway epitheliaDiscussion; Some non-mucin components of mucus and their possible biological roles; Discussion; Mucus glycoprotein structure, gel formation and gastrointestinal mucus function; Discussion; Macromolecular properties and polymeric structure of mucus glycoproteins; Discussion; Effects of the anti-oestrogens, clomiphene and tamoxifen, on the cervical factor in female infertility; Terminal glycosylation in human cervical mucin; Discussion of the two preceding papers; Comparative studies of mucus and mucin physicochemistry; Discussion Hydration kinetics of exocytosed mucins in cultured secretory cells of the rabbit trachea: a new modelDiscussion; Final general discussion Mucus swelling, secretion and effects on cilia; Epithelial preparations; Closing remarks; Index of contributors; Subject index |
| Record Nr. | UNINA-9910144665103321 |
| London, : Pitman | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Mucus and mucosa [[electronic resource]]
| Mucus and mucosa [[electronic resource]] |
| Pubbl/distr/stampa | London, : Pitman |
| Descrizione fisica | 1 online resource (258 p.) |
| Disciplina | 611/.0187 |
| Collana | Ciba Foundation symposium |
| Soggetto topico |
Mucous membrane
Mucus |
| ISBN |
0-212-79783-2
1-280-78416-4 9786613694553 0-470-72090-5 0-470-71860-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Mucus and mucosa; Contents; Introduction; Regulation of secretion from serous and mucous cells in the trachea; Discussion; Regulation of intestinal goblet cells in situ, in mucosal explants and in the isolated epithelium; Discussion; Airway mucus: composition and regulation of its secretion by neuropeptides in vitro; Discussion; Acute and chronic models for hypersecretion of intestinal mucin; Discussion; Proteinases release mucin from airways goblet cells; Discussion; General Discussion Regulation of mucus secretion; Some characteristics of duodenal epithelium; Discussion
Fluid transport across airway epitheliaDiscussion; Some non-mucin components of mucus and their possible biological roles; Discussion; Mucus glycoprotein structure, gel formation and gastrointestinal mucus function; Discussion; Macromolecular properties and polymeric structure of mucus glycoproteins; Discussion; Effects of the anti-oestrogens, clomiphene and tamoxifen, on the cervical factor in female infertility; Terminal glycosylation in human cervical mucin; Discussion of the two preceding papers; Comparative studies of mucus and mucin physicochemistry; Discussion Hydration kinetics of exocytosed mucins in cultured secretory cells of the rabbit trachea: a new modelDiscussion; Final general discussion Mucus swelling, secretion and effects on cilia; Epithelial preparations; Closing remarks; Index of contributors; Subject index |
| Record Nr. | UNISA-996202091403316 |
| London, : Pitman | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Mucus and mucosa [[electronic resource]]
| Mucus and mucosa [[electronic resource]] |
| Pubbl/distr/stampa | London, : Pitman |
| Descrizione fisica | 1 online resource (258 p.) |
| Disciplina | 611/.0187 |
| Collana | Ciba Foundation symposium |
| Soggetto topico |
Mucous membrane
Mucus |
| ISBN |
0-212-79783-2
1-280-78416-4 9786613694553 0-470-72090-5 0-470-71860-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Mucus and mucosa; Contents; Introduction; Regulation of secretion from serous and mucous cells in the trachea; Discussion; Regulation of intestinal goblet cells in situ, in mucosal explants and in the isolated epithelium; Discussion; Airway mucus: composition and regulation of its secretion by neuropeptides in vitro; Discussion; Acute and chronic models for hypersecretion of intestinal mucin; Discussion; Proteinases release mucin from airways goblet cells; Discussion; General Discussion Regulation of mucus secretion; Some characteristics of duodenal epithelium; Discussion
Fluid transport across airway epitheliaDiscussion; Some non-mucin components of mucus and their possible biological roles; Discussion; Mucus glycoprotein structure, gel formation and gastrointestinal mucus function; Discussion; Macromolecular properties and polymeric structure of mucus glycoproteins; Discussion; Effects of the anti-oestrogens, clomiphene and tamoxifen, on the cervical factor in female infertility; Terminal glycosylation in human cervical mucin; Discussion of the two preceding papers; Comparative studies of mucus and mucin physicochemistry; Discussion Hydration kinetics of exocytosed mucins in cultured secretory cells of the rabbit trachea: a new modelDiscussion; Final general discussion Mucus swelling, secretion and effects on cilia; Epithelial preparations; Closing remarks; Index of contributors; Subject index |
| Record Nr. | UNINA-9910829171103321 |
| London, : Pitman | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||