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Medical biostatistics for complex diseases [[electronic resource] /] / edited by Frank Emmert-Streib and Matthias Dehmer
| Medical biostatistics for complex diseases [[electronic resource] /] / edited by Frank Emmert-Streib and Matthias Dehmer |
| Pubbl/distr/stampa | Weimheim, : Wiley-VCH, 2010 |
| Descrizione fisica | 1 online resource (413 p.) |
| Disciplina |
610.72721
614.4015195 |
| Altri autori (Persone) |
Emmert-StreibFrank
DehmerMatthias |
| Soggetto topico |
Medicine - Research - Statistical methods
Medical statistics |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-282-68778-6
9786612687785 3-527-63033-3 3-527-63034-1 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Medical Biostatistics for Complex Diseases; Foreword; Contents; Preface; List of Contributors; Part One: General Biological and Statistical Basics; 1 The Biology of MYC in Health and Disease: A High Altitude View; 1.1 Introduction; 1.2 MYC and Normal Physiology; 1.3 Regulation of Transcription and Gene Expression; 1.4 Metabolism; 1.5 Cell-Cycle Regulation and Differentiation; 1.6 Protein Synthesis; 1.7 Cell Adhesion; 1.8 Apoptosis; 1.9 MicroRNAs; 1.10 Physiological Effects of Loss and Gain of c-myc Function in Mice; 1.10.1 Loss of Function
1.10.2 Gain of Function: Inducible Transgenic Animals1.11 Contributions of MYC to Tumor Biology; 1.12 Introduction of Hematopoietic Malignancies; 1.13 Mechanisms of MYC Dysregulation in Hematological Malignancies; 1.14 Mutation(s) in the MYC Gene in Hematological Cancers; 1.15 Role of MYC in Cell Cycle Regulation and Differentiation in Hematological Cancers; 1.16 Role of BCR Signaling in Conjunction with MYC Overexpression in Lymphoid Malignancies; 1.17 Deregulation of Auxiliary Proteins in Addition to MYC in Hematological Cancers; 1.18 Conclusion; References 2 Cancer Stem Cells - Finding and Capping the Roots of Cancer2.1 Introduction - Stem Cells and Cancer Stem Cells; 2.1.1 What are Stem Cells?; 2.1.2 Concept of Cancer Stem Cells (CSCs); 2.2 Hematopoietic Stem Cells as a Paradigm; 2.2.1 Leukemia as a Paradigmatic Disease for Cancer Research; 2.2.2 CFUs; 2.2.3 LTC-ICs; 2.2.4 In Vivo Repopulation; 2.2.5 Importance of the Bone Marrow Niche; 2.2.6 Leukemic Stem Cells; 2.2.6.1 Leukemic Stem Cells in the Bone Marrow Niche; 2.2.7 CML as a Paradigmatic Entity; 2.3 Current Technical Approach to the Isolation and Characterization of Cancer Stem Cells 2.3.1 Tools for the Detection of Cancer Stem Cells2.3.2 Phenotype of Cancer Stem Cells; 2.4 Cancer Stem Cells in Solid Tumors; 2.4.1 Breast Cancer; 2.4.2 Prostate Cancer; 2.4.3 Colon Cancer; 2.4.4 Other Cancers; 2.5 Open Questions of the Cancer Stem Cell Hypothesis; 2.6 Clinical Relevance of Cancer Stem Cells; 2.6.1 Diagnostic Relevance of Cancer Stem Cells; 2.6.2 Therapeutic Relevance - New Drugs Directed Against Cancer Stem Cells; 2.7 Outlook; References; 3 Multiple Testing Methods; 3.1 Introduction; 3.1.1 A Brief More Focused Introduction; 3.1.2 Historic Development of the Field 3.2 Statistical Background3.2.1 Tests; 3.2.2 Test Statistics and p-Values; 3.2.3 Resampling Based Testing; 3.3 Type I Error Rates; 3.4 Introduction to Multiple Testing Procedures; 3.4.1 Adjusted p-values; 3.4.2 Categories of Multiple Testing Procedures; 3.4.3 Estimation of the Proportion of False Nulls; 3.5 Multiple Testing Procedures; 3.5.1 Procedures Controlling the FWER; 3.5.2 Procedures Controlling the FDR; 3.5.3 Procedures Controlling the FDX Figure; 3.6 Type I Error Rates Control Under Dependence; 3.6.1 FWER Control; 3.6.2 FDR and FDX Control 3.7 Multiple Testing Procedures Applied to Gene Discovery in DNA Microarray Cancer Studies |
| Record Nr. | UNINA-9910140554603321 |
| Weimheim, : Wiley-VCH, 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Medical biostatistics for complex diseases [[electronic resource] /] / edited by Frank Emmert-Streib and Matthias Dehmer
| Medical biostatistics for complex diseases [[electronic resource] /] / edited by Frank Emmert-Streib and Matthias Dehmer |
| Pubbl/distr/stampa | Weimheim, : Wiley-VCH, 2010 |
| Descrizione fisica | 1 online resource (413 p.) |
| Disciplina |
610.72721
614.4015195 |
| Altri autori (Persone) |
Emmert-StreibFrank
DehmerMatthias |
| Soggetto topico |
Medicine - Research - Statistical methods
Medical statistics |
| ISBN |
1-282-68778-6
9786612687785 3-527-63033-3 3-527-63034-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Medical Biostatistics for Complex Diseases; Foreword; Contents; Preface; List of Contributors; Part One: General Biological and Statistical Basics; 1 The Biology of MYC in Health and Disease: A High Altitude View; 1.1 Introduction; 1.2 MYC and Normal Physiology; 1.3 Regulation of Transcription and Gene Expression; 1.4 Metabolism; 1.5 Cell-Cycle Regulation and Differentiation; 1.6 Protein Synthesis; 1.7 Cell Adhesion; 1.8 Apoptosis; 1.9 MicroRNAs; 1.10 Physiological Effects of Loss and Gain of c-myc Function in Mice; 1.10.1 Loss of Function
1.10.2 Gain of Function: Inducible Transgenic Animals1.11 Contributions of MYC to Tumor Biology; 1.12 Introduction of Hematopoietic Malignancies; 1.13 Mechanisms of MYC Dysregulation in Hematological Malignancies; 1.14 Mutation(s) in the MYC Gene in Hematological Cancers; 1.15 Role of MYC in Cell Cycle Regulation and Differentiation in Hematological Cancers; 1.16 Role of BCR Signaling in Conjunction with MYC Overexpression in Lymphoid Malignancies; 1.17 Deregulation of Auxiliary Proteins in Addition to MYC in Hematological Cancers; 1.18 Conclusion; References 2 Cancer Stem Cells - Finding and Capping the Roots of Cancer2.1 Introduction - Stem Cells and Cancer Stem Cells; 2.1.1 What are Stem Cells?; 2.1.2 Concept of Cancer Stem Cells (CSCs); 2.2 Hematopoietic Stem Cells as a Paradigm; 2.2.1 Leukemia as a Paradigmatic Disease for Cancer Research; 2.2.2 CFUs; 2.2.3 LTC-ICs; 2.2.4 In Vivo Repopulation; 2.2.5 Importance of the Bone Marrow Niche; 2.2.6 Leukemic Stem Cells; 2.2.6.1 Leukemic Stem Cells in the Bone Marrow Niche; 2.2.7 CML as a Paradigmatic Entity; 2.3 Current Technical Approach to the Isolation and Characterization of Cancer Stem Cells 2.3.1 Tools for the Detection of Cancer Stem Cells2.3.2 Phenotype of Cancer Stem Cells; 2.4 Cancer Stem Cells in Solid Tumors; 2.4.1 Breast Cancer; 2.4.2 Prostate Cancer; 2.4.3 Colon Cancer; 2.4.4 Other Cancers; 2.5 Open Questions of the Cancer Stem Cell Hypothesis; 2.6 Clinical Relevance of Cancer Stem Cells; 2.6.1 Diagnostic Relevance of Cancer Stem Cells; 2.6.2 Therapeutic Relevance - New Drugs Directed Against Cancer Stem Cells; 2.7 Outlook; References; 3 Multiple Testing Methods; 3.1 Introduction; 3.1.1 A Brief More Focused Introduction; 3.1.2 Historic Development of the Field 3.2 Statistical Background3.2.1 Tests; 3.2.2 Test Statistics and p-Values; 3.2.3 Resampling Based Testing; 3.3 Type I Error Rates; 3.4 Introduction to Multiple Testing Procedures; 3.4.1 Adjusted p-values; 3.4.2 Categories of Multiple Testing Procedures; 3.4.3 Estimation of the Proportion of False Nulls; 3.5 Multiple Testing Procedures; 3.5.1 Procedures Controlling the FWER; 3.5.2 Procedures Controlling the FDR; 3.5.3 Procedures Controlling the FDX Figure; 3.6 Type I Error Rates Control Under Dependence; 3.6.1 FWER Control; 3.6.2 FDR and FDX Control 3.7 Multiple Testing Procedures Applied to Gene Discovery in DNA Microarray Cancer Studies |
| Record Nr. | UNINA-9910830283903321 |
| Weimheim, : Wiley-VCH, 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Medical biostatistics for complex diseases / / edited by Frank Emmert-Streib and Matthias Dehmer
| Medical biostatistics for complex diseases / / edited by Frank Emmert-Streib and Matthias Dehmer |
| Pubbl/distr/stampa | Weimheim, : Wiley-VCH, 2010 |
| Descrizione fisica | 1 online resource (413 p.) |
| Disciplina |
610.72721
614.4015195 |
| Altri autori (Persone) |
Emmert-StreibFrank
DehmerMatthias |
| Soggetto topico |
Medicine - Research - Statistical methods
Medical statistics |
| ISBN |
9786612687785
9781282687783 1282687786 9783527630332 3527630333 9783527630349 3527630341 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Medical Biostatistics for Complex Diseases; Foreword; Contents; Preface; List of Contributors; Part One: General Biological and Statistical Basics; 1 The Biology of MYC in Health and Disease: A High Altitude View; 1.1 Introduction; 1.2 MYC and Normal Physiology; 1.3 Regulation of Transcription and Gene Expression; 1.4 Metabolism; 1.5 Cell-Cycle Regulation and Differentiation; 1.6 Protein Synthesis; 1.7 Cell Adhesion; 1.8 Apoptosis; 1.9 MicroRNAs; 1.10 Physiological Effects of Loss and Gain of c-myc Function in Mice; 1.10.1 Loss of Function
1.10.2 Gain of Function: Inducible Transgenic Animals1.11 Contributions of MYC to Tumor Biology; 1.12 Introduction of Hematopoietic Malignancies; 1.13 Mechanisms of MYC Dysregulation in Hematological Malignancies; 1.14 Mutation(s) in the MYC Gene in Hematological Cancers; 1.15 Role of MYC in Cell Cycle Regulation and Differentiation in Hematological Cancers; 1.16 Role of BCR Signaling in Conjunction with MYC Overexpression in Lymphoid Malignancies; 1.17 Deregulation of Auxiliary Proteins in Addition to MYC in Hematological Cancers; 1.18 Conclusion; References 2 Cancer Stem Cells - Finding and Capping the Roots of Cancer2.1 Introduction - Stem Cells and Cancer Stem Cells; 2.1.1 What are Stem Cells?; 2.1.2 Concept of Cancer Stem Cells (CSCs); 2.2 Hematopoietic Stem Cells as a Paradigm; 2.2.1 Leukemia as a Paradigmatic Disease for Cancer Research; 2.2.2 CFUs; 2.2.3 LTC-ICs; 2.2.4 In Vivo Repopulation; 2.2.5 Importance of the Bone Marrow Niche; 2.2.6 Leukemic Stem Cells; 2.2.6.1 Leukemic Stem Cells in the Bone Marrow Niche; 2.2.7 CML as a Paradigmatic Entity; 2.3 Current Technical Approach to the Isolation and Characterization of Cancer Stem Cells 2.3.1 Tools for the Detection of Cancer Stem Cells2.3.2 Phenotype of Cancer Stem Cells; 2.4 Cancer Stem Cells in Solid Tumors; 2.4.1 Breast Cancer; 2.4.2 Prostate Cancer; 2.4.3 Colon Cancer; 2.4.4 Other Cancers; 2.5 Open Questions of the Cancer Stem Cell Hypothesis; 2.6 Clinical Relevance of Cancer Stem Cells; 2.6.1 Diagnostic Relevance of Cancer Stem Cells; 2.6.2 Therapeutic Relevance - New Drugs Directed Against Cancer Stem Cells; 2.7 Outlook; References; 3 Multiple Testing Methods; 3.1 Introduction; 3.1.1 A Brief More Focused Introduction; 3.1.2 Historic Development of the Field 3.2 Statistical Background3.2.1 Tests; 3.2.2 Test Statistics and p-Values; 3.2.3 Resampling Based Testing; 3.3 Type I Error Rates; 3.4 Introduction to Multiple Testing Procedures; 3.4.1 Adjusted p-values; 3.4.2 Categories of Multiple Testing Procedures; 3.4.3 Estimation of the Proportion of False Nulls; 3.5 Multiple Testing Procedures; 3.5.1 Procedures Controlling the FWER; 3.5.2 Procedures Controlling the FDR; 3.5.3 Procedures Controlling the FDX Figure; 3.6 Type I Error Rates Control Under Dependence; 3.6.1 FWER Control; 3.6.2 FDR and FDX Control 3.7 Multiple Testing Procedures Applied to Gene Discovery in DNA Microarray Cancer Studies |
| Record Nr. | UNINA-9911019250003321 |
| Weimheim, : Wiley-VCH, 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||