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MARC Lista (tabellare)
Data monitoring committees in clinical trials [[electronic resource] ] : a practical perspective / / Susan S. Ellenberg, Thomas R. Fleming, David L. DeMets
Data monitoring committees in clinical trials [[electronic resource] ] : a practical perspective / / Susan S. Ellenberg, Thomas R. Fleming, David L. DeMets
Autore Ellenberg Susan Smith
Pubbl/distr/stampa Chichester ; ; Hoboken, NJ, : Wiley, c2002
Descrizione fisica 1 online resource (209 p.)
Disciplina 610/.72/4
615.190072
Altri autori (Persone) FlemingThomas R
DeMetsDavid L. <1944->
Collana Statistics in practice
Soggetto topico Clinical trials
Medical ethics committees
Soggetto genere / forma Electronic books.
ISBN 1-280-26999-5
9786610269990
0-470-32228-4
0-470-85415-4
0-470-85416-2
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Data Monitoring Committees in Clinical Trials A Practical Perspective; Contents; Preface; 1 Introduction; 1.1 Motivation; 1.2 History of data monitoring committees in government-sponsored trials; 1.3 Data monitoring committees in trials sponsored by the pharmaceutical industry; 1.4 Statistical methods for interim monitoring; 1.5 When are data monitoring committees needed?; 1.6 Where we are today; 1.7 Fundamental principles of data monitoring; References; 2 Responsibilities of the data monitoring committee and motivating illustrations; 2.1 Fundamental charges
2.2 Specific tasks of the data monitoring committee 2.2.1 Initial review; 2.2.1.1 Review of the study protocol; 2.2.1.2 Review of procedures to ensure quality of study conduct; 2.2.2 Evaluating the quality of ongoing study conduct; 2.2.3 Assessing safety and efficacy data; 2.2.3.1 Termination due to favorable benefit-to-risk; 2.2.3.2 Termination due to unfavorable benefit-to-risk; 2.2.3.3 Termination due to inability to answer trial questions; 2.2.3.4 Continuation of ongoing clinical trials; 2.2.3.5 Consideration of the overall picture: primary and secondary analyses
2.2.3.6 Modifying sample sizes based on ongoing assessment of event rates 2.2.4 Reviewing the final results; 2.3 The data monitoring committee charter; References; 3 Composition of a data monitoring committee; 3.1 Introduction; 3.2 Required areas of expertise; 3.3 Other relevant characteristics of committee members; 3.4 Committee size; 3.5 Selecting the committee chair; 3.6 Responsibility for appointing committee members; 3.7 Representation of other study components on the committee; 3.8 Preparation for service on a committee; References
4 Independence of the data monitoring committee: avoiding conflicts of interest 4.1 Introduction; 4.2 Rationale for independence; 4.3 Financial independence; 4.3.1 Sponsors; 4.3.2 Academic investigators; 4.4 Intellectual independence; 4.5 Emotional conflicts; 4.6 Individuals without conflicts; References; 5 Confidentiality issues relating to the data monitoring committee; 5.1 Rationale; 5.2 Limits of confidentiality; 5.2.1 Interim analysis reports; 5.2.2 Access to aggregate data on efficacy and safety outcomes; 5.2.3 The steering committee and maintaining confidentiality
5.2.4 Settings and procedures allowing broader unblinding 5.2.5 Some illustrations of broader unblinding; 5.2.6 Indirect challenges to confidentiality; 5.3 The need for the data monitoring committee to review unblinded data; References; 6 Data monitoring committee meetings; 6.1 Introduction; 6.2 Specific objectives and timing of meetings; 6.2.1 Organizational meeting; 6.2.2 Early safety/trial integrity reviews; 6.2.3 Formal interim efficacy analyses; 6.2.4 End-of-trial debriefing; 6.3 Preparation of meeting reports; 6.4 Format for meetings; 6.4.1 The closed session; 6.4.2 The open session
6.4.3 The final closed session
Record Nr. UNINA-9910142496903321
Ellenberg Susan Smith  
Chichester ; ; Hoboken, NJ, : Wiley, c2002
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Data monitoring committees in clinical trials [[electronic resource] ] : a practical perspective / / Susan S. Ellenberg, Thomas R. Fleming, David L. DeMets
Data monitoring committees in clinical trials [[electronic resource] ] : a practical perspective / / Susan S. Ellenberg, Thomas R. Fleming, David L. DeMets
Autore Ellenberg Susan Smith
Pubbl/distr/stampa Chichester ; ; Hoboken, NJ, : Wiley, c2002
Descrizione fisica 1 online resource (209 p.)
Disciplina 610/.72/4
615.190072
Altri autori (Persone) FlemingThomas R
DeMetsDavid L. <1944->
Collana Statistics in practice
Soggetto topico Clinical trials
Medical ethics committees
ISBN 1-280-26999-5
9786610269990
0-470-32228-4
0-470-85415-4
0-470-85416-2
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Data Monitoring Committees in Clinical Trials A Practical Perspective; Contents; Preface; 1 Introduction; 1.1 Motivation; 1.2 History of data monitoring committees in government-sponsored trials; 1.3 Data monitoring committees in trials sponsored by the pharmaceutical industry; 1.4 Statistical methods for interim monitoring; 1.5 When are data monitoring committees needed?; 1.6 Where we are today; 1.7 Fundamental principles of data monitoring; References; 2 Responsibilities of the data monitoring committee and motivating illustrations; 2.1 Fundamental charges
2.2 Specific tasks of the data monitoring committee 2.2.1 Initial review; 2.2.1.1 Review of the study protocol; 2.2.1.2 Review of procedures to ensure quality of study conduct; 2.2.2 Evaluating the quality of ongoing study conduct; 2.2.3 Assessing safety and efficacy data; 2.2.3.1 Termination due to favorable benefit-to-risk; 2.2.3.2 Termination due to unfavorable benefit-to-risk; 2.2.3.3 Termination due to inability to answer trial questions; 2.2.3.4 Continuation of ongoing clinical trials; 2.2.3.5 Consideration of the overall picture: primary and secondary analyses
2.2.3.6 Modifying sample sizes based on ongoing assessment of event rates 2.2.4 Reviewing the final results; 2.3 The data monitoring committee charter; References; 3 Composition of a data monitoring committee; 3.1 Introduction; 3.2 Required areas of expertise; 3.3 Other relevant characteristics of committee members; 3.4 Committee size; 3.5 Selecting the committee chair; 3.6 Responsibility for appointing committee members; 3.7 Representation of other study components on the committee; 3.8 Preparation for service on a committee; References
4 Independence of the data monitoring committee: avoiding conflicts of interest 4.1 Introduction; 4.2 Rationale for independence; 4.3 Financial independence; 4.3.1 Sponsors; 4.3.2 Academic investigators; 4.4 Intellectual independence; 4.5 Emotional conflicts; 4.6 Individuals without conflicts; References; 5 Confidentiality issues relating to the data monitoring committee; 5.1 Rationale; 5.2 Limits of confidentiality; 5.2.1 Interim analysis reports; 5.2.2 Access to aggregate data on efficacy and safety outcomes; 5.2.3 The steering committee and maintaining confidentiality
5.2.4 Settings and procedures allowing broader unblinding 5.2.5 Some illustrations of broader unblinding; 5.2.6 Indirect challenges to confidentiality; 5.3 The need for the data monitoring committee to review unblinded data; References; 6 Data monitoring committee meetings; 6.1 Introduction; 6.2 Specific objectives and timing of meetings; 6.2.1 Organizational meeting; 6.2.2 Early safety/trial integrity reviews; 6.2.3 Formal interim efficacy analyses; 6.2.4 End-of-trial debriefing; 6.3 Preparation of meeting reports; 6.4 Format for meetings; 6.4.1 The closed session; 6.4.2 The open session
6.4.3 The final closed session
Record Nr. UNINA-9910829980403321
Ellenberg Susan Smith  
Chichester ; ; Hoboken, NJ, : Wiley, c2002
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Data monitoring committees in clinical trials [[electronic resource] ] : a practical perspective / / Susan S. Ellenberg, Thomas R. Fleming, David L. DeMets
Data monitoring committees in clinical trials [[electronic resource] ] : a practical perspective / / Susan S. Ellenberg, Thomas R. Fleming, David L. DeMets
Autore Ellenberg Susan Smith
Pubbl/distr/stampa Chichester ; ; Hoboken, NJ, : Wiley, c2002
Descrizione fisica 1 online resource (209 p.)
Disciplina 610/.72/4
615.190072
Altri autori (Persone) FlemingThomas R
DeMetsDavid L. <1944->
Collana Statistics in practice
Soggetto topico Clinical trials
Medical ethics committees
ISBN 1-280-26999-5
9786610269990
0-470-32228-4
0-470-85415-4
0-470-85416-2
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Data Monitoring Committees in Clinical Trials A Practical Perspective; Contents; Preface; 1 Introduction; 1.1 Motivation; 1.2 History of data monitoring committees in government-sponsored trials; 1.3 Data monitoring committees in trials sponsored by the pharmaceutical industry; 1.4 Statistical methods for interim monitoring; 1.5 When are data monitoring committees needed?; 1.6 Where we are today; 1.7 Fundamental principles of data monitoring; References; 2 Responsibilities of the data monitoring committee and motivating illustrations; 2.1 Fundamental charges
2.2 Specific tasks of the data monitoring committee 2.2.1 Initial review; 2.2.1.1 Review of the study protocol; 2.2.1.2 Review of procedures to ensure quality of study conduct; 2.2.2 Evaluating the quality of ongoing study conduct; 2.2.3 Assessing safety and efficacy data; 2.2.3.1 Termination due to favorable benefit-to-risk; 2.2.3.2 Termination due to unfavorable benefit-to-risk; 2.2.3.3 Termination due to inability to answer trial questions; 2.2.3.4 Continuation of ongoing clinical trials; 2.2.3.5 Consideration of the overall picture: primary and secondary analyses
2.2.3.6 Modifying sample sizes based on ongoing assessment of event rates 2.2.4 Reviewing the final results; 2.3 The data monitoring committee charter; References; 3 Composition of a data monitoring committee; 3.1 Introduction; 3.2 Required areas of expertise; 3.3 Other relevant characteristics of committee members; 3.4 Committee size; 3.5 Selecting the committee chair; 3.6 Responsibility for appointing committee members; 3.7 Representation of other study components on the committee; 3.8 Preparation for service on a committee; References
4 Independence of the data monitoring committee: avoiding conflicts of interest 4.1 Introduction; 4.2 Rationale for independence; 4.3 Financial independence; 4.3.1 Sponsors; 4.3.2 Academic investigators; 4.4 Intellectual independence; 4.5 Emotional conflicts; 4.6 Individuals without conflicts; References; 5 Confidentiality issues relating to the data monitoring committee; 5.1 Rationale; 5.2 Limits of confidentiality; 5.2.1 Interim analysis reports; 5.2.2 Access to aggregate data on efficacy and safety outcomes; 5.2.3 The steering committee and maintaining confidentiality
5.2.4 Settings and procedures allowing broader unblinding 5.2.5 Some illustrations of broader unblinding; 5.2.6 Indirect challenges to confidentiality; 5.3 The need for the data monitoring committee to review unblinded data; References; 6 Data monitoring committee meetings; 6.1 Introduction; 6.2 Specific objectives and timing of meetings; 6.2.1 Organizational meeting; 6.2.2 Early safety/trial integrity reviews; 6.2.3 Formal interim efficacy analyses; 6.2.4 End-of-trial debriefing; 6.3 Preparation of meeting reports; 6.4 Format for meetings; 6.4.1 The closed session; 6.4.2 The open session
6.4.3 The final closed session
Record Nr. UNINA-9910841429703321
Ellenberg Susan Smith  
Chichester ; ; Hoboken, NJ, : Wiley, c2002
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Selection bias and covariate imbalances in randomzied clinical trials [[electronic resource] /] / Vance W. Berger
Selection bias and covariate imbalances in randomzied clinical trials [[electronic resource] /] / Vance W. Berger
Autore Berger Vance
Pubbl/distr/stampa Hoboken, NJ, : John Wiley & Sons, c2005
Descrizione fisica 1 online resource (220 p.)
Disciplina 610.724
610/.72/4
Collana Statistics in practice
Soggetto topico Clinical trials - Statistical methods - Evaluation
Ranking and selection (Statistics) - Evaluation
Sampling (Statistics) - Evaluation
Soggetto genere / forma Electronic books.
ISBN 1-280-55597-1
9786610555970
0-470-86364-1
0-470-86363-3
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Selection Bias and Covariate Imbalances in Randomized Clinical Trials; Contents; Preface; Part I: Is There a Problem with Reliability in Medical Studies?; 1 An Evolution of Comparative Methodology; 1.1 Single-subject studies; 1.2 Case series and cohort studies; 1.3 Historical controls; 1.4 Parallel control groups; 1.5 Matched studies; 1.6 Randomization; 1.7 Advance randomization; 1.8 Allocation concealment; 1.9 Residual selection bias; 2 Susceptibility of Randomized Trials to Subversion and Selection Bias; 2.1 Can randomized trials be subverted?
2.2 If randomized trials are subverted, do they cease to be randomized trials?2.3 What is masking?; 2.4 What is allocation concealment?; 2.5 A double standard; 2.6 What if allocation concealment could be ensured?; 3 Evidence of Selection Bias in Randomized Trials; 3.1 The burden of proof regarding the existence of selection bias in randomized trials; 3.2 Indirect population-level evidence that selection bias exists in randomized trials; 3.3 Direct trial-level evidence that selection bias exists in randomized trials; 3.3.1 Heparin for myocardial infarction
3.3.2 University Group Diabetes Program3.3.3 Talc and mustine for pleural effusions; 3.3.4 Tonsillectomy for recurrent throat infection in children; 3.3.5 Oxytocin and amniotomy for induction of labor; 3.3.6 Western Washington Intracoronary Streptokinase Trial; 3.3.7 RSV immune globulin in infants and young children with respiratory syncytial virus; 3.3.8 A trial to assess episiotomy; 3.3.9 Canadian National Breast Cancer Screening Study; 3.3.10 Surgical trial; 3.3.11 Lifestyle Heart Trial; 3.3.12 Coronary Artery Surgery Study; 3.3.13 Etanercept for children with juvenile rheumatoid arthritis
3.3.14 Edinburgh Randomized Trial of Breast-Cancer Screening3.3.15 Captopril Prevention Project; 3.3.16 Göteborg (Swedish) Mammography Trial; 3.3.17 HIP Mammography Trial; 3.3.18 Hypertension Detection and Follow-Up Program; 3.3.19 Randomized trial to prevent vertical transmission of HIV-1; 3.3.20 Effectiveness trial of a diagnostic test; 3.3.21 South African trial of high-dose chemotherapy for metastatic breast cancer; 3.3.22 Randomized study of a culturally sensitive AIDS education program; 3.3.23 Runaway Youth Study; 3.3.24 Cluster randomized trial of palliative care
3.3.25 Randomized trial of methadone with or without heroin3.3.26 Randomized NINDS trial of tissue plasminogen activator for acute ischemic stroke; 3.3.27 Norwegian Timolol Trial; 3.3.28 Laparoscopic versus open appendectomy; 3.3.29 The Losartan Intervention for Endpoint Reduction in Hypertension (LIFE) Study; 3.3.30 The Heart Outcomes Prevention Evaluation (HOPE) Study; 3.4 In search of better evidence; 4 Impact of Selection Bias in Randomized Trials; 4.1 Quantifying the prediction of future allocations: balanced blocks; 4.2 Quantifying prediction of future allocations: unbalanced blocks
4.3 Quantifying covariate imbalance resulting from selection bias
Record Nr. UNINA-9910144745303321
Berger Vance  
Hoboken, NJ, : John Wiley & Sons, c2005
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Selection bias and covariate imbalances in randomzied clinical trials [[electronic resource] /] / Vance W. Berger
Selection bias and covariate imbalances in randomzied clinical trials [[electronic resource] /] / Vance W. Berger
Autore Berger Vance
Pubbl/distr/stampa Hoboken, NJ, : John Wiley & Sons, c2005
Descrizione fisica 1 online resource (220 p.)
Disciplina 610.724
610/.72/4
Collana Statistics in practice
Soggetto topico Clinical trials - Statistical methods - Evaluation
Ranking and selection (Statistics) - Evaluation
Sampling (Statistics) - Evaluation
ISBN 1-280-55597-1
9786610555970
0-470-86364-1
0-470-86363-3
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Selection Bias and Covariate Imbalances in Randomized Clinical Trials; Contents; Preface; Part I: Is There a Problem with Reliability in Medical Studies?; 1 An Evolution of Comparative Methodology; 1.1 Single-subject studies; 1.2 Case series and cohort studies; 1.3 Historical controls; 1.4 Parallel control groups; 1.5 Matched studies; 1.6 Randomization; 1.7 Advance randomization; 1.8 Allocation concealment; 1.9 Residual selection bias; 2 Susceptibility of Randomized Trials to Subversion and Selection Bias; 2.1 Can randomized trials be subverted?
2.2 If randomized trials are subverted, do they cease to be randomized trials?2.3 What is masking?; 2.4 What is allocation concealment?; 2.5 A double standard; 2.6 What if allocation concealment could be ensured?; 3 Evidence of Selection Bias in Randomized Trials; 3.1 The burden of proof regarding the existence of selection bias in randomized trials; 3.2 Indirect population-level evidence that selection bias exists in randomized trials; 3.3 Direct trial-level evidence that selection bias exists in randomized trials; 3.3.1 Heparin for myocardial infarction
3.3.2 University Group Diabetes Program3.3.3 Talc and mustine for pleural effusions; 3.3.4 Tonsillectomy for recurrent throat infection in children; 3.3.5 Oxytocin and amniotomy for induction of labor; 3.3.6 Western Washington Intracoronary Streptokinase Trial; 3.3.7 RSV immune globulin in infants and young children with respiratory syncytial virus; 3.3.8 A trial to assess episiotomy; 3.3.9 Canadian National Breast Cancer Screening Study; 3.3.10 Surgical trial; 3.3.11 Lifestyle Heart Trial; 3.3.12 Coronary Artery Surgery Study; 3.3.13 Etanercept for children with juvenile rheumatoid arthritis
3.3.14 Edinburgh Randomized Trial of Breast-Cancer Screening3.3.15 Captopril Prevention Project; 3.3.16 Göteborg (Swedish) Mammography Trial; 3.3.17 HIP Mammography Trial; 3.3.18 Hypertension Detection and Follow-Up Program; 3.3.19 Randomized trial to prevent vertical transmission of HIV-1; 3.3.20 Effectiveness trial of a diagnostic test; 3.3.21 South African trial of high-dose chemotherapy for metastatic breast cancer; 3.3.22 Randomized study of a culturally sensitive AIDS education program; 3.3.23 Runaway Youth Study; 3.3.24 Cluster randomized trial of palliative care
3.3.25 Randomized trial of methadone with or without heroin3.3.26 Randomized NINDS trial of tissue plasminogen activator for acute ischemic stroke; 3.3.27 Norwegian Timolol Trial; 3.3.28 Laparoscopic versus open appendectomy; 3.3.29 The Losartan Intervention for Endpoint Reduction in Hypertension (LIFE) Study; 3.3.30 The Heart Outcomes Prevention Evaluation (HOPE) Study; 3.4 In search of better evidence; 4 Impact of Selection Bias in Randomized Trials; 4.1 Quantifying the prediction of future allocations: balanced blocks; 4.2 Quantifying prediction of future allocations: unbalanced blocks
4.3 Quantifying covariate imbalance resulting from selection bias
Record Nr. UNINA-9910830363103321
Berger Vance  
Hoboken, NJ, : John Wiley & Sons, c2005
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Selection bias and covariate imbalances in randomzied clinical trials [[electronic resource] /] / Vance W. Berger
Selection bias and covariate imbalances in randomzied clinical trials [[electronic resource] /] / Vance W. Berger
Autore Berger Vance
Pubbl/distr/stampa Hoboken, NJ, : John Wiley & Sons, c2005
Descrizione fisica 1 online resource (220 p.)
Disciplina 610.724
610/.72/4
Collana Statistics in practice
Soggetto topico Clinical trials - Statistical methods - Evaluation
Ranking and selection (Statistics) - Evaluation
Sampling (Statistics) - Evaluation
ISBN 1-280-55597-1
9786610555970
0-470-86364-1
0-470-86363-3
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Selection Bias and Covariate Imbalances in Randomized Clinical Trials; Contents; Preface; Part I: Is There a Problem with Reliability in Medical Studies?; 1 An Evolution of Comparative Methodology; 1.1 Single-subject studies; 1.2 Case series and cohort studies; 1.3 Historical controls; 1.4 Parallel control groups; 1.5 Matched studies; 1.6 Randomization; 1.7 Advance randomization; 1.8 Allocation concealment; 1.9 Residual selection bias; 2 Susceptibility of Randomized Trials to Subversion and Selection Bias; 2.1 Can randomized trials be subverted?
2.2 If randomized trials are subverted, do they cease to be randomized trials?2.3 What is masking?; 2.4 What is allocation concealment?; 2.5 A double standard; 2.6 What if allocation concealment could be ensured?; 3 Evidence of Selection Bias in Randomized Trials; 3.1 The burden of proof regarding the existence of selection bias in randomized trials; 3.2 Indirect population-level evidence that selection bias exists in randomized trials; 3.3 Direct trial-level evidence that selection bias exists in randomized trials; 3.3.1 Heparin for myocardial infarction
3.3.2 University Group Diabetes Program3.3.3 Talc and mustine for pleural effusions; 3.3.4 Tonsillectomy for recurrent throat infection in children; 3.3.5 Oxytocin and amniotomy for induction of labor; 3.3.6 Western Washington Intracoronary Streptokinase Trial; 3.3.7 RSV immune globulin in infants and young children with respiratory syncytial virus; 3.3.8 A trial to assess episiotomy; 3.3.9 Canadian National Breast Cancer Screening Study; 3.3.10 Surgical trial; 3.3.11 Lifestyle Heart Trial; 3.3.12 Coronary Artery Surgery Study; 3.3.13 Etanercept for children with juvenile rheumatoid arthritis
3.3.14 Edinburgh Randomized Trial of Breast-Cancer Screening3.3.15 Captopril Prevention Project; 3.3.16 Göteborg (Swedish) Mammography Trial; 3.3.17 HIP Mammography Trial; 3.3.18 Hypertension Detection and Follow-Up Program; 3.3.19 Randomized trial to prevent vertical transmission of HIV-1; 3.3.20 Effectiveness trial of a diagnostic test; 3.3.21 South African trial of high-dose chemotherapy for metastatic breast cancer; 3.3.22 Randomized study of a culturally sensitive AIDS education program; 3.3.23 Runaway Youth Study; 3.3.24 Cluster randomized trial of palliative care
3.3.25 Randomized trial of methadone with or without heroin3.3.26 Randomized NINDS trial of tissue plasminogen activator for acute ischemic stroke; 3.3.27 Norwegian Timolol Trial; 3.3.28 Laparoscopic versus open appendectomy; 3.3.29 The Losartan Intervention for Endpoint Reduction in Hypertension (LIFE) Study; 3.3.30 The Heart Outcomes Prevention Evaluation (HOPE) Study; 3.4 In search of better evidence; 4 Impact of Selection Bias in Randomized Trials; 4.1 Quantifying the prediction of future allocations: balanced blocks; 4.2 Quantifying prediction of future allocations: unbalanced blocks
4.3 Quantifying covariate imbalance resulting from selection bias
Record Nr. UNINA-9910840778103321
Berger Vance  
Hoboken, NJ, : John Wiley & Sons, c2005
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Small clinical trials [[electronic resource] ] : issues and challenges / / Charles H. Evans, Jr. and Suzanne T. Ildstad, editors ; Committee on Strategies for Small-Number-Participant Clinical Research Trials, Board on Health Sciences Policy, Institute of Medicine
Small clinical trials [[electronic resource] ] : issues and challenges / / Charles H. Evans, Jr. and Suzanne T. Ildstad, editors ; Committee on Strategies for Small-Number-Participant Clinical Research Trials, Board on Health Sciences Policy, Institute of Medicine
Pubbl/distr/stampa Washington, D.C., : National Academy Press, c2001
Descrizione fisica 1 online resource (221 p.)
Disciplina 610/.72/4
Altri autori (Persone) EvansCharles H <1940-> (Charles Hawes)
IldstadSuzanne T
Collana Compass series
Soggetto topico Clinical trials
Clinical trials - United States
Soggetto genere / forma Electronic books.
ISBN 0-309-51345-6
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto ""Front Matter""; ""Reviewers""; ""Preface""; ""Contents""; ""Executive Summary""; ""1 Introduction""; ""2 Design of Small Clinical Trials""; ""3 Statistical Approaches to Analysis of Small Clinical Trials""; ""4 General Guidelines""; ""References""; ""Appendix A Study Methods""; ""Appendix B Glossary of Statistical and Clinical Trials Terms""; ""Appendix C Selected Bibliography on Small Clinical Trials""; ""Appendix D Committee and Staff Biographies""
Record Nr. UNINA-9910456456503321
Washington, D.C., : National Academy Press, c2001
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Small clinical trials [[electronic resource] ] : issues and challenges / / Charles H. Evans, Jr. and Suzanne T. Ildstad, editors ; Committee on Strategies for Small-Number-Participant Clinical Research Trials, Board on Health Sciences Policy, Institute of Medicine
Small clinical trials [[electronic resource] ] : issues and challenges / / Charles H. Evans, Jr. and Suzanne T. Ildstad, editors ; Committee on Strategies for Small-Number-Participant Clinical Research Trials, Board on Health Sciences Policy, Institute of Medicine
Pubbl/distr/stampa Washington, D.C., : National Academy Press, c2001
Descrizione fisica 1 online resource (221 p.)
Disciplina 610/.72/4
Altri autori (Persone) EvansCharles H <1940-> (Charles Hawes)
IldstadSuzanne T
Collana Compass series
Soggetto topico Clinical trials
Clinical trials - United States
ISBN 0-309-17114-8
0-309-51345-6
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto ""Front Matter""; ""Reviewers""; ""Preface""; ""Contents""; ""Executive Summary""; ""1 Introduction""; ""2 Design of Small Clinical Trials""; ""3 Statistical Approaches to Analysis of Small Clinical Trials""; ""4 General Guidelines""; ""References""; ""Appendix A Study Methods""; ""Appendix B Glossary of Statistical and Clinical Trials Terms""; ""Appendix C Selected Bibliography on Small Clinical Trials""; ""Appendix D Committee and Staff Biographies""
Record Nr. UNINA-9910780005003321
Washington, D.C., : National Academy Press, c2001
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Small clinical trials [[electronic resource] ] : issues and challenges / / Charles H. Evans, Jr. and Suzanne T. Ildstad, editors ; Committee on Strategies for Small-Number-Participant Clinical Research Trials, Board on Health Sciences Policy, Institute of Medicine
Small clinical trials [[electronic resource] ] : issues and challenges / / Charles H. Evans, Jr. and Suzanne T. Ildstad, editors ; Committee on Strategies for Small-Number-Participant Clinical Research Trials, Board on Health Sciences Policy, Institute of Medicine
Pubbl/distr/stampa Washington, D.C., : National Academy Press, c2001
Descrizione fisica 1 online resource (221 p.)
Disciplina 610/.72/4
Altri autori (Persone) EvansCharles H <1940-> (Charles Hawes)
IldstadSuzanne T
Collana Compass series
Soggetto topico Clinical trials
Clinical trials - United States
ISBN 0-309-17114-8
0-309-51345-6
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto ""Front Matter""; ""Reviewers""; ""Preface""; ""Contents""; ""Executive Summary""; ""1 Introduction""; ""2 Design of Small Clinical Trials""; ""3 Statistical Approaches to Analysis of Small Clinical Trials""; ""4 General Guidelines""; ""References""; ""Appendix A Study Methods""; ""Appendix B Glossary of Statistical and Clinical Trials Terms""; ""Appendix C Selected Bibliography on Small Clinical Trials""; ""Appendix D Committee and Staff Biographies""
Record Nr. UNINA-9910826234503321
Washington, D.C., : National Academy Press, c2001
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Textbook of clinical trials / / edited by David Machin [and four others]
Textbook of clinical trials / / edited by David Machin [and four others]
Pubbl/distr/stampa Chichester, England : , : John Wiley & Sons Ltd, , 2004
Descrizione fisica 1 online resource (430 p.)
Disciplina 610/.72/4
Soggetto topico Clinical trials
Soggetto genere / forma Electronic books.
ISBN 1-280-54156-3
1-280-73871-5
0-470-01015-0
9786610541560
0-470-01014-2
9786610738717
0-470-01016-9
0-470-02024-5
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Textbook of Clinical Trials; Contents; Contributors; Preface; INTRODUCTION; CANCER; CARDIOVASCULAR; DENTISTRY AND MAXILLO-FACIAL; DERMATOLOGY; PSYCHIATRY; REPRODUCTIVE HEALTH; RESPIRATORY; Index
Record Nr. UNINA-9910143642203321
Chichester, England : , : John Wiley & Sons Ltd, , 2004
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui