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Cellular proteins and their fatty acids in health and disease [[electronic resource] /] / Asim K. Duttaroy and Friedrich Spener (eds.)
| Cellular proteins and their fatty acids in health and disease [[electronic resource] /] / Asim K. Duttaroy and Friedrich Spener (eds.) |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2003 |
| Descrizione fisica | 1 online resource (484 p.) |
| Disciplina |
572.6
599.019247 |
| Altri autori (Persone) |
DuttaroyAsim K
SpenerF (Friedrich) |
| Soggetto topico | Fatty acid-binding proteins |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-52037-X
9786610520374 3-527-60528-2 3-527-60154-6 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cellular Proteins and Their Fatty Acids in Health and Disease; Preface; Contents; List of Contributors; Part 1 The Molecular Basis of Protein-Lipid Interaction and Functional Consequences; 1 Structure-Function of CD36 and Evidence for its Role in Facilitating Membrane Fatty Acid Transport; 1.1 Introduction; 1.2 Primary Structure; 1.3 Ligand Binding Domains; 1.4 Membrane Localization and Role in Cell Signaling; 1.5 CD36 Gene Structure and Regulation; 1.6 CD36 Deficiency; 1.7 CD36 and Platelet Function; 1.8 CD36 and Atherosclerosis; 1.9 CD36 and Phagocytosis; 1.10 CD36 and Angiogenesis
1.11 CD36 and Malaria1.12 CD36 and Fatty Acid Transport; 1.12.1 CD36 is Identified as a Mediator of FA Uptake; 1.12.2 CD36, SHR, and Insulin Resistance; 1.12.3 CD36 Transgenic and Knockout Mice Models; 1.12.4 CD36-null Mice - the Fed Phenotype; 1.12.5 CD36-null Mice - the Fasting Phenotype; 1.12.6 CD36 and Insulin Responsiveness in the Mouse; 1.13 Perspectives and Future Directions; 1.14 References; 2 Role and Function of FATPs in Fatty Acid Uptake; 2.1 Introduction; 2.2 Identification of Fatty Acid Transporter Proteins; 2.3 Structure of FATPs; 2.4 Function of FATPs 2.5 Regulation of FATP expression2.6 Significance of FATPs; 2.7 References; 3 Function, Expression, and Regulation of Human ABC Transporters; 3.1 Introduction; 3.2 Structural Features of ATP Binding Cassette (ABC) Transporters; 3.3 Overview of Human ABC Gene Subfamilies; 3.3.1 The ABCA (ABC1) Subfamily; 3.3.2 The ABCB (MDR/TAP) Subfamily; 3.3.3 The ABCC (CFTR/MRP) Subfamily; 3.3.4 The ABCD (ALD) Subfamily; 3.3.5 The ABCE (OABP) and ABCF (GCN20) Subfamilies; 3.3.6 The ABCG (White) Subfamily; 3.4 Diseases and Phenotypes Caused by ABC Transporters; 3.4.1 Familial HDL-deficiency and ABCA1 3.4.2 Retinal Degeneration and ABCA4 (ABCR)3.4.3 Cystic Fibrosis (ABCC7/CFTR); 3.4.4 Multidrug Resistance (ABCB1/MDR1, ABCC1/MRP1, ABCG2); 3.4.5 Adrenoleukodystrophy (ABCD1/ALD); 3.4.6 Sulfonylurea Receptor (ABCC8/SUR); 3.5 Function and Regulation of ABC Transporters in Lipid Transport; 3.5.1 ABCA1 in Macrophage Lipid Transport; 3.5.2 ABCG1 and Other ABCG members in Sterol Homeostasis; 3.5.3 ABC Transporters involved in Hepatobiliary Transport; 3.6 Conclusions and Perspectives; 3.7 References; 4 Albumin Receptors - Structure and Function; 4.1 Introduction 4.2 The Search for an Albumin Receptor4.2.1 The Endothelium-Albumin Relationship: Early Concepts; 4.2.2 Identification of Receptors for Native and Modified Albumin in Endothelial Cells; 4.3 Albumin Receptors in the Kidney; 4.3.1 Glomerular Handling of Albumin; 4.3.2 Binding and Uptake of Albumin in the Kidney Proximal Tubule; 4.4 Megalin and Cubilin as Proximal Tubule Albumin Receptors; 4.4.1 Megalin; 4.4.2 Cubilin; 4.5 Albumin as a Signaling Molecule - Implications for Albumin Receptor Function; 4.5.1 LDLR Family as Signaling Receptors; 4.5.2 Megalin as a Signaling Receptor; 4.6 Summary 4.7 References |
| Record Nr. | UNINA-9910146243303321 |
| Weinheim, : Wiley-VCH, c2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cellular proteins and their fatty acids in health and disease [[electronic resource] /] / Asim K. Duttaroy and Friedrich Spener (eds.)
| Cellular proteins and their fatty acids in health and disease [[electronic resource] /] / Asim K. Duttaroy and Friedrich Spener (eds.) |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2003 |
| Descrizione fisica | 1 online resource (484 p.) |
| Disciplina |
572.6
599.019247 |
| Altri autori (Persone) |
DuttaroyAsim K
SpenerF (Friedrich) |
| Soggetto topico | Fatty acid-binding proteins |
| ISBN |
1-280-52037-X
9786610520374 3-527-60528-2 3-527-60154-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cellular Proteins and Their Fatty Acids in Health and Disease; Preface; Contents; List of Contributors; Part 1 The Molecular Basis of Protein-Lipid Interaction and Functional Consequences; 1 Structure-Function of CD36 and Evidence for its Role in Facilitating Membrane Fatty Acid Transport; 1.1 Introduction; 1.2 Primary Structure; 1.3 Ligand Binding Domains; 1.4 Membrane Localization and Role in Cell Signaling; 1.5 CD36 Gene Structure and Regulation; 1.6 CD36 Deficiency; 1.7 CD36 and Platelet Function; 1.8 CD36 and Atherosclerosis; 1.9 CD36 and Phagocytosis; 1.10 CD36 and Angiogenesis
1.11 CD36 and Malaria1.12 CD36 and Fatty Acid Transport; 1.12.1 CD36 is Identified as a Mediator of FA Uptake; 1.12.2 CD36, SHR, and Insulin Resistance; 1.12.3 CD36 Transgenic and Knockout Mice Models; 1.12.4 CD36-null Mice - the Fed Phenotype; 1.12.5 CD36-null Mice - the Fasting Phenotype; 1.12.6 CD36 and Insulin Responsiveness in the Mouse; 1.13 Perspectives and Future Directions; 1.14 References; 2 Role and Function of FATPs in Fatty Acid Uptake; 2.1 Introduction; 2.2 Identification of Fatty Acid Transporter Proteins; 2.3 Structure of FATPs; 2.4 Function of FATPs 2.5 Regulation of FATP expression2.6 Significance of FATPs; 2.7 References; 3 Function, Expression, and Regulation of Human ABC Transporters; 3.1 Introduction; 3.2 Structural Features of ATP Binding Cassette (ABC) Transporters; 3.3 Overview of Human ABC Gene Subfamilies; 3.3.1 The ABCA (ABC1) Subfamily; 3.3.2 The ABCB (MDR/TAP) Subfamily; 3.3.3 The ABCC (CFTR/MRP) Subfamily; 3.3.4 The ABCD (ALD) Subfamily; 3.3.5 The ABCE (OABP) and ABCF (GCN20) Subfamilies; 3.3.6 The ABCG (White) Subfamily; 3.4 Diseases and Phenotypes Caused by ABC Transporters; 3.4.1 Familial HDL-deficiency and ABCA1 3.4.2 Retinal Degeneration and ABCA4 (ABCR)3.4.3 Cystic Fibrosis (ABCC7/CFTR); 3.4.4 Multidrug Resistance (ABCB1/MDR1, ABCC1/MRP1, ABCG2); 3.4.5 Adrenoleukodystrophy (ABCD1/ALD); 3.4.6 Sulfonylurea Receptor (ABCC8/SUR); 3.5 Function and Regulation of ABC Transporters in Lipid Transport; 3.5.1 ABCA1 in Macrophage Lipid Transport; 3.5.2 ABCG1 and Other ABCG members in Sterol Homeostasis; 3.5.3 ABC Transporters involved in Hepatobiliary Transport; 3.6 Conclusions and Perspectives; 3.7 References; 4 Albumin Receptors - Structure and Function; 4.1 Introduction 4.2 The Search for an Albumin Receptor4.2.1 The Endothelium-Albumin Relationship: Early Concepts; 4.2.2 Identification of Receptors for Native and Modified Albumin in Endothelial Cells; 4.3 Albumin Receptors in the Kidney; 4.3.1 Glomerular Handling of Albumin; 4.3.2 Binding and Uptake of Albumin in the Kidney Proximal Tubule; 4.4 Megalin and Cubilin as Proximal Tubule Albumin Receptors; 4.4.1 Megalin; 4.4.2 Cubilin; 4.5 Albumin as a Signaling Molecule - Implications for Albumin Receptor Function; 4.5.1 LDLR Family as Signaling Receptors; 4.5.2 Megalin as a Signaling Receptor; 4.6 Summary 4.7 References |
| Record Nr. | UNINA-9910830260203321 |
| Weinheim, : Wiley-VCH, c2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||