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IPS Cells for Modelling and Treatment of Human Diseases / / edited by Michael J. Edel
| IPS Cells for Modelling and Treatment of Human Diseases / / edited by Michael J. Edel |
| Pubbl/distr/stampa | Basel : , : MDPI - Multidisciplinary Digital Publishing Institute, , 2015 |
| Descrizione fisica | 1 online resource (422 pages) : illustrations |
| Disciplina | 572.8845 |
| Soggetto topico | Genetic transcription |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | List of Contributors -- About the Guest Editor -- Preface -- Chapter 1: Neuronal -- Opportunities and Limitations of Modelling Alzheimer's Disease with Induced Pluripotent Stem Cells -- Induced Pluripotent Stem Cells Derived from Alzheimer's Disease Patients: The Promise, the Hope and the Path Ahead -- iPSC-based Models to Unravel Key Pathogenetic Processes underlying Motor Neuron Diseases Development -- Chapter 2: Cardiac -- Bioengineering and Stem Cell Technology in the Treatment of Congenital Heart Disease -- Scalable Electrophysiological Investigation of iPS Cell Derived Cardiomyocytes Obtained by a Lentiviral Purification Strategy -- Clinical Potentials of Cardiomyocytes Derived from Patient-Specific Induced Pluripotent Stem Cells -- Chapter 3: Eye -- iPS Cells for Modelling and Treatment of Retinal Diseases -- Patient-Specific iPSC-Derived RPE for Modeling of Retinal Diseases -- Potential role of Induced Pluripotent Stem Cells (IPSCs) for Cell-Based Therapy of the Ocular Surface -- Chapter 4: Spinal Cord Injury -- The Potential for iPS-Derived Stem Cells as a Therapeutic Strategy for Spinal Cord Injury: Opportunities and Challenges -- The State of Play with iPSCs and Spinal Cord Injury Models -- Chapter 5: Liver -- Potential and Challenges of Induced Pluripotent Stem Cells in Liver Diseases Treatment -- Chapter 6: Muscle -- Myogenic Precursors from iPS Cells for Skeletal Muscle Cell Replacement Therapy -- Chapter 7: Bone -- The Use of Patient-Specific Induced Pluripotent Stem Cells (iPSCs) to Identify Osteoclast Defects in Rare Genetic Bone Disorders -- Chapter 8: Germ Cells -- Human iPS Cell-derived Germ Cells: Current Status and Clinical Potential -- Chapter 9: Genetic Disorders -- Comparing ESC and iPSC-Based Models for Human Genetic Disorders -- Design of a Tumorigenicity Test for Induced Pluripotent Stem Cell (iPSC)-Derived Cell Products -- Concise Review: Methods and Cell Types Used to Generate Down Syndrome Induced Pluripotent Stem Cells -- Chapter 10: Immune Response -- The Possible Future Roles for iPSC-Derived Therapy for Autoimmune Diseases. |
| Record Nr. | UNINA-9910598175403321 |
| Basel : , : MDPI - Multidisciplinary Digital Publishing Institute, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
IPS cells for modelling and treatment of human diseases / / edited by Michael J. Edel
| IPS cells for modelling and treatment of human diseases / / edited by Michael J. Edel |
| Pubbl/distr/stampa | Basel, Switzerland : , : MDPI - Multidisciplinary Digital Publishing Institute, , [2015] |
| Descrizione fisica | 1 online resource (422 pages) : illustrations |
| Disciplina | 572.8845 |
| Soggetto topico | Genetic transcription |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | List of Contributors -- About the Guest Editor -- Preface -- Chapter 1: Neuronal -- Opportunities and Limitations of Modelling Alzheimer's Disease with Induced Pluripotent Stem Cells -- Induced Pluripotent Stem Cells Derived from Alzheimer's Disease Patients: The Promise, the Hope and the Path Ahead -- iPSC-based Models to Unravel Key Pathogenetic Processes underlying Motor Neuron Diseases Development -- Chapter 2: Cardiac -- Bioengineering and Stem Cell Technology in the Treatment of Congenital Heart Disease -- Scalable Electrophysiological Investigation of iPS Cell Derived Cardiomyocytes Obtained by a Lentiviral Purification Strategy -- Clinical Potentials of Cardiomyocytes Derived from Patient-Specific Induced Pluripotent Stem Cells -- Chapter 3: Eye -- iPS Cells for Modelling and Treatment of Retinal Diseases -- Patient-Specific iPSC-Derived RPE for Modeling of Retinal Diseases -- Potential role of Induced Pluripotent Stem Cells (IPSCs) for Cell-Based Therapy of the Ocular Surface -- Chapter 4: Spinal Cord Injury -- The Potential for iPS-Derived Stem Cells as a Therapeutic Strategy for Spinal Cord Injury: Opportunities and Challenges -- The State of Play with iPSCs and Spinal Cord Injury Models -- Chapter 5: Liver -- Potential and Challenges of Induced Pluripotent Stem Cells in Liver Diseases Treatment -- Chapter 6: Muscle -- Myogenic Precursors from iPS Cells for Skeletal Muscle Cell Replacement Therapy -- Chapter 7: Bone -- The Use of Patient-Specific Induced Pluripotent Stem Cells (iPSCs) to Identify Osteoclast Defects in Rare Genetic Bone Disorders -- Chapter 8: Germ Cells -- Human iPS Cell-derived Germ Cells: Current Status and Clinical Potential -- Chapter 9: Genetic Disorders -- Comparing ESC and iPSC-Based Models for Human Genetic Disorders -- Design of a Tumorigenicity Test for Induced Pluripotent Stem Cell (iPSC)-Derived Cell Products -- Concise Review: Methods and Cell Types Used to Generate Down Syndrome Induced Pluripotent Stem Cells -- Chapter 10: Immune Response -- The Possible Future Roles for iPSC-Derived Therapy for Autoimmune Diseases. |
| Record Nr. | UNINA-9910688474503321 |
| Basel, Switzerland : , : MDPI - Multidisciplinary Digital Publishing Institute, , [2015] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Journal of human transcriptome
| Journal of human transcriptome |
| Pubbl/distr/stampa | London : , : Taylor & Francis, , 2015-2018 |
| Descrizione fisica | 1 online resource |
| Disciplina | 572.8845 |
| Soggetto topico |
Life - Origin
RNA splicing RNA Splicing Transcriptome Humans |
| Soggetto genere / forma |
Fulltext
Internet Resources. Periodicals. |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910315219903321 |
| London : , : Taylor & Francis, , 2015-2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
A master regulator of oxidative stress : the transcription factor Nrf2 / / edited by Jose Antonio Morales-Gonzalez, Ángel Morales-González, Eduardo Osiris Madrigal-Santillan
| A master regulator of oxidative stress : the transcription factor Nrf2 / / edited by Jose Antonio Morales-Gonzalez, Ángel Morales-González, Eduardo Osiris Madrigal-Santillan |
| Pubbl/distr/stampa | Rijeka, Croatia : , : IntechOpen, , [2016] |
| Descrizione fisica | 1 online resource (210 pages) : illustrations |
| Disciplina | 572.8845 |
| Soggetto topico | Transcription factors |
| ISBN |
953-51-5462-1
953-51-2838-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti |
Master regulator of oxidative stress
A Master Regulator of Oxidative Stress â The Transcription Factor Nrf2 |
| Record Nr. | UNINA-9910317681903321 |
| Rijeka, Croatia : , : IntechOpen, , [2016] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Nrf2 and its Modulation in Inflammation / / edited by Huai Deng
| Nrf2 and its Modulation in Inflammation / / edited by Huai Deng |
| Edizione | [1st ed. 2020.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 |
| Descrizione fisica | 1 online resource (210 pages) |
| Disciplina |
572.8845
616.0473 |
| Collana | Progress in Inflammation Research |
| Soggetto topico |
Immunology
Cell physiology Gene expression Oxidative stress Cell Physiology Gene Expression Oxidative Stress Expressió gènica Proteïnes Immunitat cel·lular |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-44599-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Chapter 1. Molecular mechanisms of Nrf2 in inflammation: Interactions between Nrf2 and inflammatory mediators -- Chapter 2. Nrf2 in immune responses during inflammation -- Chapter 3. Nrf2 and Nrf2-interacting network in respiratory inflammation and diseases -- Chapter 4. Nrf2 in the regulation of endothelial cell homeostasis during inflammation -- Chapter 5. The roles of Nrf2 in cardiovascular system and atherosclerosis -- Chapter 6. Nrf2 and inflammation-triggered carcinogenesis -- Chapter 7. Role of Nrf2 in oxidative and inflammatory processes in obesity and metabolic diseases -- Chapter 8. Modulators of Nrf2 Activation during Inflammation. |
| Record Nr. | UNINA-9910409692703321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Nuclear receptors : the art and science of modulator design and discovery / / Mostafa Z. Badr, editor
| Nuclear receptors : the art and science of modulator design and discovery / / Mostafa Z. Badr, editor |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2021] |
| Descrizione fisica | 1 online resource (676 pages) |
| Disciplina | 572.8845 |
| Soggetto topico |
Nuclear receptors (Biochemistry)
Receptors nuclears (Bioquímica) |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-78315-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Preface -- Contents -- About the Editor -- Chapter 1: Molecular Pharmacology of the Youngest Member of the Nuclear Receptor Family: The Mineralocorticoid Receptor -- 1.1 An Overview of the MR Physiology -- 1.2 Evolutionary Profile of the MR -- 1.3 The Hsp90-Based Heterocomplex -- 1.4 MR Trafficking -- 1.5 Agonist Structure-Activity Relationship -- 1.6 MR Antagonism -- 1.7 MR Regulation by Phosphorylation and Redox Potential -- 1.8 Conclusions -- References -- Chapter 2: A Simple Method for Visual Assessment and Quantification of Altered Subcellular Localization of Nuclear Receptors -- 2.1 Introduction -- 2.2 Materials and Methods -- 2.3 Notes -- References -- Chapter 3: Multifaceted Effects of Ligand on Nuclear Receptor Mobility -- 3.1 Introduction -- 3.2 Nucleocytoplasmic Shuttling of the Nuclear Receptors -- 3.2.1 Nuclear Pore Complexes: Gatekeepers of the Nucleus -- 3.2.2 Nuclear Import Pathways -- 3.2.3 Nuclear Export Pathways -- 3.2.4 Dynamics of Movement Within the Nucleus -- 3.3 Ligand-Dependent Nuclear Accumulation of Nuclear Receptors -- 3.3.1 Glucocorticoid Receptor Nuclear Accumulation and Intranuclear Dynamics -- 3.3.1.1 GR Nuclear Accumulation -- 3.3.1.2 GR Intranuclear Dynamics -- 3.3.2 Mineralocorticoid Receptor Nuclear Accumulation and Intranuclear Dynamics -- 3.3.2.1 MR Nuclear Accumulation -- 3.3.2.2 MR Intranuclear Dynamics -- 3.3.3 Androgen Receptor Nuclear Accumulation and Intranuclear Dynamics -- 3.3.3.1 Androgen Receptor Nuclear Accumulation -- 3.3.3.2 Androgen Receptor Intranuclear Dynamics -- 3.4 Ligand-Dependent Intranuclear Localization -- 3.5 Ligand-Independent Trafficking -- 3.5.1 Thyroid Hormone Receptor Intracellular Trafficking -- 3.5.2 Retinoic Acid Receptor Intracellular Trafficking -- 3.6 Retinoid X Receptor and Vitamin D Receptor Intracellular Trafficking: A Bin of Their Own? -- 3.7 Conclusions.
References -- Chapter 4: Chemical Considerations in Discovery of Receptor Modulators -- 4.1 Introduction -- 4.2 Intermolecular Binding Forces Drive Ligand Action -- 4.3 Sterics and Hydrophobicity in Ligand Binding -- 4.4 Stereochemical Considerations -- 4.5 Molecular Dynamics as a Tool for Modulator Design -- 4.6 Case Study: A Holistic Approach to Liver X Receptor Modulator Design -- 4.7 Conclusions -- References -- Chapter 5: Structure-Based Design of Estrogen-Related Receptors Modulators -- 5.1 Introduction -- 5.2 Structure and Function -- 5.3 Medicinal Chemistry of ERR Modulators -- 5.3.1 ERR Inverse Agonists -- 5.3.2 ERRs Agonists -- References -- Chapter 6: PPARα and δ Ligand Design: Honing the Traditional Empirical Method with a More Holistic Overview -- 6.1 Introduction to the PPAR Protein -- 6.1.1 Overall PPAR LBD Protein Structure -- 6.1.2 Mechanism of PPAR Gene Transcription -- 6.1.3 Differences in LBD Between PPAR Subtypes -- 6.2 Catalogue of Known Ligands -- 6.2.1 PPARα Ligands -- 6.2.1.1 PPARα Full Agonists -- WY14643 or Pirinixic Acid -- GW590735/Compound 25a -- Pemafibrate -- 6.2.1.2 PPARα Antagonist -- GW6471 -- 6.2.2 PPARδ Ligands -- 6.2.2.1 PPARδ Full Agonists -- GW2433 -- GW2331 -- LC1765 -- Compound 48 -- Isoquinoline Compound 5 -- TIPP-204 -- GW0742 -- GW501516, Compounds 1-16 -- Compound 18 and Compound 13 -- 6.2.2.2 PPARδ Partial Agonists -- Compound 2 -- GW9371 -- 6.2.3 Dual or Pan Agonist Ligands -- 6.2.3.1 PPARα/γ Dual Agonists -- GW409544 -- Azetidinone Compounds 17 and 35 -- GL479 -- 6.2.3.2 PPARα/δ Dual Agonists -- TIPP-401 -- 6.2.3.3 PPARδ/γ Dual Agonists -- Phenoxyacetic Acid Compounds 10 and 21 -- Sulfonylthiadiazole Compounds 6, 11t and 20a -- 6.2.3.4 Pan Agonists -- Indeglitazar -- TIPP-703 -- AL29-26 -- 6.2.3.5 Endogenous Agonists -- Eicosapentaenoic Acid (20:5 EPA) -- Vaccenic Acid (18:1) -- Iloprost. 17(S)-oxoDHA (22:6) -- 6.3 Ligand Design Factors -- 6.4 Tools and New Information -- 6.4.1 Examples of Computer-Aided Drug Design -- 6.4.2 Pharmacokinetics and Pharmacodynamics -- 6.4.3 Wider Considerations for PPAR -- 6.4.3.1 LBD Mutations -- 6.4.3.2 PPAR Intact Structure and Implications -- 6.4.3.3 Coregulators and FABPs -- 6.5 Conclusion -- References -- Chapter 7: Pregnane X Receptor: Understanding Its Function and Activity at the Molecular Level -- 7.1 Introduction -- 7.2 The Chemical Landscape of PXR Ligands -- 7.3 The Structural Architecture of PXR -- 7.4 Dimerization of PXR -- 7.5 Coregulatory Recruitment to PXR -- 7.6 AF-2 Helix Orientation Dictates PXR's Activation -- 7.7 Ligand Binding Stabilizes the Structure of PXR -- 7.8 Ligand-Binding Site of PXR and Ligand Promiscuity -- 7.9 Species Selectivity in PXR Activation -- 7.10 PXR Inhibitors -- 7.11 PXR Agonists as Therapeutics -- 7.12 Conclusion -- References -- Chapter 8: Strategies for the Design of Vitamin D Receptor Ligands -- 8.1 Introduction -- 8.2 Secosteroid VDR Ligands -- 8.3 Non-secosteroid VDR Ligands -- 8.4 VDR Antagonists -- 8.5 Concluding Remarks and Future Directions -- References -- Chapter 9: What Makes a Good Antagonist: Lessons Learned from the Estrogen and Aryl Hydrocarbon Receptors -- 9.1 Introduction: What Is an Antagonist? -- 9.2 Identification and Development of ER Antagonists -- 9.2.1 A Brief History of the Development of ER Antagonists -- 9.2.2 Molecular Characterization of ERs -- 9.2.3 The Antagonistic Activity of SERMs Involves Repositioning of Helix 12 -- 9.2.4 Additional Classes of ERα Antagonists -- 9.3 Development of AHR Antagonists -- 9.3.1 Early Days of AHR Discovery -- 9.3.2 Molecular Structure of the AHR -- 9.3.3 Agonist-Induced Activation of the AHR -- 9.3.4 The AHR Is Activated by a Diverse Cadre of Ligands. 9.3.5 Development of Selective AHR Modulators (SAHRMs) -- 9.3.6 Toward the Development of "Pure" AHR Antagonists -- 9.3.7 Development of Flavone-Based AHR Antagonists -- 9.3.8 Development of Indole-Based AHR Antagonists -- 9.3.9 Development of Stilbene-Based AHR Antagonists -- 9.3.10 Development of AHR-PROTACs (SAHRDs) -- 9.3.11 Elucidating the Rules That Govern Agonist Versus Antagonist-Induced AHR Activity -- 9.4 Conclusions and Future Directions -- References -- Chapter 10: Design of Novel PPAR Agonist for Neurodegenerative Disease -- 10.1 Introduction -- 10.2 Overview of PPARs and Their Structures -- 10.3 PPAR-Gamma Activation Site -- 10.4 Structure of the Ligand-Binding Domain -- 10.5 Structural Dynamics of PPAR Gamma -- 10.6 Selective PPAR Modulators (SPPARMs) -- 10.7 PPAR Delta Active Site Description -- 10.8 PPAR Alpha Active Site Description -- 10.9 PPARS and Neurodegenerative Diseases -- 10.10 PPARS for Alzheimer's Disease: Overview of AD -- 10.11 PPARs and Neuroinflammation -- 10.12 PPARs and Microglia and Neurotrophins -- 10.13 PPARS, TREM2, and Amyloid Beta -- 10.14 Conclusion -- References -- Chapter 11: Functional Bioassays Lithograph Ligand Reflections in the PPARα Sphere -- 11.1 PPARs Are Nuclear Hormone Receptors -- 11.2 The RXR Obligation -- 11.3 Screening for PPAR Activators -- 11.4 Reporter Plasmids of PPAR-RXR Heterodimer Activity -- 11.5 Power of the Imperfect -- 11.6 Is It a Ligand? -- 11.7 Saturation and Competition-Binding Analyses -- 11.8 Ligand-Dependent Conformational Change -- 11.9 Altered DNA-Binding Affinity -- 11.10 Crystal Structure -- 11.11 Summary -- References -- Chapter 12: Computational Applications on Food Contact Chemicals as Nuclear Receptor Binders -- 12.1 Introduction -- 12.2 Methods to Evaluate Food Contaminants as Nuclear Receptor Modulators. 12.3 In Vitro Bioassays to Study the Mechanism of Action (MoA) of Endocrine Disruptor Compounds -- 12.3.1 Ligand-Binding Assays -- 12.3.2 Gene Reporter Assays -- 12.3.3 Steroidogenesis Assay -- 12.4 In Silico Methods for Screening Endocrine Disruptor Compounds -- 12.4.1 3D Protein Structure: The Starting Point of Computational Methods -- 12.4.2 Ligand-Based Virtual Screening -- 12.4.3 Molecular Docking -- 12.4.4 Consensus Scoring -- 12.4.5 Molecular Dynamic Simulations -- 12.5 Case Studies -- References -- Chapter 13: Nuclear Hormone Receptors and Host-Virus Interactions -- 13.1 Introduction -- 13.2 Nuclear Receptor Structure and Function -- 13.3 PPAR Signaling and Host-Virus Interactions -- 13.3.1 PPARs and Hepatitis C Virus (HCV) -- 13.3.2 PPARs and Flaviviruses -- 13.3.3 PPARs and Human Immunodeficiency Virus (HIV) -- 13.3.4 PPARs and Other Examples of Viruses -- 13.3.4.1 Hepatitis B Virus -- 13.3.4.2 Influenza A Viruses (IAVs) -- 13.3.4.3 Herpesviruses -- 13.4 Liver X Receptors (LXRs) and Host-Virus Interactions -- 13.4.1 LXR and HCV -- 13.4.2 HIV-1 and LXR -- 13.4.3 LXR and Other Examples of Viruses -- 13.4.3.1 Influenza A Viruses -- 13.4.3.2 Herpesviruses and LXR -- 13.4.3.3 HBV -- 13.5 FXR and Host-Virus Interactions -- 13.5.1 FXR Signaling -- 13.5.2 FXR Signaling During HCV Infection -- 13.5.3 FXR Signaling During HBV Infection -- 13.6 Conclusions -- References -- Chapter 14: Retinoic Acid-Related Orphan Receptor (ROR) Inverse Agonists: Potential Therapeutic Strategies for Multiple Inflammatory Diseases? -- 14.1 Introduction -- 14.2 Functions of RORs in Immune Cells -- 14.3 RORs and Autoimmune Disease -- 14.4 Vitamin D3, VDR, and RORs -- 14.5 Multiple Sclerosis (MS) -- 14.6 Psoriasis -- 14.7 Role of RORα in Cardiac Injury and Heart Failure -- 14.8 RORs in Asthma and Acute Respiratory Distress Syndrome (ARDS) -- 14.9 Rheumatoid Arthritis. 14.10 Sjögren's Syndrome (SS). |
| Record Nr. | UNINA-9910503001003321 |
| Cham, Switzerland : , : Springer, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Nuclear Receptors in Human Health and Disease / / edited by Moray J. Campbell, Charlotte L. Bevan
| Nuclear Receptors in Human Health and Disease / / edited by Moray J. Campbell, Charlotte L. Bevan |
| Edizione | [1st ed. 2022.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2022 |
| Descrizione fisica | 1 online resource (338 pages) |
| Disciplina |
572.8845
616.07 |
| Collana | Advances in Experimental Medicine and Biology |
| Soggetto topico |
Medicine - Research
Biology - Research Molecular biology Metabolism Genetics Cytology Biomedical Research Molecular Biology Genetics and Genomics Cell Biology Receptors nuclears (Bioquímica) |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-031-11836-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Introduction (Moray J Campbell & Charlotte L Bevan) -- Overview (Jason Carroll) -- Part I: Reproduction and Development -- Chapter 1. Nuclear receptors in pregnancy and outcomes: clinical perspective (Luiza Borges Manna & Catherine Williamson) -- Chapter 2. Female Reproductive Systems: hormone dependence and receptor expression (Philippa TK Saunders) -- Chapter 3. Nuclear receptors in ovarian function (Darryl Russell & Doan Thao Dinh) -- Part II: Metabolism -- Chapter 4. Nuclear receptors in energy metabolism (Alina Walth, Stephan Herzig & Maria Rohm) -- Chapter 5. Nuclear Receptors and lipid sensing (James L Thorne and Giorgia Cioccoloni) -- Part III: Central Systems -- Chapter 6. Corticosteroid receptors in Cardiac health and disease (Jessica Ivy, Gillian Gray, Megan Holmes, Martin Denvir, Karen Chapman) -- Chapter 7. Physiological convergence and antagonism between GR and PPARγ in inflammation and metabolism (Marija Dacic, Gayathri Shibu and Inez Rogatsky) -- Chapter 8. Circadian Rhythm and Nuclear Receptors (David W Ray) -- Chapter 9. Vitamin D and gut health (James C Fleet) -- Part IV: Cancer -- Chapter 10. Estrogen Receptor alpha and ESR1 Mutations in Breast Cancer (Jaymin Patel & Rinath Jeselsohn) -- Chapter 11. AR structural variants and prostate cancer (Laura Cato) -- Chapter 12. ERβ and inflammation (Linnea Hases, Amena Archer & Cecilia Williams) -- Chapter 13. Genomic insights into non-steroidal nuclear receptors in prostate and breast cancer (Sajad A Wani & Moray Campbell) -- Part V: New developments in transcriptional control by nuclear receptors -- Chapter 14. Protein condensation in the nuclear receptor family; implications for transcriptional output (Monique Appelman, Elle Hollaar, Jurian Schuijers & Saskia WC van Mil) -- Chapter 15. Prostate cancer epigenetic plasticity and enhancer heterogeneity: molecular causes, consequences and clinical implications (Jeroen Kneppers, Andries M Bergman & Wilbert Zwart) -- Chapter 16. Epigenetic coregulation of androgen receptor signaling (Rayzel Fernandes, Damien A. Leach & Charlotte Bevan) -- Part VI: Clinical Translation -- Chapter 17. Cllnical Translation: Targeting the Estrogen Receptor (Jennifer O. Lauchle & Ciara Metcalfe) -- Chapter 18. Drugging the undruggable: targeting the N-terminal domain of nuclear hormone receptors (Marianne Sadar) -- Chapter 19. Genetic Variation and Mendelian Randomization approaches (Mojgan Yazdanpanah, Nahid Yazdanpanah & Despoina Manousaki) -- Index. |
| Record Nr. | UNINA-9910595057103321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Regulation of transcription in plants [[electronic resource] /] / edited by Klaus D. Grasser
| Regulation of transcription in plants [[electronic resource] /] / edited by Klaus D. Grasser |
| Pubbl/distr/stampa | Oxford ; ; Ames, Iowa, : Blackwell Pub., 2006 |
| Descrizione fisica | 1 online resource (372 p.) |
| Disciplina |
572.8845
580.5 |
| Altri autori (Persone) | GrasserKlaus (Klaus D.) |
| Collana | Annual plant reviews |
| Soggetto topico | Plant genetic regulation |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-32030-7
9786611320300 0-470-76434-1 0-470-98888-6 0-470-99428-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Regulation of Transcription in Plants; Contents; Contributors; Preface; 1 General transcription factors and the core promoter: ancient roots; 1.1 Introduction; 1.2 Origins of the eukaryotic promoter; 1.3 Organization of the eukaryotic promoter; 1.3.1 TATA-less promoters; 1.4 Transcription factor IID; 1.5 Role of TFIID in development; 1.6 Mediator; 1.6.1 Tail module; 1.6.2 Middle complex; 1.6.3 Head module; 1.6.4 CDK8/Srb8-11 module; 1.6.5 Mediator subunits unique to metazoans and plants; 1.7 Transcription factor IIB; 1.8 Summary; References
2 Transcription factors of Arabidopsis and rice: a genomic perspective2.1 Introduction; 2.2 Arabidopsis and rice genomes: the angiosperm complement of transcription factors; 2.2.1 General considerations for genome-wide analyses; 2.2.2 Arabidopsis transcription factors; 2.2.3 Rice transcription factors: a comparison to Arabidopsis; 2.2.4 Gene duplications, functional redundancy, and the transcription factor phenome; 2.3 Plant promoters; References; 3 Chromatin-associated architectural HMGA and HMGB proteins assist transcription factor function; 3.1 Introduction; 3.2 HMGA proteins 3.2.1 Structure and expression3.2.2 DNA and chromatin interactions; 3.3 HMGB proteins; 3.3.1 Structure and expression; 3.3.2 DNA and chromatin interactions; 3.4 Dynamic interaction of histone H1 and HMG proteins with chromatin; 3.5 HMGA and HMGB proteins as architectural assistant factors; Acknowledgements; References; 4 Histone modifications and transcription in plants; 4.1 Introduction; 4.2 Histone acetylation and transcriptional activation; 4.2.1 Plant histone acetyltransferases; 4.2.1.1 GNAT/MYST family; 4.2.1.2 TAFII 250 family; 4.2.1.3 P300/CBP family; 4.2.2 Bromodomain proteins 4.2.2.1 Bromodomain extra-terminal proteins4.2.2.2 Plant bromodomain proteins; 4.2.3 Plant histone deacetylases; 4.2.3.1 RPD3/HDA1 family; 4.2.3.2 HD2 family; 4.2.3.3 SIR2 family; 4.2.4 Histone acetylation/deacetylation and environmental adaptation; 4.3 Histone methylation; 4.3.1 Plant SET-domain proteins; 4.3.1.1 E(Z)- and Trithorax-type HMTases; 4.3.1.2 Su(var)3-9-type HMTases; 4.3.1.3 ASH1-type and plant-specific HMTases; 4.3.2 Histone demethylase; 4.4 Interplay between histone acetylation and methylation in transcriptional regulation; 4.5 Conclusions; References 5 Chromatin remodeling and histone variants in transcriptional regulation and in maintaining DNA methylation5.1 Introduction; 5.2 ATP-dependent chromatin remodeling; 5.2.1 SWI/SNF-like complexes in plants; 5.2.2 Other ATPases of the SNF2 family that control plant development; 5.3 Chromatin remodeling and DNA methylation; 5.3.1 The effects of ddm1 mutation differ from those caused by met1; 5.3.2 The model of DDM1 action; 5.3.3 DDM1 and methylation of histone H3; 5.3.4 Models of DDM1 targeting; 5.3.5 DRD1 - another SNF2 family protein involved in control of DNA methylation 5.4 Histone variants in the regulation of chromatin functions |
| Record Nr. | UNINA-9910145263203321 |
| Oxford ; ; Ames, Iowa, : Blackwell Pub., 2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Regulation of transcription in plants [[electronic resource] /] / edited by Klaus D. Grasser
| Regulation of transcription in plants [[electronic resource] /] / edited by Klaus D. Grasser |
| Pubbl/distr/stampa | Oxford ; ; Ames, Iowa, : Blackwell Pub., 2006 |
| Descrizione fisica | 1 online resource (372 p.) |
| Disciplina |
572.8845
580.5 |
| Altri autori (Persone) | GrasserKlaus (Klaus D.) |
| Collana | Annual plant reviews |
| Soggetto topico | Plant genetic regulation |
| ISBN |
1-281-32030-7
9786611320300 0-470-76434-1 0-470-98888-6 0-470-99428-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Regulation of Transcription in Plants; Contents; Contributors; Preface; 1 General transcription factors and the core promoter: ancient roots; 1.1 Introduction; 1.2 Origins of the eukaryotic promoter; 1.3 Organization of the eukaryotic promoter; 1.3.1 TATA-less promoters; 1.4 Transcription factor IID; 1.5 Role of TFIID in development; 1.6 Mediator; 1.6.1 Tail module; 1.6.2 Middle complex; 1.6.3 Head module; 1.6.4 CDK8/Srb8-11 module; 1.6.5 Mediator subunits unique to metazoans and plants; 1.7 Transcription factor IIB; 1.8 Summary; References
2 Transcription factors of Arabidopsis and rice: a genomic perspective2.1 Introduction; 2.2 Arabidopsis and rice genomes: the angiosperm complement of transcription factors; 2.2.1 General considerations for genome-wide analyses; 2.2.2 Arabidopsis transcription factors; 2.2.3 Rice transcription factors: a comparison to Arabidopsis; 2.2.4 Gene duplications, functional redundancy, and the transcription factor phenome; 2.3 Plant promoters; References; 3 Chromatin-associated architectural HMGA and HMGB proteins assist transcription factor function; 3.1 Introduction; 3.2 HMGA proteins 3.2.1 Structure and expression3.2.2 DNA and chromatin interactions; 3.3 HMGB proteins; 3.3.1 Structure and expression; 3.3.2 DNA and chromatin interactions; 3.4 Dynamic interaction of histone H1 and HMG proteins with chromatin; 3.5 HMGA and HMGB proteins as architectural assistant factors; Acknowledgements; References; 4 Histone modifications and transcription in plants; 4.1 Introduction; 4.2 Histone acetylation and transcriptional activation; 4.2.1 Plant histone acetyltransferases; 4.2.1.1 GNAT/MYST family; 4.2.1.2 TAFII 250 family; 4.2.1.3 P300/CBP family; 4.2.2 Bromodomain proteins 4.2.2.1 Bromodomain extra-terminal proteins4.2.2.2 Plant bromodomain proteins; 4.2.3 Plant histone deacetylases; 4.2.3.1 RPD3/HDA1 family; 4.2.3.2 HD2 family; 4.2.3.3 SIR2 family; 4.2.4 Histone acetylation/deacetylation and environmental adaptation; 4.3 Histone methylation; 4.3.1 Plant SET-domain proteins; 4.3.1.1 E(Z)- and Trithorax-type HMTases; 4.3.1.2 Su(var)3-9-type HMTases; 4.3.1.3 ASH1-type and plant-specific HMTases; 4.3.2 Histone demethylase; 4.4 Interplay between histone acetylation and methylation in transcriptional regulation; 4.5 Conclusions; References 5 Chromatin remodeling and histone variants in transcriptional regulation and in maintaining DNA methylation5.1 Introduction; 5.2 ATP-dependent chromatin remodeling; 5.2.1 SWI/SNF-like complexes in plants; 5.2.2 Other ATPases of the SNF2 family that control plant development; 5.3 Chromatin remodeling and DNA methylation; 5.3.1 The effects of ddm1 mutation differ from those caused by met1; 5.3.2 The model of DDM1 action; 5.3.3 DDM1 and methylation of histone H3; 5.3.4 Models of DDM1 targeting; 5.3.5 DRD1 - another SNF2 family protein involved in control of DNA methylation 5.4 Histone variants in the regulation of chromatin functions |
| Record Nr. | UNISA-996218620803316 |
| Oxford ; ; Ames, Iowa, : Blackwell Pub., 2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Regulation of transcription in plants [[electronic resource] /] / edited by Klaus D. Grasser
| Regulation of transcription in plants [[electronic resource] /] / edited by Klaus D. Grasser |
| Pubbl/distr/stampa | Oxford ; ; Ames, Iowa, : Blackwell Pub., 2006 |
| Descrizione fisica | 1 online resource (372 p.) |
| Disciplina |
572.8845
580.5 |
| Altri autori (Persone) | GrasserKlaus (Klaus D.) |
| Collana | Annual plant reviews |
| Soggetto topico | Plant genetic regulation |
| ISBN |
1-281-32030-7
9786611320300 0-470-76434-1 0-470-98888-6 0-470-99428-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Regulation of Transcription in Plants; Contents; Contributors; Preface; 1 General transcription factors and the core promoter: ancient roots; 1.1 Introduction; 1.2 Origins of the eukaryotic promoter; 1.3 Organization of the eukaryotic promoter; 1.3.1 TATA-less promoters; 1.4 Transcription factor IID; 1.5 Role of TFIID in development; 1.6 Mediator; 1.6.1 Tail module; 1.6.2 Middle complex; 1.6.3 Head module; 1.6.4 CDK8/Srb8-11 module; 1.6.5 Mediator subunits unique to metazoans and plants; 1.7 Transcription factor IIB; 1.8 Summary; References
2 Transcription factors of Arabidopsis and rice: a genomic perspective2.1 Introduction; 2.2 Arabidopsis and rice genomes: the angiosperm complement of transcription factors; 2.2.1 General considerations for genome-wide analyses; 2.2.2 Arabidopsis transcription factors; 2.2.3 Rice transcription factors: a comparison to Arabidopsis; 2.2.4 Gene duplications, functional redundancy, and the transcription factor phenome; 2.3 Plant promoters; References; 3 Chromatin-associated architectural HMGA and HMGB proteins assist transcription factor function; 3.1 Introduction; 3.2 HMGA proteins 3.2.1 Structure and expression3.2.2 DNA and chromatin interactions; 3.3 HMGB proteins; 3.3.1 Structure and expression; 3.3.2 DNA and chromatin interactions; 3.4 Dynamic interaction of histone H1 and HMG proteins with chromatin; 3.5 HMGA and HMGB proteins as architectural assistant factors; Acknowledgements; References; 4 Histone modifications and transcription in plants; 4.1 Introduction; 4.2 Histone acetylation and transcriptional activation; 4.2.1 Plant histone acetyltransferases; 4.2.1.1 GNAT/MYST family; 4.2.1.2 TAFII 250 family; 4.2.1.3 P300/CBP family; 4.2.2 Bromodomain proteins 4.2.2.1 Bromodomain extra-terminal proteins4.2.2.2 Plant bromodomain proteins; 4.2.3 Plant histone deacetylases; 4.2.3.1 RPD3/HDA1 family; 4.2.3.2 HD2 family; 4.2.3.3 SIR2 family; 4.2.4 Histone acetylation/deacetylation and environmental adaptation; 4.3 Histone methylation; 4.3.1 Plant SET-domain proteins; 4.3.1.1 E(Z)- and Trithorax-type HMTases; 4.3.1.2 Su(var)3-9-type HMTases; 4.3.1.3 ASH1-type and plant-specific HMTases; 4.3.2 Histone demethylase; 4.4 Interplay between histone acetylation and methylation in transcriptional regulation; 4.5 Conclusions; References 5 Chromatin remodeling and histone variants in transcriptional regulation and in maintaining DNA methylation5.1 Introduction; 5.2 ATP-dependent chromatin remodeling; 5.2.1 SWI/SNF-like complexes in plants; 5.2.2 Other ATPases of the SNF2 family that control plant development; 5.3 Chromatin remodeling and DNA methylation; 5.3.1 The effects of ddm1 mutation differ from those caused by met1; 5.3.2 The model of DDM1 action; 5.3.3 DDM1 and methylation of histone H3; 5.3.4 Models of DDM1 targeting; 5.3.5 DRD1 - another SNF2 family protein involved in control of DNA methylation 5.4 Histone variants in the regulation of chromatin functions |
| Record Nr. | UNINA-9910829868803321 |
| Oxford ; ; Ames, Iowa, : Blackwell Pub., 2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
