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Adenosine : a key link between metabolism and brain activity / / Susan Masino, Detlev Boison ; editors
| Adenosine : a key link between metabolism and brain activity / / Susan Masino, Detlev Boison ; editors |
| Pubbl/distr/stampa | New York, : Springer, 2012, c2013 |
| Descrizione fisica | 1 online resource (679 p.) |
| Disciplina | 572.85 |
| Altri autori (Persone) |
MasinoSusan
BoisonDetlev |
| Soggetto topico |
Adenosine
Biochemistry |
| ISBN |
1-283-91209-0
1-4614-3903-5 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Adenosine and metabolism – a brief historical note -- Adenosine metabolism, adenosine kinase and evolution -- Adenosine and energy metabolism - relationship to brain bioenergetics -- Adenosine and autocrine metabolic regulation of neuronal activity -- Physiologic and metabolic regulation of adenosine – mechanisms -- The double edged sword: gaining adenosine at the expense of ATP. How to balance the books -- Downstream pathways of adenosine -- Astrocytic ATP release -- Role of striatal A2A receptor subpopulations in neurological disorder -- Sleep and adenosine: human studies -- Adenosine and Other Purinergic Products in Circadian Timing -- Adenosine in the immune system -- The bioenergetics network of adenosine in hibernation, sleep and thermoregulation -- Adenosine and stroke -- The many roles of adenosine in traumatic brain injury -- Therapeutic Perspectives of Adenosine Receptor Compounds in Functional Restitutions after Spinal Cord Injury -- Adenosine and pain -- Symptomatic and neuroprotective effects of A2A receptor antagonists in Parkinson’s Disease -- Adenosine receptors and Alzheimer’s Disease -- Adenosine receptors in Huntington’s Disease -- Adenosine and Multiple Sclerosis -- Adenosinergic perspectives on schizophrenia – Opportunity for an integrative synthesis -- The role of adenosine in the ventral striatal circuits regulating behavioral activation and effort-related decision making: Importance for normal and pathological aspects of motivation -- Adenosine and autism: Physiological symptoms and metabolic opportunities -- Stress, Brain Adenosine Signaling, and Fatigue-Related Behavioral Processes -- Disruption of adenosine homeostasis in epilepsy and therapeutic adenosine augmentation -- Ketogenic Diet and Epilepsy: The Role of Adenosine -- Silk – a biocompatible and biodegradable biopolymer for therapeutic adenosine delivery -- Anatomical Distribution of Nucleoside System in the Human Brain and Implications for Therapy. |
| Record Nr. | UNINA-9910437620003321 |
| New York, : Springer, 2012, c2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Analysis of oligonucleotides and their related substances / / edited by George Okafo, David Elder and Mike Webb
| Analysis of oligonucleotides and their related substances / / edited by George Okafo, David Elder and Mike Webb |
| Pubbl/distr/stampa | Hertfordshire, England : , : ILM Publications, , 2013 |
| Descrizione fisica | 1 online resource (346 p.) |
| Disciplina | 572.85 |
| Altri autori (Persone) |
OkafoGeorge
ElderDavid WebbMike |
| Collana | ChromSoc separation science series |
| Soggetto topico |
Oligonucleotides - Analysis
Separation (Technology) |
| Soggetto genere / forma | Electronic books. |
| ISBN | 1-906799-37-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910464187503321 |
| Hertfordshire, England : , : ILM Publications, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Analysis of oligonucleotides and their related substances / / edited by George Okafo, David Elder and Mike Webb
| Analysis of oligonucleotides and their related substances / / edited by George Okafo, David Elder and Mike Webb |
| Pubbl/distr/stampa | Hertfordshire, England : , : ILM Publications, , 2013 |
| Descrizione fisica | 1 online resource (346 p.) |
| Disciplina | 572.85 |
| Altri autori (Persone) |
OkafoGeorge
ElderDavid WebbMike |
| Collana | ChromSoc separation science series |
| Soggetto topico |
Oligonucleotides - Analysis
Separation (Technology) |
| ISBN | 1-906799-37-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910789400403321 |
| Hertfordshire, England : , : ILM Publications, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Analysis of oligonucleotides and their related substances / / edited by George Okafo, David Elder and Mike Webb
| Analysis of oligonucleotides and their related substances / / edited by George Okafo, David Elder and Mike Webb |
| Pubbl/distr/stampa | Hertfordshire, England : , : ILM Publications, , 2013 |
| Descrizione fisica | 1 online resource (346 p.) |
| Disciplina | 572.85 |
| Altri autori (Persone) |
OkafoGeorge
ElderDavid WebbMike |
| Collana | ChromSoc separation science series |
| Soggetto topico |
Oligonucleotides - Analysis
Separation (Technology) |
| ISBN | 1-906799-37-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910814870103321 |
| Hertfordshire, England : , : ILM Publications, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The aptamer handbook [[electronic resource] ] : functional oligonucleotides and their applications / / edited by Sven Klussmann
| The aptamer handbook [[electronic resource] ] : functional oligonucleotides and their applications / / edited by Sven Klussmann |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2006 |
| Descrizione fisica | 1 online resource (520 p.) |
| Disciplina | 572.85 |
| Altri autori (Persone) | KlussmannSven |
| Soggetto topico | Oligonucleotides |
| ISBN |
1-280-72339-4
9786610723393 3-527-60819-2 3-527-60791-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
The Aptamer Handbook; Contents; Preface; Foreword; List of Contributors; Part 1 History and Theoretical Background; 1 In Vitro Selection of Functional Oligonucleotides and the Origins of Biochemical Activity; 1.1 Introduction; 1.2 A Brief History of In Vitro Selection; 1.3 Lessons from the Aptamers, Ribozymes, Deoxyribozymes Generated by In Vitro Selection; 1.4 Synthetic Approaches to Understanding the Natural Origins of Function; 1.5 Recent Technological Developments and Future Directions; 1.6 Conclusion; Acknowledgments; References
2 Mathematical Models on RNA Evolution, Simulations In Silico, and Concepts for In Vitro Selection2.1 From Early Experiments and Theories to the Concept of Neutral Networks; 2.1.1 Evolution in the Test Tube; 2.1.2 Kinetic Theory of the Evolution of Molecules; 2.1.3 Sequence Space and Shape Space; 2.2 RNA Structures, Thermodynamics and Kinetic Folding; 2.2.1 Secondary Structures of Minimum Free Energies; 2.2.2 Inverse Folding; 2.2.3 Suboptimal Conformations and Kinetic Folding; 2.2.4 Cofolding and DNA Parameters; 2.3 Neutral Networks and In Silico Evolution of Molecules 2.3.1 Neutral Networks in Sequence Space2.3.2 RNA Evolution In Silico; 2.3.3 Lessons from Evolution In Silico; 2.4 Designed and Natural RNA Switches; 2.5 Outlook on Future Problems in RNA Design; Acknowledgments; References; 3 Fitness Landscapes, Error Thresholds, and Cofactors in Aptamer Evolution; 3.1 Introduction; 3.2 Functionality Landscapes Inferred from Examples; 3.2.1 Fitness Landscape; 3.2.2 Damage Selection Experiments with Ribozymes; 3.2.3 Construction of the Fitness Landscape; 3.2.3.1 Compatible Structure; 3.2.3.2 Mispairs; 3.2.3.3 Critical Sites; 3.2.3.4 Predicted Structure 3.2.4 Case Study: The Fitness Landscape of the Neurospora VS Ribozyme3.2.4.1 Compatible Structure of the VS Ribozyme; 3.2.4.2 Allowed Mispairs in the VS Ribozyme; 3.2.4.3 Critical Sites in the VS Ribozyme; 3.2.4.4 Predicted Structure for the VS Ribozyme; 3.2.4.5 Properties of the Estimated Fitness Landscape for the VS Ribozyme; 3.3 Error Thresholds Inferred from Functional Landscapes: The "Realistic" Error Threshold of the Neurospora VS Ribozyme; 3.4 Looking for Catalytic Partners: Cofactors and Aptamers; 3.4.1 Co-ribozymes (cofactor-assisted ribozymes); 3.4.2 Aptazymes 3.5 The Use of Coenzymes: From the RNA World to the Protein World via Translation and the Genetic Code3.6 Outlook; Acknowledgments; References; Part 2 In Vitro Selection of Target-binding Oligonucleotides; 4 Aptamers to Small Molecules; 4.1 Introduction; 4.2 Aptamers to Nucleotides/Nucleosides/Nucleobases; 4.3 Aptamers to Cofactors; 4.4 Aptamers to Amino Acids; 4.5 Aptamers to Carbohydrates; 4.6 Aptamers to Natural Products; 4.7 Aptamers to Organic or Fluorescent Dyes; 4.8 The Chimeric Approach for Aptamer Selection; 4.9 Conclusion; Acknowledgments; References; 5 Aptamers to Antibiotics 5.1 Introduction |
| Record Nr. | UNINA-9910830024003321 |
| Weinheim, : Wiley-VCH, c2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Aptamers for medical applications : from diagnosis to therapeutics / / Yiyang Dong, editor
| Aptamers for medical applications : from diagnosis to therapeutics / / Yiyang Dong, editor |
| Pubbl/distr/stampa | Singapore : , : Springer, , [2021] |
| Descrizione fisica | 1 online resource (xiii, 462 pages) : illustrations |
| Disciplina | 572.85 |
| Soggetto topico |
Oligonucleotides - Biotechnology
Oligonucleotides - Therapeutic use Biomedical engineering |
| ISBN | 981-334-838-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Preface -- Introduction -- Contents -- About the Editor -- 1 Introduction of Aptamer, SELEX, and Different SELEX Variants -- 1.1 Introduction -- 1.2 Systematic Evolution of Ligands by EXponential Enrichment (SELEX) -- 1.3 Different SELEX Variants for Selection Rationalization -- 1.3.1 Reducing Screening Rounds -- 1.3.2 Furnishing More Targets Applicability -- 1.3.3 Simplifying Operations -- 1.3.4 Improving the Specificity of the Aptamer -- 1.3.5 Introducing Evaluation into the Selection Process -- 1.3.6 Other Selection Strategies -- 1.4 Perspectives -- References -- 2 Aptamer-Based Probes for Molecular Imaging -- 2.1 Introduction -- 2.2 Nuclear Imaging -- 2.2.1 Single Photon Emission Computed Tomography (SPECT) -- 2.2.2 Positron Emission Tomography (PET) -- 2.3 Magnetic Resonance Imaging -- 2.4 Ultrasound Imaging -- 2.5 Fluorescence Imaging -- 2.6 Multimodal Imaging -- 2.7 Conclusions and Perspectives -- References -- 3 Aptamer-Based Point of Care Testing Schemes -- 3.1 Introduction -- 3.2 Aptamers as Sensing Probes in POCT -- 3.3 Aptasensors-Based POCT -- 3.3.1 Aptamer-Based Lateral Flow POCT Platforms -- 3.3.2 Interferometry -- 3.3.3 DNA Origami Nanobox -- 3.3.4 Capacitive Aptasensors -- 3.3.5 Smartphone Enabled Aptasensors -- 3.3.6 Microchannels/Microfluidics -- 3.3.7 Microbeads and Nanomaterial-Based Aptasensors -- 3.3.8 Multiple Aptasensing Platforms -- 3.4 Conclusion and Future Trends -- References -- 4 Aptamer-Based Drug Delivery Systems -- 4.1 Introduction -- 4.2 Aptamers as Therapeutic Agents -- 4.3 Aptamer-Drug Conjugates -- 4.3.1 Covalent Conjugation -- 4.3.2 Physical Intercalation -- 4.4 Aptamer-Functionalized Nanoparticle Drug Delivery Systems -- 4.4.1 Inorganic Nanomaterials -- 4.4.2 Organic Nanomaterials -- 4.4.3 Biological Nanomaterials -- 4.4.4 Others -- 4.5 Challenges -- 4.6 Future Perspectives -- 4.7 Conclusion.
References -- 5 Aptamer-Based Medical Devices -- 5.1 Introduction -- 5.2 Aptamer-Based Medical Devices for Diagnosis -- 5.2.1 Biomarker Detection -- 5.2.2 Detection of Other Substances -- 5.3 Aptamer-Based Medical Devices for Therapeutics -- 5.4 Perspectives and Insights -- 5.4.1 Strengthen Fundamental Research -- 5.4.2 Learn from Antibodies -- 5.4.3 Seize the Opportunities -- References -- 6 Aptamers for Targeted Therapy -- 6.1 Introduction -- 6.2 Aptamer for Targeted Therapy of Oculopathy -- 6.2.1 Macugen (Pegaptanib) Targeting VEGF -- 6.2.2 Fovista (E10030) Targeting PDGF -- 6.2.3 Zimura (ARC1905) TargetingComplement-5 (C5) -- 6.3 Aptamers for Targeted Therapy of Coagulation -- 6.3.1 REG1 Targeting Coagulation Factor IXa -- 6.3.2 ARC19499 Targeting TFPI -- 6.3.3 ARC1779 Targeting vWF -- 6.3.4 Aptamers Targeting Thrombin -- 6.4 Aptamers for Targeted Therapy of Inflammation -- 6.4.1 Aptamers Targeting Interleukins -- 6.4.2 Aptamers Targeting Tumor Necrosis Factor (TNF) -- 6.4.3 Aptamers Targeting Chemokines -- 6.4.4 Other Inflammatory-Associated Factors -- 6.5 Aptamers for Targeted Therapy of Cancer -- 6.5.1 Aptamer as Agonist -- 6.5.2 Aptamer as Inhibitor -- 6.6 Prospects of Aptamer-Based Targeted Therapy -- References -- 7 Aptamers for Personalized Therapeutics -- 7.1 Introduction -- 7.1.1 Advantages of Aptamer -- 7.1.2 DNA Versus RNA Aptamers -- 7.1.3 Therapeutic Aptamers -- 7.2 Aptamers as Unique Therapeutic Molecules -- 7.2.1 Discovery of Aptamers Against Different Types of Cancer -- 7.2.2 Aptamers for Therapeutic Applications of Infectious Diseases -- 7.3 Aptamer Systems for Targeted Drug Delivery -- 7.3.1 Target-Specific Delivery of siRNAs: Aptamer-siRNA Conjugates -- 7.3.2 Aptamer-Drug Conjugates for Therapies -- 7.3.3 Aptamer Liposome Conjugates -- 7.3.4 Aptamer-Nanoparticles Conjugates -- 7.3.5 Antidote Aptamer for Controlled Therapy. 7.4 Gaps-Issues to be Considered -- 7.5 Future Perspective -- References -- 8 Aptamers for the Diagnosis of Infectious Diseases -- 8.1 Introduction -- 8.2 Bacterial Infectious Diseases -- 8.2.1 Cholera -- 8.2.2 Tuberculosis -- 8.2.3 Anthrax -- 8.3 Viral Infectious Diseases -- 8.3.1 Viral Hepatitis -- 8.3.2 AIDS -- 8.3.3 Viral Encephalitis -- 8.3.4 COVID-19 -- 8.4 Parasitic Infectious Disease -- 8.4.1 Malaria -- 8.4.2 Schistosomiasis -- 8.5 Other Typical Infectious Diseases -- References -- 9 Aptamers for the Diagnosis of Malign Tumors -- 9.1 Introduction -- 9.2 Aptamers in Cancer Biomarkers Discovery -- 9.3 Protein Biomarkers Analysis -- 9.3.1 Electrochemical Aptasensors -- 9.3.2 Aptamer-Based Optical Assays -- 9.4 Tumor Cells Analysis -- 9.4.1 Electrochemical Cytosensors -- 9.4.2 Optical Aptasensors -- 9.4.3 Aptamer-Based Microfluidic Cytosensors -- 9.5 Tissue Section Imaging -- 9.6 In Vivo Molecular Imaging -- 9.6.1 Fluorescence Imaging -- 9.6.2 Magnetic Resonance Imaging (MRI) -- 9.6.3 Single-Photon Emission Computed Tomography (SPECT)/Positron-Emission Tomography (PET) -- 9.6.4 Computed Tomography (CT) -- 9.7 Exosome-Sensing Aptasensors -- 9.8 Conclusion and Perspectives -- References -- 10 Aptamers for Thrombotic Diseases -- 10.1 Introduction -- 10.2 Aptamers Against Thrombin -- 10.2.1 Anti-thrombin DNA Aptamers -- 10.2.2 Anti-thrombin RNA Aptamers -- 10.2.3 Anti-thrombin Bimodular Aptamers -- 10.3 Aptamers Against FVII -- 10.4 Aptamers Against FIX -- 10.4.1 Preclinical Evaluation -- 10.4.2 Clinical Evaluation -- 10.5 Aptamers Against FX -- 10.6 Aptamers Against FXI -- 10.7 Aptamers Against FXII -- 10.8 Aptamers Against Kallikrein -- 10.9 Aptamers Against P-Selectin -- 10.9.1 Aptamers Against vWF -- 10.9.2 Aptamers Against PDGFRβ -- 10.9.3 Conclusion and Perspectives -- References -- 11 Hormone Aptamers in Endocrine-Related Diseases. 11.1 Introduction -- 11.2 Hormone-Related Aptamers -- 11.2.1 Estrogen-Related Aptamers -- 11.2.2 Progesterone-Related Aptamers -- 11.2.3 Insulin-Related Aptamers -- 11.2.4 25-HydroxyvitaminD3 Related Aptamers -- 11.2.5 Cortisol-Related Aptamers -- 11.3 Aptamer Application in Endocrine-Related Disease -- 11.3.1 Application of Aptamer in Medical Diagnosis -- 11.3.2 Application of Aptamer in Real-Time Detection -- 11.3.3 Application of Aptamer in Targeted Therapy -- 11.4 Overcome the Restrictions for Commercial Use of Aptamers -- 11.5 Discussion and Outlook -- Appendix: The Abbreviation in the Paper -- References -- 12 Aptamers for the Diagnosis and Therapy of Neurodegenerative Diseases -- 12.1 Introduction -- 12.2 The Applications of Aptamers in Neurodegenerative Diseases -- 12.2.1 The Applications of Aptamers in AD -- 12.2.2 The Applications of Aptamers in PD -- 12.2.3 The Applications of Aptamers in TSEs -- 12.2.4 The Applications of Aptamers in HD -- 12.3 Conclusions and perspectives -- References -- 13 Some Frontier Technologies for Aptamers in Medical Applications -- 13.1 Introduction -- 13.2 UVMag-SELEX -- 13.2.1 Pool Enrichment and Round Determination for UVMag-SELEX -- 13.2.2 High-Throughput Sequencing for Lead Sequences and Structural Prediction for Aptamer Candidates -- 13.2.3 UV and Microarray-Based Affinity Characterization of Aptamer Candidates for SynOP -- 13.2.4 Class-Specific Binding Ability of Practical Aptamers to Seven Organophosphorus Pesticides -- 13.3 Aptamer Biochip -- 13.3.1 Aptamer Microarray Biochip -- 13.3.2 Aptamer Microfluidic Biochip -- 13.3.3 Nanoarray and Nanofluidic Biochip -- 13.4 Native Mass Spectrometry -- 13.4.1 Native ESI-MS of Aptamer and Tetracycline Complex -- 13.4.2 Calculation of Dissociation Constants of Complexes -- 13.5 Conclusions and Perspectives -- References. 14 Perspectives of Aptamers for Medical Applications -- 14.1 Introduction -- 14.2 Merits and Demerits of Aptamer in Clinical Applications -- 14.2.1 Merits -- 14.2.2 Demerits -- 14.3 The Scenario for Aptamers in Medical Application -- 14.3.1 Point-of-Care Tests -- 14.3.2 Precision Medicine -- 14.3.3 Biomarker -- 14.4 Aptamers Application in Disease -- 14.4.1 Tumor -- 14.4.2 Non-tumor -- 14.5 Challenges for Aptamer in Medical Applications: From Bench to Bedside -- 14.5.1 Stability in Biological Media -- 14.5.2 Safety for Modified Aptamer -- 14.5.3 Adapt to the Homeostasis of the Human Body -- References. |
| Record Nr. | UNINA-9910484775403321 |
| Singapore : , : Springer, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Aptamers in bioanalysis [[electronic resource] /] / edited by Marco Mascini
| Aptamers in bioanalysis [[electronic resource] /] / edited by Marco Mascini |
| Pubbl/distr/stampa | Hoboken, NJ, : Wiley, c2009 |
| Descrizione fisica | 1 online resource (346 p.) |
| Disciplina | 572.85 |
| Altri autori (Persone) | MasciniMarco |
| Soggetto topico |
Oligonucleotides
Biochemistry |
| ISBN |
1-282-11267-8
9786612112676 0-470-38077-2 0-470-38076-4 |
| Classificazione |
CHE 808f
CHE 860f WC 4150 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
APTAMERS IN BIOANALYSIS; CONTENTS; PREFACE; CONTRIBUTORS; I INTRODUCTION; 1 APTAMERS: LIGANDS FOR ALL REASONS; 1.1 Introduction; 1.2 The Power of Selection and Aptamer Refinement; 1.3 The Chemistry Drives the Shape; 1.4 Aptaregulators; 1.5 Aptasensors; 1.6 Prospects; References; 2 SELEX AND ITS RECENT OPTIMIZATIONS; 2.1 Introduction; 2.2 Aptamers and Their Selection by SELEX; 2.3 Modifications of SELEX Technology; 2.4 Advantages and Limitations of Aptamers and Their Selection Technology; 2.5 Applications of Aptamers Being Developed for the Market; 2.6 Future Perspectives; References
II BIOSENSORS3 ELECTROCHEMICAL APTASENSORS; 3.1 Introduction; 3.2 Electrochemical Aptasensor Based on Redox-Active Aptamer Monolayers Linked to Electrodes; 3.3 Enzyme-Based Amplified Electrochemical Aptasensors; 3.4 Amplified Electrochemical Aptasensors Based on Nanoparticles; 3.5 Label-Free Electrochemical Aptasensors; 3.6 Field-Effect Transistor-Based Aptasensors; 3.7 Conclusions and Perspectives; References; 4 APTAMERS: HYBRIDS BETWEEN NATURE AND TECHNOLOGY; 4.1 Introduction; 4.2 Specific Features of Aptamers; 4.3 Electrochemical Detection of Nucleic Acids 4.4 Cytochrome c Binding by Aptamers4.5 DNA Machines and Aptamers; References; 5 DETECTION OF PROTEIN-APTAMER INTERACTIONS BY MEANS OF ELECTROCHEMICAL INDICATORS AND TRANSVERSE SHEAR MODE METHOD; 5.1 Introduction; 5.2 Immobilization of Aptamers on a Solid Support; 5.3 Detection of Aptamer-Ligand Interactions; 5.3.1 Electrochemical Methods; 5.3.2 Acoustic Methods; 5.4 Conclusions; References; 6 BIOSENSORS USING THE APTAMERIC ENZYME SUBUNIT: THE USE OF APTAMERS IN THE ALLOSTERIC CONTROL OF ENZYMES; 6.1 Aptamers as Molecular Recognition Elements of Biosensors 6.1.1 Comparing Aptamers to Antibodies6.1.2 Signaling Aptamers; 6.2 Homogeneous Sensing; 6.2.1 Biosensor Systems That Do Not Require Bound-Free Separation; 6.2.2 Aptameric Enzyme Subunit; 6.3 Evolution-mimicking Algorithm for the Improvement of Aptamers; References; 7 NANOMATERIAL-BASED LABEL-FREE APTASENSORS; 7.1 Introduction; 7.2 Label-Free Electrochemical Aptasensors; 7.3 Field-Effect Transistor-Based Aptasensors; 7.4 Label-Free Aptasensors Based on Localized Surface Plasmon Resonance; 7.5 Forthcoming Challenges and Concluding Remarks; References 8 APTAMER-BASED BIOANALYTICAL ASSAYS: AMPLIFICATION STRATEGIES8.1 Introduction; 8.2 Bioanalytical Assays Based on Aptamer-Functionalized Nanoparticles; 8.3 Aptamers and Quantum Dot-Based Assays; 8.4 Aptazymes and Aptamer-Based Machines; 8.5 Polymerase Chain Reaction as an Amplification Method in Aptamer-Based Assays; 8.6 Conclusions; References; III APPLICATIONS; 9 KINETIC CAPILLARY ELECTROPHORESIS FOR SELECTION, CHARACTERIZATION, AND ANALYTICAL UTILIZATION OF APTAMERS; 9.1 Introduction; 9.1.1 Kinetic Capillary Electrophoresis; 9.1.2 The Concept of NECEEM and ECEEM 9.2 Selection of Aptamers Using KCE Methods for Partitioning and Affinity Control |
| Record Nr. | UNINA-9910146399103321 |
| Hoboken, NJ, : Wiley, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Aptamers in bioanalysis / / edited by Marco Mascini
| Aptamers in bioanalysis / / edited by Marco Mascini |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, NJ, : Wiley, c2009 |
| Descrizione fisica | 1 online resource (346 p.) |
| Disciplina | 572.85 |
| Altri autori (Persone) | MasciniMarco |
| Soggetto topico |
Oligonucleotides
Biochemistry |
| ISBN |
9786612112676
9781282112674 1282112678 9780470380772 0470380772 9780470380765 0470380764 |
| Classificazione |
CHE 808f
CHE 860f WC 4150 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
APTAMERS IN BIOANALYSIS; CONTENTS; PREFACE; CONTRIBUTORS; I INTRODUCTION; 1 APTAMERS: LIGANDS FOR ALL REASONS; 1.1 Introduction; 1.2 The Power of Selection and Aptamer Refinement; 1.3 The Chemistry Drives the Shape; 1.4 Aptaregulators; 1.5 Aptasensors; 1.6 Prospects; References; 2 SELEX AND ITS RECENT OPTIMIZATIONS; 2.1 Introduction; 2.2 Aptamers and Their Selection by SELEX; 2.3 Modifications of SELEX Technology; 2.4 Advantages and Limitations of Aptamers and Their Selection Technology; 2.5 Applications of Aptamers Being Developed for the Market; 2.6 Future Perspectives; References
II BIOSENSORS3 ELECTROCHEMICAL APTASENSORS; 3.1 Introduction; 3.2 Electrochemical Aptasensor Based on Redox-Active Aptamer Monolayers Linked to Electrodes; 3.3 Enzyme-Based Amplified Electrochemical Aptasensors; 3.4 Amplified Electrochemical Aptasensors Based on Nanoparticles; 3.5 Label-Free Electrochemical Aptasensors; 3.6 Field-Effect Transistor-Based Aptasensors; 3.7 Conclusions and Perspectives; References; 4 APTAMERS: HYBRIDS BETWEEN NATURE AND TECHNOLOGY; 4.1 Introduction; 4.2 Specific Features of Aptamers; 4.3 Electrochemical Detection of Nucleic Acids 4.4 Cytochrome c Binding by Aptamers4.5 DNA Machines and Aptamers; References; 5 DETECTION OF PROTEIN-APTAMER INTERACTIONS BY MEANS OF ELECTROCHEMICAL INDICATORS AND TRANSVERSE SHEAR MODE METHOD; 5.1 Introduction; 5.2 Immobilization of Aptamers on a Solid Support; 5.3 Detection of Aptamer-Ligand Interactions; 5.3.1 Electrochemical Methods; 5.3.2 Acoustic Methods; 5.4 Conclusions; References; 6 BIOSENSORS USING THE APTAMERIC ENZYME SUBUNIT: THE USE OF APTAMERS IN THE ALLOSTERIC CONTROL OF ENZYMES; 6.1 Aptamers as Molecular Recognition Elements of Biosensors 6.1.1 Comparing Aptamers to Antibodies6.1.2 Signaling Aptamers; 6.2 Homogeneous Sensing; 6.2.1 Biosensor Systems That Do Not Require Bound-Free Separation; 6.2.2 Aptameric Enzyme Subunit; 6.3 Evolution-mimicking Algorithm for the Improvement of Aptamers; References; 7 NANOMATERIAL-BASED LABEL-FREE APTASENSORS; 7.1 Introduction; 7.2 Label-Free Electrochemical Aptasensors; 7.3 Field-Effect Transistor-Based Aptasensors; 7.4 Label-Free Aptasensors Based on Localized Surface Plasmon Resonance; 7.5 Forthcoming Challenges and Concluding Remarks; References 8 APTAMER-BASED BIOANALYTICAL ASSAYS: AMPLIFICATION STRATEGIES8.1 Introduction; 8.2 Bioanalytical Assays Based on Aptamer-Functionalized Nanoparticles; 8.3 Aptamers and Quantum Dot-Based Assays; 8.4 Aptazymes and Aptamer-Based Machines; 8.5 Polymerase Chain Reaction as an Amplification Method in Aptamer-Based Assays; 8.6 Conclusions; References; III APPLICATIONS; 9 KINETIC CAPILLARY ELECTROPHORESIS FOR SELECTION, CHARACTERIZATION, AND ANALYTICAL UTILIZATION OF APTAMERS; 9.1 Introduction; 9.1.1 Kinetic Capillary Electrophoresis; 9.1.2 The Concept of NECEEM and ECEEM 9.2 Selection of Aptamers Using KCE Methods for Partitioning and Affinity Control |
| Record Nr. | UNINA-9910825105103321 |
| Hoboken, NJ, : Wiley, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Aptamers in Biotechnology / / edited by Katharina Urmann, Johanna-Gabriela Walter
| Aptamers in Biotechnology / / edited by Katharina Urmann, Johanna-Gabriela Walter |
| Edizione | [1st ed. 2020.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 |
| Descrizione fisica | 1 online resource (VII, 215 p. 61 illus., 47 illus. in color.) |
| Disciplina | 572.85 |
| Collana | Advances in Biochemical Engineering/Biotechnology |
| Soggetto topico |
Biotechnology
Immunology Nucleic acids Nanochemistry Chromatographic analysis Biomedical engineering Nucleic Acid Chemistry Chromatography Biomedical Engineering and Bioengineering |
| ISBN | 3-030-54061-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Biophysical Characterization of Aptamer-Target Interactions -- Impedimetric Aptamer-based Biosensors: Principles and Techniques -- Impedimetric Aptamer-based Biosensors: Applications -- Aptamer-based affinity chromatography for protein extraction and purification -- Aptamers in diagnostic and molecular imaging applications -- Aptamer-modified nanoparticles in medical applications -- Defining Target Product Profiles (TPPs) for Aptamer based diagnostics. |
| Record Nr. | UNINA-9910412150203321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Initiation and termination of cyclic nucleotide action / edited by Jackie D. Corbin, Roger A. Johnson
| Initiation and termination of cyclic nucleotide action / edited by Jackie D. Corbin, Roger A. Johnson |
| Pubbl/distr/stampa | San Diego...[etc.] : Academic Press, c1988 |
| Descrizione fisica | XXXVII, 850 p. : ill. ; 24 cm |
| Disciplina | 572.85 |
| Collana | Methods in enzymology |
| Soggetto topico | Nucleotidi - Effetti biologici |
| ISBN | 0-12-182060-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNIBAS-000016780 |
| San Diego...[etc.] : Academic Press, c1988 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. della Basilicata | ||
| ||
