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Advanced delivery and therapeutic applications of RNAi [[electronic resource] /] / edited by Kun Cheng, Ram I. Mahato
| Advanced delivery and therapeutic applications of RNAi [[electronic resource] /] / edited by Kun Cheng, Ram I. Mahato |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Chichester, West Sussex, : John Wiley & Sons Inc., 2013 |
| Descrizione fisica | 1 online resource (535 p.) |
| Disciplina | 572.8/8 |
| Altri autori (Persone) |
ChengKun
MahatoRam I |
| Soggetto topico |
RNA - Therapeutic use
Small interfering RNA - Therapeutic use |
| ISBN |
1-118-61073-3
1-118-61074-1 1-299-46528-5 1-118-61075-X |
| Classificazione | SCI013040 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Advanced Delivery and Therapeutic Applications of RNAi; Contents; Preface; Contributors; About the Editors; Part 1: Introduction and Basics of RNAi; 1 Mechanisms and Barriers to RNAi Delivery; 1.1 Introduction; 1.2 Barriers to Systemic RNAi Delivery; 1.3 Rational Design to Improve RNAi Efficacy; 1.4 Chemical Modifications to Enhance siRNA Stability and Reduce Immune Response; 1.5 Cellular Uptake and Intracellular Release of siRNA; 1.6 Combinatorial Targeting for Targeted RNAi Delivery; 1.7 Cell-Specific Aptamer-Functionalized Nanocarriers for RNAi Delivery
1.8 The Clinical Development and Challenges of siRNAs Therapeutics1.9 Conclusion and Perspectives; References; 2 Analysis of siRNA Delivery Using Various Methodologies; 2.1 Introduction; 2.2 Checkpoints for Analyzing siRNA Delivery; 2.2.1 Circulation Checkpoint; 2.2.2 Organ or Tissue Checkpoint; 2.2.3 Cellular Checkpoint; 2.2.4 RISC Checkpoint; 2.2.5 Target mRNA Knockdown (Indirect Checkpoint); 2.2.6 Protein and Outcome (Indirect Checkpoint); 2.2.7 Safety (Indirect Checkpoint); 2.3 Methods for Analysis of siRNA; 2.3.1 General Considerations; 2.3.2 Hybridization-Based (Non-Imaging) Methods 2.3.3 Non-Hybridization-Based (Non-Imaging) Methods2.3.4 Imaging-Based (Non-Hybridization) Methods; 2.3.5 Imaging-Based (Hybridization) Methods; 2.4 Case Study for siRNA Delivery Analysis; References; 3 Challenges and Opportunities in Bringing RNAi Technologies from Bench to Bed; 3.1 Introduction; 3.2 RNAi Mediator (siRNA or shRNA); 3.2.1 siRNA; 3.2.2 Vector-derived shRNA; 3.2.3 miRNAs; 3.3 Safety Issues of RNAi Mediators; 3.3.1 Immune Stimulation; 3.3.2 RNAi Overexpression; 3.4 Efficacy of RNAi Mediators; 3.4.1 Therapeutic Response; 3.5 RNAi Mediators in Clinical Trials; 3.6 Conclusion References4 Nonclinical Safety Assessments and Clinical Pharmacokinetics for Oligonucleotide Therapeutics: A Regulatory Perspective; 4.1 Introduction; 4.2 Unique Properties of Oligonucleotide-based Therapeutics; 4.3 Regulation of Oligonucleotide-Based Therapeutics; 4.3.1 Submission to the FDA; 4.3.2 Review Process for Non-clinical Studies; 4.3.3 Regulatory Issues; 4.3.4 Clinical Pharmacokinetics; 4.4 Conclusion; Disclaimer; Appendix; References; 5 Role of Promoters and MicroRNA Backbone for Efficient Gene Silencing; 5.1 Introduction; 5.2 Promoters for shRNA Expression 5.2.1 Constitutive Promoters5.2.2 Inducible Promoters; 5.2.3 Site Specific Promoters; 5.3 miRNA-based shRNAs; 5.3.1 miRNA-based shRNA Enhances Gene Silencing; 5.3.2 miRNA-based shRNA Reduces Toxicities; 5.3.3 Application of miRNA-based shRNA for Combination Gene Therapy; 5.4 Concluding Remarks; References; Part 2: RNAi Delivery Strategies; 6 Bioconjugation of siRNA for Site-specific Delivery; 6.1 Introduction; 6.2 Conjugation Strategy; 6.2.1 RNA Chemical Modification; 6.2.2 Site of Conjugation; 6.2.3 Conjugation Chemistry; 6.3 Bioconjugates for Site-specific Delivery 6.3.1 Antibody-siRNA Bioconjugates |
| Record Nr. | UNINA-9910139008603321 |
| Chichester, West Sussex, : John Wiley & Sons Inc., 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Advanced delivery and therapeutic applications of RNAi / / edited by Kun Cheng, Ram I. Mahato
| Advanced delivery and therapeutic applications of RNAi / / edited by Kun Cheng, Ram I. Mahato |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Chichester, West Sussex, : John Wiley & Sons Inc., 2013 |
| Descrizione fisica | 1 online resource (535 p.) |
| Disciplina | 572.8/8 |
| Altri autori (Persone) |
ChengKun
MahatoRam I |
| Soggetto topico |
RNA - Therapeutic use
Small interfering RNA - Therapeutic use |
| ISBN |
1-118-61073-3
1-118-61074-1 1-299-46528-5 1-118-61075-X |
| Classificazione | SCI013040 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Advanced Delivery and Therapeutic Applications of RNAi; Contents; Preface; Contributors; About the Editors; Part 1: Introduction and Basics of RNAi; 1 Mechanisms and Barriers to RNAi Delivery; 1.1 Introduction; 1.2 Barriers to Systemic RNAi Delivery; 1.3 Rational Design to Improve RNAi Efficacy; 1.4 Chemical Modifications to Enhance siRNA Stability and Reduce Immune Response; 1.5 Cellular Uptake and Intracellular Release of siRNA; 1.6 Combinatorial Targeting for Targeted RNAi Delivery; 1.7 Cell-Specific Aptamer-Functionalized Nanocarriers for RNAi Delivery
1.8 The Clinical Development and Challenges of siRNAs Therapeutics1.9 Conclusion and Perspectives; References; 2 Analysis of siRNA Delivery Using Various Methodologies; 2.1 Introduction; 2.2 Checkpoints for Analyzing siRNA Delivery; 2.2.1 Circulation Checkpoint; 2.2.2 Organ or Tissue Checkpoint; 2.2.3 Cellular Checkpoint; 2.2.4 RISC Checkpoint; 2.2.5 Target mRNA Knockdown (Indirect Checkpoint); 2.2.6 Protein and Outcome (Indirect Checkpoint); 2.2.7 Safety (Indirect Checkpoint); 2.3 Methods for Analysis of siRNA; 2.3.1 General Considerations; 2.3.2 Hybridization-Based (Non-Imaging) Methods 2.3.3 Non-Hybridization-Based (Non-Imaging) Methods2.3.4 Imaging-Based (Non-Hybridization) Methods; 2.3.5 Imaging-Based (Hybridization) Methods; 2.4 Case Study for siRNA Delivery Analysis; References; 3 Challenges and Opportunities in Bringing RNAi Technologies from Bench to Bed; 3.1 Introduction; 3.2 RNAi Mediator (siRNA or shRNA); 3.2.1 siRNA; 3.2.2 Vector-derived shRNA; 3.2.3 miRNAs; 3.3 Safety Issues of RNAi Mediators; 3.3.1 Immune Stimulation; 3.3.2 RNAi Overexpression; 3.4 Efficacy of RNAi Mediators; 3.4.1 Therapeutic Response; 3.5 RNAi Mediators in Clinical Trials; 3.6 Conclusion References4 Nonclinical Safety Assessments and Clinical Pharmacokinetics for Oligonucleotide Therapeutics: A Regulatory Perspective; 4.1 Introduction; 4.2 Unique Properties of Oligonucleotide-based Therapeutics; 4.3 Regulation of Oligonucleotide-Based Therapeutics; 4.3.1 Submission to the FDA; 4.3.2 Review Process for Non-clinical Studies; 4.3.3 Regulatory Issues; 4.3.4 Clinical Pharmacokinetics; 4.4 Conclusion; Disclaimer; Appendix; References; 5 Role of Promoters and MicroRNA Backbone for Efficient Gene Silencing; 5.1 Introduction; 5.2 Promoters for shRNA Expression 5.2.1 Constitutive Promoters5.2.2 Inducible Promoters; 5.2.3 Site Specific Promoters; 5.3 miRNA-based shRNAs; 5.3.1 miRNA-based shRNA Enhances Gene Silencing; 5.3.2 miRNA-based shRNA Reduces Toxicities; 5.3.3 Application of miRNA-based shRNA for Combination Gene Therapy; 5.4 Concluding Remarks; References; Part 2: RNAi Delivery Strategies; 6 Bioconjugation of siRNA for Site-specific Delivery; 6.1 Introduction; 6.2 Conjugation Strategy; 6.2.1 RNA Chemical Modification; 6.2.2 Site of Conjugation; 6.2.3 Conjugation Chemistry; 6.3 Bioconjugates for Site-specific Delivery 6.3.1 Antibody-siRNA Bioconjugates |
| Record Nr. | UNINA-9910815366903321 |
| Chichester, West Sussex, : John Wiley & Sons Inc., 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Handbook of RNA biochemistry / / edited by Roland K. Hartmann [and three others]
| Handbook of RNA biochemistry / / edited by Roland K. Hartmann [and three others] |
| Edizione | [Second, completely revised and enlarged edition.] |
| Pubbl/distr/stampa | Weinheim, Germany : , : Wiley-VCH, , 2014 |
| Descrizione fisica | 1 online resource (1371 p.) |
| Disciplina | 572.8/8 |
| Soggetto topico |
RNA
Biochemistry |
| Soggetto genere / forma | Electronic books. |
| ISBN |
3-527-65052-0
3-527-65054-7 3-527-65055-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Title Page; Copyright; Contents; Preface; List of Contributors; Part I RNA Synthesis and Detection; Chapter 1 Enzymatic RNA Synthesis Using Bacteriophage T7 RNA Polymerase; 1.1 Introduction; 1.2 Description of Method - T7 Transcription In vitro; 1.2.1 Templates; 1.2.1.1 Strategy (i): Insertion into a Plasmid; 1.2.1.2 Strategy (ii): Direct Use of Templates Generated by PCR; 1.2.1.3 Strategy (iii): Annealing of a T7 Promoter DNA Oligonucleotide to a Single-Stranded Template; 1.2.2 Special Demands on the RNA Product
1.2.2.1 Homogeneous 5' and 3' Ends, Small RNAs, Functional Groups at the 5' End1.2.2.2 Modified Substrates; 1.3 Transcription Protocols; 1.3.1 Transcription with Unmodified Nucleotides; 1.3.2 Transcription with 2' -Fluoro-Modified Nucleotides; 1.3.3 T7 Transcripts with 5' - Cap Structures; 1.3.4 Purification; 1.4 Troubleshooting; 1.4.1 Low or No Product Yield; 1.5 Rapid Preparation of T7 RNA Polymerase; 1.5.1 Required Material; 1.5.1.1 Medium; 1.5.1.2 Buffers and Solutions; 1.5.1.3 Electrophoresis and Chromatography; 1.5.2 Procedure 1.5.2.1 Cell Growth, Induction, and Test for Expression of T7 RNAP1.5.2.2 Purification of T7 RNAP; 1.5.3 Notes and Troubleshooting; References; Chapter 2 Production of RNAs with Homogeneous 5' - and 3' -Ends; 2.1 Introduction; 2.2 Description of Approach; 2.2.1 Cis-Cleaving Autocatalytic Ribozyme Cassettes; 2.2.1.1 The 5' -Cassette; 2.2.1.2 The 3' -Cassette; 2.2.1.3 Purification of Released RNA Product and Conversion of End Groups; 2.2.2 Trans-Cleaving Ribozymes for the Generation of Homogeneous 3' Ends; 2.2.3 Further Strategies toward Homogeneous Ends 2.3 Critical Experimental Steps, Changeable Parameters, Troubleshooting2.3.1 Construction of Cis-Cleaving 5'- and 3'-Cassettes; 2.4 PCR Protocols; 2.5 Potential Problems; References; Chapter 3 RNA Ligation; 3.1 General Introduction; 3.1.1 T4 Polynucleotide Ligases; 3.1.2 Reaction Mechanism; 3.1.3 Advantages of T4 DNA Ligase for RNA Ligation; 3.1.4 Chapter Structure; 3.2 RNA Ligation Using T4 DNA Ligase (T4 Dnl); 3.2.1 Overview of the RNA Ligation Method Using the T4 DNA Ligase (T4 Dnl); 3.2.2 Large-Scale Transcription and Purification of RNAs 3.2.3 Generating Homogeneous Acceptor 3' -Ends for Ligation3.2.4 Site-Directed Cleavage with RNase H; 3.2.5 Dephosphorylation and Phosphorylation of RNAs; 3.2.6 RNA Ligation; 3.2.7 Troubleshooting; 3.3 Simultaneous Splint Ligation of Five RNA Fragments to Generate RNAs for FRET Experiments; 3.3.1 Introduction; 3.3.2 Construct Design; 3.3.3 Troubleshooting; 3.3.3.1 Low Overall Ligation Efficiency; 3.3.3.2 Undesired Ligation By-products; 3.3.3.3 RNA Degradation; 3.4 T4 RNA Ligase(s); 3.4.1 Introduction; 3.4.2 Mechanism and Substrate Specificity; 3.4.2.1 Early Studies 3.4.2.2 Substrate Specificity and Reaction Conditions |
| Record Nr. | UNINA-9910460609803321 |
| Weinheim, Germany : , : Wiley-VCH, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Handbook of RNA biochemistry / / edited by Roland K. Hartmann [and three others]
| Handbook of RNA biochemistry / / edited by Roland K. Hartmann [and three others] |
| Edizione | [Second, completely revised and enlarged edition.] |
| Pubbl/distr/stampa | Weinheim, Germany : , : Wiley-VCH, , 2014 |
| Descrizione fisica | 1 online resource (1371 p.) |
| Disciplina | 572.8/8 |
| Soggetto topico |
RNA
Biochemistry |
| ISBN |
3-527-65052-0
3-527-65054-7 3-527-65055-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Title Page; Copyright; Contents; Preface; List of Contributors; Part I RNA Synthesis and Detection; Chapter 1 Enzymatic RNA Synthesis Using Bacteriophage T7 RNA Polymerase; 1.1 Introduction; 1.2 Description of Method - T7 Transcription In vitro; 1.2.1 Templates; 1.2.1.1 Strategy (i): Insertion into a Plasmid; 1.2.1.2 Strategy (ii): Direct Use of Templates Generated by PCR; 1.2.1.3 Strategy (iii): Annealing of a T7 Promoter DNA Oligonucleotide to a Single-Stranded Template; 1.2.2 Special Demands on the RNA Product
1.2.2.1 Homogeneous 5' and 3' Ends, Small RNAs, Functional Groups at the 5' End1.2.2.2 Modified Substrates; 1.3 Transcription Protocols; 1.3.1 Transcription with Unmodified Nucleotides; 1.3.2 Transcription with 2' -Fluoro-Modified Nucleotides; 1.3.3 T7 Transcripts with 5' - Cap Structures; 1.3.4 Purification; 1.4 Troubleshooting; 1.4.1 Low or No Product Yield; 1.5 Rapid Preparation of T7 RNA Polymerase; 1.5.1 Required Material; 1.5.1.1 Medium; 1.5.1.2 Buffers and Solutions; 1.5.1.3 Electrophoresis and Chromatography; 1.5.2 Procedure 1.5.2.1 Cell Growth, Induction, and Test for Expression of T7 RNAP1.5.2.2 Purification of T7 RNAP; 1.5.3 Notes and Troubleshooting; References; Chapter 2 Production of RNAs with Homogeneous 5' - and 3' -Ends; 2.1 Introduction; 2.2 Description of Approach; 2.2.1 Cis-Cleaving Autocatalytic Ribozyme Cassettes; 2.2.1.1 The 5' -Cassette; 2.2.1.2 The 3' -Cassette; 2.2.1.3 Purification of Released RNA Product and Conversion of End Groups; 2.2.2 Trans-Cleaving Ribozymes for the Generation of Homogeneous 3' Ends; 2.2.3 Further Strategies toward Homogeneous Ends 2.3 Critical Experimental Steps, Changeable Parameters, Troubleshooting2.3.1 Construction of Cis-Cleaving 5'- and 3'-Cassettes; 2.4 PCR Protocols; 2.5 Potential Problems; References; Chapter 3 RNA Ligation; 3.1 General Introduction; 3.1.1 T4 Polynucleotide Ligases; 3.1.2 Reaction Mechanism; 3.1.3 Advantages of T4 DNA Ligase for RNA Ligation; 3.1.4 Chapter Structure; 3.2 RNA Ligation Using T4 DNA Ligase (T4 Dnl); 3.2.1 Overview of the RNA Ligation Method Using the T4 DNA Ligase (T4 Dnl); 3.2.2 Large-Scale Transcription and Purification of RNAs 3.2.3 Generating Homogeneous Acceptor 3' -Ends for Ligation3.2.4 Site-Directed Cleavage with RNase H; 3.2.5 Dephosphorylation and Phosphorylation of RNAs; 3.2.6 RNA Ligation; 3.2.7 Troubleshooting; 3.3 Simultaneous Splint Ligation of Five RNA Fragments to Generate RNAs for FRET Experiments; 3.3.1 Introduction; 3.3.2 Construct Design; 3.3.3 Troubleshooting; 3.3.3.1 Low Overall Ligation Efficiency; 3.3.3.2 Undesired Ligation By-products; 3.3.3.3 RNA Degradation; 3.4 T4 RNA Ligase(s); 3.4.1 Introduction; 3.4.2 Mechanism and Substrate Specificity; 3.4.2.1 Early Studies 3.4.2.2 Substrate Specificity and Reaction Conditions |
| Record Nr. | UNINA-9910797047003321 |
| Weinheim, Germany : , : Wiley-VCH, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Handbook of RNA biochemistry / / edited by Roland K. Hartmann [and three others]
| Handbook of RNA biochemistry / / edited by Roland K. Hartmann [and three others] |
| Edizione | [Second, completely revised and enlarged edition.] |
| Pubbl/distr/stampa | Weinheim, Germany : , : Wiley-VCH, , 2014 |
| Descrizione fisica | 1 online resource (1371 p.) |
| Disciplina | 572.8/8 |
| Soggetto topico |
RNA
Biochemistry |
| ISBN |
3-527-65052-0
3-527-65054-7 3-527-65055-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Title Page; Copyright; Contents; Preface; List of Contributors; Part I RNA Synthesis and Detection; Chapter 1 Enzymatic RNA Synthesis Using Bacteriophage T7 RNA Polymerase; 1.1 Introduction; 1.2 Description of Method - T7 Transcription In vitro; 1.2.1 Templates; 1.2.1.1 Strategy (i): Insertion into a Plasmid; 1.2.1.2 Strategy (ii): Direct Use of Templates Generated by PCR; 1.2.1.3 Strategy (iii): Annealing of a T7 Promoter DNA Oligonucleotide to a Single-Stranded Template; 1.2.2 Special Demands on the RNA Product
1.2.2.1 Homogeneous 5' and 3' Ends, Small RNAs, Functional Groups at the 5' End1.2.2.2 Modified Substrates; 1.3 Transcription Protocols; 1.3.1 Transcription with Unmodified Nucleotides; 1.3.2 Transcription with 2' -Fluoro-Modified Nucleotides; 1.3.3 T7 Transcripts with 5' - Cap Structures; 1.3.4 Purification; 1.4 Troubleshooting; 1.4.1 Low or No Product Yield; 1.5 Rapid Preparation of T7 RNA Polymerase; 1.5.1 Required Material; 1.5.1.1 Medium; 1.5.1.2 Buffers and Solutions; 1.5.1.3 Electrophoresis and Chromatography; 1.5.2 Procedure 1.5.2.1 Cell Growth, Induction, and Test for Expression of T7 RNAP1.5.2.2 Purification of T7 RNAP; 1.5.3 Notes and Troubleshooting; References; Chapter 2 Production of RNAs with Homogeneous 5' - and 3' -Ends; 2.1 Introduction; 2.2 Description of Approach; 2.2.1 Cis-Cleaving Autocatalytic Ribozyme Cassettes; 2.2.1.1 The 5' -Cassette; 2.2.1.2 The 3' -Cassette; 2.2.1.3 Purification of Released RNA Product and Conversion of End Groups; 2.2.2 Trans-Cleaving Ribozymes for the Generation of Homogeneous 3' Ends; 2.2.3 Further Strategies toward Homogeneous Ends 2.3 Critical Experimental Steps, Changeable Parameters, Troubleshooting2.3.1 Construction of Cis-Cleaving 5'- and 3'-Cassettes; 2.4 PCR Protocols; 2.5 Potential Problems; References; Chapter 3 RNA Ligation; 3.1 General Introduction; 3.1.1 T4 Polynucleotide Ligases; 3.1.2 Reaction Mechanism; 3.1.3 Advantages of T4 DNA Ligase for RNA Ligation; 3.1.4 Chapter Structure; 3.2 RNA Ligation Using T4 DNA Ligase (T4 Dnl); 3.2.1 Overview of the RNA Ligation Method Using the T4 DNA Ligase (T4 Dnl); 3.2.2 Large-Scale Transcription and Purification of RNAs 3.2.3 Generating Homogeneous Acceptor 3' -Ends for Ligation3.2.4 Site-Directed Cleavage with RNase H; 3.2.5 Dephosphorylation and Phosphorylation of RNAs; 3.2.6 RNA Ligation; 3.2.7 Troubleshooting; 3.3 Simultaneous Splint Ligation of Five RNA Fragments to Generate RNAs for FRET Experiments; 3.3.1 Introduction; 3.3.2 Construct Design; 3.3.3 Troubleshooting; 3.3.3.1 Low Overall Ligation Efficiency; 3.3.3.2 Undesired Ligation By-products; 3.3.3.3 RNA Degradation; 3.4 T4 RNA Ligase(s); 3.4.1 Introduction; 3.4.2 Mechanism and Substrate Specificity; 3.4.2.1 Early Studies 3.4.2.2 Substrate Specificity and Reaction Conditions |
| Record Nr. | UNINA-9910811756703321 |
| Weinheim, Germany : , : Wiley-VCH, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
MicroRNA [[electronic resource] ] : expression, detection and therapeutic strategies / / James A. Mulligan, editor
| MicroRNA [[electronic resource] ] : expression, detection and therapeutic strategies / / James A. Mulligan, editor |
| Pubbl/distr/stampa | New York, : Nova Science, c2011 |
| Descrizione fisica | 1 online resource (299 p.) |
| Disciplina | 572.8/8 |
| Altri autori (Persone) | MulliganJames A |
| Collana | DNA and RNA : properties and modifications, functions and interactions, recombination and applications |
| Soggetto topico | Small interfering RNA |
| Soggetto genere / forma | Electronic books. |
| ISBN | 1-62100-152-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | MicroRNAs : potential applications in aquaporin associated pathogenesis / Sugunavathi Sepramaniam ... [et al.] -- MicroRNAs : novel biomarkers and therapeutic targets for cancer / Fanman Xiao, Linlang Guo -- MicroRNAs : targets of interest in breast cancer research / Aamir Ahmad ... [et al.] -- Amazing power of tiny microRNAs in breast cancer / Ming Shi ... [et al.] -- The impact of miRNAs on resistance to anticancer treatment : the future for miRNA-based targeted therapy? / Richard Hummel, Damian J. Hussey, Joerg Haier -- Profiling of mRNAs/microRNAs and identification of microRNA targets among human mesenchymal stem cells derived from different adipose tissues / Steven Shoei-Lung Li -- MicroRNAs in regulating EMT and blood circulation metastasis of lung cancer stem cells / Jianguo Sun ... [et al.] -- Biological functions of microRNAs in animals / Marie-Hélène Renalier, Samantha Tirmarche, Hervé Seitz -- Regulation of metabolism, aging, and lifespan by microRNAs / Junlong Zhang -- Herpesvirus microRNAs in infection and cancer / Andrea J. O'Hara, Dirk P. Dittmer. |
| Record Nr. | UNINA-9910453944203321 |
| New York, : Nova Science, c2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
MicroRNA [[electronic resource] ] : expression, detection and therapeutic strategies / / James A. Mulligan, editor
| MicroRNA [[electronic resource] ] : expression, detection and therapeutic strategies / / James A. Mulligan, editor |
| Pubbl/distr/stampa | New York, : Nova Science, c2011 |
| Descrizione fisica | 1 online resource (299 p.) |
| Disciplina | 572.8/8 |
| Altri autori (Persone) | MulliganJames A |
| Collana | DNA and RNA : properties and modifications, functions and interactions, recombination and applications |
| Soggetto topico | Small interfering RNA |
| ISBN | 1-62100-152-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | MicroRNAs : potential applications in aquaporin associated pathogenesis / Sugunavathi Sepramaniam ... [et al.] -- MicroRNAs : novel biomarkers and therapeutic targets for cancer / Fanman Xiao, Linlang Guo -- MicroRNAs : targets of interest in breast cancer research / Aamir Ahmad ... [et al.] -- Amazing power of tiny microRNAs in breast cancer / Ming Shi ... [et al.] -- The impact of miRNAs on resistance to anticancer treatment : the future for miRNA-based targeted therapy? / Richard Hummel, Damian J. Hussey, Joerg Haier -- Profiling of mRNAs/microRNAs and identification of microRNA targets among human mesenchymal stem cells derived from different adipose tissues / Steven Shoei-Lung Li -- MicroRNAs in regulating EMT and blood circulation metastasis of lung cancer stem cells / Jianguo Sun ... [et al.] -- Biological functions of microRNAs in animals / Marie-Hélène Renalier, Samantha Tirmarche, Hervé Seitz -- Regulation of metabolism, aging, and lifespan by microRNAs / Junlong Zhang -- Herpesvirus microRNAs in infection and cancer / Andrea J. O'Hara, Dirk P. Dittmer. |
| Record Nr. | UNINA-9910779603803321 |
| New York, : Nova Science, c2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
MicroRNA [[electronic resource] ] : expression, detection and therapeutic strategies / / James A. Mulligan, editor
| MicroRNA [[electronic resource] ] : expression, detection and therapeutic strategies / / James A. Mulligan, editor |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | New York, : Nova Science, c2011 |
| Descrizione fisica | 1 online resource (299 p.) |
| Disciplina | 572.8/8 |
| Altri autori (Persone) | MulliganJames A |
| Collana | DNA and RNA : properties and modifications, functions and interactions, recombination and applications |
| Soggetto topico | Small interfering RNA |
| ISBN | 1-62100-152-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | MicroRNAs : potential applications in aquaporin associated pathogenesis / Sugunavathi Sepramaniam ... [et al.] -- MicroRNAs : novel biomarkers and therapeutic targets for cancer / Fanman Xiao, Linlang Guo -- MicroRNAs : targets of interest in breast cancer research / Aamir Ahmad ... [et al.] -- Amazing power of tiny microRNAs in breast cancer / Ming Shi ... [et al.] -- The impact of miRNAs on resistance to anticancer treatment : the future for miRNA-based targeted therapy? / Richard Hummel, Damian J. Hussey, Joerg Haier -- Profiling of mRNAs/microRNAs and identification of microRNA targets among human mesenchymal stem cells derived from different adipose tissues / Steven Shoei-Lung Li -- MicroRNAs in regulating EMT and blood circulation metastasis of lung cancer stem cells / Jianguo Sun ... [et al.] -- Biological functions of microRNAs in animals / Marie-Hélène Renalier, Samantha Tirmarche, Hervé Seitz -- Regulation of metabolism, aging, and lifespan by microRNAs / Junlong Zhang -- Herpesvirus microRNAs in infection and cancer / Andrea J. O'Hara, Dirk P. Dittmer. |
| Record Nr. | UNINA-9910829195103321 |
| New York, : Nova Science, c2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
MicroRNAs in medicine / / edited by Charles H. Lawrie
| MicroRNAs in medicine / / edited by Charles H. Lawrie |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , [2014] |
| Descrizione fisica | 1 online resource (722 p.) |
| Disciplina |
572.8/8
572.88 |
| Altri autori (Persone) | LawrieCharles H |
| Soggetto topico |
RNA
Genetic regulation |
| ISBN |
1-118-30034-3
1-118-30031-9 1-118-30041-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Chapter 1. MicroRNAs : a brief introduction / Prof. Charles H. Lawrie. Section I: MicroRNAs as physiological regulators. Chapter 2. MicroRNA regulation of stem cell fate and reprogramming / Dr Erica Vivas, Dr Gustavo Tiscornia & Prof. Juan Carlos Izpisua Belmonte -- Chapter 3. MicroRNAs as regulators of immunity / Dr. Donald Gracias & Prof. Peter D. Katsikis -- Chapter 4. Regulation of senescence by microRNAs / Dr Ioannis Grammatikakis & Dr Myriam Gorospe -- Chapter 5. The emergence of geroMIRS: A group of microRNAs implicated in aging / Dr Alejandro Ugalde, Dr Agnieszka Kwarciak, Dr Xurde Caravia, Prof. Carlos Lopez-Ot¡n & Dr Andrew Ramsay -- Chapter 6. MicroRNAs and hematopoiesis / Dr Sukhinder Sandhu & Prof. Ramiro Garzon -- Chapter 7. MicroRNAs in platelet production and activation / Dr Leonard Edelstein, Dr Srikanth Nagalla & Prof. Paul Bray -- Section II: MicroRNAs in infectious disease: host-pathogen interactions. Chapter 8. MicroRNAs as key players in host-virus interactions / Dr Aur¿lie Fender & Dr S¿bastien Pfeffer -- Chapter 9. MicroRNA expression in avian herpesviruses / Dr. Yongxiu Yao & Prof. Venugopal Nair -- Chapter 10. Function of human cytomegalovirus microRNAs and potential roles in latency / Dr Natalie Reynolds, Dr Jon Pavelin & Dr Finn Grey -- Chapter 11. Involvement of small non-coding RNA in HIV-1 infection / Dr Guihua Sun, Prof. John Rossi & Dr Daniela Castanotto -- Chapter 12. MicroRNA in malaria / Dr Panote Prapansilp & Prof. Gareth Turner --
Section III: Cancer. Chapter 13. The microRNA decalog of cancer involvement / Dr Tanja Kunej, Dr Irena Godnic, Dr Minja Zorc, Dr Simon Horvat & Prof. George Calin -- Chapter 14. MicroRNAs as oncogenes and tumor suppressors / Dr Eva Rufino-Palomares, Dr Fernando Reyes-Zurita, Dr Jose Lupiez & Dr Pedro Medina -- Chapter 15. Long non-coding RNAs and their roles in cancer / Dr Yolanda Sanchez & Dr Maite Huarte -- Chapter 16. Regulation of hypoxia responses by microRNA expression / Dr Carme Camps, Prof. Adrian Harris & Dr Jiannis Ragoussis -- Chapter 17. Control of receptor function by microRNAs in breast cancer / Dr Claudia Piovan & Dr Marilena Iorio -- Chapter 18. MicroRNAs in human prostate cancer : from pathogenesis to therapeutic implications / Dr. Mustafa Ozen & Dr Omer Karatas -- Chapter 19. MicroRNA signatures as biomarkers of colorectal cancer / Dr Katrin Pfitze, Dr Xiaoya Luo & Prof. Barbara Burwinkel -- Chapter 20. Genetic variations in microRNA-encoding sequences and microRNA target sites alter lung cancer susceptibility and survival / Dr Min Yang & Prof. Dongxin Lin -- Chapter 21. MicroRNAs in myelopoiesis and myeloid disorders / Dr Sara Meyer & Prof. Lee Grimes -- Chapter 22. MicroRNA deregulation by aberrant DNA methylation in acute lymphoblastic leukemia / Dr Xabier Agirre & Dr Felipe Prosper -- Chapter 23. Role of miRNAs in the pathogenesis of chronic lymphocytic leukemia / Dr Veronica Balatti, Prof. Yuri Pekarky, Dr Lara Rizzotto & Prof. Carlo Croce -- Chapter 24. MicroRNA in B-cell non-Hodgkin lymphoma: Diagnostic markers and therapeutic targets / Dr Nerea Mart¡nez, Dr Lorena Di Lisio & Prof. Miguel Piris -- Chapter 25. MicroRNAs in diffuse large B-cell lymphoma / Prof. Izidore Lossos & Dr Alvaro Alencar -- Chapter 26. The role of microRNAs in Hodgkin lymphoma / Dr. Wouter Plattel, Dr. Joost Kluiver, Dr Arjan Diepstra, Dr Lydia Visser & Prof. Anke van den Berg -- Chapter 27. MicroRNA expression in cutaneous T-cell lymphomas / Prof. Cornelis Tensen -- Section IV: Hereditary and other non-infectious diseases. Chapter 28. MicroRNAs and hereditary disorders / Dr Matias Morin and Prof. Miguel Moreno-Pelayo -- Chapter 29. MicroRNAs and cardiovascular diseases / Prof. Koh Ono -- Chapter 30. MicroRNAs and diabetes / Prof. Ramono Regazzi -- Chapter 31. MicroRNAs in liver disease / Dr Patricia Munoz-Garrido, Dr Marco Marzioni, Dr Elizabeth Hijona, Dr Luis Bujanda & Dr Jesus Banales -- Chapter 32. MicroRNA regulation in multiple sclerosis / Dr Andreas Junker -- Chapter 33. The role of microRNAs in Alzheimer's disease / Dr Shahar Barbash & Prof. Hermona Soreq -- Chapter 34. Current views on the role microRNAs in psychosis / Dr Aoife Kearney, Dr Javier Bravo & Prof. Timothy Dinan. Section V: Circulating microRNAs as cellular messengers and novel biomarkers. Chapter 35. Circulating microRNAs as non-invasive biomarkers / Ass. Prof. Heidi Schwarzenbach & Prof. Klaus Pantel -- Chapter 36. Circulating microRNAs as cellular messengers / Prof. Kasey Vickers -- Chapter 37. Release of microRNA-containing vesicles can stimulate angiogenesis and metastasis in renal carcinoma / Dr Federica Collino, Dr Cristina Grange & Prof. Giovanni Camussi -- Section VI: Therapeutic uses of microRNAs: Current perspectives and future directions. Chapter 38. MicroRNA regulation of cancer stem cells and microRNAs as potential cancer stem cell therapeutics / Dr Can Liu & Prof. Dean Tang -- Chapter 39. Therapeutic modulation of microRNAs / Prof. Achim Aigner & Dr Hannelore Dassow -- Chapter 40. Silencing of MicroRNA-122 in primates with chronic hepatitis C virus infection / Dr Henrik Orum. |
| Record Nr. | UNINA-9910139041703321 |
| Hoboken, New Jersey : , : Wiley, , [2014] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
MicroRNAs in medicine / / edited by Charles H. Lawrie
| MicroRNAs in medicine / / edited by Charles H. Lawrie |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , [2014] |
| Descrizione fisica | 1 online resource (722 p.) |
| Disciplina |
572.8/8
572.88 |
| Altri autori (Persone) | LawrieCharles H |
| Soggetto topico |
RNA
Genetic regulation |
| ISBN |
1-118-30034-3
1-118-30031-9 1-118-30041-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Chapter 1. MicroRNAs : a brief introduction / Prof. Charles H. Lawrie. Section I: MicroRNAs as physiological regulators. Chapter 2. MicroRNA regulation of stem cell fate and reprogramming / Dr Erica Vivas, Dr Gustavo Tiscornia & Prof. Juan Carlos Izpisua Belmonte -- Chapter 3. MicroRNAs as regulators of immunity / Dr. Donald Gracias & Prof. Peter D. Katsikis -- Chapter 4. Regulation of senescence by microRNAs / Dr Ioannis Grammatikakis & Dr Myriam Gorospe -- Chapter 5. The emergence of geroMIRS: A group of microRNAs implicated in aging / Dr Alejandro Ugalde, Dr Agnieszka Kwarciak, Dr Xurde Caravia, Prof. Carlos Lopez-Ot¡n & Dr Andrew Ramsay -- Chapter 6. MicroRNAs and hematopoiesis / Dr Sukhinder Sandhu & Prof. Ramiro Garzon -- Chapter 7. MicroRNAs in platelet production and activation / Dr Leonard Edelstein, Dr Srikanth Nagalla & Prof. Paul Bray -- Section II: MicroRNAs in infectious disease: host-pathogen interactions. Chapter 8. MicroRNAs as key players in host-virus interactions / Dr Aur¿lie Fender & Dr S¿bastien Pfeffer -- Chapter 9. MicroRNA expression in avian herpesviruses / Dr. Yongxiu Yao & Prof. Venugopal Nair -- Chapter 10. Function of human cytomegalovirus microRNAs and potential roles in latency / Dr Natalie Reynolds, Dr Jon Pavelin & Dr Finn Grey -- Chapter 11. Involvement of small non-coding RNA in HIV-1 infection / Dr Guihua Sun, Prof. John Rossi & Dr Daniela Castanotto -- Chapter 12. MicroRNA in malaria / Dr Panote Prapansilp & Prof. Gareth Turner --
Section III: Cancer. Chapter 13. The microRNA decalog of cancer involvement / Dr Tanja Kunej, Dr Irena Godnic, Dr Minja Zorc, Dr Simon Horvat & Prof. George Calin -- Chapter 14. MicroRNAs as oncogenes and tumor suppressors / Dr Eva Rufino-Palomares, Dr Fernando Reyes-Zurita, Dr Jose Lupiez & Dr Pedro Medina -- Chapter 15. Long non-coding RNAs and their roles in cancer / Dr Yolanda Sanchez & Dr Maite Huarte -- Chapter 16. Regulation of hypoxia responses by microRNA expression / Dr Carme Camps, Prof. Adrian Harris & Dr Jiannis Ragoussis -- Chapter 17. Control of receptor function by microRNAs in breast cancer / Dr Claudia Piovan & Dr Marilena Iorio -- Chapter 18. MicroRNAs in human prostate cancer : from pathogenesis to therapeutic implications / Dr. Mustafa Ozen & Dr Omer Karatas -- Chapter 19. MicroRNA signatures as biomarkers of colorectal cancer / Dr Katrin Pfitze, Dr Xiaoya Luo & Prof. Barbara Burwinkel -- Chapter 20. Genetic variations in microRNA-encoding sequences and microRNA target sites alter lung cancer susceptibility and survival / Dr Min Yang & Prof. Dongxin Lin -- Chapter 21. MicroRNAs in myelopoiesis and myeloid disorders / Dr Sara Meyer & Prof. Lee Grimes -- Chapter 22. MicroRNA deregulation by aberrant DNA methylation in acute lymphoblastic leukemia / Dr Xabier Agirre & Dr Felipe Prosper -- Chapter 23. Role of miRNAs in the pathogenesis of chronic lymphocytic leukemia / Dr Veronica Balatti, Prof. Yuri Pekarky, Dr Lara Rizzotto & Prof. Carlo Croce -- Chapter 24. MicroRNA in B-cell non-Hodgkin lymphoma: Diagnostic markers and therapeutic targets / Dr Nerea Mart¡nez, Dr Lorena Di Lisio & Prof. Miguel Piris -- Chapter 25. MicroRNAs in diffuse large B-cell lymphoma / Prof. Izidore Lossos & Dr Alvaro Alencar -- Chapter 26. The role of microRNAs in Hodgkin lymphoma / Dr. Wouter Plattel, Dr. Joost Kluiver, Dr Arjan Diepstra, Dr Lydia Visser & Prof. Anke van den Berg -- Chapter 27. MicroRNA expression in cutaneous T-cell lymphomas / Prof. Cornelis Tensen -- Section IV: Hereditary and other non-infectious diseases. Chapter 28. MicroRNAs and hereditary disorders / Dr Matias Morin and Prof. Miguel Moreno-Pelayo -- Chapter 29. MicroRNAs and cardiovascular diseases / Prof. Koh Ono -- Chapter 30. MicroRNAs and diabetes / Prof. Ramono Regazzi -- Chapter 31. MicroRNAs in liver disease / Dr Patricia Munoz-Garrido, Dr Marco Marzioni, Dr Elizabeth Hijona, Dr Luis Bujanda & Dr Jesus Banales -- Chapter 32. MicroRNA regulation in multiple sclerosis / Dr Andreas Junker -- Chapter 33. The role of microRNAs in Alzheimer's disease / Dr Shahar Barbash & Prof. Hermona Soreq -- Chapter 34. Current views on the role microRNAs in psychosis / Dr Aoife Kearney, Dr Javier Bravo & Prof. Timothy Dinan. Section V: Circulating microRNAs as cellular messengers and novel biomarkers. Chapter 35. Circulating microRNAs as non-invasive biomarkers / Ass. Prof. Heidi Schwarzenbach & Prof. Klaus Pantel -- Chapter 36. Circulating microRNAs as cellular messengers / Prof. Kasey Vickers -- Chapter 37. Release of microRNA-containing vesicles can stimulate angiogenesis and metastasis in renal carcinoma / Dr Federica Collino, Dr Cristina Grange & Prof. Giovanni Camussi -- Section VI: Therapeutic uses of microRNAs: Current perspectives and future directions. Chapter 38. MicroRNA regulation of cancer stem cells and microRNAs as potential cancer stem cell therapeutics / Dr Can Liu & Prof. Dean Tang -- Chapter 39. Therapeutic modulation of microRNAs / Prof. Achim Aigner & Dr Hannelore Dassow -- Chapter 40. Silencing of MicroRNA-122 in primates with chronic hepatitis C virus infection / Dr Henrik Orum. |
| Record Nr. | UNINA-9910814872903321 |
| Hoboken, New Jersey : , : Wiley, , [2014] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
