Info
- Utilizzare la checkbox di selezione a fianco di ciascun documento per attivare le funzionalità di stampa, invio email, download nei formati disponibili del (i) record.
Enzyme assays : high-throughput screening, genetic selection, and fingerprinting / / edited by Jean-Louis Reymond
| Enzyme assays : high-throughput screening, genetic selection, and fingerprinting / / edited by Jean-Louis Reymond |
| Pubbl/distr/stampa | Weinheim, Germany, : Wiley-VCH, c2006 |
| Descrizione fisica | 1 online resource (388 p.) |
| Disciplina | 572.76 |
| Altri autori (Persone) | ReymondJean-Louis |
| Soggetto topico | Enzymes - Analysis |
| ISBN |
9786610854288
9781280854286 1280854286 9783527607846 3527607846 9783527607211 3527607218 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Enzyme Assays; Contents; Preface; List of Contributors; Introduction; Enzyme Assays; Part I: High-throughput Screening; Part II: Genetic Selection; Part III: Enzyme Fingerprinting; Enzyme Assays in Other Areas; How to Use this Book; Part I High-throughput Screening; 1 Quantitative Assay of Hydrolases for Activity and Selectivity Using Color Changes; 1.1 Overview; 1.2 Direct Assays Using Chromogenic Substrates; 1.3 Indirect Assays Using Coupled Reactions - pH Indicators; 1.3.1 Overview of Quantitative Use of pH Indicator Assay; 1.3.2 Applications
1.3.2.1 Searching for an Active Hydrolase (Testing Many Hydrolases Toward One Substrate)1.3.2.2 Substrate Mapping of New Hydrolases (Testing Many Substrates Toward Hydrolase); 1.3.3 Comparison with Other Methods; 1.4 Estimating and Measuring Selectivity; 1.4.1 Estimating Selectivity without a Reference Compound; 1.4.2 Quantitative Measure of Selectivity Using a Reference Compound (Quick E and Related Methods); 1.4.2.1 Chromogenic Substrate; 1.4.2.2 pH Indicators; 1.4.3 Application; 1.4.3.1 Substrate Mapping of Hydrolases; 1.4.3.2 Screening of Mutants in Directed Evolution 1.4.4 Advantages and DisadvantagesReferences; 2 High-throughput Screening Systems for Assaying the Enantioselectivity of Enzymes; 2.1 Introduction; 2.2 UV/Vis Spectroscopy-based Assays; 2.2.1 Assay for Screening Lipases or Esterases in the Kinetic Resolution of Chiral p-Nitrophenyl Esters; 2.2.2 Enzyme-coupled UV/Vis-based Assay for Lipases and Esterases; 2.2.3 Enzymatic Method for Determining Enantiomeric Excess (EMDee); 2.2.4 UV/Vis-based Enzyme Immunoassay as a Means to Measure Enantiomeric Excess; 2.2.5 Other UV/Vis-based ee-Assays; 2.3 Assays Using Fluorescence 2.3.1 Umbelliferone-based Systems2.3.2 Fluorescence-based Assay Using DNA Microarrays; 2.3.3 Other Fluorescence-based ee-Assays; 2.4 Assays Based on Mass Spectrometry (MS); 2.4.1 MS-based Assay Using Isotope Labeling; 2.5 Assays Based on Nuclear Magnetic Resonance Spectroscopy; 2.6 Assay Based on Fourier Transform Infrared Spectroscopy for Assaying Lipases or Esterases; 2.7 Assays Based on Gas Chromatography; 2.8 Assays Based on HPLC; 2.9 Assays Based on Capillary Array Electrophoresis; 2.10 Assays Based on Circular Dichroism (CD) 2.11 Assay Based on Surface-enhanced Resonance Raman Scattering2.12 Conclusions; References; 3 High-throughput Screening Methods Developed for Oxidoreductases; 3.1 Introduction; 3.2 High-throughput Methods for Various Oxidoreductases; 3.2.1 Dehydrogenases; 3.2.1.1 Colorimetric Screen Based on NAD(P)H Generation; 3.2.1.2 Screens Based on NAD(P)H Depletion; 3.2.2 Oxidases; 3.2.2.1 Galactose Oxidase; 3.2.2.2 D-Amino Acid Oxidase; 3.2.2.3 Peroxidases; 3.2.3 Oxygenases; 3.2.3.1 Assays Based on Optical Properties of Substrates and Products 3.2.3.2 Assays Based on Gibbs' Reagent and 4-Aminoantipyrine |
| Record Nr. | UNINA-9911019980103321 |
| Weinheim, Germany, : Wiley-VCH, c2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Handbook of proteolytic enzymes [[electronic resource] ] . Volume 1 / / edited by, Neil D. Rawlings, Guy Salvesen
| Handbook of proteolytic enzymes [[electronic resource] ] . Volume 1 / / edited by, Neil D. Rawlings, Guy Salvesen |
| Edizione | [3rd ed.] |
| Pubbl/distr/stampa | Oxford, : Academic, 2012 |
| Descrizione fisica | 1 online resource (3987 p.) |
| Disciplina | 572.76 |
| Altri autori (Persone) |
RawlingsNeil D
SalvesenG |
| Soggetto topico |
Proteolytic enzymes
Cellular control mechanisms |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-283-73425-7
0-12-382220-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Handbook of Proteolytic Enzymes; Copyright Page; Contents; Editor Biographies; Contributors; Preface; Introduction; Terminology; Organization of the Handbook; Special forms of information in the Handbook; Links to the MEROPS database; Molecular images; Alignments; Secondary structure; Description of substrate specificity; References; Aspartic Peptidases; 1 Introduction: Aspartic and Glutamic Peptidases and Their Clans; Clan AA; Family A1; Other Families in Clan AA; Clan AF; Clan AC; Clan AD; Clan AE; Other Families; Glutamic Peptidases; Asparagine Peptide Lyases
Clans NA, NC and NEInteins; Autotransporters; References; 2 Catalytic Pathways of Aspartic Peptidases; Introduction; Enzymatic Mechanism of Aspartic Peptidases; Enzymatic Mechanism of Glutamic Peptidases; References; 3 Pepsin A; Databanks; Name and History; Activity and Specificity; Structural Chemistry; Pepsinogen; Preparation; Biological Aspects; Related Peptidases; Further Reading; References; 4 Pepsin B; Databanks; Name and History; Activity and Specificity; Structural Chemistry; Preparation; Biological Aspects; Further Reading; References; 5 Chymosin; Databanks; Name and History Activity and SpecificityStructural Chemistry; Preparation; Biological Aspects; Distinguishing Features; Related Proteinases; Further Reading; References; 6 Cathepsin E; Databanks; Name and History; Activity and Specificity; Structural Chemistry; Preparation; Biological Aspects; Tissue Distribution and Subcellular Localization; Regulation of Gene Expression; Processing, Maturation and Intracellular Trafficking Of Cathepsin E; Physiological Roles of Cathepsin E; Distinguishing Features; Further Reading; References; 7 Gastricsin; Databanks; Name and History; Activity and Specificity Structural ChemistryProgastricsin; Preparation; Biological Aspects; References; 8 Cathepsin D; Databanks; Name and History; Activity and Specificity; Assay Methods; Specificity; Inhibition and Activation; Structural Chemistry; Three-dimensional Structure; Preparation; Biological Aspects; Gene and Expression Control; Knock-out Model; Organ Distribution and Cellular Localization; Apoptosis; Involvement in Cancer; Neurodegeneration; Other Biological Functions; Distinguishing Features; Related Peptidases; Acknowledgment; Further Reading; References; 9 Nothepsin; Databanks; Name and History Activity and SpecificityStructural Chemistry; Primary Structure Analysis; Distinguishing Features of This New Class of Aspartic Proteinases; Retrieval and Sequencing of Nothepsin Enzymes; Presence of a Nothepsin Enzyme in Non-Antarctic Fish; Nothepsin in Organisms Other Than Fish; Preparation; Biological Aspects; Expression Pattern of the Nothepsin in Fish and Lizard; Phylogenetic Analysis, Adaptive Evolution and Role of Nothepsin; Further Reading; References; 10 Napsin A; Databanks; Name and History; Activity and Specificity; Structural Chemistry; Preparation; Biological Aspects Further Reading |
| Record Nr. | UNINA-9910462131003321 |
| Oxford, : Academic, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Handbook of proteolytic enzymes [[electronic resource] ] . Volume 1 / / edited by, Neil D. Rawlings, Guy Salvesen
| Handbook of proteolytic enzymes [[electronic resource] ] . Volume 1 / / edited by, Neil D. Rawlings, Guy Salvesen |
| Edizione | [3rd ed.] |
| Pubbl/distr/stampa | Oxford, : Academic, 2012 |
| Descrizione fisica | 1 online resource (3987 p.) |
| Disciplina | 572.76 |
| Altri autori (Persone) |
RawlingsNeil D
SalvesenG |
| Soggetto topico |
Proteolytic enzymes
Cellular control mechanisms |
| ISBN |
1-283-73425-7
0-12-382220-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Handbook of Proteolytic Enzymes; Copyright Page; Contents; Editor Biographies; Contributors; Preface; Introduction; Terminology; Organization of the Handbook; Special forms of information in the Handbook; Links to the MEROPS database; Molecular images; Alignments; Secondary structure; Description of substrate specificity; References; Aspartic Peptidases; 1 Introduction: Aspartic and Glutamic Peptidases and Their Clans; Clan AA; Family A1; Other Families in Clan AA; Clan AF; Clan AC; Clan AD; Clan AE; Other Families; Glutamic Peptidases; Asparagine Peptide Lyases
Clans NA, NC and NEInteins; Autotransporters; References; 2 Catalytic Pathways of Aspartic Peptidases; Introduction; Enzymatic Mechanism of Aspartic Peptidases; Enzymatic Mechanism of Glutamic Peptidases; References; 3 Pepsin A; Databanks; Name and History; Activity and Specificity; Structural Chemistry; Pepsinogen; Preparation; Biological Aspects; Related Peptidases; Further Reading; References; 4 Pepsin B; Databanks; Name and History; Activity and Specificity; Structural Chemistry; Preparation; Biological Aspects; Further Reading; References; 5 Chymosin; Databanks; Name and History Activity and SpecificityStructural Chemistry; Preparation; Biological Aspects; Distinguishing Features; Related Proteinases; Further Reading; References; 6 Cathepsin E; Databanks; Name and History; Activity and Specificity; Structural Chemistry; Preparation; Biological Aspects; Tissue Distribution and Subcellular Localization; Regulation of Gene Expression; Processing, Maturation and Intracellular Trafficking Of Cathepsin E; Physiological Roles of Cathepsin E; Distinguishing Features; Further Reading; References; 7 Gastricsin; Databanks; Name and History; Activity and Specificity Structural ChemistryProgastricsin; Preparation; Biological Aspects; References; 8 Cathepsin D; Databanks; Name and History; Activity and Specificity; Assay Methods; Specificity; Inhibition and Activation; Structural Chemistry; Three-dimensional Structure; Preparation; Biological Aspects; Gene and Expression Control; Knock-out Model; Organ Distribution and Cellular Localization; Apoptosis; Involvement in Cancer; Neurodegeneration; Other Biological Functions; Distinguishing Features; Related Peptidases; Acknowledgment; Further Reading; References; 9 Nothepsin; Databanks; Name and History Activity and SpecificityStructural Chemistry; Primary Structure Analysis; Distinguishing Features of This New Class of Aspartic Proteinases; Retrieval and Sequencing of Nothepsin Enzymes; Presence of a Nothepsin Enzyme in Non-Antarctic Fish; Nothepsin in Organisms Other Than Fish; Preparation; Biological Aspects; Expression Pattern of the Nothepsin in Fish and Lizard; Phylogenetic Analysis, Adaptive Evolution and Role of Nothepsin; Further Reading; References; 10 Napsin A; Databanks; Name and History; Activity and Specificity; Structural Chemistry; Preparation; Biological Aspects Further Reading |
| Record Nr. | UNINA-9910785913503321 |
| Oxford, : Academic, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Heparanase : From Basic Research to Clinical Applications / / edited by Israel Vlodavsky, Ralph D. Sanderson, Neta Ilan
| Heparanase : From Basic Research to Clinical Applications / / edited by Israel Vlodavsky, Ralph D. Sanderson, Neta Ilan |
| Edizione | [1st ed. 2020.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 |
| Descrizione fisica | 1 online resource (XVIII, 885 p. 168 illus., 107 illus. in color.) |
| Disciplina | 572.76 |
| Collana | Advances in Experimental Medicine and Biology |
| Soggetto topico |
Cancer - Research
Oncology Molecular biology Cancer Research Molecular Medicine Enzims Cèl·lules Càncer |
| Soggetto genere / forma | Llibres electrònics |
| ISBN |
9783030345211
3030345211 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Section 1: Historical Background -- Chapter 1: Mast cell/platelet heparanase/Heparan sulfate biosynthesis and turnover -- Chapter 2: gene cloning/overview -- Chapter 3: gene cloning/melanoma metastasis -- Chapter 4: gene cloning/cancer/immune system -- Chapter 5: heparin/HS modifying enzymes -- Section 2: Crystal Structure/substrate specificity/gene regulation -- Chapter 6: crystal structure -- Chapter 7: molecular dynamics, KKDC peptide -- Chapter 8: Biochemistry/active site -- Chapter 9: substrate specificity -- Chapter 10: gene regulation, promoter/Egr1/methylation -- Chapter 11: SNPs -- polymorphism -- Chapter 12: Splice variants -- Section 3: Cell & tumor biology (general functions & mode of action) -- Chapter 13: Exosomes/heparan sulfate/heparanse -- Chapter 14: Exosomes/drug resistance -- Chapter 15: Nuclear heparanse/transcriptional activity -- Chapter 16: Non-Enzymatic functions/Signal transduction/cellular trafficking/autophagy -- Chapter 17: Heparan sulfate/stem cells/inflammation -- Chapter 18: Danger signals/HS/platelet heparanse -- Chapter 19: Heparanse/Intergrins/Melanoma -- Section 3: Immune Cells/Immnuno-Modulation -- Chapter 20: Heparain. Heparanse and Selectins in Cancer Metastasis and Inflamation --- Chapter 21: Trans-Endithelial Migration, Lymphocytes, Neutrophils/T-cells --Chapter 22: Macrophages, dendritic cells, autoimmunity -- Chapter 23: Macrophages, Heparanse and the tumor microenvironment, neutralizing antibodies -- Chapter 24: NK Cells -- Section 4: Cancer (heparanse in specific types of cancer) -- Chapter 25: Myeloma, inhbition, drug resistance -- Chapter 26: Breast Cancer/Pancreatic Cancer/Cancer and Inflammation -- Chapter 27: Brain Metastasis/MIR-1258 -- Chapter 28: Gastric cancer/immunization -- Chapter 29: Head and Neck Cancer -- Chapter 30: Glioma -- Chapter 31: Sarcoma -- Section 5: Inhibitors/clinical trails/cancer -- Chapter 32: Chemistry/synthesis of heparanse inhibitors PI-88, PG -- Chapter 33: PG series/biology/Tumor models and clinical trial -- Chapter 34:Chemically modified heparins/Heparin mimetics -- Chapter 35: Medicinal Chemistry (Ronesparstat/small molecules/clinical trials) - Section 6: Other indications/diseases -- Chapter 36: IBD/inflammation and cancer/diabetes/obesity -- Chapter 37: Immune Diabetes -- Chapter 38 Inflammation, Sepsis/Amyloidosis -- Chapter 39: Kidney dysfunction -- Chapter 40: Fibrosis -- Chapter 41: Viral infection -- Chapter 42: Cariomyocytes/Endothelial cell-cardiomyocyte crosstakl in diabetic cariomyopathy -- Chapter 43: Eye research -- Chapter 44: atheroscelerosis, nuclear localization -- Chapter 45: Yona Nadir (coagulation/tissue factor) -- Section 7: Heparanse-2 (Hpa2) -- Chapter 46: Hpa2 gene cloning -- Chapter 47: UFS -- urofacial syndrome/peripheral neuropathy -- Chapter 48: Hpa2: tumor suppressor. |
| Record Nr. | UNINA-9910409700403321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Influenza del tipo di alimentazione e dell'età sulle attività enzimatiche di cagli in pasta prodotti da capretti [Tesi di dottorato] / dottoranda: Assunta D'elia ; tutore: Paolo Riccio ; coordinatore: Giovanna Suzzi
| Influenza del tipo di alimentazione e dell'età sulle attività enzimatiche di cagli in pasta prodotti da capretti [Tesi di dottorato] / dottoranda: Assunta D'elia ; tutore: Paolo Riccio ; coordinatore: Giovanna Suzzi |
| Autore | D'elia, Assunta |
| Descrizione fisica | 1 v. (varie sequenze) : ill. ; 30 cm. |
| Disciplina |
572.76
664 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | ita |
| Record Nr. | UNIBAS-000018672 |
D'elia, Assunta
|
||
| Materiale a stampa | ||
| Lo trovi qui: Univ. della Basilicata | ||
| ||
Matrix metalloproteinase biology / / edited by Irit Sagi, Jean P. Gaffney
| Matrix metalloproteinase biology / / edited by Irit Sagi, Jean P. Gaffney |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley-Blackwell, , 2015 |
| Descrizione fisica | 1 online resource (253 p.) |
| Disciplina | 572.76 |
| Soggetto topico |
Metalloproteinases
Metalloproteins - Research - Methodology |
| ISBN |
1-118-77238-5
1-118-77228-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Matrix metalloproteinases : from structure to function / Maciej J. Stawikowski and Gregg B. Fields -- Dynamics and mechanisms of substrate recognition by matrix metalloproteinases / Ivan E. Collier and Gregory Goldberg -- Matrix metalloproteinases : structure and dynamics in substrates recognition and processing / Marco Fragai, Claudio Luchinat -- Metzincin modulators : beyond the active site / Dmitriy Minond -- Therapeutics targeting matrix metalloproteinases / Jillian Cathcard, Ashleigh Pulkoski-Gross, Stanley Zucker, and Jian Cao -- Matrix metalloproteinases : modification of extracellular matrix-medicated signaling / Howard C. Crawford and M. Sharon Stack -- Meprin and Adam metalloproteinases : two sides of the same coin? / Christopher Becker-Pauly and Stefan Rose-John -- Metalloproteinases in innate immunity and disease / Antoine Dufour and Christopher Overall -- MMPS : from genomics to degradomics / Barbara Grünwald, Pascal Schlage, Achim Krüger, and Ulrich auf dem Keller -- Biology and clinical significance of MMPS / Di Jia, Roopali Roy, and Marsha A. Moses. |
| Record Nr. | UNINA-9910140639003321 |
| Hoboken, New Jersey : , : Wiley-Blackwell, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Matrix metalloproteinase biology / / edited by Irit Sagi, Jean P. Gaffney
| Matrix metalloproteinase biology / / edited by Irit Sagi, Jean P. Gaffney |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley-Blackwell, , 2015 |
| Descrizione fisica | 1 online resource (253 p.) |
| Disciplina | 572.76 |
| Soggetto topico |
Metalloproteinases
Metalloproteins - Research - Methodology |
| ISBN |
1-118-77238-5
1-118-77228-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Matrix metalloproteinases : from structure to function / Maciej J. Stawikowski and Gregg B. Fields -- Dynamics and mechanisms of substrate recognition by matrix metalloproteinases / Ivan E. Collier and Gregory Goldberg -- Matrix metalloproteinases : structure and dynamics in substrates recognition and processing / Marco Fragai, Claudio Luchinat -- Metzincin modulators : beyond the active site / Dmitriy Minond -- Therapeutics targeting matrix metalloproteinases / Jillian Cathcard, Ashleigh Pulkoski-Gross, Stanley Zucker, and Jian Cao -- Matrix metalloproteinases : modification of extracellular matrix-medicated signaling / Howard C. Crawford and M. Sharon Stack -- Meprin and Adam metalloproteinases : two sides of the same coin? / Christopher Becker-Pauly and Stefan Rose-John -- Metalloproteinases in innate immunity and disease / Antoine Dufour and Christopher Overall -- MMPS : from genomics to degradomics / Barbara Grünwald, Pascal Schlage, Achim Krüger, and Ulrich auf dem Keller -- Biology and clinical significance of MMPS / Di Jia, Roopali Roy, and Marsha A. Moses. |
| Record Nr. | UNINA-9910824191403321 |
| Hoboken, New Jersey : , : Wiley-Blackwell, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Phosphodiesterases as drug targets / Sharron H. Francis, Marco Conti, Miles D. Houslay, editors
| Phosphodiesterases as drug targets / Sharron H. Francis, Marco Conti, Miles D. Houslay, editors |
| Pubbl/distr/stampa | Berlin : Springer, 2011 |
| Descrizione fisica | XVII, 519 p. : ill. ; 24 cm |
| Disciplina | 572.76 |
| Collana | Handbook of experimental pharmacology |
| Soggetto non controllato | Fosfodiesterasi |
| ISBN | 978-3-642-17968-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-990003571000203316 |
| Berlin : Springer, 2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Proteases in Health and Disease / / edited by Sajal Chakraborti, Naranjan S. Dhalla
| Proteases in Health and Disease / / edited by Sajal Chakraborti, Naranjan S. Dhalla |
| Edizione | [1st ed. 2013.] |
| Pubbl/distr/stampa | New York, NY : , : Springer New York : , : Imprint : Springer, , 2013 |
| Descrizione fisica | 1 online resource (407 p.) |
| Disciplina | 572.76 |
| Collana | Advances in Biochemistry in Health and Disease |
| Soggetto topico |
Biochemistry
Cytology Cell physiology Proteomics Biochemistry, general Cell Biology Cell Physiology |
| ISBN | 1-4614-9233-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Part A: Molecular and Biochemical Aspects of Proteases -- 1. An Overview of Endoplasmic Reticulum Calpain System -- 2. Mitochondrial Calpains: Who, What, Where, When and Why? -- 3. Role of Calpains in Calmodulin Regulated Systems -- 4. Exercise and Matrix Metalloproteases: A Brief Overview -- 5. Regulation of Chondrocyte Matrix Metalloproteinase Gene Expression -- 6. Microbial Source of Fibrinolytic Protease and Its Biotechnological Potential -- 7. Aspartic Proteolytic Inhibitors Induce Cellular and Biochemical Alterations in Fungal Cells -- 8. Cysteine Proteases of Human Malaria Parasites -- 9. Proteases as Virulence Factors in Leishmania: Focus on Serine Proteases as Possible Therapeutic Targets -- 10. An Updated Inventory on Properties, Pathophysiology and Therapeutic Potential of Snake Venom Thrombin-like Proteases -- 11. Macrocyclic Protease Inhibitors Constrained into a β-Strand Geometry -- Part B: Involvement of Proteases in Disease Processes -- 12. Regulation of MT1-MMP Activation and Its Relevance to Disease Processes -- 13. Role of Proteases During Intra-erythrocytic Developmental Cycle of Human Malaria Parasite Plasmodium falciparum -- 14. Proteases in Vibrio cholerae and Their Role in Pathogenesis -- 15. ADAMTS13: The von Willebrand Factor Cleaving Protease and Its Role in Thrombotic Thrombocytopenic Purpura -- 16. Role of Proteases and Their Tissue Inhibitors in Pregnancy Outcome -- 17. Matrix Metalloproteinases in Bone Health and Disease -- 18. Escalated Expression of Matrix Metalloproteinases in Osteoarthritis -- 19. Role of Proteases in Autism Spectrum Disorder -- 20. Role of Proteases in the Management of Hepatitis C Virus -- 21. Role of Protease in Inflammatory Lung Diseases -- 22. Involvement of Some Proteolytic Enzymes in Cardiac Dysfunction Due to Ischemia-Reperfusion Injury. |
| Record Nr. | UNINA-9910437843203321 |
| New York, NY : , : Springer New York : , : Imprint : Springer, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Proteases: Structure and Function / / edited by Klaudia Brix, Walter Stöcker
| Proteases: Structure and Function / / edited by Klaudia Brix, Walter Stöcker |
| Edizione | [1st ed. 2013.] |
| Pubbl/distr/stampa | Vienna : , : Springer Vienna : , : Imprint : Springer, , 2013 |
| Descrizione fisica | 1 online resource (568 p.) |
| Disciplina |
572
572.76 |
| Soggetto topico |
Enzymology
Proteins Protein Structure Protein Science |
| ISBN | 3-7091-0885-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1 Protease families, evolution and mechanisms of action "Set the stage" -- 1.1 Enzyme families, prototypes and catalytic mechanisms -- 1.2 Enzyme kinetics, mathematical modelling and perspectives -- 1.3 Structure determination and search for inhibitors -- 2 Regulation of proteolysis "Positioning and teaming-up to control activity" -- 2.1 Compartmentalization of proteolysis -- 2.2 Biosynthesis of lysosomal proteases -- 2.3 Interactions of proteases and inhibitors / networking in the degradome -- 2.4 In vivo analysis of the protease and inhibitors concert -- 3 Proteases in development "Born to be right" -- 3.1 Proteases for pattern formation during morphogenesis -- 3.2 Proteases in death pathways (apoptosis, necrosis) -- 4 Proteases in physiology and pathophysiology „Cleave to function in health or to cause disease" -- 4.1 Protein turnover and signaling functions (degrade to rebuild, remodel, process and mature for signalling) -- 4.2 Proteases in control of physiology -- 4.3 Cancer: invasion and metastasis -- 4.4 Bacterial proteases -- 4.5 Viral proteases. |
| Record Nr. | UNINA-9910437624303321 |
| Vienna : , : Springer Vienna : , : Imprint : Springer, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
