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GTPases : Versatile Regulators of Signal Transduction in Plants / / by Girdhar K. Pandey, Manisha Sharma, Amita Pandey, Thiruvenkadam Shanmugam
| GTPases : Versatile Regulators of Signal Transduction in Plants / / by Girdhar K. Pandey, Manisha Sharma, Amita Pandey, Thiruvenkadam Shanmugam |
| Autore | Pandey Girdhar K |
| Edizione | [1st ed. 2015.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015 |
| Descrizione fisica | 1 online resource (88 p.) |
| Disciplina | 572.757 |
| Collana | SpringerBriefs in Plant Science |
| Soggetto topico |
Plant genetics
Agriculture Plant pathology Plant Genetics and Genomics Plant Pathology |
| ISBN | 3-319-11611-8 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Overview of G Proteins (GTP binding proteins) in Eukaryotes -- Overview of Small GTPase Signaling Proteins in Plants -- Identification and Classification of Rho GTPases in Plants -- Sequence, Structure and Domain Analysis of GTPases in Plants -- Expression of Small GTPases Under Stress and Developmental Conditions in Plants -- Emerging Roles of Rho GTPases in Plants -- Cellular Localization of Small GTPases -- Functional Genomic Perspective of Small GTPases -- Systemic Approaches to Resolve Spatio-Temporal Regulation of GTPase Signaling -- Key Questions and Future Prospects. |
| Record Nr. | UNINA-9910298285203321 |
Pandey Girdhar K
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| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Lipase [[electronic resource] ] : functions, synthesis and role in disease / / Hamdi Sassi, Sofien Cannamela, editors
| Lipase [[electronic resource] ] : functions, synthesis and role in disease / / Hamdi Sassi, Sofien Cannamela, editors |
| Pubbl/distr/stampa | New York, : Nova Biomedical, Nova Science Publishers, c2012 |
| Descrizione fisica | 1 online resource (237 p.) |
| Disciplina | 572.757 |
| Altri autori (Persone) |
SassiHamdi
CannamelaSofien |
| Collana |
Biochemistry research trends
Biotechnology in agriculture, industry and medicine |
| Soggetto topico |
Lipase - Industrial applications
Lipase - Therapeutic use |
| Soggetto genere / forma | Electronic books. |
| ISBN | 1-62081-394-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910452903203321 |
| New York, : Nova Biomedical, Nova Science Publishers, c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Lipase [[electronic resource] ] : functions, synthesis and role in disease / / Hamdi Sassi, Sofien Cannamela, editors
| Lipase [[electronic resource] ] : functions, synthesis and role in disease / / Hamdi Sassi, Sofien Cannamela, editors |
| Pubbl/distr/stampa | New York, : Nova Biomedical, Nova Science Publishers, c2012 |
| Descrizione fisica | 1 online resource (237 p.) |
| Disciplina | 572.757 |
| Altri autori (Persone) |
SassiHamdi
CannamelaSofien |
| Collana |
Biochemistry research trends
Biotechnology in agriculture, industry and medicine |
| Soggetto topico |
Lipase - Industrial applications
Lipase - Therapeutic use |
| ISBN | 1-62081-394-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910779780503321 |
| New York, : Nova Biomedical, Nova Science Publishers, c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Lipase : functions, synthesis and role in disease / / Hamdi Sassi, Sofien Cannamela, editors
| Lipase : functions, synthesis and role in disease / / Hamdi Sassi, Sofien Cannamela, editors |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | New York, : Nova Biomedical, Nova Science Publishers, c2012 |
| Descrizione fisica | 1 online resource (237 p.) |
| Disciplina | 572.757 |
| Altri autori (Persone) |
SassiHamdi
CannamelaSofien |
| Collana |
Biochemistry research trends
Biotechnology in agriculture, industry and medicine |
| Soggetto topico |
Lipase - Industrial applications
Lipase - Therapeutic use |
| ISBN | 1-62081-394-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- LIPASE -- LIPASE -- CONTENTS -- PREFACE -- ACQUISITION OF NEW PROPERTIES UNDER THE ACTION OF LIPASES AS A BIOTECHNOLOGICAL TOOL -- ABSTRACT -- 1. INTRODUCTION -- 2. LIPASE-CATALYZED MODIFICATION OF NATURAL PRODUCTS -- 2.1. Lipase-Catalyzed Production of Lysophospholipids -- A. Natural Sources of Phospholipids -- B. Lipase-Mediated Production of LPLs -- C. Characterization of Produced LPLs -- 2.2. Lipase-Catalyzed Synthesis of Waxes -- A. What Is Wax? -- B. Ester Composition of Waxes -- C. Wax Ester Production -- 3. LIPASE-CATALYZED SYNTHESIS OF NEW DERIVATIVES -- 3.1. Lipase-Catalyzed Synthesis of Triglycerides in Solvent Free Media -- A. Triolein Synthesis -- B. Synthesis of Medium Chain Triglycerides (MCT) -- C. Synthesis of N-3 Rich Triglycerides -- D. Trierucin Synthesis -- E. TG Synthesis: Effect of Chain Length and Unsaturation -- 3.2. Lipase-Catalyzed Synthesis of Fatty Acid Sugar Esters (FASEs) -- A. Effect of the Initial Fatty Acid Concentration -- B. Effect of the Initial Fructose Concentration -- C. Effect of the Fatty Acid Chain Length -- D. Effect of the Water Content -- E. Effect of the Initial Hydrophobicity -- 3.3. Lipase-Catalyzed Synthesis of Polyphenol Derivatives -- A. Effect of the Polyphenol Structure -- B. Effect of the Solvent -- C. Effect of the Acyl Donor -- E. Effect of Temperature and Reduced Pressure -- CONCLUSION -- REFERENCES -- SYNTHESIS OF ACYL SACCHARIDES AND ASCORBATES USING IMMOBILIZED LIPASE IN AN ORGANIC SOLVENT AND THEIR FUNCTIONALITIES -- ABSTRACT -- 1. INTRODUCTION -- 2. FACTORS AFFECTING THE REACTION EQUILIBRIUM OF LIPASE-CATALYZED CONDENSATION -- 2.1. Equilibrium Constants for the Lipase-Catalyzed Synthesis of Acyl Hexoses -- 2.2. Effect of the Solvent on the Reaction Equilibrium in Tertiary Alcohol and Nitrile -- 2.3. Addition of Desiccant.
2.4. Improvement of the Product Concentration by the Use of a Sugar Derivative -- 3. KINETICS FOR THE LIPASE-CATALYZED CONDENSATION -- 3.1. Reactivity of Substrates for the Lipase-Catalyzed Condensation -- 3.2. Kinetics of the Lipase-Catalyzed Condensation of Fatty Acid and Alkyl Glucoside -- 3.3. Thermostability of Immobilized Lipase in 1-Alcohol -- 4. CONTINUOUS OR SEMI-CONTINUOUS REACTOR SYSTEMS FOR LIPASE-CATALYZED CONDENSATION -- 4.1. Continuous Reactor Systems of Plug Flow Type -- 4.2. Continuous Production of Acyl Ascorbate by a Continuous Stirred Tank Reactor -- 4.3. Semi-Continuous Production of Kojic Acid Ester -- 5. FUNCTIONALITIES OF THE PRODUCTS -- 5.1. Surfactant Properties of Acyl Saccharides, Ascorbates and Sugar Alcohols -- 5.2. Bacteriostatic Activities of Acyl Saccharides and Sugar Alcohols -- 5.3. Antioxidative Properties of Acyl Ascorbates and Alkyl Ferulates -- 5.4. Oxidation of Linoleoyl Residue of its Trehalose Ester in a Micelle System -- 5.5. Stability of Acyl Ascorbates -- ACKNOWLEDGMENTS -- REFERENCES -- SOLVENT-FREE BIOCATALYTIC SYNTHESIS OF POLYGLYCEROL POLYRICINOLEATE (PGPR) USING IMMOBILISED CANDIDA RUGOSA AND RHIZOPUS ARRHIZUS LIPASES -- ABSTRACT -- 1. INTRODUCTION -- 2. MATERIALS AND METHODS -- 2.1. Materials -- 2.1.1. Enzymes -- 2.1.2. Substrates -- 2.1.3. Immobilisation Reagents and Activators -- 2.1.4. Immobilisation Supports -- 2.2. Methods -- 2.2.1. Immobilisation by Covalent Binding -- 2.2.2. Immobilisation by Physical Adsorption -- 2.2.3. Synthesis of Polyricinoleic Acid, PR -- 2.2.3.1. With Free Candida rugosa Lipase -- Preliminary Studies -- Open Air Reactor Experiments -- 2.2.3.2. With Immobilised Candida rugosa Lipase vv -- Open Air Reactor Experiments -- Vacuum Reactor Experiments -- 2.2.4. Synthesis of Polyglycerol Polyricinoleate, PGPR -- 2.2.4.1. With Free Lipase -- Selection Studies. Open Air Reactor Experiments -- 2.2.4.2. With Immobilised Lipase -- Open Air Reactor Experiments -- Vacuum Reactor Experiments -- 2.2.5. Measurement of the Reaction Extension -- 2.2.6. Measurement of the Water Content -- 2.2.7. Recovery of the Immobilised Derivative -- 3. RESULTS AND DISCUSSION -- 3.1. Condensation of Ricinoleic Acid to Obtain Polyricinoleic Acid by Candida rugosa Lipase -- 3.1.1. Preliminary Studies with Free Candida rugosa Lipase -- 3.1.2. Immobilisation of Candida rugosa Lipase -- 3.1.2.1. Choice of the Immobilised Derivative -- 3.1.2.2. Choice of Support Activator -- 3.1.2.3. Influence of Enzyme Concentration and pH -- 3.1.2.4. Effect of Mixing in the Immobilisation Process -- 3.1.2.5. Comparison of Free and Immobilised Lipase -- 3.1.2.6. Reuse of the Immobilised Derivative -- 3.1.3. Production of Polyricinoleic Acid with Immobilised Candida rugosa Lipase -- 3.1.3.1. Influence of the Amount of Enzyme -- 3.1.3.2. Influence of the Temperature -- 3.1.3.3. Influence of the Initial Water Content -- 3.1.3.3. Influence of Pressure and Water Content -- 3.2. Esterification of Polyricinoleic Acid with Polyglycerol to Obtain PGPR -- 3.2.1. Screening and Selection of Lipases for the Enzymatic Production of PGPR -- 3.2.1.1. Selection of Lipases -- 3.2.1.2. Immobilisation of the Selected Lipases -- 3.2.2. Synthesis of Polyglycerol Polyricinoleate with Rhizopus arrhizus Lipase -- 3.2.2.1. Influence of Initial Water Content -- 3.2.2.2. Influence of Temperature -- 3.2.2.3. Influence of the Amount of Enzyme -- 3.2.2.4. Lipase Immobilisation and Comparison with Free Enzyme -- 3.2.2.5. Reuse of the Immobilised Derivative -- 3.2.2.6. Obtaining PGPR in the Vacuum Reactor -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- FUNGAL LIPASES: VERSATILE TOOLS FOR BIOCATALYSIS -- ABSTRACT -- INTRODUCTION -- ESSENTIAL CHARACTERISTICS OF FUNGAL LIPASES. BIOTECHNOLOGICAL APPLICATIONS OF FUNGAL LIPASES -- 1. Food Industry -- Fats and Oil Industry -- Dairy Industry -- Flavor Production -- Bakery Industry -- 2. Detergent Industry -- 3. Agrochemicals -- 4. Biopolymers -- 5. Biodiesel Production -- 6. Environmental Management -- 7. Biomedical Applications -- 8. Cosmetics -- 9. Biosensors -- 10. Pulp and Paper Industry -- 11. Textile Industry -- 12. Leather Industry -- REFERENCES -- SECRETED PHOSPHOLIPASE A2 INHIBITORS FROM CYNARA CARDUNCULUS L.AND ALOE VERA EXTRACTS AS POTENTIAL THERAPEUTIC DRUG FOR INFLAMMATORY DISEASES -- ABSTRACT -- INTRODUCTION -- MATERIAL AND METHODS -- Enzymes and Reagents -- Extractions -- Fractionation of Compounds -- Assay of sPLA2 Activity -- Total Phenols Determination -- Assays of Antioxidant Activity -- DPPH Radical Scavenging Assay -- Reducing Power Assay -- Statistical Analysis and Correlation Study -- RESULTS -- Extraction Yields of Cynara Cardunculus and Aloe Vera -- Total Phenolic Contents of Aloe Vera -- Antioxidant Activity of Aloe Vera -- DPPH Radical Scavenging Activity -- Reducing Power Assay -- Evaluation of the PLA2 Inhibitory Effect -- Leaves of Cynara Cardunculus -- Stems of Cynara Cardunculus L. -- Leaf Skin of Aloe Vera -- Correlation Significance Study -- DISCUSSION -- Anti-Inflammatory Activity of Cynara Cardunculus L -- Anti-Inflammatory Activity of Aloe Vera -- REFERENCES -- LIPOPROTEIN LIPASE ACTIVITY IN SICKLE CELL NEPHROPATHY: A REVIEW -- ABSTRACT -- INTRODUCTION -- RENAL CHANGES IN SICKLE CELL DISEASE -- RATE OF SYNTHESIS OF LIPOPROTEIN LIPASE -- Subclass -- EFFECT OF RACE, ENVIRONMENT AND SEX ON LIPOPROTEIN LIPASE -- Effect of Race and Environment -- Effect of Sex -- LIPOPROTEIN LIPASE ACTIVITY IN PATIENTS WITH SICKLE CELL DISEASE -- EFFECTS OF ALTERED LIPOPROTEIN LIPASE ON LIPOPROTEINS IN SICKLE CELL NEPHROPATHY. PATHOPHYSIOLOGY OF DYSLIPIDAEMIA IN CHRONIC KIDNEY DISEASE -- EFFECT OF INFLAMMATION AND ANTIOXIDANTS ON LIPOPROTEIN LIPASE IN SICKLE CELL DISEASE -- POLYMORPHISM IN GENES THAT CODE FOR LIPOPROTEIN LIPASE AND ASSOCIATION WITH LIPID METABOLISM -- REFERENCES -- LIPASES IN THE PHARMACEUTICAL INDUSTRY: AN APPROACH FOR RACEMIC DRUGS -- ABSTRACT -- INTRODUCTION -- MICROBIAL LIPASES -- Production of Microbial Lipases -- Purification, Characterization and Immobilization of Microbial Lipases -- RACEMIC DRUGS -- General Aspects -- LIPASES ON RACEMIC DRUGS -- Hydrolysys Reactions -- Esterification Reactions -- Transesterification Reactions -- Amidation Reactions -- CONCLUSION -- REFERENCES -- YEAST CELL SURFACE DISPLAY OF LIPASES -- ABSTRACT -- INTRODUCTION -- DEVELOPED SYSTEMS FOR YEAST SURFACE DISPLAY OF PROTEINS -- C-Terminal System of Cell Surface Display -- N-Terminal System of Cell Surface Display -- LIPASE CELL SURFACE DISPLAY -- Display of Lip2 on the Cell Surface of Y. Lipolytica -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- MICROBIAL LIPASES AND THEIR APPLICATIONS IN STRUCTURED LIPIDS -- ABSTRACT -- INTRODUCTION -- MICROBIAL LIPASES -- STRUCTURED LIPIDS -- Generic Aspects -- BIOCHEMICAL AND NUTRITIONAL ASPECTS OF STRUCTURED LIPIDS -- OBTAINING STRUCTURED LIPIDS USING MICROBIAL LIPASES -- CONCLUSION -- REFERENCES -- INDEX. |
| Record Nr. | UNINA-9910825970603321 |
| New York, : Nova Biomedical, Nova Science Publishers, c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Lipases / edited by Byron Rubin, Edward A. Dennis
| Lipases / edited by Byron Rubin, Edward A. Dennis |
| Pubbl/distr/stampa | San Diego, : Academic, 1997 |
| Descrizione fisica | xxxi, 408 p., [2] leaves of plates : ill. ; 24 cm. |
| Disciplina | 572.757 |
| ISBN | 01-218-2185-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNICAMPANIA-SUN0018895 |
| San Diego, : Academic, 1997 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Vanvitelli | ||
| ||
Lipases / edited by Byron Rubin, Edward A. Dennis
| Lipases / edited by Byron Rubin, Edward A. Dennis |
| Pubbl/distr/stampa | San Diego, : Academic, 1997 |
| Descrizione fisica | xxxi, 408 p., [2] leaves of plates : ill. ; 24 cm. |
| Disciplina | 572.757 |
| ISBN | 01-218-2185-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNICAMPANIA-VAN0018895 |
| San Diego, : Academic, 1997 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Vanvitelli | ||
| ||
Lipases / edited by Byron Rubin, Edward A. Dennis
| Lipases / edited by Byron Rubin, Edward A. Dennis |
| Pubbl/distr/stampa | San Diego, : Academic, 1997 |
| Descrizione fisica | xxxi, 408 p., [2] leaves of plates : ill. ; 24 cm. |
| Disciplina | 572.757 |
| ISBN | 01-218-2185-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNICAMPANIA-VAN00018895 |
| San Diego, : Academic, 1997 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Vanvitelli | ||
| ||
Lipases and phospholipases in drug development [[electronic resource] ] : from biochemistry to molecular pharmacology / / edited by Günter Müller and Stefan Petry
| Lipases and phospholipases in drug development [[electronic resource] ] : from biochemistry to molecular pharmacology / / edited by Günter Müller and Stefan Petry |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2004 |
| Descrizione fisica | 1 online resource (356 p.) |
| Disciplina |
572.75
572.757 |
| Altri autori (Persone) |
MüllerGünter
PetryStefan |
| Soggetto topico |
Lipase
Phospholipases Drug development |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-52070-1
9786610520701 3-527-60570-3 3-527-60191-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Lipases and Phospholipases in Drug Development; Contents; Preface; List of Contributors; 1 Purification of Lipase; 1.1 Introduction; 1.2 Pre-purification Steps; 1.3 Chromatographic Steps; 1.4 Unique Purification Strategies; 1.5 Theoretical Modeling; 1.5.1 Model Formulation; 1.5.1.1 Mobile Phase; 1.5.1.2 Stationary Phase; 1.5.1.3 Boundary Conditions; 1.5.2 Solution; 1.5.3 Method of Moments; 1.5.4 Model Evaluation; 1.5.5 Simulation Results; 1.5.5.1 Effect of Feed Angle; 1.5.5.2 Effect of Flow Rate; 1.5.5.3 Effect of Rotation Rate; 1.5.5.4 Effect of Column Height; 1.6 Conclusions
1.7 Acknowledgements1.8 References; 2 Phospholipase A(1) Structures, Physiological and Patho-physiological Roles in Mammals; 2.1 Introduction; 2.2 Phosphatidylserine-specific Phospholipase A(1) (PS-PLA(1)); 2.2.1 Historical Aspects; 2.2.2 Biochemical Characterization and Tissue Distribution; 2.2.3 Structural Characteristics; 2.2.4 Substrate Specificity; 2.2.5 Possible Functions; 2.3 Membrane-associated Phosphatidic Acid-selective Phospholipase A(1)s (mPA-PLA(1)α and mPA-PLA(1)β); 2.3.1 Historical Aspects; 2.3.2 Characterization and Distribution; 2.3.3 Structural Characteristics 2.3.4 Function2.4 Phosphatidic Acid-preferring Phospholipase A(1) (PA-PLA(1)); 2.4.1 Historical Aspects; 2.4.2 Characterization and Distribution; 2.4.3 Substrate Specificity; 2.4.4 Function; 2.5 KIAA0725P, a Novel PLA(1) with Sequence Homology to a Mammalian Sec23p-interacting Protein, p125; 2.5.1 Historical Aspects; 2.5.2 Characterization and Distribution; 2.6 References; 3 Rational Design of a Liposomal Drug Delivery System Based on Biophysical Studies of Phospholipase A(2) Activity on Model Lipid Membranes; 3.1 Introduction 3.2 Role for Secretory Phospholipase A(2) (sPLA(2)) in Liposomal Drug Delivery3.3 Lateral Microstructure of Lipid Bilayers and its Influence on sPLA(2); 3.4 sPLA(2) Degradation of Drug-delivery Liposomes: A New Drug-delivery Principle; 3.4.1 Liposomes Protected by Polymer Coating; 3.4.2 Biophysical Model Drug-delivery System to Study sPLA(2) Activity; 3.4.3 Effect of Lipid Composition on sPLA(2)-triggered Drug Release and Absorption; 3.4.4 Effect of Temperature on Liposomal Drug Release and Absorption by sPLA(2); 3.4.5 Liposomal Drug Release as a Function of sPLA(2) Concentration 3.5 Conclusion3.6 Acknowledgments; 3.7 References; 4 Phospholipase D; 4.1 Introduction; 4.2 Structure and Catalytic Mechanism of Mammalian Phospholipase D; 4.3 Cellular Locations of PLD1 and PLD2; 4.4 Post-translational Modification of PLD; 4.5 Regulation of PLD1 and PLD2; 4.5.1 Role of PIP(2); 4.5.2 Role of PKC; 4.6 Role of Rho Family GTPases; 4.7 Role of Arf Family GTPases; 4.8 Role of Tyrosine Kinase; 4.9 Role of Ral; 4.10 Cellular Functions of PLD; 4.11 Role of PLD in Growth and Differentiation; 4.12 Role of PLD in Vesicle Trafficking in Golgi 4.13 Role of PLD in Exocytosis and Endocytosis |
| Record Nr. | UNINA-9910146237503321 |
| Weinheim, : Wiley-VCH, c2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Lipases and phospholipases in drug development [[electronic resource] ] : from biochemistry to molecular pharmacology / / edited by Günter Müller and Stefan Petry
| Lipases and phospholipases in drug development [[electronic resource] ] : from biochemistry to molecular pharmacology / / edited by Günter Müller and Stefan Petry |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2004 |
| Descrizione fisica | 1 online resource (356 p.) |
| Disciplina |
572.75
572.757 |
| Altri autori (Persone) |
MüllerGünter
PetryStefan |
| Soggetto topico |
Lipase
Phospholipases Drug development |
| ISBN |
1-280-52070-1
9786610520701 3-527-60570-3 3-527-60191-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Lipases and Phospholipases in Drug Development; Contents; Preface; List of Contributors; 1 Purification of Lipase; 1.1 Introduction; 1.2 Pre-purification Steps; 1.3 Chromatographic Steps; 1.4 Unique Purification Strategies; 1.5 Theoretical Modeling; 1.5.1 Model Formulation; 1.5.1.1 Mobile Phase; 1.5.1.2 Stationary Phase; 1.5.1.3 Boundary Conditions; 1.5.2 Solution; 1.5.3 Method of Moments; 1.5.4 Model Evaluation; 1.5.5 Simulation Results; 1.5.5.1 Effect of Feed Angle; 1.5.5.2 Effect of Flow Rate; 1.5.5.3 Effect of Rotation Rate; 1.5.5.4 Effect of Column Height; 1.6 Conclusions
1.7 Acknowledgements1.8 References; 2 Phospholipase A(1) Structures, Physiological and Patho-physiological Roles in Mammals; 2.1 Introduction; 2.2 Phosphatidylserine-specific Phospholipase A(1) (PS-PLA(1)); 2.2.1 Historical Aspects; 2.2.2 Biochemical Characterization and Tissue Distribution; 2.2.3 Structural Characteristics; 2.2.4 Substrate Specificity; 2.2.5 Possible Functions; 2.3 Membrane-associated Phosphatidic Acid-selective Phospholipase A(1)s (mPA-PLA(1)α and mPA-PLA(1)β); 2.3.1 Historical Aspects; 2.3.2 Characterization and Distribution; 2.3.3 Structural Characteristics 2.3.4 Function2.4 Phosphatidic Acid-preferring Phospholipase A(1) (PA-PLA(1)); 2.4.1 Historical Aspects; 2.4.2 Characterization and Distribution; 2.4.3 Substrate Specificity; 2.4.4 Function; 2.5 KIAA0725P, a Novel PLA(1) with Sequence Homology to a Mammalian Sec23p-interacting Protein, p125; 2.5.1 Historical Aspects; 2.5.2 Characterization and Distribution; 2.6 References; 3 Rational Design of a Liposomal Drug Delivery System Based on Biophysical Studies of Phospholipase A(2) Activity on Model Lipid Membranes; 3.1 Introduction 3.2 Role for Secretory Phospholipase A(2) (sPLA(2)) in Liposomal Drug Delivery3.3 Lateral Microstructure of Lipid Bilayers and its Influence on sPLA(2); 3.4 sPLA(2) Degradation of Drug-delivery Liposomes: A New Drug-delivery Principle; 3.4.1 Liposomes Protected by Polymer Coating; 3.4.2 Biophysical Model Drug-delivery System to Study sPLA(2) Activity; 3.4.3 Effect of Lipid Composition on sPLA(2)-triggered Drug Release and Absorption; 3.4.4 Effect of Temperature on Liposomal Drug Release and Absorption by sPLA(2); 3.4.5 Liposomal Drug Release as a Function of sPLA(2) Concentration 3.5 Conclusion3.6 Acknowledgments; 3.7 References; 4 Phospholipase D; 4.1 Introduction; 4.2 Structure and Catalytic Mechanism of Mammalian Phospholipase D; 4.3 Cellular Locations of PLD1 and PLD2; 4.4 Post-translational Modification of PLD; 4.5 Regulation of PLD1 and PLD2; 4.5.1 Role of PIP(2); 4.5.2 Role of PKC; 4.6 Role of Rho Family GTPases; 4.7 Role of Arf Family GTPases; 4.8 Role of Tyrosine Kinase; 4.9 Role of Ral; 4.10 Cellular Functions of PLD; 4.11 Role of PLD in Growth and Differentiation; 4.12 Role of PLD in Vesicle Trafficking in Golgi 4.13 Role of PLD in Exocytosis and Endocytosis |
| Record Nr. | UNINA-9910829927703321 |
| Weinheim, : Wiley-VCH, c2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Lipases and phospholipases in drug development : from biochemistry to molecular pharmacology / / edited by Gunter Muller and Stefan Petry
| Lipases and phospholipases in drug development : from biochemistry to molecular pharmacology / / edited by Gunter Muller and Stefan Petry |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2004 |
| Descrizione fisica | 1 online resource (356 p.) |
| Disciplina |
572.75
572.757 |
| Altri autori (Persone) |
MullerGunter
PetryStefan |
| Soggetto topico |
Lipase
Phospholipases Drug development |
| ISBN |
1-280-52070-1
9786610520701 3-527-60570-3 3-527-60191-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Lipases and Phospholipases in Drug Development; Contents; Preface; List of Contributors; 1 Purification of Lipase; 1.1 Introduction; 1.2 Pre-purification Steps; 1.3 Chromatographic Steps; 1.4 Unique Purification Strategies; 1.5 Theoretical Modeling; 1.5.1 Model Formulation; 1.5.1.1 Mobile Phase; 1.5.1.2 Stationary Phase; 1.5.1.3 Boundary Conditions; 1.5.2 Solution; 1.5.3 Method of Moments; 1.5.4 Model Evaluation; 1.5.5 Simulation Results; 1.5.5.1 Effect of Feed Angle; 1.5.5.2 Effect of Flow Rate; 1.5.5.3 Effect of Rotation Rate; 1.5.5.4 Effect of Column Height; 1.6 Conclusions
1.7 Acknowledgements1.8 References; 2 Phospholipase A(1) Structures, Physiological and Patho-physiological Roles in Mammals; 2.1 Introduction; 2.2 Phosphatidylserine-specific Phospholipase A(1) (PS-PLA(1)); 2.2.1 Historical Aspects; 2.2.2 Biochemical Characterization and Tissue Distribution; 2.2.3 Structural Characteristics; 2.2.4 Substrate Specificity; 2.2.5 Possible Functions; 2.3 Membrane-associated Phosphatidic Acid-selective Phospholipase A(1)s (mPA-PLA(1)α and mPA-PLA(1)β); 2.3.1 Historical Aspects; 2.3.2 Characterization and Distribution; 2.3.3 Structural Characteristics 2.3.4 Function2.4 Phosphatidic Acid-preferring Phospholipase A(1) (PA-PLA(1)); 2.4.1 Historical Aspects; 2.4.2 Characterization and Distribution; 2.4.3 Substrate Specificity; 2.4.4 Function; 2.5 KIAA0725P, a Novel PLA(1) with Sequence Homology to a Mammalian Sec23p-interacting Protein, p125; 2.5.1 Historical Aspects; 2.5.2 Characterization and Distribution; 2.6 References; 3 Rational Design of a Liposomal Drug Delivery System Based on Biophysical Studies of Phospholipase A(2) Activity on Model Lipid Membranes; 3.1 Introduction 3.2 Role for Secretory Phospholipase A(2) (sPLA(2)) in Liposomal Drug Delivery3.3 Lateral Microstructure of Lipid Bilayers and its Influence on sPLA(2); 3.4 sPLA(2) Degradation of Drug-delivery Liposomes: A New Drug-delivery Principle; 3.4.1 Liposomes Protected by Polymer Coating; 3.4.2 Biophysical Model Drug-delivery System to Study sPLA(2) Activity; 3.4.3 Effect of Lipid Composition on sPLA(2)-triggered Drug Release and Absorption; 3.4.4 Effect of Temperature on Liposomal Drug Release and Absorption by sPLA(2); 3.4.5 Liposomal Drug Release as a Function of sPLA(2) Concentration 3.5 Conclusion3.6 Acknowledgments; 3.7 References; 4 Phospholipase D; 4.1 Introduction; 4.2 Structure and Catalytic Mechanism of Mammalian Phospholipase D; 4.3 Cellular Locations of PLD1 and PLD2; 4.4 Post-translational Modification of PLD; 4.5 Regulation of PLD1 and PLD2; 4.5.1 Role of PIP(2); 4.5.2 Role of PKC; 4.6 Role of Rho Family GTPases; 4.7 Role of Arf Family GTPases; 4.8 Role of Tyrosine Kinase; 4.9 Role of Ral; 4.10 Cellular Functions of PLD; 4.11 Role of PLD in Growth and Differentiation; 4.12 Role of PLD in Vesicle Trafficking in Golgi 4.13 Role of PLD in Exocytosis and Endocytosis |
| Record Nr. | UNINA-9910876611403321 |
| Weinheim, : Wiley-VCH, c2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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