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Fluorescent Methods for Molecular Motors / / edited by Christopher P. Toseland, Natalia Fili
| Fluorescent Methods for Molecular Motors / / edited by Christopher P. Toseland, Natalia Fili |
| Edizione | [1st ed. 2014.] |
| Pubbl/distr/stampa | Basel : , : Springer Basel : , : Imprint : Springer, , 2014 |
| Descrizione fisica | 1 online resource (306 p.) |
| Disciplina |
574.19245
572.64 |
| Collana | Experientia Supplementum |
| Soggetto topico |
Proteins
Cytology Biophysics Protein Science Cell Biology Biological and Medical Physics, Biophysics |
| ISBN | 3-0348-0856-9 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Fluorescence and Labelling: How to choose and what to do -- Fluorescent biosensors: design and application to motor proteins -- Rapid Reaction Kinetic Techniques -- Fluorescence to study the ATPase mechanism of Motor Proteins -- Use of pyrene labelled actin to probe actin myosin interactions; kinetic and equilibrium studies -- Fluorescent methods to study transcription initiation and transition into elongation -- Single-molecule and single-particle imaging of molecular motors in vitro and in vivo -- Fluorescence methods in the investigation of the DEAD-box helicase mechanism -- Use of Fluorescent Techniques to Study the In Vitro Movement of Myosins -- Fluorescence Tracking of Motor proteins in vitro -- Measuring Transport of Motor Cargos -- Measuring two at the same time: Combining Magnetic Tweezers with Single-Molecule FRET -- Using fluorescence to study actomyosin in yeasts. |
| Record Nr. | UNINA-9910298329003321 |
| Basel : , : Springer Basel : , : Imprint : Springer, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Mass spectrometry of protein interactions [[electronic resource] /] / edited by Kevin M. Downard
| Mass spectrometry of protein interactions [[electronic resource] /] / edited by Kevin M. Downard |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley-Interscience, c2007 |
| Descrizione fisica | 1 online resource (153 p.) |
| Disciplina |
543.65
572.64 572/.64 |
| Altri autori (Persone) | DownardK (Kevin) |
| Collana | Wiley-Interscience series in mass spectrometry |
| Soggetto topico |
Protein-protein interactions
Mass spectrometry |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-00190-2
9786611001902 0-470-14633-8 0-470-14632-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Direct characterization of protein complexes by electrospray ionization mass spectrometry and ion mobility analysis / Joseph A. Loo and Catherine S. Kaddis -- Softly, softly--detection of protein complexes by matrix-assisted laser desorption ionization mass spectrometry / Kevin M. Downard -- Probing protein interactions using hydrogen-deuterium exchange mass spectrometry / David D. Weis ... [et al.] -- Limited proteolysis mass spectrometry of protein complexes / Maria Monti and Piero Pucci -- Chemical cross-linking and mass spectrometry for investigation of protein-protein interactions / Andrea Sinz -- Genesis and application of radical probe mass spectrometry (RP-MS) to study protein interactions / Simin D. Maleknia and Kevin M. Downard. |
| Record Nr. | UNINA-9910144259003321 |
| Hoboken, N.J., : Wiley-Interscience, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Mass spectrometry of protein interactions [[electronic resource] /] / edited by Kevin M. Downard
| Mass spectrometry of protein interactions [[electronic resource] /] / edited by Kevin M. Downard |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley-Interscience, c2007 |
| Descrizione fisica | 1 online resource (153 p.) |
| Disciplina |
543.65
572.64 572/.64 |
| Altri autori (Persone) | DownardK (Kevin) |
| Collana | Wiley-Interscience series in mass spectrometry |
| Soggetto topico |
Protein-protein interactions
Mass spectrometry |
| ISBN |
1-281-00190-2
9786611001902 0-470-14633-8 0-470-14632-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Direct characterization of protein complexes by electrospray ionization mass spectrometry and ion mobility analysis / Joseph A. Loo and Catherine S. Kaddis -- Softly, softly--detection of protein complexes by matrix-assisted laser desorption ionization mass spectrometry / Kevin M. Downard -- Probing protein interactions using hydrogen-deuterium exchange mass spectrometry / David D. Weis ... [et al.] -- Limited proteolysis mass spectrometry of protein complexes / Maria Monti and Piero Pucci -- Chemical cross-linking and mass spectrometry for investigation of protein-protein interactions / Andrea Sinz -- Genesis and application of radical probe mass spectrometry (RP-MS) to study protein interactions / Simin D. Maleknia and Kevin M. Downard. |
| Record Nr. | UNINA-9910830173903321 |
| Hoboken, N.J., : Wiley-Interscience, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Pharmacology of the WNT Signaling System / / edited by Gunnar Schulte, Pawel Kozielewicz
| Pharmacology of the WNT Signaling System / / edited by Gunnar Schulte, Pawel Kozielewicz |
| Edizione | [1st ed. 2021.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2021 |
| Descrizione fisica | 1 online resource (420 pages) |
| Disciplina | 572.64 |
| Collana | Handbook of Experimental Pharmacology |
| Soggetto topico |
Pharmacology
Physiology Oncology Neurosciences Developmental biology Neuroscience Developmental Biology and Stem Cells |
| ISBN | 3-030-85499-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Pharmacological thinking in WNT signaling -- Controlling WNT Signaling Specificity and implications for targeting WNTs pharmacologically -- WNTs on exosomes -- Strategies to target LRPs in WNT signaling -- Targeting the receptor tyrosine kinase ROR1 by small molecules -- Assessing WNT binding and Frizzled activation employing genetically encoded, biophysical sensors -- Disheveled proteins as crucial mediators of WNT signaling -- Destruction complex and regulation of CTNNB1 -- Strategies to therapeutically target WNT/PCP like signaling in disease -- Mining natural compounds to target WNT signaling - from mushrooms to corals -- FZD7 as a therapeutic target in intestinal cancer -- Targeting oncogenic WNT signaling with WNT derived peptides -- Targeting WNT signaling in lung pathology -- The role of WNT signaling in osteoarthritis and the therapeutic potential of its pharmacological targeting -- WNT signaling in Alzheimers disease and other neurodegenerative disorders - opportunities for therapy? -- Targeting WNT signaling as a risk. |
| Record Nr. | UNINA-9910508448003321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Protein interactions : the molecular basis of interactomics / / edited by Volkhard Helms and Olga V. Kalinina
| Protein interactions : the molecular basis of interactomics / / edited by Volkhard Helms and Olga V. Kalinina |
| Pubbl/distr/stampa | Weinheim, Germany : , : Wiley-VCH, , [2023] |
| Descrizione fisica | 1 online resource (490 pages) |
| Disciplina | 572.64 |
| Soggetto topico |
Protein-protein interactions
Molecular biology Cell receptors |
| ISBN |
3-527-83050-2
3-527-83052-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Table of Contents -- Title Page -- Copyright -- Preface -- 1 Protein Structure and Conformational Dynamics -- 1.1 Structural and Hierarchical Aspects -- 1.2 Conformational Dynamics -- 1.3 From Structure to Function -- 1.4 Summary -- References -- 2 Protein-Protein-Binding Interfaces -- 2.1 Definition and Properties of Protein-Protein Interfaces -- 2.2 Growing Number of Known Protein-Protein Interface Structures -- 2.3 Surface Areas of Protein-Protein Interfaces -- 2.4 Gap Volume of Protein-Protein Interfaces -- 2.5 Amino Acid Composition of Interfaces -- 2.6 Secondary Structure of Interfaces -- 2.7 Protein-Protein‐Binding Energy -- 2.8 Interfaces of Homo‐ and Hetero‐Dimeric Complexes -- 2.9 Interfaces of Non‐obligate and Obligate Complexes -- 2.10 Interfaces of Transient and Permanent Complexes -- 2.11 Biological vs. Crystal Interfaces -- 2.12 Type I, Type II, and Type III Interfaces -- 2.13 Conserved Residues and Hot Spots in Interfaces -- 2.14 Conclusion and Future Implications -- References -- 3 Correlated Coevolving Mutations at Protein-Protein Interfaces -- 3.1 Introduction -- 3.2 A Short Introduction into Biomolecular Modeling -- 3.3 Statistical Inference of Coevolution -- 3.4 Solving the Inverse Potts Model -- 3.5 Contact Guided Protein and RNA Structure Prediction -- 3.6 Inter‐Monomer Interaction and Signaling -- 3.7 Summary -- References -- Note -- 4 Computational Protein-Protein Docking -- 4.1 Introduction -- 4.2 Rigid Body Protein-Protein Docking Approaches -- 4.3 Accounting for Conformational Changes during Docking -- 4.4 Integration of Bioinformatics and Experimental Data for Protein-Protein Docking -- 4.5 Template‐Based Protein-Protein Docking -- 4.6 Flexible Refinement of Docked Complexes -- 4.7 Scoring of Docked Complexes -- 4.8 Conclusions and Future Developments -- Acknowledgments -- References.
5 Identification of Putative Protein Complexes in Protein-Protein Interaction Networks -- 5.1 Protein-Protein Interaction Networks -- 5.2 Integration of Various PPI Resources in Public Data Repositories -- 5.3 Protein-Protein Interaction Networks of Model Organisms -- 5.4 Algorithms to Identify Protein Complexes in PPI Networks -- 5.5 Summary -- References -- 6 Structure, Composition, and Modeling of Protein Complexes -- 6.1 Protein Complex Structure -- 6.2 Methods for Automated Assignment of Biological Assemblies -- 6.3 Computational Approaches to Predicting 3D Structure of Protein Complexes -- 6.4 Conclusion and Outlook -- Acknowledgments -- References -- Notes -- 7 Live-Cell Structural Biology to Solve Molecular Mechanisms: Structural Dynamics in the Exocyst Function -- 7.1 Introduction -- 7.2 Structural Biology Using Light Microscopy Methods -- 7.3 Hybrid Methods: Integrative Structural Biology -- 7.4 Integrative Modeling: The Case of the Exocyst Complex -- 7.5 Comparing the In Situ Architecture of the Exocyst with a High‐Resolution Cryo‐EM Model -- 7.6 Discussion and Future Perspectives -- Acknowledgements -- References -- 8 Kinetics and Thermodynamics of Protein-Protein Encounter -- 8.1 Introduction -- 8.2 Thermodynamic Ensembles and Free Energy -- 8.3 Overview of Computational Methods to Determine Binding Free Energies -- References -- 9 Markov State Models of Protein-Protein Encounters -- 9.1 Introduction -- 9.2 Molecular Dynamics and Markov State Models -- 9.3 Strategies for MSM Estimation, Validation, and Analysis -- 9.4 The Connection to Experiments -- 9.5 Protein-Protein and Protein-Peptide Encounters -- 9.6 Emerging Technologies -- Acknowledgments -- References -- 10 Transcription Factor - DNA Complexes -- 10.1 Introduction -- 10.2 Principles of Sequence Recognition -- 10.3 Dimerization of Eukaryotic TFs. 10.4 Detection of Epigenetic Modifications -- 10.5 Detection of DNA Curvature/Bending -- 10.6 Modifications of Transcription Factors -- 10.7 Transcription Factor Binding Sites -- 10.8 Experimental Detection of TFBS -- 10.9 Position‐Specific Scoring Matrices -- 10.10 Molecular Modeling of TF-DNA Complexes -- 10.11 Cis‐Regulatory Modules -- 10.12 Relating Gene Expression to Binding of Transcription Factors -- 10.13 Summary -- References -- 11 The Chromatin Interaction System -- 11.1 Chromatin Is a Special Interaction Platform -- 11.2 Interaction of Proteins with Histone Posttranslational Modifications -- 11.3 Interaction of Proteins with Modified Nucleic Acids -- 11.4 UHRF1 as an Example of a Multidomain Reader/Writer Protein of Histone and DNA Modifications -- 11.5 Histone Chaperones and Chromatin Remodeling Complexes -- 11.6 Challenges in Chromatin Interactomics -- References -- 12 RNA-Protein Interactomics -- 12.1 Introduction -- 12.2 Interactions of Proteins with mRNA and ncRNA -- 12.3 The Basic Toolbox -- 12.4 RNA-Protein Interactomics -- 12.5 Outlook -- Notes -- References -- 13 Interaction Between Proteins and Biological Membranes -- 13.1 Introduction -- 13.2 The Plasma Membrane: Overview of Its Structure, Composition, and Function -- 13.3 Lipid‐Based and Protein‐Based Sorting of Plasma Membrane Components -- 13.4 Interaction of Peripheral Membrane Proteins with Membrane Lipids -- 13.5 Interactions and Conformations of Transmembrane Proteins in Lipid Membranes -- 13.6 Summary -- Acknowledgment -- References -- 14 Interactions of Proteins with Small Molecules, Allosteric Effects -- 14.1 Introduction -- 14.2 Modes of Binding to Proteins -- 14.3 Types of Interaction Between Protein and Ligand -- 14.4 Modeling Intermolecular Interactions by Force Fields and Docking Simulations -- 14.5 Entropic Aspects. 14.6 Allosteric Effects: Conformational Changes Upon Ligand Binding -- 14.7 Aspects of Ligand Design Beyond Protein-Ligand Interactions -- 14.8 Conclusions -- References -- 15 Effects of Mutations in Proteins on Their Interactions -- 15.1 Introduction -- 15.2 Structural Annotation of Mutations in Proteins -- 15.3 Methods for Predicting Effect of Protein Mutations -- 15.4 Conclusion -- Acknowledgments -- References -- 16 Not Quite the Same: How Alternative Splicing Affects Protein Interactions -- 16.1 Introduction -- 16.2 Effects of Alternative Splicing on Individual Proteins -- 16.3 Effects of Alternative Splicing on Protein-Protein Interaction Networks -- 16.4 Conclusion and Future Work -- References -- Notes -- 17 Phosphorylation-Based Molecular Switches -- 17.1 Introduction -- 17.2 Reversible Protein Phosphorylation in Cellular Signaling: Writers, Readers, and Erasers -- 17.3 Protein Kinases as Molecular Switches and as Components of Signaling Cascades -- 17.4 Mechanisms of Phosphorylation Specificity: the Importance of Short Linear Motifs -- 17.5 Examples of Phospho‐Switch‐Based Biological Regulation -- 17.6 Conclusion -- Acknowledgments -- References -- 18 Summary and Outlook -- 18.1 Technical State of the Art -- 18.2 Role of Machine Learning -- 18.3 Challenges -- 18.4 What Picture(s) May Evolve? -- References -- Index -- End User License Agreement. |
| Record Nr. | UNINA-9910686761803321 |
| Weinheim, Germany : , : Wiley-VCH, , [2023] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Protein Interactions / / edited by Jianfeng Cai, Rongsheng Wang
| Protein Interactions / / edited by Jianfeng Cai, Rongsheng Wang |
| Pubbl/distr/stampa | Rijeka, Croatia : , : InTech, , [2012] |
| Descrizione fisica | 1 online resource (vii, 464 pages) : illustrations |
| Disciplina | 572.64 |
| Soggetto topico | Protein-protein interactions |
| ISBN | 953-51-5242-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910137691303321 |
| Rijeka, Croatia : , : InTech, , [2012] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Protein-Protein and Domain-Domain Interactions / / by Pandjassarame Kangueane, Christina Nilofer
| Protein-Protein and Domain-Domain Interactions / / by Pandjassarame Kangueane, Christina Nilofer |
| Autore | Kangueane Pandjassarame |
| Edizione | [1st ed. 2018.] |
| Pubbl/distr/stampa | Singapore : , : Springer Singapore : , : Imprint : Springer, , 2018 |
| Descrizione fisica | 1 online resource (216 pages) : illustrations |
| Disciplina | 572.64 |
| Soggetto topico |
Medical genetics
Bioinformatics Proteins Vaccines Gene Function Computational Biology/Bioinformatics Protein Science Vaccine |
| ISBN | 981-10-7347-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Module 1. Preface -- Module 2. Introduction to protein complexes -- Module 3. Historical advancement -- Module 4. Databases for protein complexes -- Module 5. Types of protein complexes -- Module 6. Hetero dimer protein complexes -- Module 7. Homo dimer protein complexes -- Module 8. Multimer protein complexes -- Module 9. Interfaces in protein complexes -- Module 10. Principles of protein-protein binding -- Module 11. Homodimer folding and binding -- Module 12. Gene fusion and protein complexes -- Module 13. Domain-domain interactions -- Module 14. Protein docking: Methods, software tools and servers -- Module 15. Protein complexes, pathways and networks -- Module 16. Protein complexes and biological functions -- Module 17. Protein complexes in diseases -- Module 18. Protein complexes in drug discovery & vaccine development -- Module 19. Protein complexes in genome and proteome analysis -- Module 20. Conclusions & challenges. |
| Record Nr. | UNINA-9910298416703321 |
Kangueane Pandjassarame
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| Singapore : , : Springer Singapore : , : Imprint : Springer, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Protein-protein complexes [[electronic resource] ] : analysis, modeling and drug design / / edited by Martin Zacharias
| Protein-protein complexes [[electronic resource] ] : analysis, modeling and drug design / / edited by Martin Zacharias |
| Pubbl/distr/stampa | London, : Imperial College Press, 2010 |
| Descrizione fisica | 1 online resource (400 p.) |
| Disciplina |
572.6
572.64 |
| Altri autori (Persone) | ZachariasMartin |
| Soggetto topico |
Protein-protein interactions
Protein-protein interactions - Computer simulation Protein-protein interactions - Mathematical models Proteins - Structure Drugs - Design |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-282-75984-1
9786612759840 1-84816-340-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910456211303321 |
| London, : Imperial College Press, 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Protein-protein complexes [[electronic resource] ] : analysis, modeling and drug design / / edited by Martin Zacharias
| Protein-protein complexes [[electronic resource] ] : analysis, modeling and drug design / / edited by Martin Zacharias |
| Pubbl/distr/stampa | London, : Imperial College Press, 2010 |
| Descrizione fisica | 1 online resource (400 p.) |
| Disciplina |
572.6
572.64 |
| Altri autori (Persone) | ZachariasMartin |
| Soggetto topico |
Protein-protein interactions
Protein-protein interactions - Computer simulation Protein-protein interactions - Mathematical models Proteins - Structure Drugs - Design |
| ISBN |
1-282-75984-1
9786612759840 1-84816-340-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910780878003321 |
| London, : Imperial College Press, 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Protein-protein interaction assays / / Mahmood-ur-Rahman Ansari, editor
| Protein-protein interaction assays / / Mahmood-ur-Rahman Ansari, editor |
| Pubbl/distr/stampa | [Place of publication not identified] : , : IntechOpen, , [2018] |
| Descrizione fisica | 1 online resource (90 pages) : illustrations |
| Disciplina | 572.64 |
| Soggetto topico | Protein-protein interactions |
| ISBN |
1-83881-608-9
1-78923-391-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910317805403321 |
| [Place of publication not identified] : , : IntechOpen, , [2018] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||