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Cholesterol Modulation of Protein Function : Sterol Specificity and Indirect Mechanisms / / edited by Avia Rosenhouse-Dantsker, Anna N. Bukiya
| Cholesterol Modulation of Protein Function : Sterol Specificity and Indirect Mechanisms / / edited by Avia Rosenhouse-Dantsker, Anna N. Bukiya |
| Edizione | [1st ed. 2019.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 |
| Descrizione fisica | 1 online resource (200 pages) |
| Disciplina |
612.0153
572.5795 |
| Collana | Advances in Experimental Medicine and Biology |
| Soggetto topico |
Proteomics
Proteins Cell membranes Molecular biology Protein Science Membrane Biology Molecular Medicine |
| ISBN | 3-030-04278-2 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Part 1. Sterol specificity in modulating protein function: 1. Chirality effect on cholesterol modulation of protein function -- 2. A critical analysis of molecular mechanisms underlying membrane cholesterol sensitivity of GPCRs -- 3. Regulation of BK channel activity by cholesterol and its derivatives -- 4. Chiral specificity of cholesterol orientation within cholesterol binding sites in inwardly rectifying potassium channels -- Part 2. Indirect modulation of protein function by cholesterol: 5. Cholesterol effect on the physical properties of lipid membranes -- 6. Effect of cholesterol on the dipole potential of lipid membranes -- 7. Mass spectroscopy imaging of cholesterol -- 8. Cholesterol-dependent gating effects on ion channels. |
| Record Nr. | UNINA-9910337949603321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cholesterol Regulation of Ion Channels and Receptors [[electronic resource]]
| Cholesterol Regulation of Ion Channels and Receptors [[electronic resource]] |
| Autore | Levitan Irena |
| Pubbl/distr/stampa | Hoboken, : Wiley, 2012 |
| Descrizione fisica | 1 online resource (324 p.) |
| Disciplina |
572.5795
612.1/2 612.12 |
| Altri autori (Persone) | BarrantesFrancisco |
| Soggetto topico |
Cholesterol - metabolism
Cholesterol -- metabolism Ion Channels - metabolism Ion Channels -- metabolism Membrane Proteins - metabolism Membrane Proteins -- metabolism Cholesterol - Metabolism Ion channels - Metabolism Membrane proteins - Metabolism Proteins Membrane Glycoproteins Sterols Membrane Transport Proteins Metabolic Phenomena Cholestenes Amino Acids, Peptides, and Proteins Carrier Proteins Cholestanes Membrane Lipids Lipids Steroids Drugs Polycyclic Compounds Cholesterol Ion Channels Metabolism Membrane Proteins Human Anatomy & Physiology Health & Biological Sciences Animal Biochemistry |
| ISBN |
1-280-87984-X
9786613721150 1-118-34230-5 1-118-34231-3 1-118-34228-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
CHOLESTEROL REGULATION OF ION CHANNELS AND RECEPTORS; CONTENTS; FOREWORD; PREFACE; CONTRIBUTORS; I CHOLESTEROL REGULATION OF MEMBRANE PROPERTIES; 1 CHOLESTEROL TRAFFICKING AND DISTRIBUTION BETWEEN CELLULAR MEMBRANES; 1.1 CHOLESTEROL-AN ESSENTIAL LIPID FOR NORMAL CELL FUNCTION; 1.2 CHOLESTEROL METABOLISM, SENSING, AND DISTRIBUTION BETWEEN CELLULAR MEMBRANES; 1.3 HOW DOES CHOLESTEROL ENTER MAMMALIAN CELLS?; 1.4 VESICULAR CHOLESTEROL TRAFFICKING ALONG THE ENDOCYTIC AND SECRETORY PATHWAY; 1.5 NONVESICULAR CHOLESTEROL TRANSPORT; 1.6 CHOLESTEROL EFFLUX FROM CELLS; REFERENCES
2 CHOLESTEROL REGULATION OF MEMBRANE PROTEIN FUNCTION BY CHANGES IN BILAYER PHYSICAL PROPERTIES-AN ENERGETIC PERSPECTIVE2.1 INTRODUCTION; 2.2 CHOLESTEROL REGULATION OF MEMBRANE PROTEINS: POSSIBLE MECHANISMS; 2.3 PROTEIN REGULATION BY CHOLESTEROL-INDUCED CHANGES IN BILAYER PHYSICAL PROPERTIES; 2.4 CHOLESTEROL-INDUCED CHANGES IN DGIII bilayer - QUANTITATIVE ESTIMATES; 2.5 METHODS FOR IDENTIFYING PROTEIN REGULATION BY CHANGES IN BILAYER PHYSICAL PROPERTIES; 2.6 CHOLESTEROL REGULATION OF MEMBRANE PROTEINS IN LIVING CELLS 2.7 PHYSIOLOGICAL ROLE OF CHOLESTEROL-INDUCED CHANGES IN BILAYER PHYSICAL PROPERTIES2.8 CONCLUSION; REFERENCES; II CHOLESTEROL REGULATION OF ION CHANNELS; 3 INSIGHTS INTO STRUCTURAL DETERMINANTS OF CHOLESTEROL SENSITIVITY OF KIR CHANNELS; 3.1 INTRODUCTION; 3.2 CHOLESTEROL SUPPRESSES Kir2 ACTIVITY IN VITRO AND IN VIVO; 3.3 EVIDENCE FOR SPECIFIC STEROL-PROTEIN INTERACTIONS IN THE REGULATION OF Kir CHANNELS; 3.4 STRUCTURAL DETERMINANTS OF CHOLESTEROL SENSITIVITY OF Kir2 CHANNELS; 3.5 PHYSIOLOGICAL IMPACT OF CHOLESTEROL-INDUCED SUPPRESSION OF KIR2 CHANNELS 3.6 CONCLUDING REMARKS AND FUTURE DIRECTIONSACKNOWLEDGMENTS; REFERENCES; 4 ROLE OF LIPID RAFTS IN THE REGULATION OF STORE-OPERATED CA2+ CHANNELS; 4.1 INTRODUCTION; 4.2 MOLECULAR COMPONENTS OF SOCE; 4.3 LIPID RAFT DOMAINS AND CAVEOLAE; 4.4 THE ROLE OF LIPID RAFT DOMAINS IN THE REGULATION OF TRPC1; 4.5 MOLECULAR COMPLEXITY IN THE REGULATION OF SOCE; 4.6 CONCLUSIONS; REFERENCES; 5 CHOLESTEROL REGULATION OF CARDIAC ION CHANNELS; 5.1 INTRODUCTION; 5.2 EFFECT OF CHOLESTEROL ON CARDIAC EXCITABILITY; 5.3 MECHANISMS OF CHOLESTEROL EFFECTS ON ION CHANNELS 5.4 CHOLESTEROL AS A TARGET FOR THERAPEUTIC AGENTSREFERENCES; 6 DIFFERENTIAL CONTRIBUTION OF BK SUBUNITS TO NONGENOMIC REGULATION OF CHANNEL FUNCTION BY STEROIDS; 6.1 BK CHANNELS AND STEROIDS; 6.2 CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; 7 REGULATION OF K+ CHANNELS BY CHOLESTEROL-RICH MEMBRANE DOMAINS IN THE IMMUNE SYSTEM; 7.1 POTASSIUM CHANNELS IN THE IMMUNE SYSTEM; 7.2 REGULATION OF POTASSIUM CHANNELS BY MEMBRANE CHOLESTEROL AND LIPID RAFT MICRODOMAINS; 7.3 LOCALIZATION OF MAJOR VOLTAGE-DEPENDENT Kv1.3 AND Kv1.5 CHANNELS IN CHOLESTEROL-RICH MEMBRANE MICRODOMAINS IN LEUKOCYTES 7.4 MECHANISMS OF ION CHANNEL REGULATION: THE IMMUNOLOGICAL SYNAPSE |
| Record Nr. | UNINA-9910141264403321 |
Levitan Irena
|
||
| Hoboken, : Wiley, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cholesterol Regulation of Ion Channels and Receptors
| Cholesterol Regulation of Ion Channels and Receptors |
| Autore | Levitan Irena |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, : Wiley, 2012 |
| Descrizione fisica | 1 online resource (324 p.) |
| Disciplina |
572.5795
612.1/2 612.12 |
| Altri autori (Persone) | BarrantesFrancisco |
| Soggetto topico |
Cholesterol - metabolism
Cholesterol -- metabolism Ion Channels - metabolism Ion Channels -- metabolism Membrane Proteins - metabolism Membrane Proteins -- metabolism Cholesterol - Metabolism Ion channels - Metabolism Membrane proteins - Metabolism Proteins Membrane Glycoproteins Sterols Membrane Transport Proteins Metabolic Phenomena Cholestenes Amino Acids, Peptides, and Proteins Carrier Proteins Cholestanes Membrane Lipids Lipids Steroids Drugs Polycyclic Compounds Cholesterol Ion Channels Metabolism Membrane Proteins Human Anatomy & Physiology Health & Biological Sciences Animal Biochemistry |
| ISBN |
1-280-87984-X
9786613721150 1-118-34230-5 1-118-34231-3 1-118-34228-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
CHOLESTEROL REGULATION OF ION CHANNELS AND RECEPTORS; CONTENTS; FOREWORD; PREFACE; CONTRIBUTORS; I CHOLESTEROL REGULATION OF MEMBRANE PROPERTIES; 1 CHOLESTEROL TRAFFICKING AND DISTRIBUTION BETWEEN CELLULAR MEMBRANES; 1.1 CHOLESTEROL-AN ESSENTIAL LIPID FOR NORMAL CELL FUNCTION; 1.2 CHOLESTEROL METABOLISM, SENSING, AND DISTRIBUTION BETWEEN CELLULAR MEMBRANES; 1.3 HOW DOES CHOLESTEROL ENTER MAMMALIAN CELLS?; 1.4 VESICULAR CHOLESTEROL TRAFFICKING ALONG THE ENDOCYTIC AND SECRETORY PATHWAY; 1.5 NONVESICULAR CHOLESTEROL TRANSPORT; 1.6 CHOLESTEROL EFFLUX FROM CELLS; REFERENCES
2 CHOLESTEROL REGULATION OF MEMBRANE PROTEIN FUNCTION BY CHANGES IN BILAYER PHYSICAL PROPERTIES-AN ENERGETIC PERSPECTIVE2.1 INTRODUCTION; 2.2 CHOLESTEROL REGULATION OF MEMBRANE PROTEINS: POSSIBLE MECHANISMS; 2.3 PROTEIN REGULATION BY CHOLESTEROL-INDUCED CHANGES IN BILAYER PHYSICAL PROPERTIES; 2.4 CHOLESTEROL-INDUCED CHANGES IN DGIII bilayer - QUANTITATIVE ESTIMATES; 2.5 METHODS FOR IDENTIFYING PROTEIN REGULATION BY CHANGES IN BILAYER PHYSICAL PROPERTIES; 2.6 CHOLESTEROL REGULATION OF MEMBRANE PROTEINS IN LIVING CELLS 2.7 PHYSIOLOGICAL ROLE OF CHOLESTEROL-INDUCED CHANGES IN BILAYER PHYSICAL PROPERTIES2.8 CONCLUSION; REFERENCES; II CHOLESTEROL REGULATION OF ION CHANNELS; 3 INSIGHTS INTO STRUCTURAL DETERMINANTS OF CHOLESTEROL SENSITIVITY OF KIR CHANNELS; 3.1 INTRODUCTION; 3.2 CHOLESTEROL SUPPRESSES Kir2 ACTIVITY IN VITRO AND IN VIVO; 3.3 EVIDENCE FOR SPECIFIC STEROL-PROTEIN INTERACTIONS IN THE REGULATION OF Kir CHANNELS; 3.4 STRUCTURAL DETERMINANTS OF CHOLESTEROL SENSITIVITY OF Kir2 CHANNELS; 3.5 PHYSIOLOGICAL IMPACT OF CHOLESTEROL-INDUCED SUPPRESSION OF KIR2 CHANNELS 3.6 CONCLUDING REMARKS AND FUTURE DIRECTIONSACKNOWLEDGMENTS; REFERENCES; 4 ROLE OF LIPID RAFTS IN THE REGULATION OF STORE-OPERATED CA2+ CHANNELS; 4.1 INTRODUCTION; 4.2 MOLECULAR COMPONENTS OF SOCE; 4.3 LIPID RAFT DOMAINS AND CAVEOLAE; 4.4 THE ROLE OF LIPID RAFT DOMAINS IN THE REGULATION OF TRPC1; 4.5 MOLECULAR COMPLEXITY IN THE REGULATION OF SOCE; 4.6 CONCLUSIONS; REFERENCES; 5 CHOLESTEROL REGULATION OF CARDIAC ION CHANNELS; 5.1 INTRODUCTION; 5.2 EFFECT OF CHOLESTEROL ON CARDIAC EXCITABILITY; 5.3 MECHANISMS OF CHOLESTEROL EFFECTS ON ION CHANNELS 5.4 CHOLESTEROL AS A TARGET FOR THERAPEUTIC AGENTSREFERENCES; 6 DIFFERENTIAL CONTRIBUTION OF BK SUBUNITS TO NONGENOMIC REGULATION OF CHANNEL FUNCTION BY STEROIDS; 6.1 BK CHANNELS AND STEROIDS; 6.2 CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; 7 REGULATION OF K+ CHANNELS BY CHOLESTEROL-RICH MEMBRANE DOMAINS IN THE IMMUNE SYSTEM; 7.1 POTASSIUM CHANNELS IN THE IMMUNE SYSTEM; 7.2 REGULATION OF POTASSIUM CHANNELS BY MEMBRANE CHOLESTEROL AND LIPID RAFT MICRODOMAINS; 7.3 LOCALIZATION OF MAJOR VOLTAGE-DEPENDENT Kv1.3 AND Kv1.5 CHANNELS IN CHOLESTEROL-RICH MEMBRANE MICRODOMAINS IN LEUKOCYTES 7.4 MECHANISMS OF ION CHANNEL REGULATION: THE IMMUNOLOGICAL SYNAPSE |
| Record Nr. | UNINA-9910823465003321 |
|
Levitan Irena
|
||
| Hoboken, : Wiley, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cholesterol Transporters of the START Domain Protein Family in Health and Disease : START Proteins - Structure and Function / / edited by Barbara J. Clark, Douglas M. Stocco
| Cholesterol Transporters of the START Domain Protein Family in Health and Disease : START Proteins - Structure and Function / / edited by Barbara J. Clark, Douglas M. Stocco |
| Edizione | [1st ed. 2014.] |
| Pubbl/distr/stampa | New York, NY : , : Springer New York : , : Imprint : Springer, , 2014 |
| Descrizione fisica | 1 online resource (197 p.) |
| Disciplina |
572.5795
572.6 610 616.4 |
| Soggetto topico |
Endocrinology
Proteins Medicine Endocrinology Protein Science Biomedicine, general |
| ISBN | 1-4939-1112-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | An Introduction to the Steroidogenic Acute Regulatory Protein (StAR)-related Lipid Transfer Domain Protein Family -- The Steroidogenic Acute Regulatory Protein (StAR) -- START domain protein structure and ligand specificity -- Congenital Lipoid Adrenal Hyperplasia -- Steroidogenic Acute Regulatory protein (StAR) and Atherogenesis -- STARD3: a lipid transfer protein in breast cancer and cholesterol trafficking -- The STARD4 subfamily: STARD4 and STARD5 in cholesterol metabolism -- START proteins in non-vesicular cholesterol transport -- Index. |
| Record Nr. | UNINA-9910298350803321 |
| New York, NY : , : Springer New York : , : Imprint : Springer, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Direct Mechanisms in Cholesterol Modulation of Protein Function / / edited by Avia Rosenhouse-Dantsker, Anna N. Bukiya
| Direct Mechanisms in Cholesterol Modulation of Protein Function / / edited by Avia Rosenhouse-Dantsker, Anna N. Bukiya |
| Edizione | [1st ed. 2019.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 |
| Descrizione fisica | 1 online resource (179 pages) |
| Disciplina |
612.0153
572.5795 |
| Collana | Advances in Experimental Medicine and Biology |
| Soggetto topico |
Proteomics
Proteins Cell membranes Molecular biology Protein Science Membrane Biology Molecular Medicine |
| ISBN | 3-030-14265-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Introduction -- Direct binding of cholesterol to proteins -- Cholesterol-recognition motifs in membrane proteins -- Molecular determinants of cholesterol binding to proteins: overview of crystallographic studies -- Crystallographic studies of steroid-protein interactions -- Insights into cholesterol binding sites in proteins from computational studies -- Cholesterol binding to NPC1/NPC2 -- I Biophysical elements of the interaction between cholesterol and the nicotinic acetylcholine receptor -- Modulation of TRPV1 channels by cholesterol -- Cholesterol binding sites in inwardly rectifying potassium channels. |
| Record Nr. | UNINA-9910337938403321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||