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Biblioteca

MARC Lista (tabellare)
Domino and intramolecular rearrangement reactions as advanced synthetic methods in glycoscience / / edited by Zbigniew J. Witczak, Roman Bielski
Domino and intramolecular rearrangement reactions as advanced synthetic methods in glycoscience / / edited by Zbigniew J. Witczak, Roman Bielski
Pubbl/distr/stampa Hoboken, New Jersey : , : Wiley, , 2016
Descrizione fisica 1 online resource (374 p.)
Disciplina 572.567
Collana THEi Wiley ebooks
Soggetto topico Glycosides - Physiological effect
Glycosides - Analysis
ISBN 1-119-04439-1
1-119-04423-5
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910137498903321
Hoboken, New Jersey : , : Wiley, , 2016
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Domino and intramolecular rearrangement reactions as advanced synthetic methods in glycoscience / / edited by Zbigniew J. Witczak, Roman Bielski
Domino and intramolecular rearrangement reactions as advanced synthetic methods in glycoscience / / edited by Zbigniew J. Witczak, Roman Bielski
Pubbl/distr/stampa Hoboken, New Jersey : , : Wiley, , 2016
Descrizione fisica 1 online resource (374 pages)
Disciplina 572.567
Collana THEi Wiley ebooks.
Soggetto topico Glycosides - Physiological effect
Glycosides - Analysis
ISBN 1-119-04439-1
1-119-04423-5
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910826108803321
Hoboken, New Jersey : , : Wiley, , 2016
Materiale a stampa
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Enzymes involved in glycolysis, fatty acid and amino acid biosynthesis : active site mechanisms and inhibition / / authored by Marco Brito-Arias
Enzymes involved in glycolysis, fatty acid and amino acid biosynthesis : active site mechanisms and inhibition / / authored by Marco Brito-Arias
Autore Brito Arias Marco Augusto
Pubbl/distr/stampa Singapore : , : Bentham Science Publishers Pte Ltd., , [2020]
Descrizione fisica 1 online resource (334 pages)
Disciplina 572.567
Soggetto topico Glycolysis
Amino acids
Enzymes - Synthesis
Soggetto genere / forma Electronic books.
ISBN 981-14-6090-6
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910494645403321
Brito Arias Marco Augusto  
Singapore : , : Bentham Science Publishers Pte Ltd., , [2020]
Materiale a stampa
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Enzymes involved in glycolysis, fatty acid and amino acid biosynthesis : active site mechanisms and inhibition / / authored by Marco Brito-Arias
Enzymes involved in glycolysis, fatty acid and amino acid biosynthesis : active site mechanisms and inhibition / / authored by Marco Brito-Arias
Autore Brito Arias Marco Augusto
Pubbl/distr/stampa Singapore : , : Bentham Science Publishers Pte Ltd., , [2020]
Descrizione fisica 1 online resource (334 pages)
Disciplina 572.567
Soggetto topico Glycolysis
Amino acids
Enzymes - Synthesis
ISBN 981-14-6090-6
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910794337203321
Brito Arias Marco Augusto  
Singapore : , : Bentham Science Publishers Pte Ltd., , [2020]
Materiale a stampa
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Enzymes involved in glycolysis, fatty acid and amino acid biosynthesis : active site mechanisms and inhibition / / authored by Marco Brito-Arias
Enzymes involved in glycolysis, fatty acid and amino acid biosynthesis : active site mechanisms and inhibition / / authored by Marco Brito-Arias
Autore Brito Arias Marco Augusto
Pubbl/distr/stampa Singapore : , : Bentham Science Publishers Pte Ltd., , [2020]
Descrizione fisica 1 online resource (334 pages)
Disciplina 572.567
Soggetto topico Glycolysis
Amino acids
Enzymes - Synthesis
ISBN 981-14-6090-6
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910807164303321
Brito Arias Marco Augusto  
Singapore : , : Bentham Science Publishers Pte Ltd., , [2020]
Materiale a stampa
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Experimental glycoscience Glycobiology [[electronic resource] /] / N. Taniguchi ... [et al.] (eds.)
Experimental glycoscience Glycobiology [[electronic resource] /] / N. Taniguchi ... [et al.] (eds.)
Edizione [1st ed. 2008.]
Pubbl/distr/stampa [Tokyo] ; ; London, : Springer, c2008
Descrizione fisica 1 online resource (515 p.)
Disciplina 572.565
572.567
Soggetto topico Glycoconjugates
Glycosylation
Soggetto genere / forma Electronic books.
ISBN 1-282-03687-4
9786612036873
4-431-77922-1
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Glycosyltransferase Genes -- Functional Analyses of Sugar Chains -- Glycosyltransferase Gene KO Mice -- Infrastructures and Research Resources.
Record Nr. UNINA-9910454570903321
[Tokyo] ; ; London, : Springer, c2008
Materiale a stampa
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Experimental glycoscience Glycobiology [[electronic resource] /] / N. Taniguchi ... [et al.] (eds.)
Experimental glycoscience Glycobiology [[electronic resource] /] / N. Taniguchi ... [et al.] (eds.)
Edizione [1st ed. 2008.]
Pubbl/distr/stampa [Tokyo] ; ; London, : Springer, c2008
Descrizione fisica 1 online resource (515 p.)
Disciplina 572.565
572.567
Soggetto topico Glycoconjugates
Glycosylation
ISBN 1-282-03687-4
9786612036873
4-431-77922-1
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Glycosyltransferase Genes -- Functional Analyses of Sugar Chains -- Glycosyltransferase Gene KO Mice -- Infrastructures and Research Resources.
Record Nr. UNINA-9910782702603321
[Tokyo] ; ; London, : Springer, c2008
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Experimental glycoscience Glycobiology [[electronic resource] /] / N. Taniguchi ... [et al.] (eds.)
Experimental glycoscience Glycobiology [[electronic resource] /] / N. Taniguchi ... [et al.] (eds.)
Edizione [1st ed. 2008.]
Pubbl/distr/stampa [Tokyo] ; ; London, : Springer, c2008
Descrizione fisica 1 online resource (515 p.)
Disciplina 572.565
572.567
Soggetto topico Glycoconjugates
Glycosylation
ISBN 1-282-03687-4
9786612036873
4-431-77922-1
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Glycosyltransferase Genes -- Functional Analyses of Sugar Chains -- Glycosyltransferase Gene KO Mice -- Infrastructures and Research Resources.
Record Nr. UNINA-9910828325703321
[Tokyo] ; ; London, : Springer, c2008
Materiale a stampa
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Glycobiology of the nervous system / / edited by Cara-Lynne Schengrund and Robert K. Yu
Glycobiology of the nervous system / / edited by Cara-Lynne Schengrund and Robert K. Yu
Edizione [Second edition.]
Pubbl/distr/stampa Cham, Switzerland : , : Springer, , [2023]
Descrizione fisica 1 online resource (506 pages)
Disciplina 572.567
Collana Advances in Neurobiology
Soggetto topico Glycoconjugates
Neurobiology
ISBN 3-031-12390-5
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Intro -- Preface -- Postscript: In Memoriam -- Contents -- Chapter 1: Introduction to the Complexity of Cell Surface and Tissue Matrix Glycoconjugates -- 1 Introduction -- 2 Monosaccharides: Building Blocks of Glycans -- 3 Formation of Oligosaccharides -- 4 Classification of Glycans -- 5 Structural Features of N-Glycans -- 6 Structural Features of O-Glycans -- 7 Biosynthesis of N- and O-Glycans -- 8 Glycosphingolipids -- 9 Structural Features of the Glycan Moieties of Glycosphingolipids -- 10 Synthesis and Functions of the Glycan Moieties of Glycolipids -- 11 Glycosylphosphatidylinositol Anchors: A Special Group of Glycolipids -- 12 Glycosaminoglycans and Proteoglycans -- 13 Glycan-Protein Interactions -- 14 Glycans of Cell Surface Glycoconjugates Perform a Variety of Functions -- 15 Summary -- References -- Chapter 2: Cells of the Central Nervous System: An Overview of Their Structure and Function -- 1 Introduction -- 2 Neurons -- 2.1 Neuronal Cell Body -- 2.2 Cytoskeleton -- 2.3 Dendrites -- 2.4 Axon -- 2.5 Synapse -- 3 Supporting Cells -- 3.1 Astrocytes -- 3.2 Oligodendrocytes -- 3.3 Microglia -- 3.4 NG2 Cells (Polydendrocytes) -- 3.5 Ependymal Cells -- 4 Extracellular Matrix -- 5 Concluding Remarks -- References -- Chapter 3: Synthesis, Processing, and Function of N-Glycans in N-Glycoproteins -- 1 Introduction -- 2 N-glycans Are First Born on a Lipid and Then Transferred "En Bloc" onto the Nascent N-glycoprotein in the ER -- 3 Trimming, Reglycosylation, and Remodeling: There Are Many Ways of N-glycoprotein Processing in the ER and Golgi -- 4 The Essential Toolbox of a Glycobiologist: A Brief History of the Discovery of N-glycoprotein Biosynthesis Inhibitors and Their Impact on Our Understanding of N-glycan Processing.
5 Sweetening the Bond or Sugar-Coating Bad News: Recent Advances in the Role of N-glycans for Virus Infections and Immune Responses -- 6 Sweet Encounters of Glycoproteins and Glycolipids: N-glycans Affect the Subcellular Distribution and Complex Formation of Enzymes in Glycolipid Biosynthesis -- 7 Conclusions and Epilogue: The Tale of the Tail That Wags the Dog -- References -- Chapter 4: Synthesis of O-Linked Glycoconjugates in the Nervous System -- 1 Introduction -- 2 Biosynthesis of O-Linked Proteins -- 2.1 O-GalNAcylation -- 2.2 O-Mannosylation -- 2.3 O-GlcNAcylation -- 2.4 O-Xylosylation -- 2.5 O-Fucosylation -- 2.6 O-Glucosylation -- 3 Biosynthesis of O-Linked Lipids -- 3.1 Glucosylceramide and Glycosphingolipids -- 3.2 Galactosylceramide and Glycosphingolipids -- 3.3 GlcCer and GM3 Synthase Deficiency in Human and Mouse -- 3.4 Other O-Linked Lipids - New Glucose-Related Lipids -- 4 Conclusions -- References -- Chapter 5: Chemistry and Function of Glycosaminoglycans in the Nervous System -- 1 Introduction -- 2 Glycosaminoglycan Structure and Chemistry -- 2.1 Chondroitin Sulfate (CS) -- 2.1.1 Structure and Chemistry -- 2.1.2 Synthesis and Modification of CS Chains -- 2.1.3 CS Proteoglycans (CSPGs) in Brain -- 2.2 Dermatan Sulfate (DS) -- 2.3 Heparin -- 2.4 Heparan Sulfate (HS) -- 2.4.1 Structure and Chemistry -- 2.4.2 Synthesis and Modification of HS Chains -- 2.4.3 Heparan Sulfate Proteoglycans (HSPGs) in Brain -- 2.5 Keratan Sulfate (KS) -- 2.6 Hyaluronan (HA) -- 3 Function of GAGs in the Brain -- 3.1 GAG Interactions and Binding Partners -- 3.2 GAG Functions During Brain Development -- 3.2.1 Neural System Development and Lineage Specification -- 3.2.2 Brain Patterning -- 3.2.3 Neurite Outgrowth, Axonal Pathfinding and Migration -- 3.2.4 Differentiation and Stem-Cell Niche -- 3.2.5 Synaptic Plasticity.
3.3 GAG Function in CNS-Associated Disorders and Injury -- 3.3.1 Injury Response -- 3.3.2 Neurological Disorders -- 3.3.3 Inflammation -- 3.3.4 Tumorigenesis -- 4 Concluding Remarks -- References -- Chapter 6: Structural Analysis of Oligosaccharides and Glycoconjugates Using NMR -- 1 Introduction -- 2 Basic NMR Phenomena -- 3 Chemical Shifts as Structural Probes -- 4 Through "BOND" and Through "SPACE" Interactions -- 5 Relaxation and Molecular Motion -- 6 Paramagnetic Effects as Sources of Long-Distance Information -- 7 Chemical Exchange: Dynamic Aspects in NMR -- 8 NMR Tools for Intermolecular Interaction Analysis -- 8.1 Oligosaccharide-Protein Interactions -- 8.2 Protein Binding to Glycolipid Clusters -- 9 Liaisons Between NMR and Computation -- References -- Chapter 7: Glycans and Carbohydrate-Binding/Transforming Proteins in Axon Physiology -- 1 Introduction -- 2 Axon Determination/Early Neuronal Differentiation -- 3 Axon Guidance -- 3.1 Axon Guidance by Glycosylated Cell Adhesion Molecules (CAMs) -- 3.2 Glycosaminoglycans in Axon Guidance -- 3.3 Galectins and Their Interactions with Guidance Cues in the Adult Olfactory System -- 4 Axon/Glia Interactions -- 5 Nerve Impulse Generation/Transmission -- 5.1 Voltage-Gated Ion Channels -- 5.2 Voltage-Gated Sodium Channels -- 5.3 Voltage-Gated Potassium Channels -- 5.4 Voltage-Gated Calcium Channels -- 5.5 O-Linked β-N-Acetylglucosaminylation of AIS Proteins -- 6 Axon Regeneration -- 7 New Perspective in CNS Regulation Through Glycan-Lectin Interactions in the Microbiota-Gut-Brain Axis -- References -- Chapter 8: Neurological Consequences of Congenital Disorders of Glycosylation -- 1 Introduction -- 2 Classification -- 2.1 N-Linked Glycosylation Defects -- 2.2 O-Linked Glycosylation Defects -- 2.3 Disorders of Glycosylphosphatidylinositol (GPI) Anchor Biosynthesis.
2.4 Disorders of Glycosphingolipid (GSL) Glycosylation -- 2.5 Disorders of Multiple Glycosylation Pathways -- 2.6 Recently Described CDG with Neurological Presentation -- 3 Markers/Biochemical Abnormalities -- 4 Congenital Brain Abnormalities -- 5 Epilepsy -- 6 Developmental Delay/Intellectual Disability -- 7 Ataxia -- 8 Neuromuscular Presentation -- 9 Spasticity -- 10 Autistic Features -- 11 Extrapyramidal Manifestation -- 12 Treatment Options -- 13 Conclusions and New Perspectives -- References -- Chapter 9: Brain O-GlcNAcylation: From Molecular Mechanisms to Clinical Phenotype -- 1 Introduction -- 2 O-GlcNAc Is a Ubiquitous Monosaccharide That Cycles Onto and Off Serine and Threonine -- 2.1 O-GlcNAc Is Not Elongated to Yield Complex Oligosaccharides -- 2.2 O-GlcNAc Is Mostly Expressed on the Inside of Cells in Multicellular Organisms -- 2.3 O-GlcNAc Can Be Dynamically Attached and Removed -- 3 O-GlcNAc Is Added to Proteins by OGT and Removed by OGA -- 3.1 Only Two Enzymes Regulate the Cycling of O-GlcNAc -- 3.2 O-GlcNAc Transferase -- a Highly Conserved Glycosyltransferase Present in the Nucleus & -- Cytosol -- 3.3 O-GlcNAcase -- a Cytosolic O-β-GlcNAc Hydrolase with Neutral pH Optima -- 4 O-GlcNAc Is Highly Expressed in the Nervous System -- 4.1 O-GlcNAc Is Found Throughout the Brain -- 4.2 Thousands of Neuronal Proteins Are Modified by O-GlcNAc -- 4.3 O-GlcNAc Regulates Diverse Cellular Processes -- 5 O-GlcNAc Is Essential for Brain Function -- 5.1 Early and Late Brain Development Depends Upon O-GlcNAc Cycling -- 5.2 O-GlcNAc Underlies Learning and Memory -- 5.3 Impaired O-GlcNAc Cycling Contributes to Neurodegenerative Disease -- 5.4 O-GlcNAc Mediates Central Control of Metabolism -- 6 Summary and Outlook -- References -- Chapter 10: Ganglioside Microdomains on Cellular and Intracellular Membranes Regulate Neuronal Cell Fate Determination.
1 Introduction -- 2 Ganglioside Multifunction in Cell Membranes and Intracellular Organelles -- 3 Ganglioside microdomains for Neuronal Cell Fate Determination -- 4 GD3-EGFR -- 5 GD3 Regulates Mitochondrial Dynamics by Interacting with Drp1 -- 6 GD3 Amplifies SOX2 Expression and GM1 Promotes DCX Expression -- 7 GM1 Binds to Neuronal Gene Promoter Regions -- 8 Nuclear GM1 Promotes Neuronal Gene Expression -- 9 Other Gangliosides for NSC Specification -- 10 Future Studies -- References -- Chapter 11: Gangliosides and Cell Surface Ganglioside Metabolic Enzymes in the Nervous System -- 1 Gangliosides -- 1.1 Ceramide: The Lipid Portion of Gangliosides -- 1.2 The Oligosaccharide Portion of Gangliosides -- 2 Gangliosides and Membrane Organization -- 3 Metabolic Pathways of Gangliosides -- 4 Plasma Membrane-Associated Enzymes and Ganglioside Pattern -- 5 Sialidases, Sialyltransferases and Plasma Membrane Sialidase Neu3 -- 6 β-Hexosaminidase and N-Acetylgalactosaminyltransferase -- 7 β-Glucocerebrosidase -- 8 β-Galactosidase -- 9 Membrane Dynamics: A Non-canonical Pathway Involved in the Establishment of the GSL Profile at the Plasma Membrane -- 10 Conclusions -- References -- Chapter 12: Neuronal Ganglioside and Glycosphingolipid (GSL) Metabolism and Disease -- 1 Historical Aspects of Structure, Location and Function of GSLs -- 2 Significance and Function of Neuronal GGs -- 3 Intracellular Pathways of GG and GSL Metabolism -- 4 Emerging Concepts of GSL & -- GG Metabolism at Organellar Membranes -- 5 Emerging Topology of Glycolipid Biosynthesis -- 6 Generation of Cell-Type-Specific Ganglioside Patterns -- 7 Enzyme Catalysis at Membrane Surfaces -- 8 GSL Biosynthesis and Salvage Pathways -- 8.1 Ceramide Synthesis -- 8.2 Ganglioside Synthesis and Function -- 9 Inherited Errors of GG Biosynthesis -- 10 Remodeling and Recycling of Cell Surface Gangliosides.
11 Concepts of the Constitutive Degradation of Gangliosides and Glycosphingolipids at ILVs.
Record Nr. UNINA-9910627240203321
Cham, Switzerland : , : Springer, , [2023]
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Glycobiology of the Nervous System [[electronic resource] /] / edited by Robert K. Yu, Cara-Lynne Schengrund
Glycobiology of the Nervous System [[electronic resource] /] / edited by Robert K. Yu, Cara-Lynne Schengrund
Edizione [1st ed. 2014.]
Pubbl/distr/stampa New York, NY : , : Springer New York : , : Imprint : Springer, , 2014
Descrizione fisica 1 online resource (590 p.)
Disciplina 572.567
Collana Advances in Neurobiology
Soggetto topico Neurosciences
Neurobiology
Neurochemistry
ISBN 1-4939-1154-6
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Introduction to the Complexity of Cell Surface and Tissue Matrix Glycoconjugates -- Introduction to Cells Comprising the Nervous System -- Synthesis, Processing, and Function of N-glycans in N-glycoproteins -- Synthesis of O-linked Glycoconjugates in the Nervous System -- Chemistry and Function of Glycosaminoglycans in the Nervous System -- Use of Glycan-targeted Antibodies/Lectins to Study the Expression/Function of Glycosyltransferases in the Nervous System -- From Mass Spectrometry-based Glycosylation Analysis to Glycomics and Glycoproteomic -- Structural Analysis of Oligosaccharides and Glycoconjugates using NMR -- Glycolipid and Glycoprotein Expression During Neural Development -- Gangliosides and Cell Surface Ganglioside Glycohydrolases in the Nervous System -- Role of Myelin-Associated Glycoprotein (Siglec-4a) in the Nervous System -- Role of Galactosylceramide and Sulfatide in Oligodendrocytes and CNS Myelin: Formation of a Glycosynapse -- Glycosignaling – A General Review -- Glycosphingolipids in the Regulation of the Nervous System -- Glycobiology of Ion Transport in the Nervous System -- O-GlcNAcylation of Neuronal Proteins: Roles in Neuronal Functions and in Neurodegeneration -- N-glycosylation in Regulation of the Nervous System -- Roles of Carbohydrates in the Interaction of Pathogens with Neural Cells -- Glycoconjugate Changes in Aging and Age-related Diseases -- Gangliosides and Glycolipids in Neurodegenerative Disorders -- Glycosidases: Inborn Errors of Glycosphingolipid Catabolism -- Ganglioside Storage Diseases: On the Road to Management -- Dynamic Aspects of Neural Tumor Gangliosides -- Galectins and Neuroinflammation -- Glycoconjugates and Neuroimmunological Diseases.
Record Nr. UNINA-9910298350403321
New York, NY : , : Springer New York : , : Imprint : Springer, , 2014
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