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Inorganic biochemistry of iron metabolism : from molecular mechanisms to clinical consequences / Robert Crichton ; with the collaboration of Johan R. Boelaert ... [et al.]
| Inorganic biochemistry of iron metabolism : from molecular mechanisms to clinical consequences / Robert Crichton ; with the collaboration of Johan R. Boelaert ... [et al.] |
| Autore | CRICHTON, Robert |
| Edizione | [2. ed] |
| Pubbl/distr/stampa | Chichester [etc.] : J. Whiley & Sons, copyr. 2001 |
| Descrizione fisica | XXII, 326 p. : ill. ; 26 cm |
| Disciplina | 572.5174 |
| Soggetto topico | Ricambio - Ferro |
| ISBN | 0-471-49223-X |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-990001000980203316 |
CRICHTON, Robert
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| Chichester [etc.] : J. Whiley & Sons, copyr. 2001 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
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Inorganic biochemistry of iron metabolism : from molecular mechanisms to clinical consequences / / Robert Crichton ; with the collaboration of Johan Boelart [and five others]
| Inorganic biochemistry of iron metabolism : from molecular mechanisms to clinical consequences / / Robert Crichton ; with the collaboration of Johan Boelart [and five others] |
| Autore | Crichton Robert R. |
| Edizione | [Second edition.] |
| Pubbl/distr/stampa | Chichester, West Sussex, England : , : John Wiley & Sons, Ltd, , [2001] |
| Descrizione fisica | 1 online resource (xxii, 326 pages, 16 unnumbered pages of plates) : illustrations |
| Disciplina | 572.5174 |
| Soggetto topico |
Iron - Metabolism
Iron proteins Iron - Metabolism - Disorders |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-62201-6
9786610622016 0-470-84579-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910142647603321 |
|
Crichton Robert R.
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||
| Chichester, West Sussex, England : , : John Wiley & Sons, Ltd, , [2001] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Inorganic biochemistry of iron metabolism : from molecular mechanisms to clinical consequences / / Robert Crichton ; with the collaboration of Johan Boelart [and five others]
| Inorganic biochemistry of iron metabolism : from molecular mechanisms to clinical consequences / / Robert Crichton ; with the collaboration of Johan Boelart [and five others] |
| Autore | Crichton Robert R. |
| Edizione | [Second edition.] |
| Pubbl/distr/stampa | Chichester, West Sussex, England : , : John Wiley & Sons, Ltd, , [2001] |
| Descrizione fisica | 1 online resource (xxii, 326 pages, 16 unnumbered pages of plates) : illustrations |
| Disciplina | 572.5174 |
| Soggetto topico |
Iron - Metabolism
Iron proteins Iron - Metabolism - Disorders |
| ISBN |
1-280-62201-6
9786610622016 0-470-84579-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-996203063603316 |
|
Crichton Robert R.
|
||
| Chichester, West Sussex, England : , : John Wiley & Sons, Ltd, , [2001] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Inorganic biochemistry of iron metabolism : from molecular mechanisms to clinical consequences / / Robert Crichton ; with the collaboration of Johan Boelart [and five others]
| Inorganic biochemistry of iron metabolism : from molecular mechanisms to clinical consequences / / Robert Crichton ; with the collaboration of Johan Boelart [and five others] |
| Autore | Crichton Robert R. |
| Edizione | [Second edition.] |
| Pubbl/distr/stampa | Chichester, West Sussex, England : , : John Wiley & Sons, Ltd, , [2001] |
| Descrizione fisica | 1 online resource (xxii, 326 pages, 16 unnumbered pages of plates) : illustrations |
| Disciplina | 572.5174 |
| Soggetto topico |
Iron - Metabolism
Iron proteins Iron - Metabolism - Disorders |
| ISBN |
1-280-62201-6
9786610622016 0-470-84579-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910830905603321 |
|
Crichton Robert R.
|
||
| Chichester, West Sussex, England : , : John Wiley & Sons, Ltd, , [2001] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Iron metabolism : inorganic biochemistry and regulatory mechanisms / / edited by Gloria C. Ferreira, José J. G. Moura, Ricardo Franco
| Iron metabolism : inorganic biochemistry and regulatory mechanisms / / edited by Gloria C. Ferreira, José J. G. Moura, Ricardo Franco |
| Pubbl/distr/stampa | Weinheim, Germany : , : Wiley-VCH, , 1999 |
| Descrizione fisica | 1 online resource (412 p.) |
| Disciplina |
572.517
572.5174 572/.5174 |
| Soggetto topico | Iron - Metabolism |
| ISBN |
1-281-84248-6
9786611842482 3-527-61370-6 3-527-61371-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Iron Metabolism; Contents; Iron Metabolism Regulation and Iron Storage; Iron and Regulation of Heme Biosynthesis; 1 Iron-dependent regulation of bacterial heme biosynthesis; 1.1 Introduction; 1.2 Summary of heme biosynthetic pathways; 1.3 Mediators of iron-dependent regulation of iron metabolism; 1.4 Regulation of heme synthesis by iron; 2 5-Aminolevulinate synthase and mammalian heme biosynthesis; 2.1 Introduction: 5-aminolevulinate synthase and iron; 2.2 Structure and mechanism: early studies; 2.2.1 Isolation, purification and identification of the PLP cofactor
2.2.2 Steady-state kinetics and mechanism of ALAS2.3 Structure and function: the active site of ALAS; 2.3.1 Identification of the Schiff base linkage between PLP and lysine-313; 2.3.2 Role of a glycine-rich loop as a PLP cofactor-binding site; 2.3.3 Role of aspartate-279 in enhancing the function of PLP and in ALAS catalysis; 2.3.4 Role of tyrosine-121 in the PLP cofactor binding; 2.3.5 Role of arginine-439 in substrate binding; 2.3.6 Active site intersubunit arrangement; 2.4 Conclusions; 3 Ferrochelatase: a new iron sulfur center-containing enzyme; 3.1 Introduction 3.2 Identification, purification and characterization of ferrochelatase3.3 Steady-state kinetic properties of ferrochelatase; 3.3.1 Ferrochelatase reaction mechanism; 3.3.2 Reducing conditions are not essential for ferrochelatase activity; 3.3.3 Site-directed mutagenesis; 3.3.4 Iron-substrate ligands as determined by Mossbauer spectroscopy; 3.4 The [2Fe-2S] cluster of mammalian ferrochelatases; 3.4.1 Conserved cysteines and iron-sulfur cluster binding; 3.4.2 Spectroscopic characterization of the [2Fe-2S] cluster; 3.5 The three-dimensional structure of Bacillus subtilis ferrochelatase 3.6 ConclusionsRegulation of Iron Transport and Metabolism; 4 The biochemistry and molecular biology of iron metabolism in yeast; 4.1 Introduction; 4.2 Iron transport in Saccharomyces cerevisiae; 4.2.2 Identification of FET3; 4.2.3 Fet3p is a multicopper oxidase; 4.2.4 Fet3p acts as a ferroxidase to mediate iron transport; 4.3 Oxidase-permease based iron transport systems in other species; 5 Role of redox-active metals in the regulation of the metallothionein and heme oxygenase genes by heme and hemopexin; 5.1 Introduction; 5.2 Hemopexin; 5.2.1 Structure; 5.3 Tissue expression of hemopexin 5.3.1 Liver5.3.2 Barrier tissues; 5.4 Heme- and heme-hemopexin-mediated effects; 5.4.1 Target tissues; 5.4.2 Responses; 5.4.2.1 Interactions between the hemopexin and transferrin systems; 5.5 Biochemical and cellular consequences of heme-hemopexin: comparison with free heme; 5.5.1 Protective role of hemopexin; 5.5.2 Increased oxidation state; 5.5.3 Transcription factors; 5.5.3.1 Redox sensitive; 5.5.3.2 For metallothionein regulation; 5.5.4 Links between iron and copper in iron homeostasis; 5.5.6 Links between heme and copper and cellular homeostasis 5.5.6.1 Role of copper in certain of the cellular and regulatory effects of hemopexin: intracellular oxidation state |
| Record Nr. | UNINA-9910144010103321 |
| Weinheim, Germany : , : Wiley-VCH, , 1999 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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