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Calcium Entry Pathways in Non-excitable Cells / / edited by Juan A. Rosado
Calcium Entry Pathways in Non-excitable Cells / / edited by Juan A. Rosado
Edizione [1st ed. 2016.]
Pubbl/distr/stampa Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016
Descrizione fisica 1 online resource (469 p.)
Disciplina 572.516
Collana Advances in Experimental Medicine and Biology
Soggetto topico Cytology
Human physiology
Cell Biology
Human Physiology
ISBN 3-319-26974-7
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Historical overview of store-operated Ca2+ entry -- The STIM1- Orai interaction -- The TRPCs, Orais and STIMs in ER/PM junctions -- The TRP-Na-Ca2+ exchanger coupling -- Role of TRPC channels in store-operated calcium entry -- Phospholipase A2 as a molecular determinant of store-operated calcium entry -- Extracellular calcium has multiple targets to control cell proliferation -- Regulation of platelet function by Orai, STIM and TRP -- On the roles of the Transient Receptor Potential Canonical 3 (TRPC3) channel in endothelium and macrophages: implications in atherosclerosis -- Second messenger-operated calcium entry through TRPC6 -- Transient Receptor Potential Canonical 7 (TRPC7), a Calcium (Ca2+) Permeable Nonselective Cation Channel -- Calcium entry through thermosensory channels -- Calcium signalling through ligand-gated ion channels such as P2X1 receptors in the platelet and other non-excitable cells -- The calcium entry-calcium refilling coupling -- Microdomains associated to lipid rafts -- Role of scaffolding proteins in the regulation of TRPC-dependent calcium entry -- Modulation of calcium entry by mitochondria -- Modulation of calcium entry by the endo-lysosomal system -- Remodeling of calcium entry pathways in cancer.
Record Nr. UNINA-9910253866703321
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016
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Calcium Signaling / / edited by Md. Shahidul Islam
Calcium Signaling / / edited by Md. Shahidul Islam
Edizione [2nd ed. 2020.]
Pubbl/distr/stampa Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020
Descrizione fisica 1 online resource (1,103 pages)
Disciplina 612.8
572.516
Collana Advances in Experimental Medicine and Biology
Soggetto topico Neurosciences
Proteins
Cytology
Neuroscience
Cell Biology
ISBN 3-030-12457-6
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Preface -- Calcium signaling: from basics to bedside -- Measuring Ca2+ in living cells -- High-throughput fluorescence assays for Ion Channels and GPCRs -- Imaging Native Calcium Currents in Brain Slices -- Molecular diversity of plasma membrane Ca2+ transporting ATPases: their function under normal and pathological conditions -- A role for SERCA pumps in the neurobiology of neuropsychiatric and neurodegenerative disorders -- Cytoplasmic Calcium Buffering: An Integrative Crosstalk -- An update on calcium binding proteins -- Manuel Campos‐Toimil -- New insights in the IP3 receptor and its regulation -- Expression of the inositol 1,4,5-trisphosphate receptor and the ryanodine receptor Ca2+-release channels in the beta-cells and alpha- cells of the human islets of Langerhans -- Evolution of Excitation-Contraction Coupling -- Molecular Insights into Calcium Dependent Regulation of Ryanodine Receptor Calcium Release Channels -- Sarco-endoplasmic reticulum calcium release model based on changes in the luminal calcium content visualized from the luminal side -- Pyridine Nucleotide Metabolites and Calcium Release from Intracellular Stores -- Calcium Signaling in the Heart -- Molecular basis and regulation of store-operated calcium entry -- Structure and activation mechanisms of CRAC channels -- Canonical Transient Potential Receptor-3 Channels in Normal and Diseased Airway Smooth Muscle Cells -- Pathophysiological significance of store-operated calcium entry in cardiovascular and skeletal muscle disorders and angiogenesis -- Calcium signalling and the regulation of chemosensitivity in cancer cells: role of the Transient Receptor Potential channels -- Targeting Transient Receptor Potential Channels by microRNAs drives tumor development and progression -- Calcium channels and Calcium-regulated channels in human red blood cells -- Regulation of multifunctional calcium/calmodulin stimulated protein kinases by molecular targeting -- Widespread roles of CaMK-II in Developmental Pathways -- Readily releasable stores of calcium in neuronal endolysosomes: Physiological and pathophysiological relevance -- At the crossing of ER stress and MAMs: A key role of Sigma-1 receptor?- ER-mitochondria calcium transfer, organelle contacts and neurodegenerative diseases -- The Role of Mitochondrial Calcium Signaling in the Pathophysiology of Cancer Cells -- Calcium Signaling and Gene Expression -- Simulation Strategies for Calcium Microdomains and Calcium Noise -- A statistical view on calcium oscillations -- Calcium Regulation of Bacterial Virulence -- Ca2+ Signaling in Drosophila Photoreceptor Cells -- Calcium imaging in Drosophila melanogaster -- Calcium imaging in the zebrafish -- Stimulation-secretion coupling in the beta cells: from basic to bedside -- Calcium dynamics and synaptic plasticity -- Calcium signaling during brain aging and its influence on the hippocampal synaptic plasticity -- Calcium Signaling in Endothelial Colony Forming Cells in Health and Disease -- Sensing Extracellular Calcium - An Insight into the Structure and Function of the Calcium-Sensing Receptor (CaSR) -- Extracellular Ca2+ in bone marrow -- Calcium in Cell-Extracellular Matrix Interactions -- Index.
Record Nr. UNINA-9910367258403321
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020
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Calcium signalling : approaches and findings in the heart and blood / / Lars Kaestner
Calcium signalling : approaches and findings in the heart and blood / / Lars Kaestner
Autore Kaestner Lars
Edizione [1st ed. 2013.]
Pubbl/distr/stampa Berlin, : Springer, 2013
Descrizione fisica 1 online resource (246 p.)
Disciplina 572.516
Soggetto topico Calcium - Physiological effect - Research - Methodology
Calcium - Analysis
Second messengers (Biochemistry) - Research - Methodology
Cellular signal transduction - Research - Methodology
ISBN 1-283-93540-6
3-642-34617-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Summary -- Calcium Signalling Methodology -- Calcium Signalling in Cardiac Myocytes -- Calcium Signalling in Red Blood Cells -- Index.
Record Nr. UNINA-9910437828103321
Kaestner Lars  
Berlin, : Springer, 2013
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Cell calcium
Cell calcium
Pubbl/distr/stampa Glasgow, : Churchill Livingstone
Disciplina 596/.01/921
572.516
571
ISSN 0143-4160
Formato Materiale a stampa
Livello bibliografico Periodico
Lingua di pubblicazione eng
Record Nr. UNINA-990008937510403321
Glasgow, : Churchill Livingstone
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Membrane Dynamics and Calcium Signaling / / edited by Joachim Krebs
Membrane Dynamics and Calcium Signaling / / edited by Joachim Krebs
Edizione [1st ed. 2017.]
Pubbl/distr/stampa Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017
Descrizione fisica 1 online resource (409 pages)
Disciplina 572.516
Collana Advances in Experimental Medicine and Biology
Soggetto topico Cell membranes
Proteins
Biophysics
Membrane Biology
Protein-Ligand Interactions
Biological and Medical Physics, Biophysics
ISBN 3-319-55858-7
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto PMCA -- Calcium channel -- Sodium/calcium exchanger -- Endoplasmic Reticulum -- SERCA Pump H -- IP3R -- IP3R -- RyR -- History of  the SOCE concept -- STIM/Orai -- TRPC channel -- MCU complex -- VDAC -- Annexins -- Cytokinesis and Ca2+ signaling.
Record Nr. UNINA-9910279578403321
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017
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Mineral metabolism : an advanced treatise / edited by C. L. Comar, Felix Bronner
Mineral metabolism : an advanced treatise / edited by C. L. Comar, Felix Bronner
Pubbl/distr/stampa New York : Academic Press, 1960-
Descrizione fisica v. : ill. ; 24 cm
Disciplina 572.516
Altri autori (Persone) Comar, C. L.
Bronner, Felix
Soggetto topico Calcium metabolism - Biochemistry
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Vol.3: Calcium physiology
Record Nr. UNISALENTO-991003518969707536
New York : Academic Press, 1960-
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Study of the Calcium Regulation Mechanism of TCR Activation Using Nanodisc and NMR Technologies / / by Yunchen Bi
Study of the Calcium Regulation Mechanism of TCR Activation Using Nanodisc and NMR Technologies / / by Yunchen Bi
Autore Bi Yunchen
Edizione [1st ed. 2018.]
Pubbl/distr/stampa Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2018
Descrizione fisica 1 online resource (XII, 79 p. 41 illus.)
Disciplina 572.516
Collana Springer Theses, Recognizing Outstanding Ph.D. Research
Soggetto topico Biomedical engineering
Biophysics
Cell membranes
Immunology
Atomic structure
Molecular structure
Biomedical Engineering and Bioengineering
Biological and Medical Physics, Biophysics
Membrane Biology
Atomic/Molecular Structure and Spectra
ISBN 3-662-54618-3
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Introduction -- Review -- Nanodisc assembly and the study on the interaction between the lipid and ion -- Calcium regulates T cell receptor activation through phospholipid electrostatic manipulation -- The preliminary study on the structure of Dengue Virus NS2B-NS3p in complex with aprotinin -- Summary and prospect of this dissertation.
Record Nr. UNINA-9910299585403321
Bi Yunchen  
Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2018
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Voltage-gated calcium channels / / Gerald Werner Zamponi and Norbert Weiss, editors
Voltage-gated calcium channels / / Gerald Werner Zamponi and Norbert Weiss, editors
Pubbl/distr/stampa Cham, Switzerland : , : Springer, , 2022
Descrizione fisica 1 online resource (705 pages)
Disciplina 572.516
Soggetto topico Calcium channels
RNA editing
Neurosciences
ISBN 3-031-08881-6
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Intro -- Preface -- Contents -- A Lived History of Early Calcium Channel Discoveries Over the Past Half-Century -- Ca2+ as Central Ion for Muscle Contraction -- The "Ca-Spikes" of Crustacean Skeletal Muscles -- "Ca-Spikes" in Heart and Neurons -- How to Look at Ca2+ Currents Through Voltage-Clamp Recordings -- Ca2+ Currents in the Heart and Mollusc Neurons: The Problem of Blocking K+ Currents -- A Convergent View on the Existence of "a" Ca2+ Channel in Excitable Cells -- The "Patch-Clamp" Technique and the Explosive Interest on Ca2+ Channels -- The Discovery of the "Low-Voltage Activated" T-Type Channel -- The Unique Properties of T-Type (LVA) Channels -- The Explosive Interest on T-Type Channels -- The Ca2+ Channel Family Growths -- The N-Type Channel -- The P/Q-Type Channel -- The R-Type Channel -- From Ionic Currents to the Molecular Structure of Ca2+ Channels -- The cAMP-Mediated Enhancement of Cardiac L-Type Channels as First Example of Ca2+ Channel Modulation -- Early Observations on the GPCR-Mediated Inhibition of Neuronal Ca2+ Channels -- Towards a Full Understanding of the GPCR-Induced Delayed Activation of HVA Channels -- Looking Deeper to the Structure and Function of Cav2 Channels Modulation by G proteins -- Take-Home Message -- References -- Part I: Structural and Molecular Aspects of VGCCs -- Subunit Architecture and Atomic Structure of Voltage-Gated Ca2+ Channels -- Introduction -- Purification and Biochemical Characterization of Skeletal Muscle Calcium Channels -- Structures of NaVAb and CaVAb Channels -- Structure of the Skeletal Muscle CaV1.1 Calcium Channel -- Molecular Properties of the CaV2 Family of Calcium Channels -- Structure of CaV2.2 Calcium Channels and Implications for Regulation -- Molecular Properties and Structure of CaV3 Calcium Channels -- Pharmacology of Calcium Channels -- Conclusion -- References.
Splicing and Editing to Fine-Tune Activity of High Voltage-Activated Calcium Channels -- Generation of mRNA Diversity by A-to-I RNA Editing and Alternative Splicing -- Splice Variations in High Voltage-Activated Calcium Channels -- CaV1.1 Splice Variant in Myotonic Dystrophy -- CaV1.2 Splice Variants in Health and Disease -- Exon 9* in Cardiovascular Diseases -- Mutually Exclusive Exons 1a/1 and Exons 8a/8 -- Exons 21/22 -- Exon 33 and Exon 33L -- CaV1.3 in Health and Disease -- The Pathophysiological Roles of CaV1.3 -- The Unique Biophysical and Pharmacological Properties of CaV1.3 Channels and Modulation -- Regulation of α1D Transcripts by Alternative Splicing and A-to-I RNA Editing -- CaV1.4 in Health and Disease -- Structure-Function Relationship Learnt from Human Mutations and Alternative Splicing Patterns -- The CaV2 Channel Family -- Pathophysiological Roles of CaV2 Channel Family -- Alternative Splicing in CaV2 Channel Family -- Exon 37 -- Exon 43/44 -- Exon 47 -- Novel Approaches to Uncover the Pathophysiological Consequences of Alternative Splicing or Gene Mutations of Ion Channels: Moving Away from Heterologous Systems -- Summary -- References -- Voltage-Gated Calcium Channel Auxiliary β Subunits -- Physiological Roles of High-Voltage-Activated Calcium Channels -- Subunits of Voltage-Gated Calcium Channels -- Physiological Roles of CaVβ Subunits -- Functional Effects of CaVβ Subunits in HVACC Complexes -- CaVβ Regulation of HVACC Membrane Trafficking -- CaVβ Regulation of HVACC Activation Gating -- CaVβ Regulation of HVACC Open Probability -- CaVβ Regulation of HVACC Inactivation Gating -- Structure-Function of CaVβ Regulation of HVACCs -- CaVβ-Interacting Proteins That Regulate HVACCs -- Regulation of HVACCs by RGK Proteins -- Roles of CaVβ and Rad in Sympathetic Regulation of Cardiac CaV1.2 -- RIM-Binding Protein Regulation of HVACCs.
Association of CaVβ Subunits with Disease -- Pharmacological Targeting of CaVβ Subunits -- References -- Regulation of Calcium Channels and Synaptic Function by Auxiliary α2δ Subunits -- Introduction -- Discovery of α2δ Subunits -- Identification of α2δ Subunits -- Cloning -- Splice Variants -- Tissue Distribution of α2δ Subunits -- α2δ-1 -- α2δ-2 -- α2δ-3 -- α2δ-4 -- Structure of α2δ Subunits -- Biochemical and Bioinformatic Studies -- GPI Anchoring -- VWA Domain -- Cache Domains -- Proteolytic Maturation of α2δ -- Cachd1 Protein -- Molecular Structure of α2δ-1 -- Functions of α2δ Subunits as Calcium Channel Subunits -- Effects of Cloned α2δ Subunits on Calcium Currents -- Effects of α2δ Subunits on Biophysical Properties of Calcium Currents -- Effects of α2δ Subunits on Calcium Channel Trafficking -- Cachd1 Function -- Synaptic Functions of α2δ Proteins Beyond Their Role as Calcium Channel Subunits -- Importance of α2δ Proteins in Neuronal and Synaptic Functions -- Postsynaptic Functions of α2δ-1 -- Presynaptic and Trans-synaptic Roles of α2δ Proteins -- Diseases Associated with α2δ Subunits -- Ducky Mice and Human Mutations of the α2δ-2 Gene -- Mutations in the α2δ-1 Gene Associated with Cardiac Phenotypes -- Neuropathic Injury and the Role of α2δ-1 -- Disorders Associated with α2δ-3 -- Disorders Associated with α2δ-4 -- Psychiatric Disorders -- Pharmacology Involving α2δ Subunits -- Therapeutic Uses of Gabapentinoids -- Gabapentinoid Drug Binding to α2δ Subunits and Potential Mechanisms of Action -- The First Double Cache Domain in α2δ-1 Has Structural Homology to a Universal Amino Acid Binding Domain -- Effect of α2δ Subunits on Ziconotide Binding -- Other Interactions of α2δ Proteins -- Summary and Outlook -- References -- Voltage-Gated Calcium Channels in Invertebrates -- Introduction: Invertebrates and Calcium Channel Discovery.
Phylogenetic Properties of the CaV Channel α1 Subunit -- Phylogenetic Properties of the CaV Channel β Subunit -- Phylogenetic Properties of the CaV Channel α2δ Subunit -- CaV Channels in Deuterostome Invertebrates -- Since Hagiwara's Discovery of LVA and HVA Ca2+ Currents in Starfish Eggs -- Tunicates and the Evolution of CaV1.1 Channels and Ryanodine Receptor Tetrad Coupling -- CaV Channels in Protostome Invertebrates -- The Atypical Nature of Calcium Channels in Parasitic Flatworms -- Functional Studies of Calcium Channels of the Pond Snail Lymnaea Stagnalis -- Genetic Studies of Ecdysozoan β and α2δ Subunits Highlight Gene Duplication as a Mechanism for Functional Diversification and the Emergence of Pleiotropic Functions -- Genetic and Functional Studies of Ecdysozoan CaV1-CaV3 Channels Reveal Deep Conservation of C-Terminal Protein Interactions and Sub-cellular Localization -- CaV Channels in Early-Diverging Animals -- Cnidaria: Our Most Distant Neural Ancestors? -- Evolutionary Insights from Functional Studies of the Placozoan CaV1 to CaV3 Channels -- A Calcium Channel Regulates Choanocyte Ciliary Beating and the Feeding Current in Sponges -- Ctenophores -- Conclusions -- References -- Untitled -- Part II: Regulation of VGCCs -- Modulation of VGCCs by G-Protein Coupled Receptors and Their Second Messengers -- Introduction -- Modulation of Cav1 Channels by GPCRs and Second Messengers -- β-Adrenergic Modulation of L-Type Channels: Activation of the Gs Signaling Pathway -- Gq-Coupled GPCR Modulation of L-Type Channels -- Gi/o-Coupled GPCR Modulation of L-Type Channels -- GPCR-Mediated Modulation of Cav1.4 in the Retina -- Modulation of Cav2 Channels by GPCRs and Second Messengers -- Mechanisms Gi/o Mediated Inhibition: Fast, Direct, Voltage-Dependent -- Cav2 Channel Interaction Sites with Gβγ Subunits.
Gβγ and Cavβ Subunit Diversity and Interaction Sites with Cav2 Channels -- Modulation of G Protein-Mediated Inhibition by Synaptic Associated and Other Proteins -- Regulation of Cav2 Channels by Lipids -- Mechanisms of Gq/11-Mediated Inhibition: Slow, Indirect, Voltage-Independent -- Conclusion for Cav2 Channels -- Modulation of Cav3 Channels by GPCRs and Second Messengers -- Direct Modulation by Gβγ Subunits -- Modulation by Kinases -- Protein Kinase A -- Protein Kinase C -- Calmodulin-Dependent Kinase II -- Protein Kinase G -- Rho-Kinase -- Tyrosine Kinase -- GPCR-Mediated Change in T-Type Channel Expression -- Conclusion for T-Type Channels -- Summary -- References -- Trafficking of Neuronal Calcium Channels -- Introduction -- Regulation of VGCCs by Ancillary Subunits -- Cavβ-Subunit -- Cavα2δ-Subunit -- Cavγ-Subunit -- Regulation of VGCCs by Other Interacting Proteins -- Calmodulin -- Collapsin Response Mediator Proteins -- Stac Adaptor Proteins -- Kelch-like 1 -- Calnexin -- Secretory Carrier-Associated Membrane Proteins -- Receptor for Activated C kinase 1 -- Regulation of VGCCs by Posttranslational Modifications -- Ubiquitination -- Glycosylation -- Subcellular Targeting of VGCCs -- Concluding Remarks and Perspectives -- References -- Calmodulin Regulation of Voltage-Gated Calcium Channels -- Introduction -- Ca2+/CaM-Dependent Regulation of VGCCs -- Ca2+/CaM-Dependent Regulation Responds Differentially to Spatially Distinct Ca2+ Sources -- Molecular Mechanism of Calmodulation -- Ca2+ Regulation of VGCCs in Disease -- References -- Cav3 Calcium Channel Interactions with Potassium Channels -- Introduction -- Cav3-Kv4 Complex -- Cav3.2-IK Complex -- Cav3.2-BK Complex -- Perspectives and Conclusions -- References -- Part III: (Patho)physiology of VGCCs -- Voltage-Gated Ca2+ Channels. Lessons from Knockout and Knock-in Mice -- Introduction -- CaV1.
CaV1.1.
Record Nr. UNISA-996499863803316
Cham, Switzerland : , : Springer, , 2022
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Voltage-Gated Calcium Channels / / edited by Gerald Werner Zamponi, Norbert Weiss
Voltage-Gated Calcium Channels / / edited by Gerald Werner Zamponi, Norbert Weiss
Edizione [1st ed. 2022.]
Pubbl/distr/stampa Cham : , : Springer International Publishing : , : Imprint : Springer, , 2022
Descrizione fisica 1 online resource (705 pages)
Disciplina 572.516
572.3
Collana Physics and Astronomy Series
Soggetto topico Cytology
Neurosciences
Human physiology
Biophysics
Pharmacology
Cell Biology
Neuroscience
Human Physiology
ISBN 3-031-08881-6
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto 1. Measuring and manipulating calcium -- 2. Structure, function and subunit assembly of VGCC -- 3. Splice variation and RNA editing of VGCCs -- 4. Mechanisms of calcium channel permeation -- 5. Regulation by beta subunits -- 6. Regulation by alpha2 delta subunits -- 7. VGCCs in invertebrates -- 8. Modulation by GPCRs and second messengers -- 9. Trafficking of VGCCs -- 10. Calcium regulation -- 11. Calcium channel complexes with other channels -- 12. Regulation of gene transcription by VGCCs -- 13. Lessons from knock-out and knock-in mice -- 14. VGCCs and synaptic transmission -- 15. Cardiovascular syste -- 16. Calcium channels and exocytosis in chromaffin cells -- 17. Calcium channels in the pancreas in health and disease -- 18. Skeletal muscle system -- 19. Auditory and visual systems -- 20. Calcium channels and pain transmission -- 21. Migraine -- 22. Epilepsy -- 23. Psychiatric disorders -- 24. Parkinson’s disease.-25. Reproductive system -- 26. Cancer -- 27. Molecular determinants of VGCC pharmacology -- 28. Interactions with peptide toxins -- 29. Clinical pharmacology and drug discovery.
Record Nr. UNINA-9910624309903321
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2022
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