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Biophysical analysis of membrane proteins : investigating structure and function / / edited by Eva Pebay-Peyroula
| Biophysical analysis of membrane proteins : investigating structure and function / / edited by Eva Pebay-Peyroula |
| Pubbl/distr/stampa | Weinheim, [Germany] : , : Wiley-VCH Verlag GmbH & Co. KGaA, , 2008 |
| Descrizione fisica | 1 online resource (369 p.) |
| Disciplina |
572.6
572/.69 |
| Soggetto topico |
Membrane proteins - Structure-activity relationships
Membrane proteins - Analysis Cell membranes - Physiology Physical biochemistry |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-282-78421-8
9786612784217 3-527-62122-9 3-527-62123-7 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | ger |
| Nota di contenuto |
Biophysical Analysis of Membrane Proteins; Contents; Preface; The Editor; List of Contributors; Part I Introduction; 1 High-Resolution Structures of Membrane Proteins: From X-Ray Crystallography to an Integrated Approach of Membranes; 1.1 Membranes: A Soft Medium?; 1.2 Current Knowledge on Membrane Protein Structures; 1.2.1 An Overview of the Protein Data Bank; 1.2.2 Protein Sources for Structural Studies; 1.2.3 The Diversity of Membrane Protein Topologies; 1.2.4 Genome Analyses; 1.3 X-Ray Crystallography; 1.3.1 Crystallization of Membrane Proteins; 1.3.2 General Aspects of Crystallography
1.3.3 Determining the Phases Associated with Diffracted Waves1.3.4 Structure Determination of Membrane Proteins; 1.3.4.1 Crystal Quality; 1.3.4.2 Phase Determination; 1.3.4.3 Crystal Freezing; 1.4 Recent Examples; 1.4.1 Bacterial Rhodopsins; 1.4.2 ADP/ATP Carrier; 1.4.3 Oligomerization of Membrane Proteins in their Natural Environment; 1.5 Future Developments in X-Ray Crystallography of Membrane Proteins; 1.6 Conclusions; Part II Structural Approaches; 2 Membrane Protein Structure Determination by Electron Cryo-Microscopy; 2.1 Introduction; 2.1.1 The Electron Microscope 2.2 Single-Particle Electron Microscopy2.2.1 Sample Preparation and Requirements; 2.2.1.1 Negative Staining of Specimens; 2.2.1.2 Cryo-EM of Unstained Specimens; 2.2.1.3 Choice of detergent; 2.2.2 Image Analysis; 2.2.2.1 Classification of Images; 2.2.2.2 Model Building and Refinement; 2.2.2.3 Assessing Resolution; 2.2.3 Future Perspectives; 2.3 Structure Determination from 2-Dimensional Crystals; 2.3.1 Two-Dimensional Crystallization of Membrane Proteins; 2.3.2 Image Acquisition and Structure Determination; 2.3.3 Future Perspectives; 2.4 Helical Analysis of Tubes; 2.5 Conclusions 3 Introduction to Solid-State NMR and its Application to Membrane Protein-Ligand Binding Studies3.1 Introduction; 3.1.1 Membrane Proteins: A Challenge; 3.1.2 Why Solid-State NMR?; 3.2 Solid-State NMR; 3.2.1 Sample Preparation: What is an Ideal Sample?; 3.2.1.1 Availability; 3.2.1.2 Stability; 3.2.1.3 Secondary Structure; 3.2.1.4 Sample Form: Local Order; 3.2.2 NMR Active Isotopes and Labeling; 3.2.3 Assignment and Structure Determination; 3.2.4 NMR Techniques: Solution- versus Solid-State NMR; 3.2.4.1 Isotropic Liquids; 3.2.4.2 Anisotropic Liquids; 3.2.4.3 Solids 3.3 Examples: Receptor-Ligand Studies by Solid-State NMR3.3.1 Transport Proteins; 3.3.1.1 LacS; 3.3.2 G-Protein-Coupled Receptors and Related Proteins; 3.3.2.1 Bacteriorhodopsin, Rhodopsin, and Sensory Rhodopsin (NpSRII); 3.3.2.2 Human H(1) Receptor; 3.3.2.3 Neurotensin Receptor; 3.3.3 Ion Channels; 3.3.3.1 Nicotinic Acetylcholine Receptor; 3.3.3.2 K(+) Ion Channel, KcsA; 3.3.4 P-type ATPases; 3.3.5 Membrane Protein Soluble Alternatives; Part III Molecular Interaction and Large Assemblies; 4 Analytical Ultracentrifugation: Membrane Protein Assemblies in the Presence of Detergent 4.1 Introduction |
| Record Nr. | UNINA-9910144732103321 |
| Weinheim, [Germany] : , : Wiley-VCH Verlag GmbH & Co. KGaA, , 2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biophysical analysis of membrane proteins : investigating structure and function / / edited by Eva Pebay-Peyroula
| Biophysical analysis of membrane proteins : investigating structure and function / / edited by Eva Pebay-Peyroula |
| Pubbl/distr/stampa | Weinheim, [Germany] : , : Wiley-VCH Verlag GmbH & Co. KGaA, , 2008 |
| Descrizione fisica | 1 online resource (369 p.) |
| Disciplina |
572.6
572/.69 |
| Soggetto topico |
Membrane proteins - Structure-activity relationships
Membrane proteins - Analysis Cell membranes - Physiology Physical biochemistry |
| ISBN |
1-282-78421-8
9786612784217 3-527-62122-9 3-527-62123-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | ger |
| Nota di contenuto |
Biophysical Analysis of Membrane Proteins; Contents; Preface; The Editor; List of Contributors; Part I Introduction; 1 High-Resolution Structures of Membrane Proteins: From X-Ray Crystallography to an Integrated Approach of Membranes; 1.1 Membranes: A Soft Medium?; 1.2 Current Knowledge on Membrane Protein Structures; 1.2.1 An Overview of the Protein Data Bank; 1.2.2 Protein Sources for Structural Studies; 1.2.3 The Diversity of Membrane Protein Topologies; 1.2.4 Genome Analyses; 1.3 X-Ray Crystallography; 1.3.1 Crystallization of Membrane Proteins; 1.3.2 General Aspects of Crystallography
1.3.3 Determining the Phases Associated with Diffracted Waves1.3.4 Structure Determination of Membrane Proteins; 1.3.4.1 Crystal Quality; 1.3.4.2 Phase Determination; 1.3.4.3 Crystal Freezing; 1.4 Recent Examples; 1.4.1 Bacterial Rhodopsins; 1.4.2 ADP/ATP Carrier; 1.4.3 Oligomerization of Membrane Proteins in their Natural Environment; 1.5 Future Developments in X-Ray Crystallography of Membrane Proteins; 1.6 Conclusions; Part II Structural Approaches; 2 Membrane Protein Structure Determination by Electron Cryo-Microscopy; 2.1 Introduction; 2.1.1 The Electron Microscope 2.2 Single-Particle Electron Microscopy2.2.1 Sample Preparation and Requirements; 2.2.1.1 Negative Staining of Specimens; 2.2.1.2 Cryo-EM of Unstained Specimens; 2.2.1.3 Choice of detergent; 2.2.2 Image Analysis; 2.2.2.1 Classification of Images; 2.2.2.2 Model Building and Refinement; 2.2.2.3 Assessing Resolution; 2.2.3 Future Perspectives; 2.3 Structure Determination from 2-Dimensional Crystals; 2.3.1 Two-Dimensional Crystallization of Membrane Proteins; 2.3.2 Image Acquisition and Structure Determination; 2.3.3 Future Perspectives; 2.4 Helical Analysis of Tubes; 2.5 Conclusions 3 Introduction to Solid-State NMR and its Application to Membrane Protein-Ligand Binding Studies3.1 Introduction; 3.1.1 Membrane Proteins: A Challenge; 3.1.2 Why Solid-State NMR?; 3.2 Solid-State NMR; 3.2.1 Sample Preparation: What is an Ideal Sample?; 3.2.1.1 Availability; 3.2.1.2 Stability; 3.2.1.3 Secondary Structure; 3.2.1.4 Sample Form: Local Order; 3.2.2 NMR Active Isotopes and Labeling; 3.2.3 Assignment and Structure Determination; 3.2.4 NMR Techniques: Solution- versus Solid-State NMR; 3.2.4.1 Isotropic Liquids; 3.2.4.2 Anisotropic Liquids; 3.2.4.3 Solids 3.3 Examples: Receptor-Ligand Studies by Solid-State NMR3.3.1 Transport Proteins; 3.3.1.1 LacS; 3.3.2 G-Protein-Coupled Receptors and Related Proteins; 3.3.2.1 Bacteriorhodopsin, Rhodopsin, and Sensory Rhodopsin (NpSRII); 3.3.2.2 Human H(1) Receptor; 3.3.2.3 Neurotensin Receptor; 3.3.3 Ion Channels; 3.3.3.1 Nicotinic Acetylcholine Receptor; 3.3.3.2 K(+) Ion Channel, KcsA; 3.3.4 P-type ATPases; 3.3.5 Membrane Protein Soluble Alternatives; Part III Molecular Interaction and Large Assemblies; 4 Analytical Ultracentrifugation: Membrane Protein Assemblies in the Presence of Detergent 4.1 Introduction |
| Record Nr. | UNINA-9910829991203321 |
| Weinheim, [Germany] : , : Wiley-VCH Verlag GmbH & Co. KGaA, , 2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Calcium binding proteins / / Eugene A. Permyakov, Robert H. Kretsinger
| Calcium binding proteins / / Eugene A. Permyakov, Robert H. Kretsinger |
| Autore | Permiakov E. A (Evgenii Anatolevich) |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, NJ, : John Wiley & Sons, c2011 |
| Descrizione fisica | 1 online resource (600 p.) |
| Disciplina |
572.69
572/.69 |
| Altri autori (Persone) | KretsingerRobert H |
| Collana | Wiley series in protein and peptide science |
| Soggetto topico |
Calcium-binding proteins
Calcium in the body |
| ISBN |
1-118-09954-0
1-283-02501-9 9786613025012 0-470-87238-1 0-470-87239-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
CALCIUM BINDING PROTEINS; CONTENTS; Preface; 1 Historical Perspective; 1.1 Biomineralization; 1.2 Coagulation; 1.3 Secondary Messengers (Anticipated); 1.4 Colloids; 1.5 Cross-Linking and Cell Surfaces; 1.6 Secondary Messengers (Updated); 1.7 Pumps, Channels, and Ionophores; 1.8 Calcium Binding Proteins; 1.9 Secondary Messengers (Yet Again); 1.10 Mitochondria; 1.11 Pumps, Channels, and Ionophores; 1.12 Hormones; 1.13 Measurement; 1.14 Biomineralization: Redux; 2 Physiological Processes Involving Calcium Binding Proteins; 2.1 Calcium as a Secondary Messenger; 2.2 Calcium Buffers
2.3 Calcium Pumps and Channels2.4 Mitochondria; 2.5 Eubacteria; 2.6 Calcium and Extracellular Proteins; 2.7 Biomineralization; 2.8 Calcium and Viruses; 3 Comparison of the Ca2+ Ion with Other Metal Cations; 3.1 Calcium Isotopes; 3.2 Calcium in the Environment; 3.3 Uses of Calcium; 3.4 Health Effects of Calcium; 3.5 Biologically Significant Metals in the Periodic Table; 3.6 Hydration of Metal Ions; 3.7 "Hard" and "Soft" Metal Ions; 4 Complexes of Calcium and Other Cations with Compounds of Low Molecular Weight; 4.1 Crystal Structures of Complexes of Calcium with Low Molecular Weight Compounds 4.2 Dissociation Constants of Calcium and Analogs with Small Compounds4.3 Solubilities of Calcium and Analogs with Small Compounds; 5 Stoichiometry, Kinetics, and Thermodynamics of Calcium Binding; 5.1 Stoichiometry, Affinity, and Cooperativity of Binding; 5.2 Kinetics of Binding; 5.3 Partition of Free Energy of Binding (G) Among Enthalpy (H) and Entropy (S); 6 Experimental Methods Used to Study Calcium Binding to Proteins; 6.1 Radioactivity; 6.2 Ion-Selective Electrodes; 6.3 Calcium Buffers; 6.4 Dialysis, Equilibrium, and Flow; 6.5 Proteolysis; 6.6 Deuterium Exchange 6.7 Isothermal Titration Calorimetry6.8 Differential Scanning Calorimetry; 6.9 Mass Spectroscopy; 6.10 Calcium-Specific Dyes and Fluors; 6.11 Atomic Flame Absorption Spectroscopy; 6.12 Absorption Spectroscopy; 6.13 Fluorescence Spectroscopy; 6.14 Circular Dichroic and Optical Rotatory Dispersion Spectroscopy; 6.15 Nuclear Magnetic Resonance; 6.16 Electron Spin Resonance; 6.17 Surface Plasmon Resonance; 6.18 Extended X-ray Absorption Spectroscopy; 6.19 Small Angle X-ray Scattering; 6.20 Crystallography; 7 Structure and Evolution of Proteins; 7.1 Domain; 7.2 Structure; 7.3 Evolution 8 Protein Complexes with Metals Other than Calcium8.1 Essential Hard Cations; 8.2 Essential Metals with Several Valence States; 8.3 Conclusions; 9 Nonessential Metals; 9.1 Alkali Metals (Group Ia); 9.2 Alkali Earth Metals (Group IIa); 9.3 Group IIIa; 9.4 Group IVa; 9.5 Group Va; 9.6 Group VIIa; 9.7 Group VIII; 9.8 Group Ib; 9.9 Mercury (Group IIb); 9.10 Group IIIb; 9.11 Group IVb; 9.12 Group Vb; 9.13 Polonium (Group VIb); 9.14 Conclusions and Generalizations; 10 Parvalbumin; 10.1 Structure; 10.2 Function; 11 EF-Hand Proteins 11.1 CTER (Calmodulin, Troponin C, Essential and Regulatory Light Chain) Subfamily |
| Record Nr. | UNINA-9910810531303321 |
Permiakov E. A (Evgenii Anatolevich)
|
||
| Hoboken, NJ, : John Wiley & Sons, c2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Calcium binding proteins [[electronic resource] /] / Eugene A. Permyakov, Robert H. Kretsinger
| Calcium binding proteins [[electronic resource] /] / Eugene A. Permyakov, Robert H. Kretsinger |
| Autore | Permi͡akov E. A (Evgeniĭ Anatolʹevich) |
| Pubbl/distr/stampa | Hoboken, NJ, : John Wiley & Sons, c2011 |
| Descrizione fisica | 1 online resource (600 p.) |
| Disciplina |
572.69
572/.69 |
| Altri autori (Persone) | KretsingerRobert H |
| Collana | Wiley series in protein and peptide science |
| Soggetto topico |
Calcium-binding proteins
Calcium in the body |
| ISBN |
1-118-09954-0
1-283-02501-9 9786613025012 0-470-87238-1 0-470-87239-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
CALCIUM BINDING PROTEINS; CONTENTS; Preface; 1 Historical Perspective; 1.1 Biomineralization; 1.2 Coagulation; 1.3 Secondary Messengers (Anticipated); 1.4 Colloids; 1.5 Cross-Linking and Cell Surfaces; 1.6 Secondary Messengers (Updated); 1.7 Pumps, Channels, and Ionophores; 1.8 Calcium Binding Proteins; 1.9 Secondary Messengers (Yet Again); 1.10 Mitochondria; 1.11 Pumps, Channels, and Ionophores; 1.12 Hormones; 1.13 Measurement; 1.14 Biomineralization: Redux; 2 Physiological Processes Involving Calcium Binding Proteins; 2.1 Calcium as a Secondary Messenger; 2.2 Calcium Buffers
2.3 Calcium Pumps and Channels2.4 Mitochondria; 2.5 Eubacteria; 2.6 Calcium and Extracellular Proteins; 2.7 Biomineralization; 2.8 Calcium and Viruses; 3 Comparison of the Ca2+ Ion with Other Metal Cations; 3.1 Calcium Isotopes; 3.2 Calcium in the Environment; 3.3 Uses of Calcium; 3.4 Health Effects of Calcium; 3.5 Biologically Significant Metals in the Periodic Table; 3.6 Hydration of Metal Ions; 3.7 "Hard" and "Soft" Metal Ions; 4 Complexes of Calcium and Other Cations with Compounds of Low Molecular Weight; 4.1 Crystal Structures of Complexes of Calcium with Low Molecular Weight Compounds 4.2 Dissociation Constants of Calcium and Analogs with Small Compounds4.3 Solubilities of Calcium and Analogs with Small Compounds; 5 Stoichiometry, Kinetics, and Thermodynamics of Calcium Binding; 5.1 Stoichiometry, Affinity, and Cooperativity of Binding; 5.2 Kinetics of Binding; 5.3 Partition of Free Energy of Binding (G) Among Enthalpy (H) and Entropy (S); 6 Experimental Methods Used to Study Calcium Binding to Proteins; 6.1 Radioactivity; 6.2 Ion-Selective Electrodes; 6.3 Calcium Buffers; 6.4 Dialysis, Equilibrium, and Flow; 6.5 Proteolysis; 6.6 Deuterium Exchange 6.7 Isothermal Titration Calorimetry6.8 Differential Scanning Calorimetry; 6.9 Mass Spectroscopy; 6.10 Calcium-Specific Dyes and Fluors; 6.11 Atomic Flame Absorption Spectroscopy; 6.12 Absorption Spectroscopy; 6.13 Fluorescence Spectroscopy; 6.14 Circular Dichroic and Optical Rotatory Dispersion Spectroscopy; 6.15 Nuclear Magnetic Resonance; 6.16 Electron Spin Resonance; 6.17 Surface Plasmon Resonance; 6.18 Extended X-ray Absorption Spectroscopy; 6.19 Small Angle X-ray Scattering; 6.20 Crystallography; 7 Structure and Evolution of Proteins; 7.1 Domain; 7.2 Structure; 7.3 Evolution 8 Protein Complexes with Metals Other than Calcium8.1 Essential Hard Cations; 8.2 Essential Metals with Several Valence States; 8.3 Conclusions; 9 Nonessential Metals; 9.1 Alkali Metals (Group Ia); 9.2 Alkali Earth Metals (Group IIa); 9.3 Group IIIa; 9.4 Group IVa; 9.5 Group Va; 9.6 Group VIIa; 9.7 Group VIII; 9.8 Group Ib; 9.9 Mercury (Group IIb); 9.10 Group IIIb; 9.11 Group IVb; 9.12 Group Vb; 9.13 Polonium (Group VIb); 9.14 Conclusions and Generalizations; 10 Parvalbumin; 10.1 Structure; 10.2 Function; 11 EF-Hand Proteins 11.1 CTER (Calmodulin, Troponin C, Essential and Regulatory Light Chain) Subfamily |
| Record Nr. | UNINA-9910139396903321 |
|
Permi͡akov E. A (Evgeniĭ Anatolʹevich)
|
||
| Hoboken, NJ, : John Wiley & Sons, c2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Carnosine : physiological effects and research insights / / Dominic Wells, editor
| Carnosine : physiological effects and research insights / / Dominic Wells, editor |
| Pubbl/distr/stampa | Hauppauge, New York : , : Nova Science Publisher's, Incorporated, , [2016] |
| Descrizione fisica | 1 online resource (224 pages) : illustrations |
| Disciplina | 572/.69 |
| Collana | Biochemistry research trends |
| Soggetto topico |
Carnosine - Health aspects
Carnosine - Physiological effect |
| ISBN | 1-5361-0153-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910148704603321 |
| Hauppauge, New York : , : Nova Science Publisher's, Incorporated, , [2016] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Galectins [[electronic resource] /] / edited by Anatole A. Klyosov, Zbigniew J. Witczak, David Platt
| Galectins [[electronic resource] /] / edited by Anatole A. Klyosov, Zbigniew J. Witczak, David Platt |
| Pubbl/distr/stampa | Hoboken, N.J., : John Wiley & Sons, c2008 |
| Descrizione fisica | 1 online resource (302 p.) |
| Disciplina | 572/.69 |
| Altri autori (Persone) |
KlesovA. A (Anatoliĭ Alekseevich)
WitczakZbigniew J. <1947-> PlattDavid <1953-> |
| Soggetto topico |
Lectins
Galactose |
| ISBN |
1-281-38211-6
9786611382117 0-470-37807-7 0-470-37778-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
GALECTINS; CONTENTS; Preface; Contributors; 1 Stumbling on Galectins; 2 Galectins and Their Functions in Plain Language; 3 Understanding Galectin Structure-Function Relationships to Design Effective Antagonists; 4 Galectins as Regulators of Tumor Growth and Invasion by Targeting Distinct Cell Surface Glycans and Implications for Drug Design; 5 Nuclear and Cytoplasmic Localization of Galectin-1 and Galectin-3 and Their Roles in Pre-mRNA Splicing; 6 Galectins in Regulation of Inflammation and Immunity
7 Galectins as Danger Signals in Host-Pathogen and Host-Tumor Interactions: New Members of the Growing Group of ""Alarmins""?8 The Role of Galectins in Organ Fibrosis; 9 Galectin-1, Cancer Cell Migration, Angiogenesis, and Chemoresistance; 10 Galectin-3 in the Progression and Metastasis of Colorectal Neoplasia; 11 Galectins in Malignant Gliomas: Expression, Functions, and Possible Therapeutic Options; 12 Food-Related Carbohydrate Ligands for Galectins; Index |
| Record Nr. | UNINA-9910143829803321 |
| Hoboken, N.J., : John Wiley & Sons, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Galectins / / edited by Anatole A. Klyosov, Zbigniew J. Witczak, David Platt
| Galectins / / edited by Anatole A. Klyosov, Zbigniew J. Witczak, David Platt |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, N.J., : John Wiley & Sons, c2008 |
| Descrizione fisica | 1 online resource (302 p.) |
| Disciplina | 572/.69 |
| Altri autori (Persone) |
KlesovA. A (Anatolii Alekseevich)
WitczakZbigniew J. <1947-> PlattDavid <1953-> |
| Soggetto topico |
Lectins
Galactose |
| ISBN |
1-281-38211-6
9786611382117 0-470-37807-7 0-470-37778-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
GALECTINS; CONTENTS; Preface; Contributors; 1 Stumbling on Galectins; 2 Galectins and Their Functions in Plain Language; 3 Understanding Galectin Structure-Function Relationships to Design Effective Antagonists; 4 Galectins as Regulators of Tumor Growth and Invasion by Targeting Distinct Cell Surface Glycans and Implications for Drug Design; 5 Nuclear and Cytoplasmic Localization of Galectin-1 and Galectin-3 and Their Roles in Pre-mRNA Splicing; 6 Galectins in Regulation of Inflammation and Immunity
7 Galectins as Danger Signals in Host-Pathogen and Host-Tumor Interactions: New Members of the Growing Group of ""Alarmins""?8 The Role of Galectins in Organ Fibrosis; 9 Galectin-1, Cancer Cell Migration, Angiogenesis, and Chemoresistance; 10 Galectin-3 in the Progression and Metastasis of Colorectal Neoplasia; 11 Galectins in Malignant Gliomas: Expression, Functions, and Possible Therapeutic Options; 12 Food-Related Carbohydrate Ligands for Galectins; Index |
| Record Nr. | UNINA-9910825567803321 |
| Hoboken, N.J., : John Wiley & Sons, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Protein aggregation in bacteria : functional and structural properties of inclusion bodies in bacterial cells / / edited by Silvia Maria Doglia, Marina Lotti
| Protein aggregation in bacteria : functional and structural properties of inclusion bodies in bacterial cells / / edited by Silvia Maria Doglia, Marina Lotti |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , 2014 |
| Descrizione fisica | 1 online resource (300 p.) |
| Disciplina | 572/.69 |
| Collana | Wiley Series in Protein and Peptide Science |
| Soggetto topico | Bacterial proteins |
| ISBN |
1-118-84536-6
1-118-85503-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Protein Aggregation in Bacteria: Functional and Structural Properties of Inclusion Bodies in Bacterial Cells; Copyright; Contents; Contributors; Preface ; Introduction to the WileySeries in Protein and PeptideScience; 1 Fundamentals of Protein Folding ; 1.1 Folding-misfolding-nonfolding crossroads; 1.2 Protein folding; 1.2.1 Protein-Folding Code; 1.2.2 Protein-Folding Models; 1.2.3 Polymer Aspects of Protein Folding; 1.2.4 Different Conformations Seen in Protein Folding; 1.3 Nonfolding; 1.3.1 Intrinsically Disordered Proteins and Their Abundance; 1.3.2 Some Functional Advantages of IDPs
1.3.3 Function-Induced Folding of IDPs1.3.4 IDPs and Human Diseases; 1.3.5 How Does an Amino Acid Sequence Encode Intrinsic Disorder?; 1.3.6 Polymer Aspects of Nonfolding; 1.4 Misfolding; 1.4.1 Molecular Mechanisms of Protein Misfolding; 1.4.2 Fibrillogenesis of Globular Proteins: Requirement for Partial Unfolding; 1.4.3 Fibrillogenesis of IDPs: Requirement for Partial Folding; 1.4.4 Conformational Prerequisites for Amyloidogenesis; 1.4.5 Multiple Pathways of Protein Misfolding; 1.4.6 Polymer Aspects of Protein Misfolding; References 2 Recruiting Unfolding Chaperones to Solubilize Misfolded Recombinant Proteins 2.1 Introduction; 2.2 Chemical Chaperones; 2.3 PPIs and PDIs are folding enzymes; 2.4 Molecular Chaperones; 2.5 The small Hsps; 2.6 Hsp90 ; 2.7 Hsp70/Hsp40; 2.8 GroEL Chaperonins; 2.9 Conclusions; References; 3 Osmolytes as Chemical Chaperones to Use in Protein Biotechnology ; 3.1 Introduction; 3.2 Protein-destabilizing conditions and counteracting mechanisms: shared or independent routes?; 3.3 Proposed molecular mechanisms for osmolyte activities; 3.4 Osmolytes and expression of recombinant proteins 3.5 Biotechnological relevance of osmolytes for preserving purified proteins3.6 Conclusions; References; 4 Inclusion Bodies in the Study of Amyloid Aggregation ; 4.1 Introduction; 4.2 Structure of IBs ; 4.2.1 Amyloid-like Nature of IBs ; 4.2.2 Detection and Characterization of Amyloid Conformations Inside IBs ; 4.3 Formation of IBs ; 4.3.1 In Vivo Formation Kinetics; 4.3.2 Molecular Determinants of IB Aggregation; 4.3.3 Sequence Specificity in IB Formation; 4.4 IBs as the simplest model for in vivo amyloid toxicity; 4.4.1 The Fitness Cost of Amyloid Aggregation 4.4.2 Citotoxicity of Amyloid IBs 4.4.3 Infectious Properties of IBs ; 4.5 Using IBs to screen for amyloid inhibitors; 4.6 Conclusions; References; 5 Protein Aggregation in Unicellular Eukaryotes ; 5.1 Introduction; 5.2 UPR: Unfolded protein response in the ER; 5.3 Removing persistent misfolded proteins with the proteasome; 5.4 Lysosomal/vacuolar proteolysis (overload UPS); 5.4.1 Autophagy; 5.4.2 Selective Types of Autophagy; 5.5 Refolding of protein aggregates in cytosol and nucleus; 5.6 JUNQ and IPOD; 5.7 Segregation of aggregates in yeast 5.8 Proteins forming nonpathological amyloid-like fibrils in unicellular eukaryotes |
| Record Nr. | UNINA-9910139119803321 |
| Hoboken, New Jersey : , : Wiley, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Protein aggregation in bacteria : functional and structural properties of inclusion bodies in bacterial cells / / edited by Silvia Maria Doglia, Marina Lotti
| Protein aggregation in bacteria : functional and structural properties of inclusion bodies in bacterial cells / / edited by Silvia Maria Doglia, Marina Lotti |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , 2014 |
| Descrizione fisica | 1 online resource (300 p.) |
| Disciplina | 572/.69 |
| Collana | Wiley Series in Protein and Peptide Science |
| Soggetto topico | Bacterial proteins |
| ISBN |
1-118-84536-6
1-118-85503-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Protein Aggregation in Bacteria: Functional and Structural Properties of Inclusion Bodies in Bacterial Cells; Copyright; Contents; Contributors; Preface ; Introduction to the WileySeries in Protein and PeptideScience; 1 Fundamentals of Protein Folding ; 1.1 Folding-misfolding-nonfolding crossroads; 1.2 Protein folding; 1.2.1 Protein-Folding Code; 1.2.2 Protein-Folding Models; 1.2.3 Polymer Aspects of Protein Folding; 1.2.4 Different Conformations Seen in Protein Folding; 1.3 Nonfolding; 1.3.1 Intrinsically Disordered Proteins and Their Abundance; 1.3.2 Some Functional Advantages of IDPs
1.3.3 Function-Induced Folding of IDPs1.3.4 IDPs and Human Diseases; 1.3.5 How Does an Amino Acid Sequence Encode Intrinsic Disorder?; 1.3.6 Polymer Aspects of Nonfolding; 1.4 Misfolding; 1.4.1 Molecular Mechanisms of Protein Misfolding; 1.4.2 Fibrillogenesis of Globular Proteins: Requirement for Partial Unfolding; 1.4.3 Fibrillogenesis of IDPs: Requirement for Partial Folding; 1.4.4 Conformational Prerequisites for Amyloidogenesis; 1.4.5 Multiple Pathways of Protein Misfolding; 1.4.6 Polymer Aspects of Protein Misfolding; References 2 Recruiting Unfolding Chaperones to Solubilize Misfolded Recombinant Proteins 2.1 Introduction; 2.2 Chemical Chaperones; 2.3 PPIs and PDIs are folding enzymes; 2.4 Molecular Chaperones; 2.5 The small Hsps; 2.6 Hsp90 ; 2.7 Hsp70/Hsp40; 2.8 GroEL Chaperonins; 2.9 Conclusions; References; 3 Osmolytes as Chemical Chaperones to Use in Protein Biotechnology ; 3.1 Introduction; 3.2 Protein-destabilizing conditions and counteracting mechanisms: shared or independent routes?; 3.3 Proposed molecular mechanisms for osmolyte activities; 3.4 Osmolytes and expression of recombinant proteins 3.5 Biotechnological relevance of osmolytes for preserving purified proteins3.6 Conclusions; References; 4 Inclusion Bodies in the Study of Amyloid Aggregation ; 4.1 Introduction; 4.2 Structure of IBs ; 4.2.1 Amyloid-like Nature of IBs ; 4.2.2 Detection and Characterization of Amyloid Conformations Inside IBs ; 4.3 Formation of IBs ; 4.3.1 In Vivo Formation Kinetics; 4.3.2 Molecular Determinants of IB Aggregation; 4.3.3 Sequence Specificity in IB Formation; 4.4 IBs as the simplest model for in vivo amyloid toxicity; 4.4.1 The Fitness Cost of Amyloid Aggregation 4.4.2 Citotoxicity of Amyloid IBs 4.4.3 Infectious Properties of IBs ; 4.5 Using IBs to screen for amyloid inhibitors; 4.6 Conclusions; References; 5 Protein Aggregation in Unicellular Eukaryotes ; 5.1 Introduction; 5.2 UPR: Unfolded protein response in the ER; 5.3 Removing persistent misfolded proteins with the proteasome; 5.4 Lysosomal/vacuolar proteolysis (overload UPS); 5.4.1 Autophagy; 5.4.2 Selective Types of Autophagy; 5.5 Refolding of protein aggregates in cytosol and nucleus; 5.6 JUNQ and IPOD; 5.7 Segregation of aggregates in yeast 5.8 Proteins forming nonpathological amyloid-like fibrils in unicellular eukaryotes |
| Record Nr. | UNINA-9910813330403321 |
| Hoboken, New Jersey : , : Wiley, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Protein trafficking in neurons [[electronic resource] /] / editor, Andrew Bean
| Protein trafficking in neurons [[electronic resource] /] / editor, Andrew Bean |
| Pubbl/distr/stampa | Amsterdam ; ; Boston, : Elsevier/Academic Press, c2007 |
| Descrizione fisica | 1 online resource (466 p.) |
| Disciplina | 572/.69 |
| Altri autori (Persone) | BeanAndrew J |
| Soggetto topico |
Proteins - Physiological transport
Neurons |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-70761-5
9786610707614 0-08-046589-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front cover; Title page; Copyright page; Table of contents; Contributors; Acknowledgments; SECTION I: PROTEIN MOVEMENT; CHAPTER 1: Molecular Mobility in Cells Examined with Optical Methods; I. BROWNIAN MOTION AND THE FUNDAMENTALS OF DIFFUSION; II. A VIEW OF CYTOPLASM AND MEMBRANE FROM THE SINGLE MOLECULE PERSPECTIVE; III. DIFFUSION AND MOBILITY OF PROTEINS IN CELLS STUDIED WITH BIOPHYSICAL TECHNIQUES; IV. CONCLUSIONS AND FUTURE DIRECTIONS; CHAPTER 2: The Role of Molecular Motors in Axonal Transport; I. INTRODUCTION; II. KINESIN; III. CYTOPLASMIC DYNEIN; IV. DYNACTIN; V. MYOSIN
VI. TRANSPORT REGULATION AND CONTROLVII. AXONAL TRANSPORT; VIII. PROTEIN DEGRADATION; IX. mRNA LOCALIZATION; X. MITOCHONDRIA TRANSPORT; XI. AXON SIGNALING STRATEGY; XII. SIGNALING ADAPTORS; XIII. SURVIVAL SIGNALING; XIV. DEATH SIGNALS; XV. VIRUSES; XVI. NEURODEGENERATIVE DISEASE; XVII. SUMMARY; References; CHAPTER 3: Role of APC Complexes and the Microtubule Cytoskeleton in Neuronal Morphogenesis; I. INTRODUCTION; II. ROLE OF MICROTUBULES IN NEURONAL POLARIZATION; III. TARGETING OF APC TO TIPS OF NEURITES; IV. ROLE OF APC IN MICROTUBULE DYNAMICS AT TIPS OF NEURITES; V. SUMMARY; References SECTION II: SYNAPTIC DEVELOPMENTCHAPTER 4: Assembly of Synapses in the Vertebrate Central Nervous System; I. INTRODUCTION; II. CELL BIOLOGY OF CNS SYNAPSES; III. MOLECULAR MECHANISMS OF SYNAPSE FORMATION; IV. SYNAPTIC SPECIFICITY AND MOLECULAR DIVERSITY OF CELL SURFACE RECEPTORS; V. CONCLUDING REMARKS; References; CHAPTER 5: Presynaptic Terminal Differentiation; I. MORPHOLOGY OF THE PRESYNAPTIC TERMINI OF VERTEBRATE AND INVERTEBRATE SYNAPSES; II. PROTEIN COMPONENTS OF PRESYNAPTIC TERMINI; III. SNAREs; IV. FUTURE PERSPECTIVES; References; SECTION III: EXO-/ENDOCYTOSIS CHAPTER 6: Neuronal ExocytosisI. INTRODUCTION; II. CONCLUSIONS; References; CHAPTER 7: Endocytosis in Neurons; I. ENDOCYTOSIS IN NEURONS; II. THE CLATHRIN-DEPENDENT ENDOCYTIC MACHINERY; III. MECHANISMS OF PRESYNAPTIC VESICLE CYCLING; IV. ENDOCYTOSIS OF POSTSYNAPTIC NEUROTRANSMITTER RECEPTORS; V. CONCLUSIONS; References; SECTION IV: RECEPTOR TRAFFICKING; CHAPTER 8: Postsynaptic Machinery for Receptor Trafficking; I. POSTSYNAPTIC MICROANATOMY: DENDRITES AND SPINES; II. TRAFFICKING OF NEW RECEPTORS: DENDRITIC SECRETORY ORGANELLES; III. ENDOCYTOSIS AND THE ENDOCYTIC ZONE IV. ENDOSOMES AND RECEPTOR RECYCLINGV. THE EXTRASYNAPTIC PLASMA MEMBRANE AND LATERAL MOVEMENT OF RECEPTORS; VI. PERSPECTIVES; References; CHAPTER 9: Synaptic Trafficking of AMPA Receptors; I. INTRODUCTION; II. REGULATED RECEPTOR ASSEMBLY AND EXIT FROM THE ER; III. DENDRITIC LOCALIZATION AND MEMBRANE INSERTION; IV. RETENTION AND CONSTITUTIVE CYCLING AT THE SYNAPSE; V. REGULATED SYNAPTIC TARGETING; VI. CONCLUSIONS; References; CHAPTER 10: Subunit-Specific NMDA Receptor Trafficking to Synapses; I. INTRODUCTION; II. ASSEMBLY OF NMDA-Rs III. EXITING THE ENDOPLASMIC RETICULUM-THE ROLE OF NR1 SUBUNIT |
| Record Nr. | UNINA-9910458654503321 |
| Amsterdam ; ; Boston, : Elsevier/Academic Press, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
