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Lyophilized Biologics and Vaccines : Modality-Based Approaches / / edited by Dushyant Varshney, Manmohan Singh
| Lyophilized Biologics and Vaccines : Modality-Based Approaches / / edited by Dushyant Varshney, Manmohan Singh |
| Edizione | [1st ed. 2015.] |
| Pubbl/distr/stampa | New York, NY : , : Springer New York : , : Imprint : Springer, , 2015 |
| Descrizione fisica | 1 online resource (399 p.) |
| Disciplina |
571967
610 615.19 615372 616.0798 |
| Soggetto topico |
Vaccines
Antibodies Pharmaceutical technology Vaccine Pharmaceutical Sciences/Technology |
| ISBN | 1-4939-2383-8 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Preface -- Part I – Lyophilization History and Fundamentals -- History of Lyophilization -- Heterogeneity of protein environments in frozen solutions and in the dried state -- Advance understanding of buffer behavior during lyophilization -- Advances in Instrumental Analysis Applied to the Development of Lyophilization Cycles -- New Developments in Controlled Nucleation: Commercializing VERISEQ® Nucleation technology -- Part II – Lyophilized Biologics and Vaccines – Modality Considerations -- Lyophilized Biologics -- Lyophilization of Therapeutic Proteins in Vials - Process Scale-up and Advances in Quality by Design -- Advances in Process Analytical Technology in Freeze Drying -- Process Scale-up and Optimization of Lyophilized Vaccine Products -- Stabilization of Plasmid DNA and Lipid-based Therapeutics as Dehydrated Formulations -- Part III – Advances in Alternate Drying -- Alternatives to Vial Lyophilization -- Spray Drying of Biopharmaceuticals -- Current Trends and Advances in Bulk Crystallization and Freeze Drying of Biopharmaceuticals -- Case Studies and Examples of Biopharmaceutical Modalities -- Processed by Bulk Crystallization or Bulk Freeze Drying -- Part IV– Regulatory, Packaging and Technology Transfer Considerations -- Lyophilization of Biologics - An FDA Perspective -- Recent Trends in Lyophilized Delivery Devices and Packaging -- Lyophilization Technology Transfer towards Product Launch. |
| Record Nr. | UNINA-9910298290903321 |
| New York, NY : , : Springer New York : , : Imprint : Springer, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Macrophages: Biology and Role in the Pathology of Diseases / / edited by Subhra K. Biswas, Alberto Mantovani
| Macrophages: Biology and Role in the Pathology of Diseases / / edited by Subhra K. Biswas, Alberto Mantovani |
| Edizione | [1st ed. 2014.] |
| Pubbl/distr/stampa | New York, NY : , : Springer New York : , : Imprint : Springer, , 2014 |
| Descrizione fisica | 1 online resource (603 p.) |
| Disciplina |
571967
610 616.0798 616.9041 |
| Soggetto topico |
Immunology
Antibodies Medical microbiology Medical Microbiology |
| ISBN | 1-4939-1311-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Part I Macrophage: Origin, Activation And Polarization -- Blood monocytes and their subsets in health and disease -- Polarized activation of macrophages -- Alternative activation of macrophages: concepts and prospects -- Regulatory macrophages and the maintenance of homeostasis -- Part II Macrophages And Their Diverse Functions -- Phagocytosis -- The antimicrobial functions of macrophages -- Vascular modulatory functions of macrophages -- Part III Macrophages In Different Tissues -- Airway macrophages: sentinels of health -- Microglial ontogeny and functions in shaping brain circuits -- Kupffer cells in health and disease -- Intestinal Macrophages: Specialized antigen-presenting cells at the front line -- Part IV Macrophages In Pathology -- The wound macrophage - Macrophages and the entrance of resolution phase lipid mediators -- Macrophages in sepsis progression -- Adaptive characteristics of innate immune responses in macrophages -- African trypanosomiasis as paradigm for involvement of the mononuclear phagocyte system in pathogenicity during parasite infection -- Macrophages in obesity and insulin resistance -- Macrophages govern the progression and termination of inflammation in atherosclerosis and metabolic diseases -- Myelomonocytic subsets in tumor microenvironment -- Tumor associated macrophages -- Part V Transcriptional And Epigenetic Mechanisms -- Role of NF-kB activation in macrophages -- Interferon Regulatory Factors: Role in transcriptional regulation of macrophage plasticity and activation -- Kruppel-like factors in Monocyte-Macrophage Biology -- Regulation of macrophage polarization by the STAT-SOCS signaling axis -- Functions of the large Maf transcription factors and macrophages -- The Control of Gene Expression in Macrophages -- Role of microRNA in macrophage activation and polarization -- Part VI Systems Biology Of Macrophages -- The macrophage transcriptome -- Omics approaches in macrophage biology -- Appendix. |
| Record Nr. | UNINA-9910298334103321 |
| New York, NY : , : Springer New York : , : Imprint : Springer, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Multiple Sclerosis, Mad Cow Disease and Acinetobacter / / by Alan Ebringer
| Multiple Sclerosis, Mad Cow Disease and Acinetobacter / / by Alan Ebringer |
| Autore | Ebringer Alan |
| Edizione | [1st ed. 2015.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015 |
| Descrizione fisica | 1 online resource (208 p.) |
| Disciplina |
571967
610 616.0798 616.9 |
| Soggetto topico |
Antibodies
Immunology Infectious diseases Veterinary medicine Infectious Diseases Veterinary Medicine/Veterinary Science |
| ISBN | 3-319-02735-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1. Multiple Sclerosis as a Scientific Problem -- 2. History of the Attempts to find the Origin of Multiple Sclerosis -- 3. The Problem of Bovine Spongiform Encephalopathy also known as "Mad Cow Disease" in the United Kingdom -- 4. Experimental Allergic Encephalomyelitis as a Model of Multiple Sclerosis -- 5. Bovine Spongiform Encephalopathy: Comparison between the "Prion" Hypothesis in EAE and BSE Point to Acinetobacter Bacteria -- 6. Molecular Sequences in EAE and BSE Point to Acinetobacter Bacteria -- 7. Autoantibodies to Brain Components and Antibodies to Acinetobacter are Present in Bovine Spongiform Encephalopathy -- 8. Antibodies to Acinetobacter Bacteria but not to other Microbes are Present in Animals with Bovine Spongiform Encephalopathy -- 9. An Ante-Mortem Test for Bovine Spongiform Encephalopathy involving "Myelin-Acinetobacter-Neurofilaments" (MAN) Tested in 12 Strains of Acinetobacter Bacteria -- 10. Antibodies to Acinetobacter and Pseudomonas Bacteria in Bovine Spongiform Encephalopathy -- 11. Antibodies to Acinetobacter and Pseudomonas Bacteria in Multiple Sclerosis Patients -- 12. Antibodies to Acinetobacter Peptide Sequences Resembling Myelin and Neurofilaments in Multiple Sclerosis Patients -- 13. The Myelin Acinetobacter Neurofilament Index in an Attempt to Diagnose Multiple Sclerosis -- 14. Antibodies to Short Synthetic Acinetobacter and Pseudomonas Peptide Sequences Resembling Myelin and Neurofilaments in Multiple Sclerosis Patients -- 15. Antibodies to Acinetobacter and Myelin in Multiple Sclerosis and Creutzfeldt-Jakob Disease Patients -- 16. Creutzfeldt-Jakob Disease and its Variants -- 17. Sinusitis in Multiple Sclerosis and Acinetobacter -- 18. The Theory that Multiple Sclerosis, CJD and BSE are Caused by Acinetobacter -- 19. The Scientific Method of Sir Karl Popper -- 20. Multiple Sclerosis and "Popper Sequences". |
| Record Nr. | UNINA-9910298281603321 |
Ebringer Alan
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| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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