Info
- Utilizzare la checkbox di selezione a fianco di ciascun documento per attivare le funzionalità di stampa, invio email, download nei formati disponibili del (i) record.
Apoptosis and beyond : the many ways cells die / / edited by James Radosevich, University of Chicago, United States
| Apoptosis and beyond : the many ways cells die / / edited by James Radosevich, University of Chicago, United States |
| Pubbl/distr/stampa | Hoboken, NJ : , : Wiley-Blackwell, , 2018 |
| Descrizione fisica | 1 online resource (xiii, 749 pages) : colour illustrations |
| Disciplina | 571.9/36 |
| Soggetto topico |
Cell death
Apoptosis Cell Death |
| ISBN |
1-119-43243-X
1-119-43246-4 1-119-43235-9 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910555061803321 |
| Hoboken, NJ : , : Wiley-Blackwell, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Aspartic acid proteases as therapeutic targets / / edited by Arun K. Ghosh
| Aspartic acid proteases as therapeutic targets / / edited by Arun K. Ghosh |
| Pubbl/distr/stampa | Weinheim, Germany : , : Wiley-VCH, , 2010 |
| Descrizione fisica | 1 online resource (641 p.) |
| Disciplina |
571.9/36
612.01516 |
| Collana | Methods and Principles in Medicinal Chemistry |
| Soggetto topico |
Aspartic proteinases
Aspartic proteinases - Inhibitors - Therapeutic use |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-282-77490-5
9786612774904 3-527-64162-9 3-527-63094-5 3-527-63095-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Aspartic Acid Proteases as Therapeutic Targets; Contents; List of Contributors; Preface; A Personal Foreword; Part: One Overview of Aspartic Acid Proteases; 1 Introduction to the Aspartic Proteinase Family; 2 Aspartic Proteases: Structure, Function, and Inhibition; 3 Human Aspartic Proteinases; 4 Structure-Based Drug Design Strategies for Inhibition of Aspartic Proteinases; Part Two: HIV-1 Protease as Target for the Treatment of HIV/AIDS; 5 HIV-1 Protease: Role in Viral Replication, Protein-Ligand X-Ray Crystal Structures and Inhibitor Design
6 First-Generation HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS7 Second-Generation Approved HIV Protease Inhibitors for the Treatment of HIV/AIDS; 8 Darunavir, a New PI with Dual Mechanism: From a Novel Drug Design Concept to New Hope Against Drug-Resistant HIV; 9 Development of HIV-1 Protease Inhibitors, Antiretroviral Resistance, and Current Challenges of HIV/AIDS Management; Part Three: Renin as Target for the Treatment of Hypertension; 10 Discovery and Development of Aliskiren, the First-in-Class Direct Renin Inhibitor for the Treatment of Hypertension 11 Evolution of Diverse Classes of Renin Inhibitors Through the YearsPart Four: ?-Secretase as Target for the Treatment of Alzheimer""s Disease; 12: ?-Secretase: An Unusual Enzyme with Many Possible Disease Targets, Including Alzheimer""s Disease; 13 ?-Secretase Inhibition: An Overview of Development of Inhibitors for the Treatment of Alzheimer's Disease; Part Five: ß-Secretase as Target for the Treatment of Alzheimer's Disease; 14 BACE: A (Almost) Perfect Target for Staving Off Alzheimer's Disease 15 The Discovery of ß-Secretase and Development Toward a Clinical Inhibitor for AD: An Exciting Academic Collaboration16 Peptidomimetic BACE1 Inhibitors for Treatment of Alzheimer.s Disease: Design and Evolution; 17 Nonpeptide BACE1 Inhibitors: Design and Synthesis; Part Six: Plasmepsins and Other Aspartic Proteases as Drug Targets; 18 The Plasmepsin Family as Antimalarial Drug Targets; 19 Plasmepsins Inhibitors as Potential Drugs Against Malaria: Starving the Parasite; 20 Fungal Aspartic Proteases as Possible Therapeutic Targets; Index |
| Record Nr. | UNINA-9910140801803321 |
| Weinheim, Germany : , : Wiley-VCH, , 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Aspartic acid proteases as therapeutic targets / / edited by Arun K. Ghosh
| Aspartic acid proteases as therapeutic targets / / edited by Arun K. Ghosh |
| Pubbl/distr/stampa | Weinheim, Germany : , : Wiley-VCH, , 2010 |
| Descrizione fisica | 1 online resource (641 p.) |
| Disciplina |
571.9/36
612.01516 |
| Collana | Methods and Principles in Medicinal Chemistry |
| Soggetto topico |
Aspartic proteinases
Aspartic proteinases - Inhibitors - Therapeutic use |
| ISBN |
1-282-77490-5
9786612774904 3-527-64162-9 3-527-63094-5 3-527-63095-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Aspartic Acid Proteases as Therapeutic Targets; Contents; List of Contributors; Preface; A Personal Foreword; Part: One Overview of Aspartic Acid Proteases; 1 Introduction to the Aspartic Proteinase Family; 2 Aspartic Proteases: Structure, Function, and Inhibition; 3 Human Aspartic Proteinases; 4 Structure-Based Drug Design Strategies for Inhibition of Aspartic Proteinases; Part Two: HIV-1 Protease as Target for the Treatment of HIV/AIDS; 5 HIV-1 Protease: Role in Viral Replication, Protein-Ligand X-Ray Crystal Structures and Inhibitor Design
6 First-Generation HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS7 Second-Generation Approved HIV Protease Inhibitors for the Treatment of HIV/AIDS; 8 Darunavir, a New PI with Dual Mechanism: From a Novel Drug Design Concept to New Hope Against Drug-Resistant HIV; 9 Development of HIV-1 Protease Inhibitors, Antiretroviral Resistance, and Current Challenges of HIV/AIDS Management; Part Three: Renin as Target for the Treatment of Hypertension; 10 Discovery and Development of Aliskiren, the First-in-Class Direct Renin Inhibitor for the Treatment of Hypertension 11 Evolution of Diverse Classes of Renin Inhibitors Through the YearsPart Four: ?-Secretase as Target for the Treatment of Alzheimer""s Disease; 12: ?-Secretase: An Unusual Enzyme with Many Possible Disease Targets, Including Alzheimer""s Disease; 13 ?-Secretase Inhibition: An Overview of Development of Inhibitors for the Treatment of Alzheimer's Disease; Part Five: ß-Secretase as Target for the Treatment of Alzheimer's Disease; 14 BACE: A (Almost) Perfect Target for Staving Off Alzheimer's Disease 15 The Discovery of ß-Secretase and Development Toward a Clinical Inhibitor for AD: An Exciting Academic Collaboration16 Peptidomimetic BACE1 Inhibitors for Treatment of Alzheimer.s Disease: Design and Evolution; 17 Nonpeptide BACE1 Inhibitors: Design and Synthesis; Part Six: Plasmepsins and Other Aspartic Proteases as Drug Targets; 18 The Plasmepsin Family as Antimalarial Drug Targets; 19 Plasmepsins Inhibitors as Potential Drugs Against Malaria: Starving the Parasite; 20 Fungal Aspartic Proteases as Possible Therapeutic Targets; Index |
| Record Nr. | UNINA-9910829994603321 |
| Weinheim, Germany : , : Wiley-VCH, , 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Aspartic acid proteases as therapeutic targets / / edited by Arun K. Ghosh
| Aspartic acid proteases as therapeutic targets / / edited by Arun K. Ghosh |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, 2010 |
| Descrizione fisica | 1 online resource (641 p.) |
| Disciplina |
571.9/36
612.01516 |
| Altri autori (Persone) | GhoshArun K., Prof. Dr. |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Aspartic proteinases
Aspartic proteinases - Inhibitors - Therapeutic use |
| ISBN |
9786612774904
9781282774902 1282774905 9783527641628 3527641629 9783527630943 3527630945 9783527630950 3527630953 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Aspartic Acid Proteases as Therapeutic Targets; Contents; List of Contributors; Preface; A Personal Foreword; Part: One Overview of Aspartic Acid Proteases; 1 Introduction to the Aspartic Proteinase Family; 2 Aspartic Proteases: Structure, Function, and Inhibition; 3 Human Aspartic Proteinases; 4 Structure-Based Drug Design Strategies for Inhibition of Aspartic Proteinases; Part Two: HIV-1 Protease as Target for the Treatment of HIV/AIDS; 5 HIV-1 Protease: Role in Viral Replication, Protein-Ligand X-Ray Crystal Structures and Inhibitor Design
6 First-Generation HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS7 Second-Generation Approved HIV Protease Inhibitors for the Treatment of HIV/AIDS; 8 Darunavir, a New PI with Dual Mechanism: From a Novel Drug Design Concept to New Hope Against Drug-Resistant HIV; 9 Development of HIV-1 Protease Inhibitors, Antiretroviral Resistance, and Current Challenges of HIV/AIDS Management; Part Three: Renin as Target for the Treatment of Hypertension; 10 Discovery and Development of Aliskiren, the First-in-Class Direct Renin Inhibitor for the Treatment of Hypertension 11 Evolution of Diverse Classes of Renin Inhibitors Through the YearsPart Four: ?-Secretase as Target for the Treatment of Alzheimer""s Disease; 12: ?-Secretase: An Unusual Enzyme with Many Possible Disease Targets, Including Alzheimer""s Disease; 13 ?-Secretase Inhibition: An Overview of Development of Inhibitors for the Treatment of Alzheimer's Disease; Part Five: ß-Secretase as Target for the Treatment of Alzheimer's Disease; 14 BACE: A (Almost) Perfect Target for Staving Off Alzheimer's Disease 15 The Discovery of ß-Secretase and Development Toward a Clinical Inhibitor for AD: An Exciting Academic Collaboration16 Peptidomimetic BACE1 Inhibitors for Treatment of Alzheimer.s Disease: Design and Evolution; 17 Nonpeptide BACE1 Inhibitors: Design and Synthesis; Part Six: Plasmepsins and Other Aspartic Proteases as Drug Targets; 18 The Plasmepsin Family as Antimalarial Drug Targets; 19 Plasmepsins Inhibitors as Potential Drugs Against Malaria: Starving the Parasite; 20 Fungal Aspartic Proteases as Possible Therapeutic Targets; Index |
| Record Nr. | UNINA-9911018822903321 |
| Weinheim, : Wiley-VCH, 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Autophagy and cancer / / Hong-Gang Wang, editor
| Autophagy and cancer / / Hong-Gang Wang, editor |
| Edizione | [1st ed. 2013.] |
| Pubbl/distr/stampa | New York, NY, : Springer, c2013 |
| Descrizione fisica | 1 online resource (261 p.) |
| Disciplina |
571.9
571.9/36 |
| Altri autori (Persone) | WangHong-Gang |
| Collana | Current cancer research |
| Soggetto topico |
Carcinogenesis
Cancer - Immunological aspects |
| ISBN | 1-4614-6561-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Preface -- Historical Overview of Autophagy -- The Core Molecular Machinery of Autophagosome Formation -- The origin of autophagosomes: The beginning of an end -- Signal Transduction Regulation of Autophagy -- Role of Autophagy in Tumorigenesis -- Selective autophagy and cancer -- Oncogenes and tumor suppressor genes in autophagy -- Autophagy and Immunity -- Autophagy and the Tumor Microenvironment -- Autophagy and Cancer Therapy -- The Crosstalk between Apoptosis & Autophagy -- Autophagy and Cancer Drug Discovery -- Index. |
| Record Nr. | UNINA-9910438129503321 |
| New York, NY, : Springer, c2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Caspases : roles and significance in cell death and disease / / Jeffrey Warren, editor
| Caspases : roles and significance in cell death and disease / / Jeffrey Warren, editor |
| Pubbl/distr/stampa | Hauppauge, New York : , : Nova Science Publisher's, Incorporated, , [2016] |
| Descrizione fisica | 1 online resource (160 pages) : illustrations |
| Disciplina | 571.9/36 |
| Collana | Cell biology research progress |
| Soggetto topico |
Apoptosis
Cell death |
| ISBN | 1-5361-0260-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910150313603321 |
| Hauppauge, New York : , : Nova Science Publisher's, Incorporated, , [2016] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cell death [[electronic resource] /] / editors, Gerry Melino, David Vaux
| Cell death [[electronic resource] /] / editors, Gerry Melino, David Vaux |
| Pubbl/distr/stampa | Chichester, West Sussex ; ; Hoboken, NJ, : John Wiley & Sons, 2010 |
| Descrizione fisica | 1 online resource (317 p.) |
| Disciplina | 571.9/36 |
| Altri autori (Persone) |
MelinoGerry
VauxDavid |
| Soggetto topico |
Apoptosis
Cell death |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-282-54809-3
9786612548093 0-470-68657-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Cell Death; Copyright Page; Contents; Contributors; Preface; The Siren's Song: This Death That Makes Life Live; References; Further Reading; The Origin and Evolution of Programmed Cell Death; Introduction; Origins: From the Question 'When' to the Question 'How'; From Predator/Prey Coevolution to Symbioses: A 'Red Queen' Hypothesis in the Bacteria World; A Stable Evolutionary Strategy despite High Individual Costs; The 'Original Sin' Hypothesis: Self-destruction as an Unavoidable Consequence of Life; C. elegans Model: From Paradigm to Paradox; Walking Around the Evolutionary Bush
From the Origins of Programmed Cell Death to the Origins of Ageing'There is Grandeur in This View of Life...'; References; Further Reading; Cell Death in C. elegans; ced-3, ced-4, ced-9 and egl-1 are Conserved Genes Essential for Programmed Cell Death in C. elegans; Regulation of Cell Death during Somatic Development; Engulfment of Dying Cells; Germline Apoptosis; DNA Damage-induced Germline Apoptosis; Conclusion; References; Further Reading; Caspases and Cell Death; History and Classification; Structure and Active Site; Substrate Recognition and Mechanism of Action; Sequence of Action Substrates during ApoptosisInhibitors; Caspase Knockouts; Pathological Implications; Therapeutic Outlook; References; Further Reading; The Apoptosome: The Executioner of Mitochondria-mediated Apoptosis; Introduction; The Apoptosome Structure: Its Components and Its Assembly; Apaf1; Apoptosome assembly; Caspase-9; Cytochrome c; Modulation of the Apoptosome Formation; Apoptosome-like Complexes in Evolution. Is the Mitochondrial Pathway of Apoptosis Conserved?; Caenorhabditis elegans; Drosophila melanogaster; The Role of the Apoptosome in Mammalian Development; Caspase-9 knockout; Apaf1 knockout Cytochrome c deficiencyFinal Remarks; References; Further Reading; Caspases, Substrates and Sequential Activation; Introduction; Caspases Classification and Structure; Pathways That Lead to Caspase Activation; Extrinsic pathway; Granzyme B pathway; Intrinsic pathway; Effectors of demolition; Demolition Phase of Apoptosis; Detachment, rounding and blebbing; Nuclear fragmentation, DNA condensation and degradation; Undermining cell physiology; Immune Clearance and Immune Tolerance of Apoptotic Cells; Conclusions; Acknowledgements; References; Further Reading; Dismantling the Apoptotic Cell IntroductionCaspases: Regulators of the Apoptotic Process; Activation of the apoptotic caspases; Effect of caspase-mediated cleavage on target substrates - gain- or loss-of-function; Cleavage of caspase substrates leads to key morphological changes during apoptosis; Cytoskeletal events and membrane blebbing; Nuclear events; Changes in the Golgi apparatus; Caspases alter the transcriptional and translational machinery; Survival pathways are targeted during apoptosis; The apoptotic cell calls for its own disposal; Caspase-independent cell death; Concluding Remarks; References; Further Reading The BCL-2 Family Proteins - Key Regulators and Effectors of Apoptosis |
| Record Nr. | UNINA-9910459346203321 |
| Chichester, West Sussex ; ; Hoboken, NJ, : John Wiley & Sons, 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cell death [[electronic resource] /] / editors, Gerry Melino, David Vaux
| Cell death [[electronic resource] /] / editors, Gerry Melino, David Vaux |
| Pubbl/distr/stampa | Chichester, West Sussex ; ; Hoboken, NJ, : John Wiley & Sons, 2010 |
| Descrizione fisica | 1 online resource (317 p.) |
| Disciplina | 571.9/36 |
| Altri autori (Persone) |
MelinoGerry
VauxDavid |
| Soggetto topico |
Apoptosis
Cell death |
| ISBN |
1-282-54809-3
9786612548093 0-470-68657-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Cell Death; Copyright Page; Contents; Contributors; Preface; The Siren's Song: This Death That Makes Life Live; References; Further Reading; The Origin and Evolution of Programmed Cell Death; Introduction; Origins: From the Question 'When' to the Question 'How'; From Predator/Prey Coevolution to Symbioses: A 'Red Queen' Hypothesis in the Bacteria World; A Stable Evolutionary Strategy despite High Individual Costs; The 'Original Sin' Hypothesis: Self-destruction as an Unavoidable Consequence of Life; C. elegans Model: From Paradigm to Paradox; Walking Around the Evolutionary Bush
From the Origins of Programmed Cell Death to the Origins of Ageing'There is Grandeur in This View of Life...'; References; Further Reading; Cell Death in C. elegans; ced-3, ced-4, ced-9 and egl-1 are Conserved Genes Essential for Programmed Cell Death in C. elegans; Regulation of Cell Death during Somatic Development; Engulfment of Dying Cells; Germline Apoptosis; DNA Damage-induced Germline Apoptosis; Conclusion; References; Further Reading; Caspases and Cell Death; History and Classification; Structure and Active Site; Substrate Recognition and Mechanism of Action; Sequence of Action Substrates during ApoptosisInhibitors; Caspase Knockouts; Pathological Implications; Therapeutic Outlook; References; Further Reading; The Apoptosome: The Executioner of Mitochondria-mediated Apoptosis; Introduction; The Apoptosome Structure: Its Components and Its Assembly; Apaf1; Apoptosome assembly; Caspase-9; Cytochrome c; Modulation of the Apoptosome Formation; Apoptosome-like Complexes in Evolution. Is the Mitochondrial Pathway of Apoptosis Conserved?; Caenorhabditis elegans; Drosophila melanogaster; The Role of the Apoptosome in Mammalian Development; Caspase-9 knockout; Apaf1 knockout Cytochrome c deficiencyFinal Remarks; References; Further Reading; Caspases, Substrates and Sequential Activation; Introduction; Caspases Classification and Structure; Pathways That Lead to Caspase Activation; Extrinsic pathway; Granzyme B pathway; Intrinsic pathway; Effectors of demolition; Demolition Phase of Apoptosis; Detachment, rounding and blebbing; Nuclear fragmentation, DNA condensation and degradation; Undermining cell physiology; Immune Clearance and Immune Tolerance of Apoptotic Cells; Conclusions; Acknowledgements; References; Further Reading; Dismantling the Apoptotic Cell IntroductionCaspases: Regulators of the Apoptotic Process; Activation of the apoptotic caspases; Effect of caspase-mediated cleavage on target substrates - gain- or loss-of-function; Cleavage of caspase substrates leads to key morphological changes during apoptosis; Cytoskeletal events and membrane blebbing; Nuclear events; Changes in the Golgi apparatus; Caspases alter the transcriptional and translational machinery; Survival pathways are targeted during apoptosis; The apoptotic cell calls for its own disposal; Caspase-independent cell death; Concluding Remarks; References; Further Reading The BCL-2 Family Proteins - Key Regulators and Effectors of Apoptosis |
| Record Nr. | UNINA-9910792418603321 |
| Chichester, West Sussex ; ; Hoboken, NJ, : John Wiley & Sons, 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cell death / / editors, Gerry Melino, David Vaux
| Cell death / / editors, Gerry Melino, David Vaux |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Chichester, West Sussex ; ; Hoboken, NJ, : John Wiley & Sons, 2010 |
| Descrizione fisica | 1 online resource (317 p.) |
| Disciplina | 571.9/36 |
| Altri autori (Persone) |
MelinoGerry
VauxDavid |
| Soggetto topico |
Apoptosis
Cell death |
| ISBN |
9786612548093
9781282548091 1282548093 9780470686577 047068657X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Cell Death; Copyright Page; Contents; Contributors; Preface; The Siren's Song: This Death That Makes Life Live; References; Further Reading; The Origin and Evolution of Programmed Cell Death; Introduction; Origins: From the Question 'When' to the Question 'How'; From Predator/Prey Coevolution to Symbioses: A 'Red Queen' Hypothesis in the Bacteria World; A Stable Evolutionary Strategy despite High Individual Costs; The 'Original Sin' Hypothesis: Self-destruction as an Unavoidable Consequence of Life; C. elegans Model: From Paradigm to Paradox; Walking Around the Evolutionary Bush
From the Origins of Programmed Cell Death to the Origins of Ageing'There is Grandeur in This View of Life...'; References; Further Reading; Cell Death in C. elegans; ced-3, ced-4, ced-9 and egl-1 are Conserved Genes Essential for Programmed Cell Death in C. elegans; Regulation of Cell Death during Somatic Development; Engulfment of Dying Cells; Germline Apoptosis; DNA Damage-induced Germline Apoptosis; Conclusion; References; Further Reading; Caspases and Cell Death; History and Classification; Structure and Active Site; Substrate Recognition and Mechanism of Action; Sequence of Action Substrates during ApoptosisInhibitors; Caspase Knockouts; Pathological Implications; Therapeutic Outlook; References; Further Reading; The Apoptosome: The Executioner of Mitochondria-mediated Apoptosis; Introduction; The Apoptosome Structure: Its Components and Its Assembly; Apaf1; Apoptosome assembly; Caspase-9; Cytochrome c; Modulation of the Apoptosome Formation; Apoptosome-like Complexes in Evolution. Is the Mitochondrial Pathway of Apoptosis Conserved?; Caenorhabditis elegans; Drosophila melanogaster; The Role of the Apoptosome in Mammalian Development; Caspase-9 knockout; Apaf1 knockout Cytochrome c deficiencyFinal Remarks; References; Further Reading; Caspases, Substrates and Sequential Activation; Introduction; Caspases Classification and Structure; Pathways That Lead to Caspase Activation; Extrinsic pathway; Granzyme B pathway; Intrinsic pathway; Effectors of demolition; Demolition Phase of Apoptosis; Detachment, rounding and blebbing; Nuclear fragmentation, DNA condensation and degradation; Undermining cell physiology; Immune Clearance and Immune Tolerance of Apoptotic Cells; Conclusions; Acknowledgements; References; Further Reading; Dismantling the Apoptotic Cell IntroductionCaspases: Regulators of the Apoptotic Process; Activation of the apoptotic caspases; Effect of caspase-mediated cleavage on target substrates - gain- or loss-of-function; Cleavage of caspase substrates leads to key morphological changes during apoptosis; Cytoskeletal events and membrane blebbing; Nuclear events; Changes in the Golgi apparatus; Caspases alter the transcriptional and translational machinery; Survival pathways are targeted during apoptosis; The apoptotic cell calls for its own disposal; Caspase-independent cell death; Concluding Remarks; References; Further Reading The BCL-2 Family Proteins - Key Regulators and Effectors of Apoptosis |
| Record Nr. | UNINA-9910968344203321 |
| Chichester, West Sussex ; ; Hoboken, NJ, : John Wiley & Sons, 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Plant cell death processes [[electronic resource] /] / edited by Larry D. Noodén
| Plant cell death processes [[electronic resource] /] / edited by Larry D. Noodén |
| Pubbl/distr/stampa | Amsterdam, : Boston, : Elsevier Academic Press, c2004 |
| Descrizione fisica | 1 online resource (419 p.) |
| Disciplina | 571.9/36 |
| Altri autori (Persone) | NoodénLarry D |
| Soggetto topico |
Plant physiology
Cell death |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-00554-1
9786611005542 0-08-049208-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Plant Cell Death Processes; Copyright Page; Contents; Contributors; Foreword-Aging and Death; Preface; Chapter 1. Introduction; I. What this Book Covers; II. The Processes-Senescence, Aging, Programmed Cell Death, Apoptosis, etc.-Evolving Concepts; III. Apoptosis in Animals; IV. Apoptosis in Plants; V. The Senescence Syndrome; VI. Hormonal Controls; VII. Evolution; References; Chapter 2. Plant Cell Death and Cell Differentiation; I. Introduction; II. The Scope of PCD in Plants; III. Prereproductive Cell Death; IV. Reproductive Cell Death; V. Conclusions; References
Chapter 3. Cell Death in Plant Disease: Mechanisms and Molecular Markers I. Introduction; II. Role of Cell Death during Plant-Pathogen Interactions; III. Structural and Biochemical Changes Accompanying Cell Death during Plant Disease; IV. Definition of Steps Involved in the Signaling Process of Cell Death Induction during Plant-Pathogen Interactions; V. Molecular Components for Cell Death Control during Plant-Pathogen Interactions; VI. Global Analyses of Markers for Cell Death Induction by Plant Pathogens; References; Chapter 4. Changes in Gene Expression during Senescence; I. Introduction II. Changes in Patterns of Nucleic Acids and Proteins during Senescence III. Similarities between Senescing and Ripening Tissues; IV. Identification and Classification of Senescence-related Genes; V. Senescence-related Genes; VI. Function of SR Genes in Senescence; VII. Summary; References; Chapter 5. Genes that Alter Senescence; I. Introduction; II. Senescence as a Genetically Programmed Process; III. Genes Involved in Execution of Senescence; IV. Genes Affecting Senescence through Action on the Hormonal Controls; V. Genes that Alter Senescence in Response to Environmental Factors VI. Genes Controlling Vegetative Growth (Regeneration) and Monocarpic Senescence VII. Regulatory Genes and Intracellular Signaling; VIII. Conclusions; References; Chapter 6. Senescence and Genetic Engineering; I. Introduction; II. The Relationship of Cytokinins and Senescence; III. The Relationship of Ethylene and Senescence; IV. Concluding Remarks; References; Chapter 7. Proteolysis; I. Introduction; II. Selective Hydrolysis of Peptide Bonds; III. Proteolytic Activities in Plants; IV. Proteolysis in Relation to Cell Death; V. Regulation of Protein Catabolism; VI. Conclusions; References Chapter 8. Ethylene Signaling in Plant Cell Death I. Introduction; II. Ethylene Biosynthesis Pathways; III. Temporal and Spatial Regulation of Ethylene Biosynthesis; IV. Ethylene Signal Transduction Pathway; V. Ethylene Cross Talk with Other Plant Hormones; VI. Protease Involvement and Ethylene Biosynthesis in PCD; VII. Hormonal Regulation of Plant PCD; VIII. Perspective; References; Chapter 9. Jasmonates - Biosynthesis and Role in Stress Responses and Developmental Processes; I. Introduction; II. Jasmonates and Related Compounds III. LOX-derived Compounds and the Biosynthesis of Octadecanoids and Jasmonates |
| Record Nr. | UNINA-9910458074503321 |
| Amsterdam, : Boston, : Elsevier Academic Press, c2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
