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Aging of the genome [[electronic resource] ] : the dual role of DNA in life and death / / Jan Vijg
| Aging of the genome [[electronic resource] ] : the dual role of DNA in life and death / / Jan Vijg |
| Autore | Vijg Jan |
| Pubbl/distr/stampa | Oxford, : Oxford University Press, 2007 |
| Descrizione fisica | 1 online resource (385 p.) |
| Disciplina | 571.878 |
| Soggetto topico |
Aging - Genetic aspects
Genomes |
| Soggetto genere / forma | Electronic books. |
| ISBN |
9786611145255
1-281-14525-4 0-19-856922-X 0-19-152458-1 1-4294-6993-5 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Preface; 1 Introduction: the coming of age of the genome; 1.1 The age of biology; 1.2 From genetics to genomics; 1.3 A return to function; 1.4 The causes of aging: a random affair; 2 The logic of aging; 2.1 Aging genes; 2.2 Pleiotropy in aging; 2.3 Interrupting the pathways of aging; 2.4 Longevity-assurance genes; 2.5 Somatic damage and the aging genome; 3 Genome structure and function; 3.1 DNA primary structure; 3.2 Higher-order DNA structure; 3.3 Nuclear architecture; 3.4 Transcription regulation; 3.5 Conclusions; 4 Genome maintenance; 4.1 Why genome maintenance?
4.2 DNA-damage signaling and cellular responses4.3 DNA-repair mechanisms; 4.4 Genome maintenance and aging; 5 Genome instability and accerated aging; 5.1 Premature aging; 5.2 Validity of accelerated-aging phenotypes; 5.3 Genome maintenance and accelerated aging in mice; 5.4 Conclusions; 6 The aging genome; 6.1 DNA damage; 6.2 DNA-sequence changes; 6.3 Changes in DNA modification and conformation; 6.4 Summary and conclusions: a DNA damage report of aging; 7 From genome to phenome; 7.1 The causes of cancer; 7.2 Genome instability and tissue dysfunction 7.3 Testing the role of genome instability in aging8 A genomic limit to life?; 8.1 Aiming for immortality; 8.2 SENS, and does it make sense?; EPILOGUE; GLOSSARY; A; B; C; D; E; F; G; H; I; L; M; N; O; P; R; S; T; X; Y; Z; REFERENCES; INDEX; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; Q; R; S; T; U; V; W; X; Y; Z |
| Record Nr. | UNINA-9910465172503321 |
Vijg Jan
|
||
| Oxford, : Oxford University Press, 2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Aging of the genome [[electronic resource] ] : the dual role of DNA in life and death / / Jan Vijg
| Aging of the genome [[electronic resource] ] : the dual role of DNA in life and death / / Jan Vijg |
| Autore | Vijg Jan |
| Pubbl/distr/stampa | Oxford, : Oxford University Press, 2007 |
| Descrizione fisica | 1 online resource (385 p.) |
| Disciplina | 571.878 |
| Soggetto topico |
Aging - Genetic aspects
Genomes |
| ISBN |
9786611145255
1-281-14525-4 0-19-856922-X 0-19-152458-1 1-4294-6993-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Preface; 1 Introduction: the coming of age of the genome; 1.1 The age of biology; 1.2 From genetics to genomics; 1.3 A return to function; 1.4 The causes of aging: a random affair; 2 The logic of aging; 2.1 Aging genes; 2.2 Pleiotropy in aging; 2.3 Interrupting the pathways of aging; 2.4 Longevity-assurance genes; 2.5 Somatic damage and the aging genome; 3 Genome structure and function; 3.1 DNA primary structure; 3.2 Higher-order DNA structure; 3.3 Nuclear architecture; 3.4 Transcription regulation; 3.5 Conclusions; 4 Genome maintenance; 4.1 Why genome maintenance?
4.2 DNA-damage signaling and cellular responses4.3 DNA-repair mechanisms; 4.4 Genome maintenance and aging; 5 Genome instability and accerated aging; 5.1 Premature aging; 5.2 Validity of accelerated-aging phenotypes; 5.3 Genome maintenance and accelerated aging in mice; 5.4 Conclusions; 6 The aging genome; 6.1 DNA damage; 6.2 DNA-sequence changes; 6.3 Changes in DNA modification and conformation; 6.4 Summary and conclusions: a DNA damage report of aging; 7 From genome to phenome; 7.1 The causes of cancer; 7.2 Genome instability and tissue dysfunction 7.3 Testing the role of genome instability in aging8 A genomic limit to life?; 8.1 Aiming for immortality; 8.2 SENS, and does it make sense?; EPILOGUE; GLOSSARY; A; B; C; D; E; F; G; H; I; L; M; N; O; P; R; S; T; X; Y; Z; REFERENCES; INDEX; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; Q; R; S; T; U; V; W; X; Y; Z |
| Record Nr. | UNINA-9910792273803321 |
|
Vijg Jan
|
||
| Oxford, : Oxford University Press, 2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Aging of the genome : the dual role of DNA in life and death / / Jan Vijg
| Aging of the genome : the dual role of DNA in life and death / / Jan Vijg |
| Autore | Vijg Jan |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Oxford, : Oxford University Press, 2007 |
| Descrizione fisica | 1 online resource (385 p.) |
| Disciplina | 571.878 |
| Soggetto topico |
Aging - Genetic aspects
Genomes |
| ISBN |
9786611145255
1-281-14525-4 0-19-856922-X 0-19-152458-1 1-4294-6993-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Preface; 1 Introduction: the coming of age of the genome; 1.1 The age of biology; 1.2 From genetics to genomics; 1.3 A return to function; 1.4 The causes of aging: a random affair; 2 The logic of aging; 2.1 Aging genes; 2.2 Pleiotropy in aging; 2.3 Interrupting the pathways of aging; 2.4 Longevity-assurance genes; 2.5 Somatic damage and the aging genome; 3 Genome structure and function; 3.1 DNA primary structure; 3.2 Higher-order DNA structure; 3.3 Nuclear architecture; 3.4 Transcription regulation; 3.5 Conclusions; 4 Genome maintenance; 4.1 Why genome maintenance?
4.2 DNA-damage signaling and cellular responses4.3 DNA-repair mechanisms; 4.4 Genome maintenance and aging; 5 Genome instability and accerated aging; 5.1 Premature aging; 5.2 Validity of accelerated-aging phenotypes; 5.3 Genome maintenance and accelerated aging in mice; 5.4 Conclusions; 6 The aging genome; 6.1 DNA damage; 6.2 DNA-sequence changes; 6.3 Changes in DNA modification and conformation; 6.4 Summary and conclusions: a DNA damage report of aging; 7 From genome to phenome; 7.1 The causes of cancer; 7.2 Genome instability and tissue dysfunction 7.3 Testing the role of genome instability in aging8 A genomic limit to life?; 8.1 Aiming for immortality; 8.2 SENS, and does it make sense?; EPILOGUE; GLOSSARY; A; B; C; D; E; F; G; H; I; L; M; N; O; P; R; S; T; X; Y; Z; REFERENCES; INDEX; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; Q; R; S; T; U; V; W; X; Y; Z |
| Record Nr. | UNINA-9910807682603321 |
|
Vijg Jan
|
||
| Oxford, : Oxford University Press, 2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Aspects of the biology of ageing
| Aspects of the biology of ageing |
| Pubbl/distr/stampa | Cambridge, : University Press, 1967 |
| Descrizione fisica | vii, 634 p. : ill. ; 25 cm |
| Disciplina | 571.878 |
| Collana | Symposia of Society for experimental botany |
| Soggetto non controllato | Biologia, invecchiamento |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-990001463850403321 |
| Cambridge, : University Press, 1967 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The Biology of Senescence : A Translational Approach / / by Bernard Swynghedauw
| The Biology of Senescence : A Translational Approach / / by Bernard Swynghedauw |
| Autore | Swynghedauw Bernard |
| Edizione | [1st ed. 2019.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 |
| Descrizione fisica | 1 online resource (127 pages) |
| Disciplina |
305.26
571.878 |
| Collana | Practical Issues in Geriatrics |
| Soggetto topico |
Geriatrics
General practice (Medicine) Human genetics Geriatrics/Gerontology General Practice / Family Medicine Human Genetics |
| ISBN | 3-030-15111-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1. Introduction -- 2. The emerging medical landscape -- 3. Origins of ageing -- 4. The senescent cell -- 5. « Benign » clinical manifestations and their relationships with the senescent cell -- 6. Age-linked non transmissible diseases -- 7. The senescent cardiovascular system -- 8. « To treat» or prevent ageing -- 9. Senescence and darwinian evolution -- 10. Conclusions -- 11. Summary -- 12. Annexes -- 13. References. |
| Record Nr. | UNINA-9910337522903321 |
|
Swynghedauw Bernard
|
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| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Epidemiology applied to problems of aging and nutrition ... annual report
| Epidemiology applied to problems of aging and nutrition ... annual report |
| Pubbl/distr/stampa | [Washington, D.C.], : U.S. Dept. of Agriculture, Agricultural Research Service |
| Descrizione fisica | : HTML files |
| Disciplina | 571.878 |
| Soggetto topico |
Aging - Nutritional aspects - United States
Nutritionally induced diseases - Epidemiology Aging - Nutritional aspects |
| Soggetto genere / forma | Periodicals. |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910703114603321 |
| [Washington, D.C.], : U.S. Dept. of Agriculture, Agricultural Research Service | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Handbook of the biology of aging / / editors, Edward J. Masoro and Steven N. Austad
| Handbook of the biology of aging / / editors, Edward J. Masoro and Steven N. Austad |
| Edizione | [6th ed.] |
| Pubbl/distr/stampa | Amsterdam ; ; Boston, : Elsevier Academic Press, c2006 |
| Descrizione fisica | 1 online resource (681 p.) |
| Disciplina |
612.6/7
571.878 |
| Altri autori (Persone) |
MasoroEdward J
AustadSteven N. <1946-> |
| Collana | The handbooks of aging |
| Soggetto topico | Aging - Physiological aspects |
| ISBN |
1-280-92693-7
9786610926930 0-08-049140-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Handbook of The Biology of Aging; Copyright Page; Contents; Contributors; Foreword; Preface; About the Editors; Section I. Conceptual and Technical Issues; Chapter 1. Reliability Theory of Aging and Longevity; I. Introduction; II. General Overview of the Reliability Theory Approach; III. Mortality, Failure, and Aging in Biological and Technical Systems; IV. Explanations of Aging Phenomena Using Reliability Theory; V. The Idea of High Initial Damage Load: The HIDL Hypothesis; VI. Reliability Models of Aging for Biological Systems; VII. Evolution of Species Reliability
VIII. ConclusionsReferences; Chapter 2. Are Age-Associated Diseases an Integral Part of Aging?; I. Introduction; II. Concepts of Biological Gerontology; III. Age-Associated Diseases; IV. Primary Aging, Secondary Aging, and "Normal Aging"; V. Evolutionary Theory and Age-Associated Diseases; VI. Analysis of Two Major Age-Associated Disease Processes; VII. Summary and Conclusions; References; Chapter 3. Dietary Restriction, Hormesis, and Small Molecule Mimetics; I. Introduction; II. Key Discoveries; III. Physiological Effects of DR on Mammals; IV. Mechanisms of DR; V. Small-Molecule CR Mimetics VI. ConclusionsReferences; Chapter 4. Hematopoietic Stem Cells, Aging, and Cancer; I. Stem Cells; II. Stem Cell Aging; III. Stem Cells and Cancer; IV. Conclusions; References; Chapter 5. Mitochondria: A Critical Role in Aging; I. The Mitochondrion; II. Evidence for Increased Oxidative Damage to Mitochondrial Components with Age; III. Mitochondrial Dysfunction and Aging; IV. Mitochondrial Dysfunction and Age-Associated Disease; V. Conclusions; References; Chapter 6. p53 and Mouse Aging Models; I. Introduction to p53; II. p53 and Cellular Senescence III. Linkage of IGF-1, Sir2, and p53 SignalingIV. Mouse Models of Aging; V. Mouse Models of Accelerated Aging; VI. Mouse Models of Delayed Aging; VII. Links to p53 in Mouse Aging Models; VIII. Mutant Mouse p53 Models, Aging, and Cancer; IX. Influence of p53 on Longevity in Humans; X. How Might p53 Influence Organismal Aging?; References; Chapter 7. Complex Genetic Architecture of Drosophila Longevity; I. Introduction; II. Genome Scan for Quantitative Trait Loci (QTLs); III. Deficiency Complementation Mapping; IV. Complementation Tests to Mutations at Positional Candidate Genes V. Linkage Disequilibrium (LD) MappingVI. Conclusions and Future Prospects; References; Chapter 8. Evolutionary Biology of Aging: Future Directions; I. Introduction; II. Genetics of Senescence; III. From Physiology to Demography; IV. Parasites and Immune Function; V. Sex, Sexual Selection, and Sexual Conflict; VI. Genetic Variation in Natural Populations; VII. Conclusions; References; Chapter 9. Senescence in Wild Populations of Mammals and Birds; I. Introduction; II. Evidence of Senescence in Wild Populations; III. Patterns of Senescence IV. Methodological Difficulties in Evaluating Senescence in Wild Populations |
| Record Nr. | UNINA-9910811457103321 |
| Amsterdam ; ; Boston, : Elsevier Academic Press, c2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Inevitable Aging? [[electronic resource] ] : Contributions to Evolutionary-Demographic Theory / / by Annette Baudisch
| Inevitable Aging? [[electronic resource] ] : Contributions to Evolutionary-Demographic Theory / / by Annette Baudisch |
| Autore | Baudisch Annette |
| Edizione | [1st ed. 2008.] |
| Pubbl/distr/stampa | Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2008 |
| Descrizione fisica | 1 online resource (187 p.) |
| Disciplina | 571.878 |
| Collana | Demographic Research Monographs, A Series of the Max Planck Institute for Demographic Research |
| Soggetto topico |
Population
Aging Demography Medicine Evolutionary biology Applied mathematics Engineering mathematics Population Economics Medicine/Public Health, general Evolutionary Biology Applications of Mathematics |
| ISBN |
1-281-17964-7
9786611179649 3-540-76656-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Hamilton -- Hamilton’s Indicators of the Force of Selection -- Further Challenges -- Optimization Models -- Optimization Models Based on Size -- An Optimization Model Based on Vitality -- Directions for Research. |
| Record Nr. | UNISA-996320675803316 |
|
Baudisch Annette
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||
| Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Inevitable Aging? : Contributions to Evolutionary-Demographic Theory / / by Annette Baudisch
| Inevitable Aging? : Contributions to Evolutionary-Demographic Theory / / by Annette Baudisch |
| Autore | Baudisch Annette |
| Edizione | [1st ed. 2008.] |
| Pubbl/distr/stampa | Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2008 |
| Descrizione fisica | 1 online resource (187 p.) |
| Disciplina | 571.878 |
| Collana | Demographic Research Monographs, A Series of the Max Planck Institute for Demographic Research |
| Soggetto topico |
Population
Aging Demography Medicine Evolutionary biology Applied mathematics Engineering mathematics Population Economics Medicine/Public Health, general Evolutionary Biology Applications of Mathematics |
| ISBN |
1-281-17964-7
9786611179649 3-540-76656-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Hamilton -- Hamilton’s Indicators of the Force of Selection -- Further Challenges -- Optimization Models -- Optimization Models Based on Size -- An Optimization Model Based on Vitality -- Directions for Research. |
| Record Nr. | UNINA-9910146563803321 |
|
Baudisch Annette
|
||
| Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Redox signaling and biomarkers in ageing / / edited by Ufuk Çakatay
| Redox signaling and biomarkers in ageing / / edited by Ufuk Çakatay |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2022] |
| Descrizione fisica | 1 online resource (447 pages) |
| Disciplina | 571.878 |
| Collana | Healthy Ageing and Longevity |
| Soggetto topico |
Biochemical markers
Oxidation-reduction reaction Aging - Molecular aspects |
| ISBN |
9783030849658
9783030849641 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910523764103321 |
| Cham, Switzerland : , : Springer, , [2022] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||