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The biostatistics of aging : from Gompertzian mortality and to an index of aging-relatedness / / Gilberto Levy, Bruce Levin
| The biostatistics of aging : from Gompertzian mortality and to an index of aging-relatedness / / Gilberto Levy, Bruce Levin |
| Autore | Levy Gilberto |
| Pubbl/distr/stampa | Hoboken, NJ : , : John Wiley & Sons Inc., , [2014] |
| Descrizione fisica | 1 online resource (270 p.) |
| Disciplina | 571.8/78 |
| Altri autori (Persone) | LevinBruce A |
| Soggetto topico |
Aging - Statistical methods
Mortality - Statistical methods Life spans (Biology) |
| ISBN |
1-118-64584-7
1-118-64567-7 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
THE BIOSTATISTICS OF AGING: From Gompertzian Mortality to an Index of Aging-Relatedness; Copyright; CONTENTS; PREFACE AND ACKNOWLEDGMENT; 1 Introduction; 2 An Account of Gompertzian Mortality through Statistical and Evolutionary Arguments; 2.1 The Statistical Theory of Extreme Values; 2.1.1 Background to Results; 2.1.2 Original Results; 2.2 The Evolutionary Theory of Aging; 2.2.1 The Argument for Gompertzian Mortality; 2.2.2 Boundaries of the Argument; 3 The Argument against Gompertzian Mortality; 3.1 Departures from the Gompertz Model; 3.2 An Evolution-Based Model of Causation
4 The Index of Aging-Relatedness 4.1 A Survival Mixture Model of the Gompertz and Weibull Distributions; 4.2 Definition and Interpretation of the Index of Aging-Relatedness; 4.3 The Survival Mixture Model and Competing Risks; 4.4 Estimation of the Model Parameters; 4.5 Illustrative Application: The Israeli Ischemic Heart Disease Study; 4.6 Precision of Estimation; 5 Discussion: Implications; 5.1 The Meaning of the Gompertz Parameter; 5.2 Age as a Risk Factor for Disease; 5.3 Are Aging-Related Diseases an Integral Part of Aging?; 5.4 Biological versus Chronological Aging 5.5 The Public Health Notion of Compression of Morbidity 5.6 A Picture of Aging for the Twenty-First Century; APPENDIX A: PROOFS OF RESULTS IN SECTION 2.1.2 WITH SOME EXTENSIONS; APPENDIX B: DERIVATION OF HAMILTON'S EQUATION FOR THE FORCE OF NATURAL SELECTION ON MORTALITY; APPENDIX C: SOME PROPERTIES OF THE GOMPERTZ AND WEIBULL DISTRIBUTIONS; APPENDIX D: FIRST AND SECOND PARTIAL DERIVATIVES OF THE MIXTURE LOG-LIKELIHOOD FUNCTION; APPENDIX E: EXPECTATION-CONDITIONAL MAXIMIZATION(ECM) ALGORITHM; APPENDIX F: R PROGRAM; REFERENCES; AUTHOR INDEX; SUBJECT INDEX |
| Record Nr. | UNINA-9910132241703321 |
Levy Gilberto
|
||
| Hoboken, NJ : , : John Wiley & Sons Inc., , [2014] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The biostatistics of aging : from Gompertzian mortality and to an index of aging-relatedness / / Gilberto Levy, Bruce Levin
| The biostatistics of aging : from Gompertzian mortality and to an index of aging-relatedness / / Gilberto Levy, Bruce Levin |
| Autore | Levy Gilberto |
| Pubbl/distr/stampa | Hoboken, NJ : , : John Wiley & Sons Inc., , [2014] |
| Descrizione fisica | 1 online resource (270 p.) |
| Disciplina | 571.8/78 |
| Altri autori (Persone) | LevinBruce A |
| Soggetto topico |
Aging - Statistical methods
Mortality - Statistical methods Life spans (Biology) |
| ISBN |
1-118-64584-7
1-118-64567-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
THE BIOSTATISTICS OF AGING: From Gompertzian Mortality to an Index of Aging-Relatedness; Copyright; CONTENTS; PREFACE AND ACKNOWLEDGMENT; 1 Introduction; 2 An Account of Gompertzian Mortality through Statistical and Evolutionary Arguments; 2.1 The Statistical Theory of Extreme Values; 2.1.1 Background to Results; 2.1.2 Original Results; 2.2 The Evolutionary Theory of Aging; 2.2.1 The Argument for Gompertzian Mortality; 2.2.2 Boundaries of the Argument; 3 The Argument against Gompertzian Mortality; 3.1 Departures from the Gompertz Model; 3.2 An Evolution-Based Model of Causation
4 The Index of Aging-Relatedness 4.1 A Survival Mixture Model of the Gompertz and Weibull Distributions; 4.2 Definition and Interpretation of the Index of Aging-Relatedness; 4.3 The Survival Mixture Model and Competing Risks; 4.4 Estimation of the Model Parameters; 4.5 Illustrative Application: The Israeli Ischemic Heart Disease Study; 4.6 Precision of Estimation; 5 Discussion: Implications; 5.1 The Meaning of the Gompertz Parameter; 5.2 Age as a Risk Factor for Disease; 5.3 Are Aging-Related Diseases an Integral Part of Aging?; 5.4 Biological versus Chronological Aging 5.5 The Public Health Notion of Compression of Morbidity 5.6 A Picture of Aging for the Twenty-First Century; APPENDIX A: PROOFS OF RESULTS IN SECTION 2.1.2 WITH SOME EXTENSIONS; APPENDIX B: DERIVATION OF HAMILTON'S EQUATION FOR THE FORCE OF NATURAL SELECTION ON MORTALITY; APPENDIX C: SOME PROPERTIES OF THE GOMPERTZ AND WEIBULL DISTRIBUTIONS; APPENDIX D: FIRST AND SECOND PARTIAL DERIVATIVES OF THE MIXTURE LOG-LIKELIHOOD FUNCTION; APPENDIX E: EXPECTATION-CONDITIONAL MAXIMIZATION(ECM) ALGORITHM; APPENDIX F: R PROGRAM; REFERENCES; AUTHOR INDEX; SUBJECT INDEX |
| Record Nr. | UNINA-9910818426803321 |
|
Levy Gilberto
|
||
| Hoboken, NJ : , : John Wiley & Sons Inc., , [2014] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||