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Glycogen synthase kinase 3 (GSK-3) and its inhibitors [[electronic resource] ] : drug discovery and development / / edited by Ana Martinez, Ana Castro, Miguel Medina
| Glycogen synthase kinase 3 (GSK-3) and its inhibitors [[electronic resource] ] : drug discovery and development / / edited by Ana Martinez, Ana Castro, Miguel Medina |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley-Interscience, c2006 |
| Descrizione fisica | 1 online resource (388 p.) |
| Disciplina |
547.12
572.567 572/.567 |
| Altri autori (Persone) |
MartínezAna <1961->
CastroAna MedinaMiguel <1959-> |
| Collana | Wiley series in drug discovery and development |
| Soggetto topico |
Glycogen synthase kinase-3
Glycogen synthase kinase-3 - Inhibitors |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-64906-2
9786610649068 0-470-05217-1 0-470-05215-5 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Glycogen synthase kinase 3: an introductory synopsis -- Glycogen synthase kinase-3[beta] (GSK-3[beta]) a key signaling enzyme: a developmental neurobiological perspective -- Role of GSK-3/Shaggy in neuronal cell biology -- The crystal structures of glycogen synthase kinase 3 -- Kinase-kinase and site-site interactions in the phosphorylation of tau by GSK-3 -- GSK-3, a key player in Alzheimer's disease -- Glycogen synthase kinase 3 : a target for novel mood disorder treatments -- GSK-3 and stem cells -- Glycogen synthase kinase 3 : role in neurodegeneration and neuroprotection --
Protein kinase assays for drug discovery -- Animal models with modified expression of GSK-3 for the study of its physiology and of its implications in human pathologies -- Lithium, the seminal GSK-3 inhibitor -- Inhibition of GSK-3 as therapeutic strategy in disease : efficacy of AR-A014418 -- TDZD's: selective and ATP noncompetitive glycogen synthase kinase 3 inhibitors -- 3-amino pyrazoles as potent and selective glycogen kinase synthase (GSK-3) inhibitors -- Marine compounds as a new source for glycogen synthase kinase 3 inhibitors. |
| Record Nr. | UNINA-9910143411203321 |
| Hoboken, N.J., : Wiley-Interscience, c2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Glycogen synthase kinase 3 (GSK-3) and its inhibitors [[electronic resource] ] : drug discovery and development / / edited by Ana Martinez, Ana Castro, Miguel Medina
| Glycogen synthase kinase 3 (GSK-3) and its inhibitors [[electronic resource] ] : drug discovery and development / / edited by Ana Martinez, Ana Castro, Miguel Medina |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley-Interscience, c2006 |
| Descrizione fisica | 1 online resource (388 p.) |
| Disciplina |
547.12
572.567 572/.567 |
| Altri autori (Persone) |
MartínezAna <1961->
CastroAna MedinaMiguel <1959-> |
| Collana | Wiley series in drug discovery and development |
| Soggetto topico |
Glycogen synthase kinase-3
Glycogen synthase kinase-3 - Inhibitors |
| ISBN |
1-280-64906-2
9786610649068 0-470-05217-1 0-470-05215-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Glycogen synthase kinase 3: an introductory synopsis -- Glycogen synthase kinase-3[beta] (GSK-3[beta]) a key signaling enzyme: a developmental neurobiological perspective -- Role of GSK-3/Shaggy in neuronal cell biology -- The crystal structures of glycogen synthase kinase 3 -- Kinase-kinase and site-site interactions in the phosphorylation of tau by GSK-3 -- GSK-3, a key player in Alzheimer's disease -- Glycogen synthase kinase 3 : a target for novel mood disorder treatments -- GSK-3 and stem cells -- Glycogen synthase kinase 3 : role in neurodegeneration and neuroprotection --
Protein kinase assays for drug discovery -- Animal models with modified expression of GSK-3 for the study of its physiology and of its implications in human pathologies -- Lithium, the seminal GSK-3 inhibitor -- Inhibition of GSK-3 as therapeutic strategy in disease : efficacy of AR-A014418 -- TDZD's: selective and ATP noncompetitive glycogen synthase kinase 3 inhibitors -- 3-amino pyrazoles as potent and selective glycogen kinase synthase (GSK-3) inhibitors -- Marine compounds as a new source for glycogen synthase kinase 3 inhibitors. |
| Record Nr. | UNINA-9910830425203321 |
| Hoboken, N.J., : Wiley-Interscience, c2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Structure determination of organic compounds : tables of spectral data / E. Pretsch, P. Bulmann, C. Affolter
| Structure determination of organic compounds : tables of spectral data / E. Pretsch, P. Bulmann, C. Affolter |
| Autore | Pretsch, Ernèo |
| Edizione | [3rd completely revised and English edition corrected first printing] |
| Pubbl/distr/stampa | Berlin : Springer, c2000 |
| Descrizione fisica | xv, 421 p. : ill. ; 24 cm + 1 computer optical disc (4 3/4 in.) |
| Disciplina | 547.12 |
| Altri autori (Persone) |
Buhlmann, Philippe
Affolter, Christian |
| Soggetto topico |
Organic compounds - Spectra - Tables
Chemical structure - Tables |
| ISBN | 9783540678151 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISALENTO-991002405309707536 |
Pretsch, Ernèo
|
||
| Berlin : Springer, c2000 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. del Salento | ||
| ||
Structure elucidation in organic chemistry : the search for the right tools / / edited by María-Magdalena Cid and Jorge Bravo
| Structure elucidation in organic chemistry : the search for the right tools / / edited by María-Magdalena Cid and Jorge Bravo |
| Pubbl/distr/stampa | Weinheim, Germany : , : Wiley-VCH, , 2015 |
| Descrizione fisica | 1 online resource (1216 p.) |
| Disciplina | 547.12 |
| Soggetto topico |
Organic compounds - Structure
Nuclear magnetic resonance spectroscopy |
| ISBN |
3-527-66463-7
3-527-66461-0 3-527-66464-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Related Titles; Title Page; Copyright; Preface; List of Contributors; Chapter 1: Interaction of Radiation with Matter; 1.1 Introduction; 1.2 Spectroscopy: A Definition; 1.3 Electromagnetic Radiation; 1.4 Electromagnetic Spectrum; 1.5 Interaction of Radiation with Matter; 1.6 Magnetic Spectroscopies; 1.7 Pulse Techniques in NMR Spectroscopy; 1.8 Line Widths; 1.9 Selection Rules; 1.10 Summary of Spectroscopic Techniques; References; Chapter 2: Computational Spectroscopy Tools for Molecular Structure Analysis; 2.1 Introduction; 2.2 Potential Energy Surface and Molecular Structure
2.3 Computational Aspects for Spectroscopic Techniques2.4 Application and Case Studies; Acknowledgments; References; Chapter 3: Absolute Configuration and Conformational Analysis of Chiral Compounds via Experimental and Theoretical Prediction of Chiroptical Properties: ORD, ECD, and VCD; 3.1 Introduction; 3.2 Chirality; 3.3 What is a Chiroptical Method?; 3.4 Quantum Mechanical (Ab Initio) Methods for Predicting Chiroptical Properties; 3.5 Electronic Circular Dichroism (ECD); 3.6 Vibrational Circular Dichroism (VCD); 3.7 Optical Rotatory Dispersion (ORD) 3.8 When More than One Method is Needed3.9 Concluding Remarks; References; Chapter 4: Mass Spectrometry Strategies in the Assignment of Molecular Structure: Breaking Chemical Bonds before Bringing the Pieces of the Puzzle Together; 4.1 Introduction; 4.2 Instrumentation and Technology; 4.3 Breaking Chemical Bonds - Fragmentation Reactions; 4.4 Confirmation of Identity; 4.5 Putting the Puzzle Together - Structure Elucidation of Unknowns; 4.6 Conclusions and Perspectives; Abbreviations; References; Chapter 5: Basic Principles of IR/Raman: Applications in Small Molecules Structural Elucidation 5.1 Introduction5.2 Characteristic Vibrational Modes: Diatomics and Chemical Bonds; 5.3 Fundamental Vibrational Modes and Molecular Structure; 5.4 Selection Rules and Finding the Number of Normal Modes in Each Symmetry Species; 5.5 The Vibrational Assignment of Raman and Infrared Spectra; 5.6 Conclusions; References; Chapter 6: Solid-State NMR Applications in the Structural Elucidation of Small Molecules; 6.1 Introduction; 6.2 Line-Narrowing and Sensitivity Enhancement Methods in ssNMR Spectroscopy; 6.3 Probing Dynamics in Solids; 6.4 Application of ssNMR Spectroscopy to Small Molecules 6.5 NMR of Molecules on Surfaces (DNP)6.6 NMR Crystallography; Acronyms; References; Chapter 7: Simplified NMR Procedures for the Assignment of the Absolute Configuration; 7.1 Introduction; 7.2 Single Derivatization Methods for Mono- and Polyfunctional Compounds; 7.3 Resin-Bound Chiral Derivatizing Agents (Mix and Shake Method); 7.4 Non-resin in Tube Assignment (BPG and BINOL Borates); 7.5 Tandem HPLC-NMR: Simultaneous Enantioresolution and Configurational Assignment; 7.6 Assignment Based on the Chemical Shifts from the Auxiliaries; 7.7 Scope and Conclusions; References Chapter 8: Structural Elucidation of Small Organic Molecules Assistedby NMR in Aligned Media |
| Record Nr. | UNINA-9910132294703321 |
| Weinheim, Germany : , : Wiley-VCH, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Structure elucidation in organic chemistry : the search for the right tools / / edited by María-Magdalena Cid and Jorge Bravo
| Structure elucidation in organic chemistry : the search for the right tools / / edited by María-Magdalena Cid and Jorge Bravo |
| Pubbl/distr/stampa | Weinheim, Germany : , : Wiley-VCH, , 2015 |
| Descrizione fisica | 1 online resource (1216 p.) |
| Disciplina | 547.12 |
| Soggetto topico |
Organic compounds - Structure
Nuclear magnetic resonance spectroscopy |
| ISBN |
3-527-66463-7
3-527-66461-0 3-527-66464-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Related Titles; Title Page; Copyright; Preface; List of Contributors; Chapter 1: Interaction of Radiation with Matter; 1.1 Introduction; 1.2 Spectroscopy: A Definition; 1.3 Electromagnetic Radiation; 1.4 Electromagnetic Spectrum; 1.5 Interaction of Radiation with Matter; 1.6 Magnetic Spectroscopies; 1.7 Pulse Techniques in NMR Spectroscopy; 1.8 Line Widths; 1.9 Selection Rules; 1.10 Summary of Spectroscopic Techniques; References; Chapter 2: Computational Spectroscopy Tools for Molecular Structure Analysis; 2.1 Introduction; 2.2 Potential Energy Surface and Molecular Structure
2.3 Computational Aspects for Spectroscopic Techniques2.4 Application and Case Studies; Acknowledgments; References; Chapter 3: Absolute Configuration and Conformational Analysis of Chiral Compounds via Experimental and Theoretical Prediction of Chiroptical Properties: ORD, ECD, and VCD; 3.1 Introduction; 3.2 Chirality; 3.3 What is a Chiroptical Method?; 3.4 Quantum Mechanical (Ab Initio) Methods for Predicting Chiroptical Properties; 3.5 Electronic Circular Dichroism (ECD); 3.6 Vibrational Circular Dichroism (VCD); 3.7 Optical Rotatory Dispersion (ORD) 3.8 When More than One Method is Needed3.9 Concluding Remarks; References; Chapter 4: Mass Spectrometry Strategies in the Assignment of Molecular Structure: Breaking Chemical Bonds before Bringing the Pieces of the Puzzle Together; 4.1 Introduction; 4.2 Instrumentation and Technology; 4.3 Breaking Chemical Bonds - Fragmentation Reactions; 4.4 Confirmation of Identity; 4.5 Putting the Puzzle Together - Structure Elucidation of Unknowns; 4.6 Conclusions and Perspectives; Abbreviations; References; Chapter 5: Basic Principles of IR/Raman: Applications in Small Molecules Structural Elucidation 5.1 Introduction5.2 Characteristic Vibrational Modes: Diatomics and Chemical Bonds; 5.3 Fundamental Vibrational Modes and Molecular Structure; 5.4 Selection Rules and Finding the Number of Normal Modes in Each Symmetry Species; 5.5 The Vibrational Assignment of Raman and Infrared Spectra; 5.6 Conclusions; References; Chapter 6: Solid-State NMR Applications in the Structural Elucidation of Small Molecules; 6.1 Introduction; 6.2 Line-Narrowing and Sensitivity Enhancement Methods in ssNMR Spectroscopy; 6.3 Probing Dynamics in Solids; 6.4 Application of ssNMR Spectroscopy to Small Molecules 6.5 NMR of Molecules on Surfaces (DNP)6.6 NMR Crystallography; Acronyms; References; Chapter 7: Simplified NMR Procedures for the Assignment of the Absolute Configuration; 7.1 Introduction; 7.2 Single Derivatization Methods for Mono- and Polyfunctional Compounds; 7.3 Resin-Bound Chiral Derivatizing Agents (Mix and Shake Method); 7.4 Non-resin in Tube Assignment (BPG and BINOL Borates); 7.5 Tandem HPLC-NMR: Simultaneous Enantioresolution and Configurational Assignment; 7.6 Assignment Based on the Chemical Shifts from the Auxiliaries; 7.7 Scope and Conclusions; References Chapter 8: Structural Elucidation of Small Organic Molecules Assistedby NMR in Aligned Media |
| Record Nr. | UNINA-9910819924703321 |
| Weinheim, Germany : , : Wiley-VCH, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||