Info
- Utilizzare la checkbox di selezione a fianco di ciascun documento per attivare le funzionalità di stampa, invio email, download nei formati disponibili del (i) record.
Enterobacter sakazakii and Salmonella in powdered infant formula : meeting report
| Enterobacter sakazakii and Salmonella in powdered infant formula : meeting report |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | [Place of publication not identified], : Food and Agriculture Organization of the United Nations, 2006 |
| Descrizione fisica | 1 online resource (75 pages) |
| Disciplina | 363.1922 |
| Collana | Microbiological risk assessment series Enterobacter sakazakii and Salmonella in powdered infant formula |
| Soggetto topico |
Enterobacter - Contamination
Salmonella - Microbiology Infant formulas Food Food contamination Infant Formula Risk Assessment Enterobacter sakazakii Food Contamination Food Preservation Enterobacter Epidemiologic Measurements Milk Substitutes Milk Risk Food Safety Infant Food Environmental Pollution Risk Management Food, Formulated Food Technology Dairy Products Public Health Organization and Administration Foods, Specialized Probability Beverages Enterobacteriaceae Food Industry Food and Beverages Industry Environment and Public Health Gammaproteobacteria Statistics as Topic Health Services Administration Gram-Negative Facultatively Anaerobic Rods Epidemiologic Methods Technology, Industry, and Agriculture Gram-Negative Bacteria Health Care Health Care Evaluation Mechanisms Proteobacteria Bacteria Investigative Techniques Quality of Health Care Health Care Quality, Access, and Evaluation Microbiology & Immunology Biology Health & Biological Sciences |
| Soggetto genere / forma |
Congress
Publication Formats |
| ISBN |
1-280-84164-8
9786610841646 92-4-068193-0 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Intro -- Enterobacter sakazakii and other microorganisms in powdered infant formaula -- CONTENTS -- ACKNOWLEDGMENTS -- CONTRIBUTORS -- FOREWORD -- ABBREVIATIONS -- EXECUTIVE SUMMARY -- 1. INTRODUCTION -- 2. EPIDEMIOLOGY AND PUBLIC HEALTH ASPECTS -- 3. HAZARD IDENTIFICATION -- 4. HAZARD CHARACTERIZATION -- 5. EXPOSURE ASSESSMENT -- 6. RISK CHARACTERIZATION -- 7. RISK REDUCTION STRATEGIES FOR FORMULA-FED INFANTS -- 8. KEY FINDINGS AND RECOMMENDATIONS -- REFERENCES -- Appendix A -- Appendix B -- Appendix C. |
| Record Nr. | UNINA-9910818631303321 |
| [Place of publication not identified], : Food and Agriculture Organization of the United Nations, 2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Risk assessment of phytochemicals in food [[electronic resource] ] : novel approaches : symposium / / editors, DFG Senate Commission on Food Safety ; editorial committee, Gerhard Eisenbrand ... [et al.] ; scientists of the SKLM secretariat, Sabine Guth, Michael Habermeyer and Barbara Kochte-Clemens
| Risk assessment of phytochemicals in food [[electronic resource] ] : novel approaches : symposium / / editors, DFG Senate Commission on Food Safety ; editorial committee, Gerhard Eisenbrand ... [et al.] ; scientists of the SKLM secretariat, Sabine Guth, Michael Habermeyer and Barbara Kochte-Clemens |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Weinheim [Germany], : Wiley-VCH, 2010 |
| Descrizione fisica | 1 online resource (476 p. ) : ill. (some col.) |
| Disciplina | 363.1922 |
| Altri autori (Persone) |
EisenbrandGerhard
GuthSabine HabermeyerMichael Kochte-ClemensBarbara |
| Collana | Forschungsberichte (DFG) |
| Soggetto topico |
Phytochemicals
Food - Safety measures |
| Soggetto genere / forma | Electronic books. |
| ISBN |
9786613302489
1-283-30248-9 3-527-63471-1 3-527-63470-3 3-527-63483-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Title page -- copyright -- Vorwort -- Preface -- 1: Bericht und Schlussfolgerungen -- 1.1 Einleitung -- 1.2 Methodenübergreifende Aspekte -- 1.3 Methoden -- 1.4 Schlussfolgerungen und Empfehlungen -- 1.5 Fazit -- 2: Report and Conclusions -- 2.1 Preface -- 2.2 Transdisciplinary Aspects -- 2.3 Methodologies -- 2.4 Conclusions and Recommendations -- 2.5 Concluding Remarks -- 3: Contributions -- 3.1: Visions on Toxicity Testing in the 21st Century: Reflections on a Strategy Document of the US National Research Council -- 3.1.1 Introduction -- 3.1.2 A New Vision of Toxicity Testing -- 3.1.3 Testing the Vision -- 3.1.4 Steps toward a New Toxicology -- 3.1.5 The Precautionary Principle -- 3.1.6 The European Side -- 3.1.7 Tasks Ahead -- Acknowledgements -- Abbreviations and Glossary of Terms -- References -- 3.2: Safety Assessment of Botanicals and Botanical Preparations Used as Ingredients in Food Supplements: Testing an European Food Safety AuthorityTiered Approach -- 3.2.1 Introduction -- 3.2.2 Materials and Methods -- 3.2.3 Results -- 3.2.4 Discussion -- Acknowledgement -- References -- 3.3: In Silico Toxicology Screening of the Rodent Carcinogenic Potential of Phytochemicals Using Quantitative Structure-Activity Relationship Analysis -- 3.3.1 Introduction -- 3.3.2 Why Use In Silico Predictive Models at FDA? -- 3.3.3 What In Silico Predictive Models does the FDA Use? -- 3.3.4 What In Silico Predictive Software does the FDA Use? -- 3.3.5 Why Use In Silico Strategies as a Novel Approach to Assess Toxicity of Phytochemicals? -- 3.3.6 Prediction of Rodent Carcinogenicity of Phytochemicals in an External Validation Study -- 3.3.7 Conclusions -- Acknowledgements -- Conflict of Interest Statement -- References -- 3.4: Testing Computational Toxicology Models with Phytochemicals -- 3.4.1 Introduction -- 3.4.2 Materials and Methods -- 3.4.3 Results.
3.4.4 Discussion -- Acknowledgements -- Abbreviations -- Conflict of Interest Statement -- References -- 3.5: In Silico Models to Establish Level of Safety Concern in Absence of Sufficient Toxicological Data -- 3.5.1 Introduction -- 3.5.2 Computational Toxicology Models Relevant for the Food Sectors: Requirements -- 3.5.3 Available Computational Toxicology Models for Food Applications -- 3.5.4 Model Integration and Application -- 3.5.5 Computational Toxicology and Safety Assessment of Botanical Extracts -- 3.5.6 Discussion and Conclusion -- References -- 3.6: In Silico Methods for Physiologically Based Biokinetic (PBBK) Models Describing Bioactivation and Detoxification of Coumarin and Estragole: Implications for Risk Assessment -- 3.6.1 Introduction -- 3.6.2 Methods -- 3.6.3 Results -- 3.6.4 Discussion -- Acknowledgements -- Abbreviations -- Conflict of Interest Statement -- References -- 3.7: In Vitro Models for Carcinogenicity Testing Reality or Fantasy? -- 3.7.1 Introduction -- 3.7.2 BALB/c 3T3 Cell Transformation Assay -- 3.7.3 Automated Soft Agar Assay -- 3.7.4 Concluding Remarks -- Acknowledgments -- References -- 3.8: Carcinogen Specific Expression Profiling: Prediction of Carcinogenic Potential? -- 3.9: Safety and Biological Efficacy Testing of Phytochemicals: An Industry Approach -- 3.9.1 Introduction -- 3.9.2 Screening Process -- 3.9.3 Regulatory Pre-Clinical Safety -- 3.9.4 Overall Conclusion -- References -- 3.10: Metabolite Profiling in Rat Plasma as a Potential New Tool for the Assessment of Chemically Induced Toxicity -- 3.10.1 Introduction -- 3.10.2 Materials and Methods -- 3.10.3 Results and Discussion -- 3.10.4 Concluding Remarks -- Acknowledgements -- References -- 3.11: Profiling Techniques in Nutrition and Food Research -- Hannelore Daniel1 -- 3.11.1 Introduction. 3.11.2 Genomics Applications in Basic and Pre-Clinical Nutrition and Food Research -- 3.11.3 Profiling Technologies Applied in Human Studies -- 3.11.4 Evidence for a Significant Role of the Gut Microbiota in Human Responses to Dietary Interventions -- 3.11.5 Summary -- References -- 3.12: The Complex Links between Dietary Phytochemicals and Human Health Deciphered by Metabolomics -- 3.12.1 Introduction -- 3.12.2 Measuring Dietary Intake of Phytochemicals: Current Limitations -- 3.12.3 Biomarkers of Phytochemical Intake -- 3.12.4 Metabolomics and Biomarker Discovery -- 3.12.5 Metabolomics and Phytochemical Intake -- 3.12.6 Metabolomics and Biological Effects of Phytochemicals -- 3.12.7 Conclusion -- Acknowledgments -- Glossary4 -- Conflict of Interest Statement -- References -- 3.13: Anti-Oxidative and Antigenotoxic Properties of Vegetables and Dietary Phytochemicals: The Value of Genomics Biomarkers in Molecular Epidemiology -- 3.13.1 Introduction -- 3.13.2 Colorectal Cancer Risk Prevention by Vegetables -- 3.13.3 Gene Expression Modulation in the Colon by Vegetables and Phytochemicals -- 3.13.4 Genetic Polymorphisms and Anti-Oxidative Response -- 3.13.5 Risk-Benefit Analysis of Dietary Phytochemicals -- 3.13.6 Concluding Remarks -- References -- 3.14: The Japanese Toxicogenomics Project: Application of Toxicogenomics - Utilizing Toxicogenomics into Drug Safety Screening -- 3.14.1 Introduction -- 3.14.2 Current Status of Worldwide Toxicogenomics Database Creation -- 3.14.3 The Toxicogenomics Project in Japan -- 3.14.4 Application of Toxicogenomics -- 3.14.5 Future Perspectives -- Acknowledgements -- Conflict of Interest Statement -- References -- 3.15: Toxicology and Risk Assessment of Coumarin: Focus on Human Data -- 3.15.1 Introduction -- 3.15.2 Hazard of Coumarin -- 3.15.3 Human Exposure -- 3.15.4 Risk Assessment -- 3.15.5 Summary and Conclusion. Abbreviations -- Conflict of Interest Statement -- References -- 3.16: Risk from Furocoumarins in Food? An Exposure Assessment -- 3.16.1 Introduction -- 3.16.2 Materials and Methods -- 3.16.3 Results and Discussion -- 3.16.4 Conclusions -- Acknowledgements -- References -- 3.17: Transcriptome Analysis in Benefit-Risk Assessment of Micronutrients and Bioactive Food Components -- 3.17.1 Introduction -- 3.17.2 Whole Genome Transcriptome Analysis as a Tool for Benefit-Risk Analysis -- 3.17.3 Data Confirmation by qRT-PCR -- 3.17.4 Magnitude of Micronutrient Effects -- 3.17.5 Data Interpretation -- 3.17.6 In Vivo and In Vitro Approaches -- 3.17.7 Animal Models and Diets -- 3.17.8 Sensitivity and Power -- 3.17.9 Conclusion -- Acknowledgements -- Conflict of Interest Statement -- References -- 3.18: Colorectal and Prostate Cancer: The Role of Candidate Genes in Nutritional Pathways -- 3.18.1 Selenium: Biologic Mechanisms of the Chemopreventive Effects of Selenium -- 3.18.3 Overall Evidence from Candidate-Gene Association Studies for Cancer -- References -- 3.19: Glucosinolates: DNA Adduct Formation In Vivo and Mutagenicity In Vitro -- 3.19.1 Introduction -- 3.19.2 Formation of DNA-Reactive Molecules in Plant Homogenates -- 3.19.3 Formation of DNA Adducts in Animals Fed with Broccoli -- 3.19.4 Elucidation of the Structure of Broccoli-Associated DNA Adducts and Identification of the Substances Involved -- 3.19.5 Mutagenicity of GLS-A -- 3.19.6 Conclusions and Perspectives -- Acknowledgements -- References -- 3.20: Defence Mechanisms against Toxic Phytochemicals in the Diet of Domestic Animals -- 3.20.1 Introduction -- 3.20.2 Polygastric Herbivory: Pre-Systemic Detoxification of Phytochemicals by the Rumen Microbiota -- 3.20.3 Monogastric Herbivory: Are Acquired Feeding Strategies Sufficiently Protective?. 3.20.4 Efflux Transporters: Functional Elements of the Intestinal Barrier -- 3.20.5 Pre-Systemic Elimination by Biotransformation -- 3.20.6 Transcriptional Regulation of Efflux Transporters and Biotransformation Enzymes -- 3.20.7 Carnivorous Species: When Plant Metabolites Become Lethal -- 3.20.8 Risk Assessment of Phytochemicals in Animal Feeds -- References -- 4: Posters -- 4.1: Coumarin Risk Assessment: Lessons from Human Data -- References -- 4.2: Coffee and Coffee Compounds are Effective Antioxidants in Human Cells and In Vivo -- 4.2.1 Introduction -- 4.2.2 Materials and Methods -- 4.2.3 Results and Discussion -- Acknowledgments -- References -- 4.3: Studying Absorption, Distribution, Metabolism, and Excretion of a Complex Extract -- 4.4: Polyphenolic Apple Extracts and their Constituents Modulate DNA Strand Breaks and Oxidation Damage in Human Colon Carcinoma Cells -- 4.4.1 Introduction -- 4.4.2 Methods -- 4.4.3 Results and Discussion -- 4.4.4 Conclusion -- Acknowledgements -- References -- 4.5: Comparative Evaluation of Experimental Data on α-Amylase Inhibition by Flavonoids Using Molecular Modelling -- 4.6: Potential Risk of Furan in Foods -- 4.7: Comparative Study on the Toxicity of Alternariol and Alternariol Monomethyl Ether in Human Tumour Cells of Different Origin -- References -- 4.8: A Role for Resveratrol and Curcumine in Sensitization of Glioblastoma Cells to Genotoxic Stress Induced by Alkylating Chemotherapeutics -- 4.9: BfR Risk Assessment of Alkaloids as Ingredients and Contaminants of Food: Quinine, Opium Alkaloids, and Senecio Pyrrolizidine Alkaloids -- 4.9.1 Quinine in Bitter Soft Drinks - Are there Special Risk Groups? -- 4.9.2 Opium Alkaloids as Contaminants of Poppy Seeds -- 4.9.3 Senecio vulgaris L. as Contaminant of Mixed Salad -- References. 4.10: Elucidation of the Genotoxic Activity of the Alkaloid Ellipticine in Human Cell Lines. |
| Record Nr. | UNINA-9910265225503321 |
| Weinheim [Germany], : Wiley-VCH, 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Risk assessment of phytochemicals in food [[electronic resource] ] : novel approaches : symposium / / editors, DFG Senate Commission on Food Safety ; editorial committee, Gerhard Eisenbrand ... [et al.] ; scientists of the SKLM secretariat, Sabine Guth, Michael Habermeyer and Barbara Kochte-Clemens
| Risk assessment of phytochemicals in food [[electronic resource] ] : novel approaches : symposium / / editors, DFG Senate Commission on Food Safety ; editorial committee, Gerhard Eisenbrand ... [et al.] ; scientists of the SKLM secretariat, Sabine Guth, Michael Habermeyer and Barbara Kochte-Clemens |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Weinheim [Germany], : Wiley-VCH, 2010 |
| Descrizione fisica | 1 online resource (476 p. ) : ill. (some col.) |
| Disciplina | 363.1922 |
| Altri autori (Persone) |
EisenbrandGerhard
GuthSabine HabermeyerMichael Kochte-ClemensBarbara |
| Collana | Forschungsberichte (DFG) |
| Soggetto topico |
Phytochemicals
Food - Safety measures |
| ISBN |
9786613302489
1-283-30248-9 3-527-63471-1 3-527-63470-3 3-527-63483-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Title page -- copyright -- Vorwort -- Preface -- 1: Bericht und Schlussfolgerungen -- 1.1 Einleitung -- 1.2 Methodenübergreifende Aspekte -- 1.3 Methoden -- 1.4 Schlussfolgerungen und Empfehlungen -- 1.5 Fazit -- 2: Report and Conclusions -- 2.1 Preface -- 2.2 Transdisciplinary Aspects -- 2.3 Methodologies -- 2.4 Conclusions and Recommendations -- 2.5 Concluding Remarks -- 3: Contributions -- 3.1: Visions on Toxicity Testing in the 21st Century: Reflections on a Strategy Document of the US National Research Council -- 3.1.1 Introduction -- 3.1.2 A New Vision of Toxicity Testing -- 3.1.3 Testing the Vision -- 3.1.4 Steps toward a New Toxicology -- 3.1.5 The Precautionary Principle -- 3.1.6 The European Side -- 3.1.7 Tasks Ahead -- Acknowledgements -- Abbreviations and Glossary of Terms -- References -- 3.2: Safety Assessment of Botanicals and Botanical Preparations Used as Ingredients in Food Supplements: Testing an European Food Safety AuthorityTiered Approach -- 3.2.1 Introduction -- 3.2.2 Materials and Methods -- 3.2.3 Results -- 3.2.4 Discussion -- Acknowledgement -- References -- 3.3: In Silico Toxicology Screening of the Rodent Carcinogenic Potential of Phytochemicals Using Quantitative Structure-Activity Relationship Analysis -- 3.3.1 Introduction -- 3.3.2 Why Use In Silico Predictive Models at FDA? -- 3.3.3 What In Silico Predictive Models does the FDA Use? -- 3.3.4 What In Silico Predictive Software does the FDA Use? -- 3.3.5 Why Use In Silico Strategies as a Novel Approach to Assess Toxicity of Phytochemicals? -- 3.3.6 Prediction of Rodent Carcinogenicity of Phytochemicals in an External Validation Study -- 3.3.7 Conclusions -- Acknowledgements -- Conflict of Interest Statement -- References -- 3.4: Testing Computational Toxicology Models with Phytochemicals -- 3.4.1 Introduction -- 3.4.2 Materials and Methods -- 3.4.3 Results.
3.4.4 Discussion -- Acknowledgements -- Abbreviations -- Conflict of Interest Statement -- References -- 3.5: In Silico Models to Establish Level of Safety Concern in Absence of Sufficient Toxicological Data -- 3.5.1 Introduction -- 3.5.2 Computational Toxicology Models Relevant for the Food Sectors: Requirements -- 3.5.3 Available Computational Toxicology Models for Food Applications -- 3.5.4 Model Integration and Application -- 3.5.5 Computational Toxicology and Safety Assessment of Botanical Extracts -- 3.5.6 Discussion and Conclusion -- References -- 3.6: In Silico Methods for Physiologically Based Biokinetic (PBBK) Models Describing Bioactivation and Detoxification of Coumarin and Estragole: Implications for Risk Assessment -- 3.6.1 Introduction -- 3.6.2 Methods -- 3.6.3 Results -- 3.6.4 Discussion -- Acknowledgements -- Abbreviations -- Conflict of Interest Statement -- References -- 3.7: In Vitro Models for Carcinogenicity Testing Reality or Fantasy? -- 3.7.1 Introduction -- 3.7.2 BALB/c 3T3 Cell Transformation Assay -- 3.7.3 Automated Soft Agar Assay -- 3.7.4 Concluding Remarks -- Acknowledgments -- References -- 3.8: Carcinogen Specific Expression Profiling: Prediction of Carcinogenic Potential? -- 3.9: Safety and Biological Efficacy Testing of Phytochemicals: An Industry Approach -- 3.9.1 Introduction -- 3.9.2 Screening Process -- 3.9.3 Regulatory Pre-Clinical Safety -- 3.9.4 Overall Conclusion -- References -- 3.10: Metabolite Profiling in Rat Plasma as a Potential New Tool for the Assessment of Chemically Induced Toxicity -- 3.10.1 Introduction -- 3.10.2 Materials and Methods -- 3.10.3 Results and Discussion -- 3.10.4 Concluding Remarks -- Acknowledgements -- References -- 3.11: Profiling Techniques in Nutrition and Food Research -- Hannelore Daniel1 -- 3.11.1 Introduction. 3.11.2 Genomics Applications in Basic and Pre-Clinical Nutrition and Food Research -- 3.11.3 Profiling Technologies Applied in Human Studies -- 3.11.4 Evidence for a Significant Role of the Gut Microbiota in Human Responses to Dietary Interventions -- 3.11.5 Summary -- References -- 3.12: The Complex Links between Dietary Phytochemicals and Human Health Deciphered by Metabolomics -- 3.12.1 Introduction -- 3.12.2 Measuring Dietary Intake of Phytochemicals: Current Limitations -- 3.12.3 Biomarkers of Phytochemical Intake -- 3.12.4 Metabolomics and Biomarker Discovery -- 3.12.5 Metabolomics and Phytochemical Intake -- 3.12.6 Metabolomics and Biological Effects of Phytochemicals -- 3.12.7 Conclusion -- Acknowledgments -- Glossary4 -- Conflict of Interest Statement -- References -- 3.13: Anti-Oxidative and Antigenotoxic Properties of Vegetables and Dietary Phytochemicals: The Value of Genomics Biomarkers in Molecular Epidemiology -- 3.13.1 Introduction -- 3.13.2 Colorectal Cancer Risk Prevention by Vegetables -- 3.13.3 Gene Expression Modulation in the Colon by Vegetables and Phytochemicals -- 3.13.4 Genetic Polymorphisms and Anti-Oxidative Response -- 3.13.5 Risk-Benefit Analysis of Dietary Phytochemicals -- 3.13.6 Concluding Remarks -- References -- 3.14: The Japanese Toxicogenomics Project: Application of Toxicogenomics - Utilizing Toxicogenomics into Drug Safety Screening -- 3.14.1 Introduction -- 3.14.2 Current Status of Worldwide Toxicogenomics Database Creation -- 3.14.3 The Toxicogenomics Project in Japan -- 3.14.4 Application of Toxicogenomics -- 3.14.5 Future Perspectives -- Acknowledgements -- Conflict of Interest Statement -- References -- 3.15: Toxicology and Risk Assessment of Coumarin: Focus on Human Data -- 3.15.1 Introduction -- 3.15.2 Hazard of Coumarin -- 3.15.3 Human Exposure -- 3.15.4 Risk Assessment -- 3.15.5 Summary and Conclusion. Abbreviations -- Conflict of Interest Statement -- References -- 3.16: Risk from Furocoumarins in Food? An Exposure Assessment -- 3.16.1 Introduction -- 3.16.2 Materials and Methods -- 3.16.3 Results and Discussion -- 3.16.4 Conclusions -- Acknowledgements -- References -- 3.17: Transcriptome Analysis in Benefit-Risk Assessment of Micronutrients and Bioactive Food Components -- 3.17.1 Introduction -- 3.17.2 Whole Genome Transcriptome Analysis as a Tool for Benefit-Risk Analysis -- 3.17.3 Data Confirmation by qRT-PCR -- 3.17.4 Magnitude of Micronutrient Effects -- 3.17.5 Data Interpretation -- 3.17.6 In Vivo and In Vitro Approaches -- 3.17.7 Animal Models and Diets -- 3.17.8 Sensitivity and Power -- 3.17.9 Conclusion -- Acknowledgements -- Conflict of Interest Statement -- References -- 3.18: Colorectal and Prostate Cancer: The Role of Candidate Genes in Nutritional Pathways -- 3.18.1 Selenium: Biologic Mechanisms of the Chemopreventive Effects of Selenium -- 3.18.3 Overall Evidence from Candidate-Gene Association Studies for Cancer -- References -- 3.19: Glucosinolates: DNA Adduct Formation In Vivo and Mutagenicity In Vitro -- 3.19.1 Introduction -- 3.19.2 Formation of DNA-Reactive Molecules in Plant Homogenates -- 3.19.3 Formation of DNA Adducts in Animals Fed with Broccoli -- 3.19.4 Elucidation of the Structure of Broccoli-Associated DNA Adducts and Identification of the Substances Involved -- 3.19.5 Mutagenicity of GLS-A -- 3.19.6 Conclusions and Perspectives -- Acknowledgements -- References -- 3.20: Defence Mechanisms against Toxic Phytochemicals in the Diet of Domestic Animals -- 3.20.1 Introduction -- 3.20.2 Polygastric Herbivory: Pre-Systemic Detoxification of Phytochemicals by the Rumen Microbiota -- 3.20.3 Monogastric Herbivory: Are Acquired Feeding Strategies Sufficiently Protective?. 3.20.4 Efflux Transporters: Functional Elements of the Intestinal Barrier -- 3.20.5 Pre-Systemic Elimination by Biotransformation -- 3.20.6 Transcriptional Regulation of Efflux Transporters and Biotransformation Enzymes -- 3.20.7 Carnivorous Species: When Plant Metabolites Become Lethal -- 3.20.8 Risk Assessment of Phytochemicals in Animal Feeds -- References -- 4: Posters -- 4.1: Coumarin Risk Assessment: Lessons from Human Data -- References -- 4.2: Coffee and Coffee Compounds are Effective Antioxidants in Human Cells and In Vivo -- 4.2.1 Introduction -- 4.2.2 Materials and Methods -- 4.2.3 Results and Discussion -- Acknowledgments -- References -- 4.3: Studying Absorption, Distribution, Metabolism, and Excretion of a Complex Extract -- 4.4: Polyphenolic Apple Extracts and their Constituents Modulate DNA Strand Breaks and Oxidation Damage in Human Colon Carcinoma Cells -- 4.4.1 Introduction -- 4.4.2 Methods -- 4.4.3 Results and Discussion -- 4.4.4 Conclusion -- Acknowledgements -- References -- 4.5: Comparative Evaluation of Experimental Data on α-Amylase Inhibition by Flavonoids Using Molecular Modelling -- 4.6: Potential Risk of Furan in Foods -- 4.7: Comparative Study on the Toxicity of Alternariol and Alternariol Monomethyl Ether in Human Tumour Cells of Different Origin -- References -- 4.8: A Role for Resveratrol and Curcumine in Sensitization of Glioblastoma Cells to Genotoxic Stress Induced by Alkylating Chemotherapeutics -- 4.9: BfR Risk Assessment of Alkaloids as Ingredients and Contaminants of Food: Quinine, Opium Alkaloids, and Senecio Pyrrolizidine Alkaloids -- 4.9.1 Quinine in Bitter Soft Drinks - Are there Special Risk Groups? -- 4.9.2 Opium Alkaloids as Contaminants of Poppy Seeds -- 4.9.3 Senecio vulgaris L. as Contaminant of Mixed Salad -- References. 4.10: Elucidation of the Genotoxic Activity of the Alkaloid Ellipticine in Human Cell Lines. |
| Record Nr. | UNINA-9910830691103321 |
| Weinheim [Germany], : Wiley-VCH, 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||