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70 Years of China’s Bridges / / by Zhongfu Xiang, Wei Xu, Anshuang Liu, Fanchao Meng
| 70 Years of China’s Bridges / / by Zhongfu Xiang, Wei Xu, Anshuang Liu, Fanchao Meng |
| Autore | Xiang Zhongfu |
| Edizione | [1st ed. 2023.] |
| Pubbl/distr/stampa | Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2023 |
| Descrizione fisica | 1 online resource (314 pages) |
| Disciplina | 016.22 |
| Collana | History Series |
| Soggetto topico |
Technology
History Engineering design Materials Statics Sustainable architecture History of Technology Engineering Design Materials Engineering Mechanical Statics and Structures Sustainable Architecture/Green Buildings |
| ISBN | 981-9928-78-8 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Chapter 1 The Origin and Development of Bridges -- Chapter 2 Using Foreign Experience for Reference and Laying a Foundation for Further Bridge Development -- Chapter 3 Taking Full Advantage of Local Materials and Innovating in Bridge Technology -- Chapter 4 Learning Advanced Technology and Starting Rising -- Chapter 5 Rapid Development and Becoming a World Power in the Number of Bridges. Chapter 6 Making Technological Breakthrough and Becoming a World Power in Bridge Technology -- Chapter 7 Entering Foreign Lands and Becoming Established on the World Stage -- Chapter 8 Looking Back at the Past whilst Looking Forward to the Future. |
| Record Nr. | UNINA-9910799482003321 |
Xiang Zhongfu
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| Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2023 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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A classified bibliography of the Septuagint / compiled by Sebastian P. Brock, Charles T. Fritsch, Sidney Jellicoe
| A classified bibliography of the Septuagint / compiled by Sebastian P. Brock, Charles T. Fritsch, Sidney Jellicoe |
| Autore | Brock, Sebastian P. |
| Pubbl/distr/stampa | Leiden : E. J. Brill, 1973 |
| Descrizione fisica | XVIII, 217 p. ; 25 cm |
| Disciplina | 016.22 |
| Altri autori (Persone) |
Fritsch, Charles T.
Jellicoe, Sidney |
| Collana | Arbeiten zur Literatur und Geschichte des hellenistischen Judentums |
| Soggetto non controllato | Bibliografie |
| ISBN | 90-04-03596-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-990009724340403321 |
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Brock, Sebastian P.
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| Leiden : E. J. Brill, 1973 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Advances on Broad-Band Wireless Computing, Communication and Applications : Proceedings of the 17th International Conference on Broad-Band Wireless Computing, Communication and Applications (BWCCA-2022) / / edited by Leonard Barolli
| Advances on Broad-Band Wireless Computing, Communication and Applications : Proceedings of the 17th International Conference on Broad-Band Wireless Computing, Communication and Applications (BWCCA-2022) / / edited by Leonard Barolli |
| Edizione | [1st ed. 2023.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2023 |
| Descrizione fisica | 1 online resource (419 pages) |
| Disciplina | 016.22 |
| Collana | Lecture Notes in Networks and Systems |
| Soggetto topico |
Telecommunication
Computational intelligence Communications Engineering, Networks Computational Intelligence |
| ISBN |
9783031200298
9783031200281 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Welcome Message of BWCCA-2022 International Conference Organizers -- BWCCA-2022 Organizing Committee -- Honorary Chair -- General Co-chairs -- Program Committee Co-chairs -- International Advisory Committee -- Publicity Co-chairs -- Finance Chair -- Web Administrator Chairs -- Local Organizing Co-chairs -- Steering Committee Chair -- Track Areas -- Next Generation Wireless Networks -- Track Co-chairs -- PC Members -- Cloud and Service Computing -- Track Co-chairs -- PC Members -- Multimedia and Web Applications -- Track Co-chairs -- PC Members -- Security and Privacy -- Track Co-chairs -- PC Members -- Network Protocols and Performance Analysis -- Track Co-chairs -- PC Members -- Intelligent and Cognitive Computing -- Track Co-chairs -- PC Members -- Distributed and Parallel Computing -- Track Co-chairs -- PC Members -- IoT and Smart Environment -- Track Co-chairs -- PC Members -- Database, Data Mining, and Big Data -- Track Co-chairs -- PC Members -- Ubiquitous and Pervasive Computing -- Track Co-chairs -- PC Members -- BWCCA-2022 Reviewers -- BWCCA-2022 Keynote Talks -- Humanics Information Security: How to Go Above and Beyond? -- Multi-objective Methods for Wireless Sensor Network Optimization -- Contents -- A Comparison Study of UNDX and UNDX-m Methods for LDVM and RDVM Router Replacement Methods by WMN-PSODGA Hybrid Intelligent System Considering Stadium Distribution -- 1 Introduction -- 2 Intelligent Algorithms for Proposed Hybrid Simulation System -- 2.1 Particle Swarm Optimization -- 2.2 Distributed Genetic Algorithm -- 3 Proposed and Implemented WMN-PSODGA Hybrid Intelligent Simulation System -- 4 Simulation Results -- 5 Conclusions -- References -- Performance Comparison of Roulette Wheel and Random Selection Methods by WMN-PSODGA Simulation System Considering Stadium Distribution and LDIWM -- 1 Introduction.
2 Intelligent Algorithms for Proposed Hybrid Simulation System -- 2.1 Particle Swarm Optimization -- 2.2 Distributed Genetic Algorithm -- 3 Proposed and Implemented WMN-PSODGA Hybrid Intelligent Simulation System -- 4 Simulation Results -- 5 Conclusions -- References -- A Fuzzy-Based System for Handover in 5G Wireless Networks Considering Different Network Slicing Constraints: Effects of Slice Reliability Parameter on Handover Decision -- 1 Introduction -- 2 Software-Defined Networks (SDNs) -- 3 5G Network Slicing -- 4 Proposed Fuzzy-Based System -- 5 Simulation Results -- 6 Conclusions and Future Work -- References -- A Simulated Annealing Based Simulation System for Optimization of Wild Deer Damage Prevention Devices -- 1 Introduction -- 2 Proposed System -- 2.1 OSM Extraction for DD Placement Candidate Locations -- 2.2 DD Placement Optimization -- 3 Simulation Results -- 4 Conclusions -- References -- Techno-Economic Analysis of Cloud Computing Supported by 5G: A Cloud vs on Premise Based Solutions Comparison -- 1 Introduction -- 2 Proposed Models -- 2.1 Cloud Based Solution -- 2.2 On Premise Based Solution -- 3 Pricing Model -- 3.1 Cloud Based Solution -- 3.2 On Premise Based Solution -- 4 Parameter Selection -- 4.1 Cost Comparison -- 4.2 On Premises Solution Cost Adjustments -- 4.3 Cloud Based Solution Cost Adjustments -- 4.4 Performance Evaluation -- 5 5G and Cloud Computing -- 6 Conclusions and Future Work -- References -- An Integrated Fog-VDTN Architecture for Data Dissemination -- 1 Introduction -- 2 Proposed Architecture -- 3 Simulation System and Scenarios -- 4 Simulation Results -- 5 Conclusions -- References -- Energy-Consumption Evaluation of the Tree-Based Fog Computing (TBFC) Model -- 1 Introduction -- 2 The TBFC Model -- 3 Power Consumption and Computation Models of the TBFC Model -- 4 Evaluation -- 5 Concluding Remarks. References -- Evaluation of the Information Flow Control in the Fog Computing Model -- 1 Introduction -- 2 System Model -- 2.1 CBAC (Capability-Based Access Control) Model -- 2.2 Information Flow Relations -- 2.3 FC (Fog Computing) Model -- 3 Information Flow Control -- 3.1 Protocols -- 3.2 FC-Based Protocols -- 4 Evaluation -- 5 Concluding Remarks -- References -- A Study of Network Attack Strategy Using AS Topology Map -- 1 Introduction -- 2 Preliminaries -- 2.1 Outline -- 2.2 Adjacency Matrix -- 2.3 Laplacian Matrix -- 3 Proposed Attack Strategy -- 3.1 Topology Map of AS -- 3.2 Attack Strategy -- 4 Example Execution -- 4.1 Preparation (Step-1 Step-3) -- 4.2 Simulation of Tactics and Result (Step-4) -- 4.3 Select of Attack Strategy (Step-5) -- 4.4 Consideration -- 5 Discussion -- 5.1 Feasibility of Proposed Attack Strategy -- 5.2 Effectiveness of Stopped Terminal AS -- 5.3 Appropriate Values of max(A) and R -- 6 Conclusion -- References -- Improving Classification Accuracy by Optimizing Activation Function for Convolutional Neural Network on Homomorphic Encryption -- 1 Introduction -- 2 Related Work -- 3 Proposed Method -- 3.1 Polynomial Approximation of the Mish Function -- 3.2 Accuracy Optimization -- 4 Evaluation -- 4.1 Evaluation Setup -- 4.2 Experimental Results for Classification Accuracy -- 4.3 Experimental Results for Different Networks -- 5 Disucussion -- 5.1 Effective Optimization Method for Activation Functions in CNN -- 5.2 Application of Optimization to Different Networks -- 5.3 Limitations -- 6 Conclusion -- References -- An Attention Mechanism for Visualizing Word Weights in Source Code of PowerShell Samples: Experimental Results and Analysis -- 1 Introduction -- 2 Related Work -- 3 Related Technique -- 3.1 Long Short-Term Memory -- 3.2 Attention Mechanism -- 4 Experimental Method -- 4.1 Outline -- 4.2 Preprocessing. 4.3 Training Phase -- 4.4 Test Phase -- 5 Experimental Model and Evaluation Results -- 5.1 Experimental Model -- 5.2 Dataset -- 5.3 Environment -- 5.4 Evaluation Metrics -- 5.5 Experiment Contents -- 5.6 Result -- 6 Discussion -- 6.1 Important Words -- 6.2 Possibility of Evasion Attack -- 6.3 Research Ethics -- 6.4 Limitations -- 7 Conclusion -- References -- Improving Palmprint-Region Estimation for ID-Less Palmprint Recognition -- 1 Introduction -- 2 Related Work -- 2.1 Palmprint-Region Estimation Using Hand Shape -- 2.2 Palmprint-Region Estimation Using Interdigital Spaces -- 2.3 Palmprint-Region Estimation Using Skeletal Information -- 3 Proposed Methods -- 3.1 Improvement of Region Quality -- 3.2 Proposed Method 1 -- 3.3 Proposed Method 2 -- 3.4 Proposed Method 3 -- 4 Evaluation -- 4.1 Evaluation Dataset -- 4.2 Evaluation Method -- 4.3 Verification Process -- 4.4 Results -- 4.5 Discussions -- 5 Conclusion -- References -- Real Vehicle-Based Attack Dataset for Security Threat Analysis in a Vehicle -- 1 Introduction -- 2 Related Work -- 3 Method of Generate Attack CAN Dataset Based on Actual Vehicle -- 3.1 Method for Collection CAN Dataset in Vehicle -- 3.2 Vehicle Internal CAN Network Attack Tool -- 3.3 Collection of Attack CAN Data Packet Based on Actual Vehicle -- 4 Evaluation -- 4.1 Result of DoS Attack -- 4.2 Result of Fuzzing Attack -- 4.3 Result of Replay Attack -- 5 Conclusion and Future Work -- References -- Performance Analysis of HARQ in 2-step RACH Procedure Using Markov Chain Model -- 1 Introduction -- 2 2-step RACH Procedure -- 3 Hybrid Automatic Repeat and Request -- 4 Analytical Markov Chain Model -- 5 Simulation -- 6 Conclusion -- References -- A Comparison Study of FC-RDVM with LDVM Router Replacement Methods by WMN-PSOHC Simulation System Considering Weibull Distribution of Mesh Clients -- 1 Introduction. 2 Intelligent Algorithms -- 2.1 Particle Swarm Optimization -- 2.2 Hill Climbing -- 3 WMN-PSOHC Hybrid Simulation System and FC-RDVM -- 4 Simulation Results -- 5 Conclusions -- References -- A Fuzzy-Based System for Estimation of Landslide Disasters Risk Considering Digital Elevation Model -- 1 Introduction -- 2 Proposed System -- 2.1 LDR Estimation -- 2.2 Danger Area Estimation Based on LDR -- 3 Evaluation Results -- 3.1 LDR Estimation Results -- 3.2 Evaluation Results for Danger Area Estimation Based on LDR -- 4 Conclusions -- References -- Human-Centered Protocols for Secure Data Management in Distributed Systems -- 1 Introduction -- 2 Human-Centered Protocols for Secure Data Management -- 3 Secure Data Management in Distributed Systems -- 4 Conclusions -- References -- Multi-Version Concurrency Control to Reduce the Electric Energy Consumption of Servers -- 1 Introduction -- 2 System Model -- 2.1 Object-Based Systems -- 2.2 Multi-Version Timestamp Ordering (MVTO) Algorithm -- 2.3 Data Access Model -- 2.4 Power Consumption Model of a Server -- 3 Improved EEMVTO (IEEMVTO) Algorithm -- 3.1 Meaningless Methods -- 3.2 IEEMVTO Algorithm -- 4 Evaluation -- 4.1 Environment -- 4.2 Total Processing Electric Energy Consumption -- 4.3 Average Execution Time of Each Transaction -- 5 Concluding Remarks -- References -- A Study on Increasing Simultaneous Transmissions After Extended RTS/CTS Handshake on Full-duplex Wireless LANs -- 1 Introduction -- 2 Full-duplex Wireless Transmission -- 2.1 Full-duplex Transmission Fassions -- 2.2 Challenges of Full-duplex Wireless Transmission -- 3 Method for Selecting Multiple Nodes for Synchronous Transmission -- 3.1 Transmission Procedure -- 3.2 Selection Algorithm of Candidate Transmitters -- 3.3 Method for Selecting Destination of Synchronous Transmission -- 4 Performance Evaluation. 4.1 Characteristics of Throughput Performance. |
| Record Nr. | UNINA-9910627279303321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2023 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Bibbie miniate della Biblioteca Medicea Laurenziana di Firenze / Biblioteca Medicea Laurenziana di Firenze ; Fondazione Ezio Franceschini ; a cura di Laura Alidori ... [et al.] ; premessa di Carla Guiducci Bonanni ; presentazione di Franca Arduini ; prefazione di Claudio Leonardi ; con un saggio introduttivo di Maria Grazia Ciardi Dupré Dal Poggetto
| Bibbie miniate della Biblioteca Medicea Laurenziana di Firenze / Biblioteca Medicea Laurenziana di Firenze ; Fondazione Ezio Franceschini ; a cura di Laura Alidori ... [et al.] ; premessa di Carla Guiducci Bonanni ; presentazione di Franca Arduini ; prefazione di Claudio Leonardi ; con un saggio introduttivo di Maria Grazia Ciardi Dupré Dal Poggetto |
| Autore | Biblioteca Medicea Laurenziana |
| Pubbl/distr/stampa | Tavarnuzze, Impruneta : SISMEL Edizioni del Galluzzo, 2003 |
| Descrizione fisica | XXXIV, 452 p., XVI, 30 p. di tav. : ill. ; 30 cm |
| Disciplina | 016.22 |
| Collana | Biblioteche e archivi |
| Soggetto topico | Bibbia - Manoscritti miniati - Collezioni [della] Biblioteca Medicea Laurenziana - Cataloghi bibliografici |
| ISBN | 88-8450-080-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | ita |
| Record Nr. | UNISA-990003148560203316 |
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Biblioteca Medicea Laurenziana
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| Tavarnuzze, Impruneta : SISMEL Edizioni del Galluzzo, 2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
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Bibbie miniate della Biblioteca Medicea Laurenziana di Firenze. Secondo contributo / Biblioteca Medicea Laurenziana di Firenze ; Fondazione Ezio Franceschini ONLUS ; a cura di Laura Alidori Battaglia ... [et al.] ; presentazione di Franca Arduini ; prefazione di Claudio Leonardi
| Bibbie miniate della Biblioteca Medicea Laurenziana di Firenze. Secondo contributo / Biblioteca Medicea Laurenziana di Firenze ; Fondazione Ezio Franceschini ONLUS ; a cura di Laura Alidori Battaglia ... [et al.] ; presentazione di Franca Arduini ; prefazione di Claudio Leonardi |
| Autore | Biblioteca Medicea Laurenziana |
| Pubbl/distr/stampa | Firenze : SISMEL Edizioni del Galluzzo, 2006 |
| Descrizione fisica | XXII, 358 p., XVI, 32 p. di tav. : ill. ; 30 cm |
| Disciplina | 016.22 |
| Collana | Biblioteche e archivi |
| Soggetto topico | Bibbia - Manoscritti miniati - Collezioni [della] Biblioteca Medicea Laurenziana - Cataloghi bibliografici |
| ISBN |
88-8450-217-9
978-88-8450-217-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | ita |
| Record Nr. | UNISA-990003097030203316 |
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Biblioteca Medicea Laurenziana
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| Firenze : SISMEL Edizioni del Galluzzo, 2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
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Bronchiectasis / / edited by Charlotte C. Teneback, Bryan Garcia
| Bronchiectasis / / edited by Charlotte C. Teneback, Bryan Garcia |
| Edizione | [1st ed. 2022.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Humana, , 2022 |
| Descrizione fisica | 1 online resource (240 pages) |
| Disciplina |
016.22
616.23 |
| Collana | Respiratory Medicine |
| Soggetto topico |
Respiratory organs - Diseases
Pneumology |
| ISBN | 3-031-12926-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Bronchiectasis: An Introduction to the Patient from the Clinician's Perspective -- Global epidemiology and impact of bronchiectasis in adults without cystic fibrosis -- Systemic diseases associated with Bronchiectasis -- Environmental and Infectious causes of Bronchiectasis -- Approach to Etiological Diagnosis and Initial Management -- Radiographic Phenotyping, Diagnosing, and Monitoring of Bronchiectatic Diseases -- Acute Exacerbations of Bronchiectasis and the Airway Microbiology -- Host-Directed Therapy -- Challenges and Considerations for Clinical Trials Design in Bronchiectasis -- Non-CF Bronchiectasis and Nontuberculous Mycobacteria: Integration of Mental Health and Quality of Life into Patient Care. |
| Record Nr. | UNINA-9910619270803321 |
| Cham : , : Springer International Publishing : , : Imprint : Humana, , 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Cómo Crear Tu Marca de Moda / / Covadonga Jaquete and Covadonga González-Pola
| Cómo Crear Tu Marca de Moda / / Covadonga Jaquete and Covadonga González-Pola |
| Autore | Jaquete Covadonga |
| Edizione | [First edition.] |
| Pubbl/distr/stampa | Madrid, Spain : , : Lid Editorial Empresarial S.L., , [2018] |
| Descrizione fisica | 1 online resource (140 pages) |
| Disciplina | 016.22 |
| Soggetto topico | Branding (Marketing) |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | spa |
| Record Nr. | UNINA-9910793952403321 |
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Jaquete Covadonga
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| Madrid, Spain : , : Lid Editorial Empresarial S.L., , [2018] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Cómo Crear Tu Marca de Moda / / Covadonga Jaquete and Covadonga González-Pola
| Cómo Crear Tu Marca de Moda / / Covadonga Jaquete and Covadonga González-Pola |
| Autore | Jaquete Covadonga |
| Edizione | [First edition.] |
| Pubbl/distr/stampa | Madrid, Spain : , : Lid Editorial Empresarial S.L., , [2018] |
| Descrizione fisica | 1 online resource (140 pages) |
| Disciplina | 016.22 |
| Soggetto topico | Branding (Marketing) |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | spa |
| Record Nr. | UNINA-9910827077403321 |
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Jaquete Covadonga
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| Madrid, Spain : , : Lid Editorial Empresarial S.L., , [2018] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Cross-sectional atlas of rhesus monkey head : with 0.024-mm pixel size color images / / Jin Seo Park
| Cross-sectional atlas of rhesus monkey head : with 0.024-mm pixel size color images / / Jin Seo Park |
| Autore | Park Jin Seo |
| Pubbl/distr/stampa | Singapore : , : Springer, , [2022] |
| Descrizione fisica | 1 online resource (348 pages) |
| Disciplina | 016.22 |
| Soggetto topico | Brain |
| ISBN |
9789811932540
9789811932533 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Intro -- Contents -- 1: Introduction -- 1 Introduction -- 2 Producing Sectioned Images of Rhesus Monkey -- 3 Reference System -- 4 Terminology and Labelling -- 5 Conclusion -- References -- Part I: Whole Head -- 2: Axial -- 3: Coronal -- 4: Sagittal -- Part II: Deep Head -- 5: Axial (Expanded) -- 6: Coronal (Expanded) -- 7: Sagittal (Expanded). |
| Record Nr. | UNINA-9910624305403321 |
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Park Jin Seo
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| Singapore : , : Springer, , [2022] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Drug and therapy development for triple negative breast cancer / / edited by Pravin Kendrekar, Vinayak Adimule, and Tara Hurst
| Drug and therapy development for triple negative breast cancer / / edited by Pravin Kendrekar, Vinayak Adimule, and Tara Hurst |
| Pubbl/distr/stampa | Weinheim, Germany : , : WILEY-VCH GmbH, , [2023] |
| Descrizione fisica | 1 online resource (323 pages) |
| Disciplina | 016.22 |
| Soggetto topico | Breast - Cancer - Treatment |
| ISBN |
3-527-84116-4
3-527-84118-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Title Page -- Contents -- Preface -- Part I History of Breast Cancer -- 1 Early-Stage Diagnosis of Breast Cancer: Amelioration in Approaches -- 1.1 Introduction -- 1.2 Imaging Techniques -- 1.2.1 Mammography (MG) -- 1.2.2 Ultrasonography (US) -- 1.2.3 Magnetic Resonance Imaging (MRI) -- 1.3 Microwave Breast Imaging Methods -- 1.3.1 Microwave Tomography -- 1.3.2 Radio-Based Microwave Imaging -- 1.4 Biomarkers and Biosensors for Breast Cancer Detection -- 1.4.1 Biomarkers -- 1.4.2 Biosensors -- 1.5 Conclusion -- Acknowledgment -- Conflict of Interest -- Authors Contribution -- References -- 2 DNA Replication Stress and Genome Instability in Breast Cancer -- 2.1 Introduction -- 2.2 Causes of Replication Stress and Genomic Instability -- 2.2.1 Replication Dysfunction -- 2.2.2 Transcription-Induced Stress -- 2.2.3 Genomic Aberrations and Instability -- 2.3 Molecular Mechanism of Genomic Instability -- 2.3.1 Problems Faced During DNA Damage Repair -- 2.3.2 Transcriptional Stress -- 2.3.3 CIN: Result of Defective Mitosis -- 2.4 Aftermath of Replication Stress on Cell and Its Fate -- 2.4.1 Conservation of Stalled Replication Forks -- 2.4.2 Chromosome Segregation Defect Check by HR Repair -- 2.4.3 Aging, Cell Death, and Senescence -- 2.5 Therapeutic Approach -- 2.6 Conclusion -- Abbreviations -- References -- 3 Recent Advancement of Nanotherapeutics to Treat Breast Cancer -- 3.1 Introduction -- 3.2 Pathophysiology of Breast Cancer -- 3.3 Classification of Breast Cancer -- 3.4 Techniques for Breast Cancer Detection -- 3.5 Current Breast Cancer Therapies -- 3.6 Nanotherapeutics for Breast Cancer Treatment and Metastasis -- 3.6.1 Nanodiamonds (NDs) -- 3.6.2 Intrinsic Toxicity Reduction -- 3.6.3 Diminishing Chemoresistance (CR) -- 3.6.4 Delivery of Combination Therapeutics Through NDs -- 3.7 Polymer-Based Nanoparticles (PBNPs).
3.8 Inorganic Nanoparticles (IONPs) -- 3.9 Hydrogels (HGLs) and Microbubbles (MBs) -- 3.10 Recent Patents of Nanotherapeutics for Breast Cancer Treatment -- 3.11 Clinical Trials of Nanotherapeutics for Breast Cancer -- 3.12 Conclusion and Future Perspectives -- References -- 4 HER Receptor in Breast Cancer -- 4.1 Introduction -- 4.2 Role of HER Receptors in the Human Body -- 4.3 HER2 Receptor in Breast Cancer Progression -- 4.4 Conclusion -- Conflict of Interest -- References -- 5 Human Endogenous Retroviruses in Triple-Negative Breast Cancer -- 5.1 Introduction -- 5.2 HERVs in Breast Cancer and TNBC -- 5.3 TROJAN lncRNA and TNBC -- 5.4 HERVs and Breast Cancer Treatments -- 5.5 Conclusion -- 5.6 Search Strategy -- References -- Part II Novel Drug Discovery and Development -- 6 Development in Drug Repurposing for the Treatment of Acute Leukemia Complicating Metastatic Breast Cancer -- 6.1 Introduction -- 6.1.1 Acute Leukemia's -- 6.1.2 Mitochondrial cAMP-PKA Signaling -- 6.1.3 Nuclear Compartment -- 6.1.4 Cytosolic Compartment and Plasma Membrane -- 6.2 Conclusion -- Conflict of Interest -- References -- 7 Novel Pharmaceutical Nanomaterials to Advance the Current Breast Cancer Treatment - Current Trends and Future Perspective -- 7.1 Introduction -- 7.2 Graphene-Based Nanomaterials for Breast Cancer -- 7.3 Light-Based Nanotechnology for Breast Cancer -- 7.3.1 Photodynamic Therapeutic Nanomaterials -- 7.3.2 Photothermal Therapeutic Nanomaterials -- 7.4 Green Synthesis of Gold Nanoparticles for Breast Cancer -- 7.5 Nanocarriers for Gene Therapy and Immunotherapy -- 7.6 Conclusion and Recommendations -- References -- Part III Advanced Technologies in Breast Cancer Therapy -- 8 Artificial Intelligence-Driven Decisions in Breast Cancer Diagnosis -- 8.1 Introduction -- 8.2 Breast Cancer -- 8.3 Diagnosis of Breast Cancer -- 8.4 Artificial Intelligence. 8.4.1 Artificial Intelligence and Medical Imaging -- 8.5 Conclusion -- 8.6 Future Challenges -- References -- 9 Establishing Nanotechnology-Based Drug Development for Triple-Negative Breast Cancer Treatment -- 9.1 Introduction -- 9.2 Triple-Negative Breast Cancer -- 9.2.1 Molecular Mechanisms (Signaling Pathways) Involved in TNBC Therapeutics -- 9.2.2 Conventional Therapeutics -- 9.2.3 Promising Nanotechnology Innovations for TNBC Therapy -- 9.2.4 Vaccines Under the Clinical Trial (CT) for TNBC Treatment -- 9.2.5 USFDA-Approved Clinical Trials -- 9.2.6 Current Status of TNBC Treatment -- 9.2.7 Recent Patents Based on Nanoformulations for TNBC Treatment -- 9.3 Challenges -- 9.4 Future Perspectives on TNBC Metastasis Therapy -- 9.4.1 NEO Adjuvant Modeling -- 9.4.2 Execution of In Vivo Genetic Screening -- 9.4.3 Identification of Effective Drugs for TNBC -- 9.4.4 Synergistic Effect of Drugs that Almost Eliminate Tumor -- 9.5 Conclusion -- References -- 10 Etiology and Therapy of Hormone Receptor-Positive Breast Cancer -- 10.1 Introduction -- 10.2 Etiology -- 10.2.1 Role of Estrogen Hormone -- 10.2.2 Role of Progesterone Hormone -- 10.2.3 Estrogen Receptor (ER) -- 10.2.4 Progesterone Receptor (PR) -- 10.3 Human Epidermal Growth Factor-2 (HER-2) -- 10.4 Various Types of Breast Cancer Detected Under Hormone Receptor Breast Cancer -- 10.4.1 Estrogen Receptor (ER) Positive -- 10.4.2 Progesterone Receptor (PR) Positive -- 10.4.3 Hormone Receptor (HR) Negative -- 10.5 Detection -- 10.6 Therapy -- 10.6.1 Selective Estrogen-Receptor Response Modulators (SERMs) -- 10.6.2 Aromatase Inhibitors -- 10.6.3 Estrogen-Receptor Down Regulators (ERDs) -- 10.6.4 Luteinizing Hormone-Releasing Hormone Agents (LHRH) -- 10.7 Limitations of Hormone Therapy -- 10.7.1 Tamoxifen -- 10.7.2 Raloxifene -- 10.7.3 Aromatase Inhibitors -- 10.7.4 Fulvestrant. 10.8 Triple-Negative Breast Cancer -- 10.8.1 Clinical History of Triple-Negative Breast Cancer -- 10.8.2 Imaging Characteristics/Features of Triple-Negative Breast Cancer -- 10.8.3 Subtypes of TNBC -- 10.8.4 Treatment of Triple-Negative Breast Cancer -- 10.8.5 Advance TNBC -- 10.8.6 Pharmacogenomics -- 10.9 Conclusion -- References -- 11 Donor-Acceptor-Based Heterocyclic Compounds as Chemotherapy and Photothermal Agents in Treatment of Breast Cancer Cell -- 11.1 Introduction -- 11.2 Causes for Breast Cancer -- 11.3 Imaging and Screening of Breast Cancer -- 11.4 Photothermal Therapy (PTT) -- 11.5 Acceptor-Donor-Based Heterocyclic Compounds -- 11.6 Examples of Organic-Based Donor-Acceptor -- 11.6.1 Indocyanine -- 11.7 Polymers-Based Agents -- 11.7.1 Phthalocyanine -- 11.8 Conclusion -- References -- Part IV Regulatory, Clinical Aspects and Case Studies -- 12 An Insight into Drug Regulatory Affairs and the Procedures -- 12.1 Endpoints of Clinical Trials for the Approval of Cancer Drugs and Biologics -- 12.2 Statutory and Regulatory Requirements for Effectiveness -- 12.2.1 Endpoints Supporting Previous Oncology Approvals -- 12.2.2 Endpoints Based on Tumor Assessments -- 12.2.3 Clinical Practice Guideline for the Diagnosis, Staging, and Treatment of Patients with Metastatic Breast Cancer -- 12.2.4 Cancer Drug and Diagnostic Regulation by the FDA -- 12.2.5 Considerations for Clinical Trial Design and Analysis -- 12.2.6 Single-Arm Studies -- 12.2.7 Randomized Studies Designed to Demonstrate Noninferiority -- 12.3 Clinical Trial Design Considerations -- 12.4 Clinical Trial Analysis Issues -- 12.5 Use of Pathological Complete Response as an Endpoint to Support Accelerated Approval in Neoadjuvant Treatment of High-Risk Early-Stage Breast Cancer -- 12.6 Developing Treatments for Premenopausal Women with Breast Cancer -- 12.7 Recommendations by FDA. 12.7.1 Access to Experimental Cancer Drugs -- 12.7.2 How to Get a Hold of an Experimental Drug -- 12.7.3 Access to More Information (Compassionate Use) -- 12.8 What is Right to Try? -- 12.9 Examples of Drugs Approved for Breast Cancer -- References -- 13 A Comprehensive Review of Some Heat-Shock Proteins in the Development and Progression of Human Breast Cancer -- 13.1 Introduction -- 13.1.1 Cancer and Its Economic Burden on Human -- 13.2 Structure-Functional Features of HSPs -- 13.2.1 Heat-Shock Protein 40 -- 13.2.2 Heat-Shock Protein 60 -- 13.2.3 Heat-Shock Protein 70 -- 13.2.4 Heat-Shock Protein 90 -- 13.3 Conclusion and Future Perspectives -- Acknowledgments -- References -- 14 Nanoparticle-Based Therapeutics for Triple Negative Breast Cancer -- 14.1 Breast Cancer: State of Research and Practice -- 14.2 Triple Negative Breast Cancer (TNBC) and Treatment Approaches -- 14.3 Nanoparticle Therapeutics for TNBC -- 14.3.1 Metallic Nanoparticles -- 14.3.2 Dendrimers -- 14.3.3 Lipid-Based Nanoparticles (LNPs) -- 14.3.4 CRISPR Nanoparticles -- 14.3.5 Exosomes (Exo) -- 14.3.6 Nucleic Acid (NA)-Based Therapeutics -- 14.4 Ligands Used to Enhance Nanoparticle Therapeutics in TNBC -- 14.4.1 Antibodies -- 14.4.2 Peptides -- 14.4.3 Aptamers -- 14.4.4 Small Molecules -- 14.5 Conclusion -- References -- 15 Current Updates in Breast Cancer Drugs -- 15.1 Introduction -- 15.2 Therapeutic Approaches -- 15.2.1 Hormonotherapy -- 15.2.2 Chemotherapy -- 15.3 Targeted Therapy -- 15.3.1 Drug Repurposing -- 15.3.2 HER2 Inhibitors -- 15.3.3 PARP Inhibitors -- 15.3.4 Immunotherapy -- 15.3.5 Others Novel Targets -- 15.4 Conclusion -- Acknowledgment -- Conflict of Interest -- Authors Contribution -- References -- Index -- EULA. |
| Record Nr. | UNINA-9910831190103321 |
| Weinheim, Germany : , : WILEY-VCH GmbH, , [2023] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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