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Post-transcriptional gene regulation [[electronic resource]] : RNA processing in eukaryotes / / edited by Jane Wu
| Post-transcriptional gene regulation [[electronic resource]] : RNA processing in eukaryotes / / edited by Jane Wu |
| Pubbl/distr/stampa | West Sussex, England, : Wiley-Blackwell, c2013 |
| Descrizione fisica | 1 online resource (278 p.) |
| Disciplina | 572.865 |
| Altri autori (Persone) | WuJane |
| Soggetto topico |
Genetic regulation
Eukaryotic cells |
| ISBN |
3-527-66541-2
3-527-66543-9 3-527-66542-0 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Related Titles; Title page; Copyright page; Contents; Foreword; List of Contributors; 1: The Role of Cotranscriptional Recruitment of RNA-Binding Proteins in the Maintenance of Genomic Stability; 1.1 Introduction; 1.2 THO/TREX; 1.2.1 THO/TREX in Saccharomyces cerevisiae; 1.2.2 THO/TREX in Higher Eukaryotes; 1.2.3 THO/TREX and R-loop Formation; 1.3 Linking Transcription to Export of mRNP; 1.3.1 The Thp1-Sac3-Sus1-Cdc31 (THSC) Complex; 1.3.2 SR Proteins; 1.3.3 The Exon Junction Complex; 1.3.4 The Exosome; 1.4 Cotranscriptional R-loop Formation; 1.4.1 R-loops in Escherichia coli
1.4.2 Naturally Occurring R-loops1.4.3 TREX Protects against R-loop Formation; 1.4.4 SR Proteins Protect against R-loop Formation; 1.5 R-loop-induced Double-Stranded (ds) DNA Breaks; 1.5.1 Class Switch Recombination; 1.5.2 Formation of Double-Strand Breaks; 1.5.3 Rrm3 and Pif1 DNA Helicases; 1.6 Concluding Remarks; References; 2: Transcription Termination by RNA Polymerase II; 2.1 Messenger RNA Gene Termination; 2.1.1 The Allosteric Model; 2.1.2 The Torpedo Model; 2.2 Small Nucleolar RNA Gene Termination Pathway; 2.3 Choice between the Two Termination Pathways 2.4 Regulation of Transcription by Termination2.4.1 Transcription Attenuation, Promoter Upstream/Associated Transcription, and Pausing of RNApII; 2.4.2 Alternative Polyadenylation and Termination; 2.5 Mechanisms of Termination by Other RNA Polymerases; 2.6 Future Perspectives; Acknowledgments; References; 3: Posttranscriptional Gene Regulation by an Editor: ADAR and its Role in RNA Editing; 3.1 Introduction; 3.2 The RNA Editing Kinship; 3.3 The ADAR Gene Family; 3.4 The Role of RNA in the A-to-I Editing Mechanism; 3.5 Splice Site Alterations 3.6 A-to-I RNA Recoding Modifies Proteins Such As Neurotransmitters3.6.1 Glutamate Receptor Editing - GluR-B; 3.6.2 Serotonin Receptor Editing - 5-HT2CR; 3.7 Cellular Effects and in Vivo Phenotypes of ADAR Gene Inactivation; 3.8 Noncoding RNA and Repetitive Sequences; 3.9 Effects on the RNA Interference Silencing Pathway; 3.10 Effects on MicroRNA Processing and Target Selection; 3.11 RNA Editing Role as an Antiviral Mechanism; 3.12 Conclusions; Acknowledgments; References; 4: Posttranslational Modification of Sm Proteins: Diverse Roles in snRNP Assembly and Germ Line Specification 4.1 Introduction4.2 Protein Methylation - Flavors and Functions; 4.3 Sm Proteins Contain sDMA- and aDMA-Modified Arginines; 4.4 SnRNP Assembly, the Survival Motor Neuron (SMN) Complex, and Spinal Muscular Atrophy (SMA); 4.5 PRMT5 and PRMT7 - The Sm Protein Methyltransferases; 4.6 Sm Protein Methylation is Required for sn/RNP Assembly in Mammals; 4.7 Sm Protein Methylation in Drosophila; 4.8 Unresolved Questions: Sm Protein Methylation and snRNP Assembly; 4.9 Conclusion - The Evolution of snRNP Assembly; 4.10 Sm Proteins Are Required for Germ Cell Specification 4.11 Dart5, Valois, Sm Proteins, and Tudor Anchoring |
| Record Nr. | UNINA-9910141610003321 |
| West Sussex, England, : Wiley-Blackwell, c2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Post-transcriptional gene regulation : RNA processing in eukaryotes / / edited by Jane Wu
| Post-transcriptional gene regulation : RNA processing in eukaryotes / / edited by Jane Wu |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | West Sussex, England, : Wiley-Blackwell, c2013 |
| Descrizione fisica | 1 online resource (278 p.) |
| Disciplina | 572.865 |
| Altri autori (Persone) | WuJane |
| Soggetto topico |
Genetic regulation
Eukaryotic cells |
| ISBN |
3-527-66541-2
3-527-66543-9 3-527-66542-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Related Titles; Title page; Copyright page; Contents; Foreword; List of Contributors; 1: The Role of Cotranscriptional Recruitment of RNA-Binding Proteins in the Maintenance of Genomic Stability; 1.1 Introduction; 1.2 THO/TREX; 1.2.1 THO/TREX in Saccharomyces cerevisiae; 1.2.2 THO/TREX in Higher Eukaryotes; 1.2.3 THO/TREX and R-loop Formation; 1.3 Linking Transcription to Export of mRNP; 1.3.1 The Thp1-Sac3-Sus1-Cdc31 (THSC) Complex; 1.3.2 SR Proteins; 1.3.3 The Exon Junction Complex; 1.3.4 The Exosome; 1.4 Cotranscriptional R-loop Formation; 1.4.1 R-loops in Escherichia coli
1.4.2 Naturally Occurring R-loops1.4.3 TREX Protects against R-loop Formation; 1.4.4 SR Proteins Protect against R-loop Formation; 1.5 R-loop-induced Double-Stranded (ds) DNA Breaks; 1.5.1 Class Switch Recombination; 1.5.2 Formation of Double-Strand Breaks; 1.5.3 Rrm3 and Pif1 DNA Helicases; 1.6 Concluding Remarks; References; 2: Transcription Termination by RNA Polymerase II; 2.1 Messenger RNA Gene Termination; 2.1.1 The Allosteric Model; 2.1.2 The Torpedo Model; 2.2 Small Nucleolar RNA Gene Termination Pathway; 2.3 Choice between the Two Termination Pathways 2.4 Regulation of Transcription by Termination2.4.1 Transcription Attenuation, Promoter Upstream/Associated Transcription, and Pausing of RNApII; 2.4.2 Alternative Polyadenylation and Termination; 2.5 Mechanisms of Termination by Other RNA Polymerases; 2.6 Future Perspectives; Acknowledgments; References; 3: Posttranscriptional Gene Regulation by an Editor: ADAR and its Role in RNA Editing; 3.1 Introduction; 3.2 The RNA Editing Kinship; 3.3 The ADAR Gene Family; 3.4 The Role of RNA in the A-to-I Editing Mechanism; 3.5 Splice Site Alterations 3.6 A-to-I RNA Recoding Modifies Proteins Such As Neurotransmitters3.6.1 Glutamate Receptor Editing - GluR-B; 3.6.2 Serotonin Receptor Editing - 5-HT2CR; 3.7 Cellular Effects and in Vivo Phenotypes of ADAR Gene Inactivation; 3.8 Noncoding RNA and Repetitive Sequences; 3.9 Effects on the RNA Interference Silencing Pathway; 3.10 Effects on MicroRNA Processing and Target Selection; 3.11 RNA Editing Role as an Antiviral Mechanism; 3.12 Conclusions; Acknowledgments; References; 4: Posttranslational Modification of Sm Proteins: Diverse Roles in snRNP Assembly and Germ Line Specification 4.1 Introduction4.2 Protein Methylation - Flavors and Functions; 4.3 Sm Proteins Contain sDMA- and aDMA-Modified Arginines; 4.4 SnRNP Assembly, the Survival Motor Neuron (SMN) Complex, and Spinal Muscular Atrophy (SMA); 4.5 PRMT5 and PRMT7 - The Sm Protein Methyltransferases; 4.6 Sm Protein Methylation is Required for sn/RNP Assembly in Mammals; 4.7 Sm Protein Methylation in Drosophila; 4.8 Unresolved Questions: Sm Protein Methylation and snRNP Assembly; 4.9 Conclusion - The Evolution of snRNP Assembly; 4.10 Sm Proteins Are Required for Germ Cell Specification 4.11 Dart5, Valois, Sm Proteins, and Tudor Anchoring |
| Record Nr. | UNINA-9910810503803321 |
| West Sussex, England, : Wiley-Blackwell, c2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||