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Biology of Depression: From Novel Insights to Therapeutic Strategies
| Biology of Depression: From Novel Insights to Therapeutic Strategies |
| Autore | Licinio Julio |
| Pubbl/distr/stampa | [Place of publication not identified], : John Wiley & Sons Incorporated, 2005 |
| Soggetto topico |
Psychiatric Disorders, Individual
Psychiatry Health & Biological Sciences |
| ISBN | 3-527-61967-4 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910144727803321 |
Licinio Julio
|
||
| [Place of publication not identified], : John Wiley & Sons Incorporated, 2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biology of Depression: From Novel Insights to Therapeutic Strategies
| Biology of Depression: From Novel Insights to Therapeutic Strategies |
| Autore | Licinio Julio |
| Pubbl/distr/stampa | [Place of publication not identified], : John Wiley & Sons Incorporated, 2005 |
| Soggetto topico |
Psychiatric Disorders, Individual
Psychiatry Health & Biological Sciences |
| ISBN | 3-527-61967-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910830742503321 |
|
Licinio Julio
|
||
| [Place of publication not identified], : John Wiley & Sons Incorporated, 2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biology of Depression: From Novel Insights to Therapeutic Strategies
| Biology of Depression: From Novel Insights to Therapeutic Strategies |
| Autore | Licinio Julio |
| Pubbl/distr/stampa | [Place of publication not identified], : John Wiley & Sons Incorporated, 2005 |
| Soggetto topico |
Psychiatric Disorders, Individual
Psychiatry Health & Biological Sciences |
| ISBN | 3-527-61967-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9911020050703321 |
|
Licinio Julio
|
||
| [Place of publication not identified], : John Wiley & Sons Incorporated, 2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Pharmacogenomics [[electronic resource] ] : the search for individualized therapies / / edited by Julio Licinio and Ma-Li Wong
| Pharmacogenomics [[electronic resource] ] : the search for individualized therapies / / edited by Julio Licinio and Ma-Li Wong |
| Pubbl/distr/stampa | Weinheim ; ; [Chichester?], : Wiley-VCH, c2002 |
| Descrizione fisica | 1 online resource (601 p.) |
| Disciplina |
615.1
615.19 615.7 |
| Altri autori (Persone) |
LicinioJ
WongMa-Li |
| Soggetto topico | Pharmacogenomics |
| Soggetto genere / forma | Electronic books. |
| ISBN |
9786612278976
1-282-27897-5 3-527-61630-6 1-280-55845-8 9786610558452 3-527-60075-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Pharmacogenomics The Search for Individualized Therapies; Acknowledgements; Preface; Contents; List of Contributors; Color Plates; 1 Introduction to Pharmacogenomics: Promises, Opportunities, and Limitations; Abstract; 1.1 Pharmacogenetics - The Roots of Pharmacogenomis; 1.2 Pharmacogenomics - It is Not just Pharmacogenetics; 1.2.1 Genetic Drug Response Profiles; 1.2.2 The Effect of Drugs on Gene Expression; 1.2.3 Pharmacogenomics in Drug Discovery and Drug Development; 1.3 Pharmacogenomics - Hopfe or Hype?; 1.4 References; 2 The Human Genome; Abstract; 2.1 Introduction
2.2 Expressed Sequence Tags (ESTs) and Computational Biology: The Foundation of Modern Genomic Science2.3 Microbial Genomics; 2.3.1 Computational Analysis of Whole Genomes; 2.3.2 Comparative Genome Analysis; 2.4 Genomic Differences that Affect the Outcome of Host-Pathogen Interactions: A Template for the Future of Whole-Genome-Based Pharmacologic Science; 2.5 More Lessons from the Human Genome; 2.5.1 Protein-Coding Genes; 2.5.2 Repeat Elements; 2.5.3 Genome Duplication; 2.5.4 Analysis of the Proteome; 2.5.5 DNA Variation 2.6 Biological Complexity and the Role of Medicine in the Future of the Genome2.7 Conclusion; 2.8 References; 3 Turning SNPs into Useful Markers of Drug Response; Abstract; 3.1 Introduction; 3.2 Two Approaches for Employing SNPs in Pharmacogenomics; 3.2.1 Candidate Gene Studies; 3.2.2 Whole Genome Linkage Disequilibrium Mapping Studies; 3.2.3 Comparison of Candidate Gene and Whole Genome LD Mapping; 3.3 How Many SNPs are Needed and What Kind are Useful for Pharmacogenomic Studies; 3.3.1 Location; 3.3.2 Frequency; 3.3.3 Haplotype Analysis 3.3.4 Number of SNPs Required for Whole Genome LD Mapping Studies3.4 Study Designs for Pharmacogenomic Analysis; 3.4.1 Challenges Unique to Pharmacogenomics; 3.4.2 Clinical Trials, Case-Control and Cohort Studies; 3.5 Analytical Issues is Pharmacogenomic Studies; 3.5.1 Effect of LD on Sample Size; 3.5.2 Multiple Hypothesis Testing; 3.5.3 Gene-Drug Interaction; 3.6 Development of Pharmacogenomic Markers; 3.7 Conclusion; 3.8 References; 4 Association Studies in Pharmacogenomics; Abstract; 4.1 Introduction; 4.2 Variability and ADR in Drug Response: Contribution of Genetic Factors 4.3 Multiple Inherited Genetic Factors Influence the Outcome of Drug Treatments4.3.1 Background; 4.3.2 Liver Metabolism Enzymes; 4.3.3 Transporters; 4.3.4 Plasma Binding Proteins; 4.3.5 Drug Targets; 4.4 Association Studies in Pharmacogenomics; 4.4.1 The Principles of Association Studies; 4.4.2 Study Design; 4.4.3 Direct Approach: A Hypothesis-Driven Strategy; 4.4.4 Indirect Approach: A Hypothesis-Generating Strategy; 4.5 SNP Assembly into Maps; 4.6 Strategies for Pharmacogenomic Association Studies; 4.6.1 Candidate Genes; 4.6.2 Genome-Wide Scan 4.7 Expected Benefits of Pharmacogenomics in Drug R & D |
| Record Nr. | UNINA-9910146245003321 |
| Weinheim ; ; [Chichester?], : Wiley-VCH, c2002 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Pharmacogenomics [[electronic resource] ] : the search for individualized therapies / / edited by Julio Licinio and Ma-Li Wong
| Pharmacogenomics [[electronic resource] ] : the search for individualized therapies / / edited by Julio Licinio and Ma-Li Wong |
| Pubbl/distr/stampa | Weinheim ; ; [Chichester?], : Wiley-VCH, c2002 |
| Descrizione fisica | 1 online resource (601 p.) |
| Disciplina |
615.1
615.19 615.7 |
| Altri autori (Persone) |
LicinioJ
WongMa-Li |
| Soggetto topico | Pharmacogenomics |
| ISBN |
9786612278976
1-282-27897-5 3-527-61630-6 1-280-55845-8 9786610558452 3-527-60075-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Pharmacogenomics The Search for Individualized Therapies; Acknowledgements; Preface; Contents; List of Contributors; Color Plates; 1 Introduction to Pharmacogenomics: Promises, Opportunities, and Limitations; Abstract; 1.1 Pharmacogenetics - The Roots of Pharmacogenomis; 1.2 Pharmacogenomics - It is Not just Pharmacogenetics; 1.2.1 Genetic Drug Response Profiles; 1.2.2 The Effect of Drugs on Gene Expression; 1.2.3 Pharmacogenomics in Drug Discovery and Drug Development; 1.3 Pharmacogenomics - Hopfe or Hype?; 1.4 References; 2 The Human Genome; Abstract; 2.1 Introduction
2.2 Expressed Sequence Tags (ESTs) and Computational Biology: The Foundation of Modern Genomic Science2.3 Microbial Genomics; 2.3.1 Computational Analysis of Whole Genomes; 2.3.2 Comparative Genome Analysis; 2.4 Genomic Differences that Affect the Outcome of Host-Pathogen Interactions: A Template for the Future of Whole-Genome-Based Pharmacologic Science; 2.5 More Lessons from the Human Genome; 2.5.1 Protein-Coding Genes; 2.5.2 Repeat Elements; 2.5.3 Genome Duplication; 2.5.4 Analysis of the Proteome; 2.5.5 DNA Variation 2.6 Biological Complexity and the Role of Medicine in the Future of the Genome2.7 Conclusion; 2.8 References; 3 Turning SNPs into Useful Markers of Drug Response; Abstract; 3.1 Introduction; 3.2 Two Approaches for Employing SNPs in Pharmacogenomics; 3.2.1 Candidate Gene Studies; 3.2.2 Whole Genome Linkage Disequilibrium Mapping Studies; 3.2.3 Comparison of Candidate Gene and Whole Genome LD Mapping; 3.3 How Many SNPs are Needed and What Kind are Useful for Pharmacogenomic Studies; 3.3.1 Location; 3.3.2 Frequency; 3.3.3 Haplotype Analysis 3.3.4 Number of SNPs Required for Whole Genome LD Mapping Studies3.4 Study Designs for Pharmacogenomic Analysis; 3.4.1 Challenges Unique to Pharmacogenomics; 3.4.2 Clinical Trials, Case-Control and Cohort Studies; 3.5 Analytical Issues is Pharmacogenomic Studies; 3.5.1 Effect of LD on Sample Size; 3.5.2 Multiple Hypothesis Testing; 3.5.3 Gene-Drug Interaction; 3.6 Development of Pharmacogenomic Markers; 3.7 Conclusion; 3.8 References; 4 Association Studies in Pharmacogenomics; Abstract; 4.1 Introduction; 4.2 Variability and ADR in Drug Response: Contribution of Genetic Factors 4.3 Multiple Inherited Genetic Factors Influence the Outcome of Drug Treatments4.3.1 Background; 4.3.2 Liver Metabolism Enzymes; 4.3.3 Transporters; 4.3.4 Plasma Binding Proteins; 4.3.5 Drug Targets; 4.4 Association Studies in Pharmacogenomics; 4.4.1 The Principles of Association Studies; 4.4.2 Study Design; 4.4.3 Direct Approach: A Hypothesis-Driven Strategy; 4.4.4 Indirect Approach: A Hypothesis-Generating Strategy; 4.5 SNP Assembly into Maps; 4.6 Strategies for Pharmacogenomic Association Studies; 4.6.1 Candidate Genes; 4.6.2 Genome-Wide Scan 4.7 Expected Benefits of Pharmacogenomics in Drug R & D |
| Record Nr. | UNINA-9910830390303321 |
| Weinheim ; ; [Chichester?], : Wiley-VCH, c2002 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Pharmacogenomics : the search for individualized therapies / / edited by Julio Licinio and Ma-Li Wong
| Pharmacogenomics : the search for individualized therapies / / edited by Julio Licinio and Ma-Li Wong |
| Pubbl/distr/stampa | Weinheim ; ; [Chichester?], : Wiley-VCH, c2002 |
| Descrizione fisica | 1 online resource (601 p.) |
| Disciplina |
615.1
615.19 615.7 |
| Altri autori (Persone) |
LicinioJ
WongMa-Li |
| Soggetto topico | Pharmacogenomics |
| ISBN |
9786612278976
9786610558452 9781282278974 1282278975 9783527616305 3527616306 9781280558450 1280558458 9783527600755 3527600752 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Pharmacogenomics The Search for Individualized Therapies; Acknowledgements; Preface; Contents; List of Contributors; Color Plates; 1 Introduction to Pharmacogenomics: Promises, Opportunities, and Limitations; Abstract; 1.1 Pharmacogenetics - The Roots of Pharmacogenomis; 1.2 Pharmacogenomics - It is Not just Pharmacogenetics; 1.2.1 Genetic Drug Response Profiles; 1.2.2 The Effect of Drugs on Gene Expression; 1.2.3 Pharmacogenomics in Drug Discovery and Drug Development; 1.3 Pharmacogenomics - Hopfe or Hype?; 1.4 References; 2 The Human Genome; Abstract; 2.1 Introduction
2.2 Expressed Sequence Tags (ESTs) and Computational Biology: The Foundation of Modern Genomic Science2.3 Microbial Genomics; 2.3.1 Computational Analysis of Whole Genomes; 2.3.2 Comparative Genome Analysis; 2.4 Genomic Differences that Affect the Outcome of Host-Pathogen Interactions: A Template for the Future of Whole-Genome-Based Pharmacologic Science; 2.5 More Lessons from the Human Genome; 2.5.1 Protein-Coding Genes; 2.5.2 Repeat Elements; 2.5.3 Genome Duplication; 2.5.4 Analysis of the Proteome; 2.5.5 DNA Variation 2.6 Biological Complexity and the Role of Medicine in the Future of the Genome2.7 Conclusion; 2.8 References; 3 Turning SNPs into Useful Markers of Drug Response; Abstract; 3.1 Introduction; 3.2 Two Approaches for Employing SNPs in Pharmacogenomics; 3.2.1 Candidate Gene Studies; 3.2.2 Whole Genome Linkage Disequilibrium Mapping Studies; 3.2.3 Comparison of Candidate Gene and Whole Genome LD Mapping; 3.3 How Many SNPs are Needed and What Kind are Useful for Pharmacogenomic Studies; 3.3.1 Location; 3.3.2 Frequency; 3.3.3 Haplotype Analysis 3.3.4 Number of SNPs Required for Whole Genome LD Mapping Studies3.4 Study Designs for Pharmacogenomic Analysis; 3.4.1 Challenges Unique to Pharmacogenomics; 3.4.2 Clinical Trials, Case-Control and Cohort Studies; 3.5 Analytical Issues is Pharmacogenomic Studies; 3.5.1 Effect of LD on Sample Size; 3.5.2 Multiple Hypothesis Testing; 3.5.3 Gene-Drug Interaction; 3.6 Development of Pharmacogenomic Markers; 3.7 Conclusion; 3.8 References; 4 Association Studies in Pharmacogenomics; Abstract; 4.1 Introduction; 4.2 Variability and ADR in Drug Response: Contribution of Genetic Factors 4.3 Multiple Inherited Genetic Factors Influence the Outcome of Drug Treatments4.3.1 Background; 4.3.2 Liver Metabolism Enzymes; 4.3.3 Transporters; 4.3.4 Plasma Binding Proteins; 4.3.5 Drug Targets; 4.4 Association Studies in Pharmacogenomics; 4.4.1 The Principles of Association Studies; 4.4.2 Study Design; 4.4.3 Direct Approach: A Hypothesis-Driven Strategy; 4.4.4 Indirect Approach: A Hypothesis-Generating Strategy; 4.5 SNP Assembly into Maps; 4.6 Strategies for Pharmacogenomic Association Studies; 4.6.1 Candidate Genes; 4.6.2 Genome-Wide Scan 4.7 Expected Benefits of Pharmacogenomics in Drug R & D |
| Record Nr. | UNINA-9911019334703321 |
| Weinheim ; ; [Chichester?], : Wiley-VCH, c2002 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||