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Carbohydrate-based drug discovery [[electronic resource] /] / Chi-Huey Wong (ed.)
| Carbohydrate-based drug discovery [[electronic resource] /] / Chi-Huey Wong (ed.) |
| Pubbl/distr/stampa | Weinheim ; ; [New York], : Wiley-VCH, c2003 |
| Descrizione fisica | 1 online resource (981 p.) |
| Disciplina |
615.3
615.7 |
| Altri autori (Persone) | WongChi-Huey |
| Soggetto topico |
Carbohydrate drugs
Carbohydrates - Synthesis Glycoconjugates - Physiological effect |
| ISBN |
1-280-52072-8
9786610520725 3-527-60578-9 3-527-60243-7 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Carbohydrate-based Drug Discovery; Contents; Preface; List of Contributors; Volume 1; 1 Synthetic Methodologies; 1.1 Introduction; 1.2 Tactical Analysis for Overall Synthetic Efficiency; 1.3 Methodological Improvements; 1.3.1 Chemistry; 1.3.2 Protecting Group Manipulations; 1.3.3 Modulation of the Reactivity of Glycosyl Donors; 1.3.4 Block Synthesis; 1.4 Accessibility; 1.4.1 Solution-based Chemistry; 1.4.2 One-Pot Glycosylation; 1.4.3 Solid-Phase Chemistry; 1.4.3.1 Fundamentals of Solid-Phase Oligosaccharide Synthesis; 1.4.3.2 The Support; 1.4.3.3 Linkers to the Support
1.4.3.4 Protecting Groups used in Solid-Phase Oligosaccharide Synthesis1.4.3.5 Solid-Phase Oligosaccharide Synthesis; 1.4.3.6 Monitoring of Reaction Progress; 1.4.4 Automation; 1.5 Concluding Remarks; 1.6 References; 2 Complex Carbohydrate Synthesis; 2.1 Introduction; 2.2 Synthetic Gangliosides; 2.2.1 Gangliosides GM4 and GM3, and their Analogues and Derivatives; 2.2.2 Sialylparagloboside (SPG) Analogues and Derivatives; 2.2.3 Selectin Ligands; 2.2.3.1 Sialyl Lewis x; 2.2.3.2 Novel 6-Sulfo sLe(x) Variants; 2.2.4 Siglec Ligands; 2.2.4.1 Chol-1 (α-Series) Gangliosides 2.2.4.2 Novel Sulfated Gangliosides2.3 Toxin Receptor; 2.4 Summary and Perspectives; 2.5 References; 3 The Chemistry of Sialic Acid; 3.1 Introduction; 3.2 Chemical and Enzymatic Synthesis of Sialic Acids; 3.3 Chemical Glycosidation of Sialic Acids; 3.3.1 Direct Chemical Sialylations; 3.3.1.1 2-Chloro Derivatives as Glycosyl Donors; 3.3.1.2 2-Thio Derivatives as Glycosyl Donors; 3.3.1.3 2-Xanthates as Glycosyl Donors; 3.3.1.3 2-Phosphites as Glycosyl Donors; 3.3.1.4 Miscellaneous Direct Chemical Methods; 3.3.2 Indirect Chemical Methods with the Use of a Participating Auxiliary at C-3 4.3.2 Immobilization of the Glycosyl Donor4.3.3 Bi-directional Strategy; 4.4 Support Materials; 4.4.1 Insoluble Supports; 4.4.2 Soluble Supports; 4.5 Linkers; 4.5.1 Silyl Ethers; 4.5.2 Acid- and Base-Labile Linkers; 4.5.3 Thioglycoside Linkers; 4.5.4 Linkers Cleaved by Oxidation; 4.5.5 Photocleavable Linkers; 4.5.6 Linkers Cleaved by Olefin Metathesis; 4.6 Synthesis of Oligosaccharides on Solid Support by Use of Different Glycosylating Agents; 4.6.1 1,2-Anhydrosugars - The Glycal Assembly Approach; 4.6.2 Glycosyl Sulfoxides; 4.6.3 Glycosyl Trichloroacetimidates; 4.6.4 Thioglycosides 4.6.5 Glycosyl Fluorides |
| Record Nr. | UNINA-9910146238303321 |
| Weinheim ; ; [New York], : Wiley-VCH, c2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Catalysis from A to Z: A Concise Encyclopedia
| Catalysis from A to Z: A Concise Encyclopedia |
| Autore | Cornils Boy |
| Pubbl/distr/stampa | [Place of publication not identified], : Wiley VCH Imprint, 2013 |
| Disciplina | 541/.39503 |
| Soggetto topico | Catalysis |
| ISBN | 3-527-67138-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | v. 1. A to C -- v. 2. D to I -- v. 3. J to P -- v. 4. Q to Z. |
| Record Nr. | UNINA-9910133655103321 |
Cornils Boy
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| [Place of publication not identified], : Wiley VCH Imprint, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Catalysis from A to Z: A Concise Encyclopedia
| Catalysis from A to Z: A Concise Encyclopedia |
| Autore | Cornils Boy |
| Pubbl/distr/stampa | [Place of publication not identified], : Wiley VCH Imprint, 2013 |
| Disciplina | 541/.39503 |
| Soggetto topico | Catalysis |
| ISBN | 3-527-67138-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | v. 1. A to C -- v. 2. D to I -- v. 3. J to P -- v. 4. Q to Z. |
| Record Nr. | UNINA-9910830582703321 |
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Cornils Boy
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| [Place of publication not identified], : Wiley VCH Imprint, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Catalysis from A to Z: A Concise Encyclopedia
| Catalysis from A to Z: A Concise Encyclopedia |
| Autore | Cornils Boy |
| Pubbl/distr/stampa | [Place of publication not identified], : Wiley VCH Imprint, 2013 |
| Disciplina | 541/.39503 |
| Soggetto topico | Catalysis |
| ISBN | 3-527-67138-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | v. 1. A to C -- v. 2. D to I -- v. 3. J to P -- v. 4. Q to Z. |
| Record Nr. | UNINA-9910841091903321 |
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Cornils Boy
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| [Place of publication not identified], : Wiley VCH Imprint, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Glycoscience : biology and medicine / / editors, Tamao Endo [et al.]
| Glycoscience : biology and medicine / / editors, Tamao Endo [et al.] |
| Pubbl/distr/stampa | Tokyo : , : Springer Japan : , : Imprint : Springer, , 2020 |
| Descrizione fisica | 1 online resource (Approx. 1200 pages, 540 illustrations, 240 illustrations in color) |
| Disciplina | 572 |
| Soggetto topico |
Biochemistry
Cell biology Cancer research Cytology |
| ISBN | 4-431-54836-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | A. Analytical and Structural Approach - Technical Description for Analyzing Glycan Structures (Reviewed by Yoshiki Yamaguchi): Overview -- EMARS -- Development of glycan array -- Development of glycan array -- Development of glycan array -- Development of glycan array -- Automated programmable one-pot synthesis of glycans -- Lectin array -- Lectin-glycan interaction based on glycan array data -- Glycoform-specific protein staining by lectin and antibody -- Glycosaminoglycans analysis -- Mass analysis -- Mass analysis -- IGOT-lectin capture -- Membrane electrophoresis -- HPLC nucleotide-sugar analysis -- Capillary electrophoresis -- HPLC PA-sugar -- Congenital disorders of glycosylation, analytical aspect -- Quality control of pharmaceutical products and biosimilars -- NMR -- NMR -- STD-NMR -- Conformational analysis of glycans and glycoproteins -- Glycolipid LC-MS -- MALDI-MS -- MALDI-MS -- Sulfoglycolipids -- GAG array -- X-ray -- REMD simulation -- MD simulation and computational screening -- B. Glycoinformatics - New Approach for Informatics and Databases for Glycoscience (Reviewed by Kiyoko F. Aoki-Kinoshita): Informatics overview -- MIRAGE project -- RINGS -- JCGGDB -- UniCarb-DB -- CIRES -- GLYCOSCIENCES.de -- CSDB, Plant and Bacterial Carbohydrate Structure Database -- MonosaccharideDB -- GlycomeDB -- GlycoEpitope -- SugarBindDB -- GLYCAM -- CAZy -- 3D Lectines -- C. Chemoenzymatic Synthesis of Glycans - Chemical and Enzymatic Methods of Glycan Synthesis (Reviewed by Yasuhiro Kajihara and Peter Seeberger): Overview -- Chemical synthesis of glycans -- Chemical synthesis of glycans -- Chemical synthesis of glycans -- Synthesis of homogeneous glycoproteins -- Synthesis of homogeneous glycoproteins -- Synthesis of homogeneous glycoproteins -- Synthesis of homogeneous glycoproteins -- Synthesis of homogeneous glycoproteins -- Glycopeptide/glycoprotein synthesis -- Gangliosides synthesis -- Specific Glycosylation -- Furanoside chemistry -- Glycoside synthesis -- Carbohydrate Library Synthesis -- Development of sugar array -- Development of sugar array -- Development of sugar array -- Automated synthesis -- Automation in glycan synthesis -- GPI chemical synthesis -- Oligosialic acid synthesis -- Synthesis of sulfated glycans -- Synthesis of sulfated glycans -- Synthetic antitumor vaccines -- Synthetic carbohydrate antigens for HIV Vaccine Design -- Chemical approach in biology and disease -- Glycoenzyme inhibitors -- Glycoenzyme inhibitors -- Glycoenzymes in glycan analysis and synthesis -- Endo-enzymes -- Oxazoline derivatives -- Large-scale enzymatic synthesis of glycans with cofactor regeneration -- Large-scale enzymatic synthesis of glycans -- Chemoenzymatic synthesis -- Chemoenzymatic synthesis of heparins -- Chemoenzymatic synthesis of glycoproteins -- Multivalent glycan synthesis -- Biosynthesis of A and B blood group -- Glycosyltransferase structures -- Structural biology of oligosaccharyltransferase (OST) -- Chemoenzymatic synthesis of oligosaccharides and cancer and bacterial vaccines -- Neoglycoprotein and oligosaccharide synthesis -- Chemoenzymatic synthesis of glycoconjugates -- Synthesis of O-glycosylated proteins -- D. Imaging of Glycans - New Techniques for Imaging Glycans (Reviewed by Yasuhiro Kajihara and Chi-Huey Wong): Molecular probes for glycosylation: overview Imaging by Click Chemistry -- Imaging by Click Chemistry -- Imaging by Click Chemistry -- Chemical tools to detect Helicobacter pylori -- Enzymatic imaging -- PET imaging -- Glycoprotein imaging -- E. Neuroglycobiology - The Role of Glycans in Neurobiology and Neuroscience (Reviewed by Kenji Kadomatsu): Neuroglycobiology overview -- Neurochemistry and developmental neurobiology -- Glycans in neurobiology -- Glycosaminoglycans (GAGs) -- GAGs -- Polysialic acid -- Polysialic acid -- Glycolipids sialidase -- HNK-1 -- Ganglioside -- Single molecule imaging -- Glycolipid -- Heparan sulfate proteoglycans (HSPG) -- HSPG -- N-glycans and glial cells. |
| Record Nr. | UNINA-9910349267203321 |
| Tokyo : , : Springer Japan : , : Imprint : Springer, , 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Glycoscience: Biology and Medicine [[electronic resource] /] / edited by Naoyuki Taniguchi, Tamao Endo, Gerald W. Hart, Peter H. Seeberger, Chi-Huey Wong
| Glycoscience: Biology and Medicine [[electronic resource] /] / edited by Naoyuki Taniguchi, Tamao Endo, Gerald W. Hart, Peter H. Seeberger, Chi-Huey Wong |
| Edizione | [1st ed. 2015.] |
| Pubbl/distr/stampa | Tokyo : , : Springer Japan : , : Imprint : Springer, , 2015 |
| Descrizione fisica | 1 online resource (LXII, 1568 p. 333 illus., 233 illus. in color. eReference.) : online resource |
| Disciplina | 572.567 |
| Soggetto topico |
Biochemistry
Cell biology Cancer research Biochemistry, general Cell Biology Cancer Research |
| ISBN | 4-431-54841-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | A. Analytical and Structural Approach - Technical Description for Analyzing Glycan Structures (Reviewed by Yoshiki Yamaguchi): Overview -- EMARS -- Development of glycan array -- Development of glycan array -- Development of glycan array -- Development of glycan array -- Automated programmable one-pot synthesis of glycans -- Lectin array -- Lectin-glycan interaction based on glycan array data -- Glycoform-specific protein staining by lectin and antibody -- Glycosaminoglycans analysis -- Mass analysis -- Mass analysis -- IGOT-lectin capture -- Membrane electrophoresis -- HPLC nucleotide-sugar analysis -- Capillary electrophoresis -- HPLC PA-sugar -- Congenital disorders of glycosylation, analytical aspect -- Quality control of pharmaceutical products and biosimilars -- NMR -- NMR -- STD-NMR -- Conformational analysis of glycans and glycoproteins -- Glycolipid LC-MS -- MALDI-MS -- MALDI-MS -- Sulfoglycolipids -- GAG array -- X-ray -- REMD simulation -- MD simulation and computational screening -- B. Glycoinformatics - New Approach for Informatics and Databases for Glycoscience (Reviewed by Kiyoko F. Aoki-Kinoshita): Informatics overview -- MIRAGE project -- RINGS -- JCGGDB -- UniCarb-DB -- CIRES -- GLYCOSCIENCES.de -- CSDB, Plant and Bacterial Carbohydrate Structure Database -- MonosaccharideDB -- Glycome DB -- GlycoEpitope -- Sugar Bind DB -- GLYCAM -- CAZy -- 3D Lectines -- C. Chemoenzymatic Synthesis of Glycans - Chemical and Enzymatic Methods of Glycan Synthesis (Reviewed by Yasuhiro Kajihara and Peter Seeberger): Overview -- Chemical synthesis of glycans -- Chemical synthesis of glycans -- Chemical synthesis of glycans -- Synthesis of homogeneous glycoproteins -- Synthesis of homogeneous glycoproteins -- Synthesis of homogeneous glycoproteins -- Synthesis of homogeneous glycoproteins -- Synthesis of homogeneous glycoproteins -- Glycopeptide/glycoprotein synthesis -- Gangliosides synthesis -- Specific Glycosylation -- Furanoside chemistry -- Glycoside synthesis -- Carbohydrate Library Synthesis -- Development of sugar array -- Development of sugar array -- Development of sugar array -- Automated synthesis -- Automation in glycan synthesis -- GPI chemical synthesis -- Oligosialic acid synthesis -- Synthesis of sulfated glycans -- Synthesis of sulfated glycans -- Synthetic antitumor vaccines -- Synthetic carbohydrate antigens for HIV Vaccine Design -- Chemical approach in biology and disease -- Glycoenzyme inhibitors -- Glycoenzyme inhibitors -- Glycoenzymes in glycan analysis and synthesis -- Endo-enzymes -- Oxazoline derivatives -- Large-scale enzymatic synthesis of glycans with cofactor regeneration -- Large-scale enzymatic synthesis of glycans -- Chemoenzymatic synthesis -- Chemoenzymatic synthesis of heparins -- Chemoenzymatic synthesis of glycoproteins -- Multivalent glycan synthesis -- Biosynthesis of A and B blood group -- Glycosyltransferase structures -- Structural biology of oligosaccharyltransferase (OST) -- Chemoenzymatic synthesis of oligosaccharides and cancer and bacterial vaccines -- Neoglycoprotein and oligosaccharide synthesis -- Chemoenzymatic synthesis of glycoconjugates -- Synthesis of O-glycosylated proteins -- D. Imaging of Glycans - New Techniques for Imaging Glycans (Reviewed by Yasuhiro Kajihara and Chi-Huey Wong): Molecular probes for glycosylation: overview Imaging by Click Chemistry -- Imaging by Click Chemistry -- Imaging by Click Chemistry -- Chemical tools to detect Helicobacter pylori -- Enzymatic imaging -- PET imaging -- Glycoprotein imaging -- E. Neuroglycobiology - The Role of Glycans in Neurobiology and Neuroscience (Reviewed by Kenji Kadomatsu): Neuroglycobiology overview -- Neurochemistry and developmental neurobiology -- Glycans in neurobiology -- Glycosaminoglycans (GAGs) -- GAGs -- Polysialic acid -- Polysialic acid -- Glycolipids sialidase -- HNK-1 -- Ganglioside -- Single molecule imaging -- Glycolipid -- Heparan sulfate proteoglycans (HSPG) -- HSPG -- N-glycans and glial cells. |
| Record Nr. | UNINA-9910298283503321 |
| Tokyo : , : Springer Japan : , : Imprint : Springer, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||