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Antibiotics : challenges, mechanisms, opportunities / / by Christopher Walsh and Timothy Wencewicz
| Antibiotics : challenges, mechanisms, opportunities / / by Christopher Walsh and Timothy Wencewicz |
| Autore | Walsh Christopher |
| Pubbl/distr/stampa | Washington, District of Columbia : , : ASM Press, , 2016 |
| Descrizione fisica | 1 online resource (490 p.) |
| Disciplina | 615.329 |
| Soggetto topico |
Antibiotics
Drug resistance in microorganisms |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-68367-331-X
1-55581-931-1 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Preface; Section I: Challenges for Antibiotics; 1 Antibiotics: Initial Concepts and Considerations; Waves of Resistant Bacterial Infections; Differential Susceptibility to Antibiotics; Empiric Therapy and Broad-spectrum Antibiotics; Antibiotic Flow Chart; Recent Approvals and the Current Antibiotic Pipeline; Recognition of Pressing Need for New Antibiotics: "The End is Near" Scenarios; Approach and Organization of This Volume; 2 Major Classes of Antibiotics and Their Modes of Action; Antibiotics Versus Antimicrobials: Antibacterial Versus Antifungal Versus Antiprotozoal Agents
What Bacteria to TargetHow to Test for Antibiotic Activity; How to Find Antibiotics; A Golden Age of Antibiotic Medicinal Chemistry; What is the Capacity for Microbes to Make Antibiotics?; Target Classes Identified from the Major Antibiotic Groups; A Common Pathway for Bactericidal Antibiotics?; Section II: Mechanisms: Antibiotic Action by Bacterial Target Class; 3 Assembly of the Peptidoglycan Layer of Bacterial Cell Walls; Introduction; Nature of the PG Layer of the Cell Envelope; Biosynthesis and Insertion of PG Monomer Units PG Assembly: Phase 1 in the Cytoplasm-Generation of UDP-Muramyl PentapeptidePG Assembly: Phase 2 at the Inner Face of the Cytoplasmic Membrane-the C55 Bactoprenol Lipid Carrier; PG Assembly: Phase III-Chain Extension and Cross-Linking at the Outer Face of the Cytoplasmic Membrane; Summary; 4 Antibiotics That Block Peptidoglycan Assembly and Integrity; Introduction; PG Transpeptidase Inhibition: β-Lactam Antibiotics; Four Subclasses of Antibiotics: Penams, Cephems, Carbapenems, and Monobactams; Mechanisms of Action of Lactam Antibiotics: Acylation of Transpeptidases; The Families of PBPs Acyl Enzyme Lifetimes Are CrucialPBP Inventories; Many Side Chain Variants in Semisynthetic β-Lactam Antibiotics; The Future for β-Lactam Antibiotics?; Moenomycin: Inhibition of PG Transglycosylases; Antibiotics That Act as Substrate Binders and Sequestrants in the Bactoprenol Metabolic Cycle; MraY and Peptidyl Nucleoside Antibiotics; How Do Bacteria Respond to Categories of Antibiotics That Target the Cell Wall?; 5 Antibiotics That Disrupt Membrane Integrity; Introduction; Antimicrobial Peptides and Defensins; Lantibiotic Peptides Calprotectin, an Antimicrobial Protein That Complexes Mn(II) and Fe(II)Bacterial Lipopeptides; Surfactin; Daptomycin Disrupts Bacterial Membrane Integrity; Polymyxin: an Old Antibiotic Revisited; Dual Mechanisms for SecondGeneration Lipoglycopeptide Antibiotics; 6 Antibiotics That Block Protein Synthesis; Overview of Bacterial Protein Synthesis; Antibiotics That Target Aminoacyl-tRNA Synthetases; Antibiotics That Target the Bacterial Ribosome; EF-Tu: an Aminoacyl-tRNA Chaperone as Antibiotic Target; 7 Antibiotics That Target DNA and RNA Information Transfer Antibiotics Directed against Type II Topoisomerases |
| Record Nr. | UNINA-9910555016503321 |
Walsh Christopher
|
||
| Washington, District of Columbia : , : ASM Press, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Antibiotics : challenges, mechanisms, opportunities / / by Christopher Walsh and Timothy Wencewicz
| Antibiotics : challenges, mechanisms, opportunities / / by Christopher Walsh and Timothy Wencewicz |
| Autore | Walsh Christopher |
| Pubbl/distr/stampa | Washington, District of Columbia : , : ASM Press, , 2016 |
| Descrizione fisica | 1 online resource (490 p.) |
| Disciplina | 615.329 |
| Soggetto topico |
Antibiotics
Drug resistance in microorganisms |
| ISBN |
1-68367-331-X
1-55581-931-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Preface; Section I: Challenges for Antibiotics; 1 Antibiotics: Initial Concepts and Considerations; Waves of Resistant Bacterial Infections; Differential Susceptibility to Antibiotics; Empiric Therapy and Broad-spectrum Antibiotics; Antibiotic Flow Chart; Recent Approvals and the Current Antibiotic Pipeline; Recognition of Pressing Need for New Antibiotics: "The End is Near" Scenarios; Approach and Organization of This Volume; 2 Major Classes of Antibiotics and Their Modes of Action; Antibiotics Versus Antimicrobials: Antibacterial Versus Antifungal Versus Antiprotozoal Agents
What Bacteria to TargetHow to Test for Antibiotic Activity; How to Find Antibiotics; A Golden Age of Antibiotic Medicinal Chemistry; What is the Capacity for Microbes to Make Antibiotics?; Target Classes Identified from the Major Antibiotic Groups; A Common Pathway for Bactericidal Antibiotics?; Section II: Mechanisms: Antibiotic Action by Bacterial Target Class; 3 Assembly of the Peptidoglycan Layer of Bacterial Cell Walls; Introduction; Nature of the PG Layer of the Cell Envelope; Biosynthesis and Insertion of PG Monomer Units PG Assembly: Phase 1 in the Cytoplasm-Generation of UDP-Muramyl PentapeptidePG Assembly: Phase 2 at the Inner Face of the Cytoplasmic Membrane-the C55 Bactoprenol Lipid Carrier; PG Assembly: Phase III-Chain Extension and Cross-Linking at the Outer Face of the Cytoplasmic Membrane; Summary; 4 Antibiotics That Block Peptidoglycan Assembly and Integrity; Introduction; PG Transpeptidase Inhibition: β-Lactam Antibiotics; Four Subclasses of Antibiotics: Penams, Cephems, Carbapenems, and Monobactams; Mechanisms of Action of Lactam Antibiotics: Acylation of Transpeptidases; The Families of PBPs Acyl Enzyme Lifetimes Are CrucialPBP Inventories; Many Side Chain Variants in Semisynthetic β-Lactam Antibiotics; The Future for β-Lactam Antibiotics?; Moenomycin: Inhibition of PG Transglycosylases; Antibiotics That Act as Substrate Binders and Sequestrants in the Bactoprenol Metabolic Cycle; MraY and Peptidyl Nucleoside Antibiotics; How Do Bacteria Respond to Categories of Antibiotics That Target the Cell Wall?; 5 Antibiotics That Disrupt Membrane Integrity; Introduction; Antimicrobial Peptides and Defensins; Lantibiotic Peptides Calprotectin, an Antimicrobial Protein That Complexes Mn(II) and Fe(II)Bacterial Lipopeptides; Surfactin; Daptomycin Disrupts Bacterial Membrane Integrity; Polymyxin: an Old Antibiotic Revisited; Dual Mechanisms for SecondGeneration Lipoglycopeptide Antibiotics; 6 Antibiotics That Block Protein Synthesis; Overview of Bacterial Protein Synthesis; Antibiotics That Target Aminoacyl-tRNA Synthetases; Antibiotics That Target the Bacterial Ribosome; EF-Tu: an Aminoacyl-tRNA Chaperone as Antibiotic Target; 7 Antibiotics That Target DNA and RNA Information Transfer Antibiotics Directed against Type II Topoisomerases |
| Record Nr. | UNINA-9910831000803321 |
|
Walsh Christopher
|
||
| Washington, District of Columbia : , : ASM Press, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||