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Cell migration in development and disease [[electronic resource] /] / edited by Doris Wedlich
| Cell migration in development and disease [[electronic resource] /] / edited by Doris Wedlich |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2005 |
| Descrizione fisica | 1 online resource (399 p.) |
| Disciplina |
571.6
571.8 571.835 |
| Altri autori (Persone) | WedlichDoris |
| Soggetto topico | Cell migration - Diseases |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-51954-1
9786610519545 3-527-60466-9 3-527-60407-3 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cell Migrationin Development and Disease; Contents; Preface; List of Contributors; Color Plates; I Cell Shape Modulations and Cell Surface-Nucleus Connections: Prerequisites for Cell Migration; 1 Functional Phases in Cell Attachment and Spreading; 1.1 Introduction; 1.2 Fibroblast Spreading on Matrices; 1.3 Summary of Spreading Process; 1.3.1 Steps in Cell Spreading; 1.3.1.1 Basal Motility Phase (Cells in Suspension); 1.3.1.2 Adhesion to the Surface; 1.3.1.3 Initiation of Actin Assembly and Spreading (Rate-limiting Step); 1.3.1.4 Continued Spreading; 1.3.1.5 Transition to Fully Spread State
1.3.2 Binding to Rigid Matrices Causes Strengthening of Cytoskeleton-Integrin Linkages1.3.2.1 Initial Binding of Fibronectin Multimers at the Leading Edge and Over Actin Cables; 1.3.2.2 Force-dependent Activation of the ECM-Integrin Complexes; 1.3.2.3 Additional Steps in the Spreading Process; 1.3.3 MTs and Motility; 1.3.4 Conclusion; 1.4 References; 2 Polarized Cell Motility: Microtubules Show the Way; 2.1 Introduction; 2.1.1 The Vasiliev Conundrum; 2.1.2 Cell Polarity and Adhesion; 2.2 Microtubules Meet the Actin Cytoskeleton at Focal Adhesions 2.3 Microtubule Targeting Promotes Focal Adhesion Turnover2.4 Contractility, the Functional Link; 2.5 Kinesin and Signal Transmission; 2.6 Tip Complexes Meet Adhesion Complexes; 2.7 Focal Adhesions Influence Microtubule Dynamics; 2.8 Actin Talks Back: Tension and Microtubule Guidance; 2.9 Conclusions and Perspectives; 2.10 Acknowledgments; 2.11 References; 3 Mechanisms of Eukaryotic Chemotaxis; 3.1 Chemotaxis is a Fundamental Cellular Response; 3.2 Directional Sensing Occurs Downstream of G Protein Activation and Upstream of the Accumulation of PI(3,4,5)P(3) 3.3 Input-Output Relationships Reveal Gradient Amplification in Polarized and Unpolarized Cells3.4 Increase in Local PI(3,4,5)P(3) Precedes Actin Polymerization Responses; 3.5 Positive Feedback and the Actin Cytoskeleton May Stabilize Directional Sensing and Establish Polarity; 3.6 References; 4 Dual Location Proteins: Communication Between Cell Adhesions and the Nucleus; 4.1 Introduction; 4.2 LIM Protein Family; 4.2.1 Zyxin Subfamily; 4.2.1.1 Zyxin; 4.2.1.2 LPP (Lipoma-Prefered Partner); 4.2.1.3 Trip6; 4.2.1.4 WTIP (Wilms Tumor protein 1 Interaction Protein); 4.2.1.5 Ajuba 4.2.2 Paxillin Subfamily4.2.2.1 Paxillin; 4.2.2.2 Hic-5; 4.3 MAGUK Protein Family; 4.3.1 ZO-1; 4.3.2 ZO-2; 4.3.3 CASK; 4.4 Armadillo Repeat Protein Family; 4.4.1 β-catenin Armadillo Repeat Subfamily; 4.4.1.1 β-catenin; 4.4.1.2 Plakoglobin; 4.4.2 p120 Armadillo Repeat Subfamily; 4.4.2.1 p120; 4.4.2.2 ARVCF; 4.4.2.3 Plakophilins; 4.5 Other Proteins - Symplekin; 4.6 Dual Location; 4.6.1 Sequestration of Transcriptional Regulators; 4.6.2 mRNA Localization; 4.6.3 Scaffolding; 4.7 Conclusion; 4.8 Acknowledgments; 4.9 References; II Classical Examples of Cell Migration in Development 5 Cell Migration During Zebrafish Gastrulation |
| Record Nr. | UNINA-9910144557503321 |
| Weinheim, : Wiley-VCH, c2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cell migration in development and disease [[electronic resource] /] / edited by Doris Wedlich
| Cell migration in development and disease [[electronic resource] /] / edited by Doris Wedlich |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2005 |
| Descrizione fisica | 1 online resource (399 p.) |
| Disciplina |
571.6
571.8 571.835 |
| Altri autori (Persone) | WedlichDoris |
| Soggetto topico | Cell migration - Diseases |
| ISBN |
1-280-51954-1
9786610519545 3-527-60466-9 3-527-60407-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cell Migrationin Development and Disease; Contents; Preface; List of Contributors; Color Plates; I Cell Shape Modulations and Cell Surface-Nucleus Connections: Prerequisites for Cell Migration; 1 Functional Phases in Cell Attachment and Spreading; 1.1 Introduction; 1.2 Fibroblast Spreading on Matrices; 1.3 Summary of Spreading Process; 1.3.1 Steps in Cell Spreading; 1.3.1.1 Basal Motility Phase (Cells in Suspension); 1.3.1.2 Adhesion to the Surface; 1.3.1.3 Initiation of Actin Assembly and Spreading (Rate-limiting Step); 1.3.1.4 Continued Spreading; 1.3.1.5 Transition to Fully Spread State
1.3.2 Binding to Rigid Matrices Causes Strengthening of Cytoskeleton-Integrin Linkages1.3.2.1 Initial Binding of Fibronectin Multimers at the Leading Edge and Over Actin Cables; 1.3.2.2 Force-dependent Activation of the ECM-Integrin Complexes; 1.3.2.3 Additional Steps in the Spreading Process; 1.3.3 MTs and Motility; 1.3.4 Conclusion; 1.4 References; 2 Polarized Cell Motility: Microtubules Show the Way; 2.1 Introduction; 2.1.1 The Vasiliev Conundrum; 2.1.2 Cell Polarity and Adhesion; 2.2 Microtubules Meet the Actin Cytoskeleton at Focal Adhesions 2.3 Microtubule Targeting Promotes Focal Adhesion Turnover2.4 Contractility, the Functional Link; 2.5 Kinesin and Signal Transmission; 2.6 Tip Complexes Meet Adhesion Complexes; 2.7 Focal Adhesions Influence Microtubule Dynamics; 2.8 Actin Talks Back: Tension and Microtubule Guidance; 2.9 Conclusions and Perspectives; 2.10 Acknowledgments; 2.11 References; 3 Mechanisms of Eukaryotic Chemotaxis; 3.1 Chemotaxis is a Fundamental Cellular Response; 3.2 Directional Sensing Occurs Downstream of G Protein Activation and Upstream of the Accumulation of PI(3,4,5)P(3) 3.3 Input-Output Relationships Reveal Gradient Amplification in Polarized and Unpolarized Cells3.4 Increase in Local PI(3,4,5)P(3) Precedes Actin Polymerization Responses; 3.5 Positive Feedback and the Actin Cytoskeleton May Stabilize Directional Sensing and Establish Polarity; 3.6 References; 4 Dual Location Proteins: Communication Between Cell Adhesions and the Nucleus; 4.1 Introduction; 4.2 LIM Protein Family; 4.2.1 Zyxin Subfamily; 4.2.1.1 Zyxin; 4.2.1.2 LPP (Lipoma-Prefered Partner); 4.2.1.3 Trip6; 4.2.1.4 WTIP (Wilms Tumor protein 1 Interaction Protein); 4.2.1.5 Ajuba 4.2.2 Paxillin Subfamily4.2.2.1 Paxillin; 4.2.2.2 Hic-5; 4.3 MAGUK Protein Family; 4.3.1 ZO-1; 4.3.2 ZO-2; 4.3.3 CASK; 4.4 Armadillo Repeat Protein Family; 4.4.1 β-catenin Armadillo Repeat Subfamily; 4.4.1.1 β-catenin; 4.4.1.2 Plakoglobin; 4.4.2 p120 Armadillo Repeat Subfamily; 4.4.2.1 p120; 4.4.2.2 ARVCF; 4.4.2.3 Plakophilins; 4.5 Other Proteins - Symplekin; 4.6 Dual Location; 4.6.1 Sequestration of Transcriptional Regulators; 4.6.2 mRNA Localization; 4.6.3 Scaffolding; 4.7 Conclusion; 4.8 Acknowledgments; 4.9 References; II Classical Examples of Cell Migration in Development 5 Cell Migration During Zebrafish Gastrulation |
| Record Nr. | UNINA-9910830409203321 |
| Weinheim, : Wiley-VCH, c2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cell migration in development and disease / / edited by Doris Wedlich
| Cell migration in development and disease / / edited by Doris Wedlich |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2005 |
| Descrizione fisica | 1 online resource (399 p.) |
| Disciplina | 571.8/35 |
| Altri autori (Persone) | WedlichDoris |
| Soggetto topico | Cell migration - Diseases |
| ISBN |
1-280-51954-1
9786610519545 3-527-60466-9 3-527-60407-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cell Migrationin Development and Disease; Contents; Preface; List of Contributors; Color Plates; I Cell Shape Modulations and Cell Surface-Nucleus Connections: Prerequisites for Cell Migration; 1 Functional Phases in Cell Attachment and Spreading; 1.1 Introduction; 1.2 Fibroblast Spreading on Matrices; 1.3 Summary of Spreading Process; 1.3.1 Steps in Cell Spreading; 1.3.1.1 Basal Motility Phase (Cells in Suspension); 1.3.1.2 Adhesion to the Surface; 1.3.1.3 Initiation of Actin Assembly and Spreading (Rate-limiting Step); 1.3.1.4 Continued Spreading; 1.3.1.5 Transition to Fully Spread State
1.3.2 Binding to Rigid Matrices Causes Strengthening of Cytoskeleton-Integrin Linkages1.3.2.1 Initial Binding of Fibronectin Multimers at the Leading Edge and Over Actin Cables; 1.3.2.2 Force-dependent Activation of the ECM-Integrin Complexes; 1.3.2.3 Additional Steps in the Spreading Process; 1.3.3 MTs and Motility; 1.3.4 Conclusion; 1.4 References; 2 Polarized Cell Motility: Microtubules Show the Way; 2.1 Introduction; 2.1.1 The Vasiliev Conundrum; 2.1.2 Cell Polarity and Adhesion; 2.2 Microtubules Meet the Actin Cytoskeleton at Focal Adhesions 2.3 Microtubule Targeting Promotes Focal Adhesion Turnover2.4 Contractility, the Functional Link; 2.5 Kinesin and Signal Transmission; 2.6 Tip Complexes Meet Adhesion Complexes; 2.7 Focal Adhesions Influence Microtubule Dynamics; 2.8 Actin Talks Back: Tension and Microtubule Guidance; 2.9 Conclusions and Perspectives; 2.10 Acknowledgments; 2.11 References; 3 Mechanisms of Eukaryotic Chemotaxis; 3.1 Chemotaxis is a Fundamental Cellular Response; 3.2 Directional Sensing Occurs Downstream of G Protein Activation and Upstream of the Accumulation of PI(3,4,5)P(3) 3.3 Input-Output Relationships Reveal Gradient Amplification in Polarized and Unpolarized Cells3.4 Increase in Local PI(3,4,5)P(3) Precedes Actin Polymerization Responses; 3.5 Positive Feedback and the Actin Cytoskeleton May Stabilize Directional Sensing and Establish Polarity; 3.6 References; 4 Dual Location Proteins: Communication Between Cell Adhesions and the Nucleus; 4.1 Introduction; 4.2 LIM Protein Family; 4.2.1 Zyxin Subfamily; 4.2.1.1 Zyxin; 4.2.1.2 LPP (Lipoma-Prefered Partner); 4.2.1.3 Trip6; 4.2.1.4 WTIP (Wilms Tumor protein 1 Interaction Protein); 4.2.1.5 Ajuba 4.2.2 Paxillin Subfamily4.2.2.1 Paxillin; 4.2.2.2 Hic-5; 4.3 MAGUK Protein Family; 4.3.1 ZO-1; 4.3.2 ZO-2; 4.3.3 CASK; 4.4 Armadillo Repeat Protein Family; 4.4.1 β-catenin Armadillo Repeat Subfamily; 4.4.1.1 β-catenin; 4.4.1.2 Plakoglobin; 4.4.2 p120 Armadillo Repeat Subfamily; 4.4.2.1 p120; 4.4.2.2 ARVCF; 4.4.2.3 Plakophilins; 4.5 Other Proteins - Symplekin; 4.6 Dual Location; 4.6.1 Sequestration of Transcriptional Regulators; 4.6.2 mRNA Localization; 4.6.3 Scaffolding; 4.7 Conclusion; 4.8 Acknowledgments; 4.9 References; II Classical Examples of Cell Migration in Development 5 Cell Migration During Zebrafish Gastrulation |
| Record Nr. | UNINA-9910877369903321 |
| Weinheim, : Wiley-VCH, c2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||