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Textbook of influenza [[electronic resource] /] / edited by Robert G. Webster ... [et al.]
| Textbook of influenza [[electronic resource] /] / edited by Robert G. Webster ... [et al.] |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Chichester, West Sussex, U.K., : Wiley-Blackwell, 2013 |
| Descrizione fisica | 1 online resource (522 p.) |
| Disciplina | 616.2/03 |
| Altri autori (Persone) | WebsterRobert G. <1932-> |
| Soggetto topico | Influenza |
| ISBN |
9781118636848
1-118-63683-X 1-118-63681-3 1-118-63684-8 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
PART 1: Influenza: Perspective -- 1: Human influenza: One health, one world -- Introduction -- Global impact of influenza -- Influenza in a crowded, connected, and converging world -- Increasingly crowded -- Increasingly connected -- Convergence: poultry, pigs, people, and pandemics -- Global interconnectedness requires global coordination and response -- Global challenges for surveillance -- Global regulations for detection and control -- Global network for surveillance -- New opportunities in a changing world -- New tools for global detection and surveillance -- Instant and converging information -- Conclusions -- Acknowledgments -- References -- 2: Influenza pandemics: History and lessons learned -- Introduction -- Past and recent influenza pandemics -- The 1889 and 1918 pandemics -- The 1957 and 1968 pandemics -- Events in 1976 and 1977 -- The threat of an A (H5N1) pandemic -- Response to the H5N1 threat -- The 2009 H1N1 influenza pandemic -- Lessons learned from past influenza pandemics -- Zoonotic origins and unpredictability of pandemics -- Surveillance in swine was inadequate -- Antigenic and structural similarities are not predictors of severity -- An influenza pandemic can arise anywhere in the world -- Pandemic influenza can emerge in any season -- Initial retention of avian receptor binding characteristics in pandemic influenza viruses -- Vaccines to pandemic influenza viruses are not available during the first wave of infection -- Antivirals are the first line of defense -- Conclusions -- Acknowledgments -- References -- PART 2: Structure and replication -- 3: Structure, disassembly, assembly, and budding of influenza viruses -- Introduction -- Structure and virus morphology -- Structure.
Virus morphology -- Disassembly -- Fusion process -- Release of viral RNP -- Transport and assembly -- Budding -- Role of viral proteins -- Role of the eight RNP segments -- Role of host components -- Bud initiation -- Bud elongation and closure -- Conclusions -- Acknowledgments -- References -- 4: The virus genome and its replication -- The segmented RNA virus genome of influenza A and B viruses -- Viral mRNA synthesis (transcription) and viral RNA replication -- Regulation of viral RNA synthesis in infected cells -- The role of host factors in viral RNA synthesis -- Splicing and nuclear export of viral mRNAs -- Nuclear export of viral RNPs -- References -- 5: Influenza glycoproteins: Hemagglutinin and neuraminidase -- HA and NA structures, functions, antigenicity and classification: An overview -- Functions of hemagglutinin -- Receptor binding -- Receptor binding summary -- Hemagglutinin-mediated membrane fusion -- Membrane fusion summary -- Neuraminidase -- Inhibitors of HA and NA functions and potential antiviral drugs -- Receptor binding -- Membrane fusion -- Anti-NA drugs -- Prospects for additional targets for inhibition -- Antigenicity of HA and NA -- Structures of complexes formed by HA and NA with antibodies -- Infectivity neutralization -- Variation of HA and NA -- Effects of HA and NA glycosylation -- Cross-reactive anti-HA antibodies -- HA/NA co-variation of activity and specificity -- References -- 6: Proton channels of influenza A and B viruses -- Influenza A virus M2 protein -- The A/M2 protein has ion channel activity that is required for efficient viral replication -- M2 proton conduction mechanism -- Atomic structures of the A/M2 channel -- Inhibition of the A/M2 channel -- New development of A/M2 channel inhibitors -- Influenza B virus BM2 protein is also a proton channel 7: The NS1 protein: A master regulator of host and viral functions -- Introduction -- General features and structures of the influenza A virus NS1 protein -- Molecular and cellular functions -- Inhibition of the RIG-I pathway -- Inhibition of host gene expression -- Inhibition of the activity of two antiviral proteins: PKR and 2′-5′-oligoadenylate synthetase (OAS) -- Induction of the PI3 K by the NS1 protein -- Roles of the C-terminal motifs of the NS1 protein -- Other NS1 functions -- Unique function of the NS1 protein of influenza B virus (B/NS1): Binding IFN-induced ISG15 -- Regulation of the function of the NS1 protein of influenza A virus -- Impact of the NS1 protein of influenza A virus in virulence, host tropism, and immune responses -- NS1 protein as an antiviral target -- NS1-modified viruses as potential live attenuated vaccines -- Conclusions -- References -- 8: Structure and function of the influenza virus replication machinery and PB1-F2 -- Architecture of the vRNP -- Atomic structure of the influenza polymerase -- PA -- PB2 -- Role of PB1-F2 -- Composition and structure -- Functions -- Evolution and adaptation -- Perspectives -- Note added in proof -- Acknowledgments -- References -- 9: The genome and its manipulation: Recovery of the 1918 virus and vaccine virus generation -- The pandemic 1918 virus - an elusive killer virus is identified -- Virulence and pathogenicity of pandemic 1918 virus infections -- Host responses to infection with pandemic 1918 virus -- Bacterial coinfections in pandemic 1918 virus infections -- Viral determinants of pandemic 1918 virus pathogenicity -- Hemagglutinin (HA) -- Replication complex -- NS1 -- PB1-F2 -- NA -- Generation of vaccine viruses -- References -- 10: Pathogenesis -- Introduction -- Disease in mammalian and avian hosts -- Mammalian influenza -- Avian influenza. Avian influenza virus infections in mammalian host -- Pathogenic mechanisms -- Tropism -- Spread of infection -- Virus load -- Escape of host defense -- Modulation of inflammatory response -- Synergism between influenza viruses and bacteria -- Hemagglutinin determines tropism and spread of infection -- Receptor specificity -- Fusion activation -- Pathogenicity is a multifactorial trait: receptor specificity, N-glycosylation and fusion activity of HA determine lung pathogenicity in mice -- Neuraminidase promotes virus release and destroys decoy receptors -- Polymerase determines replication rates -- NS1 modulates host responses -- Modulation of the IFN response -- Modulation of signaling cascades -- Modulation of apoptosis -- PB1-F2 and PA-X - other modulators of host responses -- Acknowledgments -- References -- PART 3: Evolution and ecology of influenza viruses -- 11: Ecology and evolution of influenza viruses in wild and domestic birds -- Introduction -- Recognition of the influenza ecosystem -- Aquatic birds as the natural reservoir of influenza A viruses -- Interspecies transmission of avian influenza viruses -- Natural reservoirs -- Recognition of influenza viruses in wild birds worldwide -- Wild birds: anseriformes -- Wild birds: charadriiformes -- Wild birds: other species -- Perpetuation, replication, and transmission in the wild bird populations -- Influenza in domestic birds -- Recognition of influenza viruses in domestic birds worldwide -- Interaction between wild and domestic birds -- Terrestrial poultry -- Prevalence and perpetuation in poultry -- Maintenance in domestic ducks and geese -- Establishment and development in terrestrial poultry -- Genesis and development of highly pathogenic H5 and H7 influenza viruses -- HPAI H5N1 virus -- H5N1 outbreaks in domestic birds -- H5N1 in wild birds -- H5N1 in mammals. Interspecies transmission -- Interspecies transmission from aquatic birds to terrestrial poultry -- Interspecies transmission to humans and other mammals -- Evolution of influenza A virus in different hosts -- Evolution of influenza viruses in aquatic birds and the formation of Eurasian and American influenza gene pools -- Reassortment -- Evolution of influenza viruses in domestic birds -- Evolution of the HPAI H5N1 virus -- Conclusions and outlook -- References -- 12: Influenza in swine -- Influenza as a swine disease -- Molecular epidemiology of swine influenza viruses -- Molecular epidemiology in North America -- Molecular epidemiology in Europe -- Molecular epidemiology in South-East Asia -- Cross-species transmission of swine influenza viruses -- Swine as intermediate hosts -- Challenges to the control of swine influenza -- Challenges in swine influenza surveillance -- Knowledge gaps -- Acknowledgments -- References -- 13: Equine/Canine/Feline/Seal influenza -- Equine influenza -- History -- Pathology -- Virus characterization -- Vaccines -- Experimental challenge models -- Infectivity of EIV for humans -- Canine influenza -- Equine origin CIV (H3N8) -- Avian origin influenza A virus H3N2 -- Avian origin influenza A virus H5N1 -- A/H1N1pdm09 virus -- Other -- Feline influenza -- Influenza in marine mammals -- Acknowledgments -- References -- 14: Emergence and evolution of the 1918, 1957, 1968, and 2009 pandemic virus strains -- Definition of pandemic influenza disease -- Background -- Determinants of evolution and emergence of pandemic influenza virus strains -- Evolution resulting from gene segment reassortment -- Evolution resulting from fixation of genomic mutations -- Emergence of novel virus strains -- Extinction of seasonal strains -- The 1918, 1957, 1968, and 2009 influenza virus pandemics -- The H1N1 "Spanish" influenza pandemic of 1918 -- The H2N2 "Asian" pandemic virus of 1957. pt. 1. Influenza : perspective -- pt. 2. Structure and replication -- pt. 3. Evolution and ecology of influenza viruses -- pt. 4. Epidemiology and surveillance -- pt. 5. Immunology of influenza -- pt. 6. Vaccines and vaccine development -- pt. 7. Clinical aspects and antivirals -- pt. 8. The outbreak of H7N9. |
| Record Nr. | UNINA-9910139034003321 |
| Chichester, West Sussex, U.K., : Wiley-Blackwell, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Textbook of influenza / / edited by Robert G. Webster ... [et al.]
| Textbook of influenza / / edited by Robert G. Webster ... [et al.] |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Chichester, West Sussex, U.K., : Wiley-Blackwell, 2013 |
| Descrizione fisica | 1 online resource (522 p.) |
| Disciplina | 616.2/03 |
| Altri autori (Persone) | WebsterRobert G. <1932-> |
| Soggetto topico | Influenza |
| ISBN |
9781118636848
1-118-63683-X 1-118-63681-3 1-118-63684-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
PART 1: Influenza: Perspective -- 1: Human influenza: One health, one world -- Introduction -- Global impact of influenza -- Influenza in a crowded, connected, and converging world -- Increasingly crowded -- Increasingly connected -- Convergence: poultry, pigs, people, and pandemics -- Global interconnectedness requires global coordination and response -- Global challenges for surveillance -- Global regulations for detection and control -- Global network for surveillance -- New opportunities in a changing world -- New tools for global detection and surveillance -- Instant and converging information -- Conclusions -- Acknowledgments -- References -- 2: Influenza pandemics: History and lessons learned -- Introduction -- Past and recent influenza pandemics -- The 1889 and 1918 pandemics -- The 1957 and 1968 pandemics -- Events in 1976 and 1977 -- The threat of an A (H5N1) pandemic -- Response to the H5N1 threat -- The 2009 H1N1 influenza pandemic -- Lessons learned from past influenza pandemics -- Zoonotic origins and unpredictability of pandemics -- Surveillance in swine was inadequate -- Antigenic and structural similarities are not predictors of severity -- An influenza pandemic can arise anywhere in the world -- Pandemic influenza can emerge in any season -- Initial retention of avian receptor binding characteristics in pandemic influenza viruses -- Vaccines to pandemic influenza viruses are not available during the first wave of infection -- Antivirals are the first line of defense -- Conclusions -- Acknowledgments -- References -- PART 2: Structure and replication -- 3: Structure, disassembly, assembly, and budding of influenza viruses -- Introduction -- Structure and virus morphology -- Structure.
Virus morphology -- Disassembly -- Fusion process -- Release of viral RNP -- Transport and assembly -- Budding -- Role of viral proteins -- Role of the eight RNP segments -- Role of host components -- Bud initiation -- Bud elongation and closure -- Conclusions -- Acknowledgments -- References -- 4: The virus genome and its replication -- The segmented RNA virus genome of influenza A and B viruses -- Viral mRNA synthesis (transcription) and viral RNA replication -- Regulation of viral RNA synthesis in infected cells -- The role of host factors in viral RNA synthesis -- Splicing and nuclear export of viral mRNAs -- Nuclear export of viral RNPs -- References -- 5: Influenza glycoproteins: Hemagglutinin and neuraminidase -- HA and NA structures, functions, antigenicity and classification: An overview -- Functions of hemagglutinin -- Receptor binding -- Receptor binding summary -- Hemagglutinin-mediated membrane fusion -- Membrane fusion summary -- Neuraminidase -- Inhibitors of HA and NA functions and potential antiviral drugs -- Receptor binding -- Membrane fusion -- Anti-NA drugs -- Prospects for additional targets for inhibition -- Antigenicity of HA and NA -- Structures of complexes formed by HA and NA with antibodies -- Infectivity neutralization -- Variation of HA and NA -- Effects of HA and NA glycosylation -- Cross-reactive anti-HA antibodies -- HA/NA co-variation of activity and specificity -- References -- 6: Proton channels of influenza A and B viruses -- Influenza A virus M2 protein -- The A/M2 protein has ion channel activity that is required for efficient viral replication -- M2 proton conduction mechanism -- Atomic structures of the A/M2 channel -- Inhibition of the A/M2 channel -- New development of A/M2 channel inhibitors -- Influenza B virus BM2 protein is also a proton channel 7: The NS1 protein: A master regulator of host and viral functions -- Introduction -- General features and structures of the influenza A virus NS1 protein -- Molecular and cellular functions -- Inhibition of the RIG-I pathway -- Inhibition of host gene expression -- Inhibition of the activity of two antiviral proteins: PKR and 2′-5′-oligoadenylate synthetase (OAS) -- Induction of the PI3 K by the NS1 protein -- Roles of the C-terminal motifs of the NS1 protein -- Other NS1 functions -- Unique function of the NS1 protein of influenza B virus (B/NS1): Binding IFN-induced ISG15 -- Regulation of the function of the NS1 protein of influenza A virus -- Impact of the NS1 protein of influenza A virus in virulence, host tropism, and immune responses -- NS1 protein as an antiviral target -- NS1-modified viruses as potential live attenuated vaccines -- Conclusions -- References -- 8: Structure and function of the influenza virus replication machinery and PB1-F2 -- Architecture of the vRNP -- Atomic structure of the influenza polymerase -- PA -- PB2 -- Role of PB1-F2 -- Composition and structure -- Functions -- Evolution and adaptation -- Perspectives -- Note added in proof -- Acknowledgments -- References -- 9: The genome and its manipulation: Recovery of the 1918 virus and vaccine virus generation -- The pandemic 1918 virus - an elusive killer virus is identified -- Virulence and pathogenicity of pandemic 1918 virus infections -- Host responses to infection with pandemic 1918 virus -- Bacterial coinfections in pandemic 1918 virus infections -- Viral determinants of pandemic 1918 virus pathogenicity -- Hemagglutinin (HA) -- Replication complex -- NS1 -- PB1-F2 -- NA -- Generation of vaccine viruses -- References -- 10: Pathogenesis -- Introduction -- Disease in mammalian and avian hosts -- Mammalian influenza -- Avian influenza. Avian influenza virus infections in mammalian host -- Pathogenic mechanisms -- Tropism -- Spread of infection -- Virus load -- Escape of host defense -- Modulation of inflammatory response -- Synergism between influenza viruses and bacteria -- Hemagglutinin determines tropism and spread of infection -- Receptor specificity -- Fusion activation -- Pathogenicity is a multifactorial trait: receptor specificity, N-glycosylation and fusion activity of HA determine lung pathogenicity in mice -- Neuraminidase promotes virus release and destroys decoy receptors -- Polymerase determines replication rates -- NS1 modulates host responses -- Modulation of the IFN response -- Modulation of signaling cascades -- Modulation of apoptosis -- PB1-F2 and PA-X - other modulators of host responses -- Acknowledgments -- References -- PART 3: Evolution and ecology of influenza viruses -- 11: Ecology and evolution of influenza viruses in wild and domestic birds -- Introduction -- Recognition of the influenza ecosystem -- Aquatic birds as the natural reservoir of influenza A viruses -- Interspecies transmission of avian influenza viruses -- Natural reservoirs -- Recognition of influenza viruses in wild birds worldwide -- Wild birds: anseriformes -- Wild birds: charadriiformes -- Wild birds: other species -- Perpetuation, replication, and transmission in the wild bird populations -- Influenza in domestic birds -- Recognition of influenza viruses in domestic birds worldwide -- Interaction between wild and domestic birds -- Terrestrial poultry -- Prevalence and perpetuation in poultry -- Maintenance in domestic ducks and geese -- Establishment and development in terrestrial poultry -- Genesis and development of highly pathogenic H5 and H7 influenza viruses -- HPAI H5N1 virus -- H5N1 outbreaks in domestic birds -- H5N1 in wild birds -- H5N1 in mammals. Interspecies transmission -- Interspecies transmission from aquatic birds to terrestrial poultry -- Interspecies transmission to humans and other mammals -- Evolution of influenza A virus in different hosts -- Evolution of influenza viruses in aquatic birds and the formation of Eurasian and American influenza gene pools -- Reassortment -- Evolution of influenza viruses in domestic birds -- Evolution of the HPAI H5N1 virus -- Conclusions and outlook -- References -- 12: Influenza in swine -- Influenza as a swine disease -- Molecular epidemiology of swine influenza viruses -- Molecular epidemiology in North America -- Molecular epidemiology in Europe -- Molecular epidemiology in South-East Asia -- Cross-species transmission of swine influenza viruses -- Swine as intermediate hosts -- Challenges to the control of swine influenza -- Challenges in swine influenza surveillance -- Knowledge gaps -- Acknowledgments -- References -- 13: Equine/Canine/Feline/Seal influenza -- Equine influenza -- History -- Pathology -- Virus characterization -- Vaccines -- Experimental challenge models -- Infectivity of EIV for humans -- Canine influenza -- Equine origin CIV (H3N8) -- Avian origin influenza A virus H3N2 -- Avian origin influenza A virus H5N1 -- A/H1N1pdm09 virus -- Other -- Feline influenza -- Influenza in marine mammals -- Acknowledgments -- References -- 14: Emergence and evolution of the 1918, 1957, 1968, and 2009 pandemic virus strains -- Definition of pandemic influenza disease -- Background -- Determinants of evolution and emergence of pandemic influenza virus strains -- Evolution resulting from gene segment reassortment -- Evolution resulting from fixation of genomic mutations -- Emergence of novel virus strains -- Extinction of seasonal strains -- The 1918, 1957, 1968, and 2009 influenza virus pandemics -- The H1N1 "Spanish" influenza pandemic of 1918 -- The H2N2 "Asian" pandemic virus of 1957. pt. 1. Influenza : perspective -- pt. 2. Structure and replication -- pt. 3. Evolution and ecology of influenza viruses -- pt. 4. Epidemiology and surveillance -- pt. 5. Immunology of influenza -- pt. 6. Vaccines and vaccine development -- pt. 7. Clinical aspects and antivirals -- pt. 8. The outbreak of H7N9. |
| Record Nr. | UNINA-9910814767203321 |
| Chichester, West Sussex, U.K., : Wiley-Blackwell, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||