Info
- Utilizzare la checkbox di selezione a fianco di ciascun documento per attivare le funzionalità di stampa, invio email, download nei formati disponibili del (i) record.
Molecular neurology [[electronic resource] /] / Stephen Waxman
| Molecular neurology [[electronic resource] /] / Stephen Waxman |
| Autore | Waxman Stephen G |
| Pubbl/distr/stampa | Burlington, MA, : Elsevier Academic Press, c2007 |
| Descrizione fisica | 1 online resource (597 p.) |
| Disciplina |
573.84
616.8 |
| Soggetto topico |
Molecular neurobiology
Molecular biology |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-03719-2
9786611037192 0-08-054618-8 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Molecular Neurology; Copyright Page; Contents; Contributor's List; Preface; Section I: Principles of Molecular Neurology; Chapter 1: Genetics as a Tool in Neurology; I. Introduction; II. Structure and Function of Genes and Chromosomes; III. Genetic Medicine; IV. The Neurogenetic Evaluation; V. Identification of Human Disease Genes; VI. Methods for Human Molecular Genetic Analysis; VII. Treatment of Genetic Diseases; References; Chapter 2: Neurology and Genomic Medicine; I. Introduction; II. Basic Concepts; III. The Human Genome Project (HGP) and Haplotype Mapping (HapMap) Project
IV. Family HistoryV. Genetic Mechanisms; VI. Pharmacogenetics; VII. Gene-Gene and Gene-Environment Interactions; VIII. Comparative Genomic Hybridization (CGH); IX. Mitochondria and the Mitochondrial Genome (mtDNA); X. Summary; References; Chapter 3: Mitochondrial Function and Dysfunction in the Nervous System; I. Introduction; II. Structure and Functions of Mitochondria; III. Mitochondria in Mechanisms of Neuronal Cell Death and Neurological Disease; IV. Roles of Mitochondrial Dysfunction in Common Neurodegenerative Diseases; V. Conclusions; References Cahpter 4: Neuronal Channels and ReceptorsI. Introduction; II. Nomenclature; III. Structure and Function; IV. Physiological Roles; V. Neurological Disorders Caused by Channelopathies; References; Chapter 5: Protein Misfolding, Chaperone Networks, and the Heat Shock Response in the Nervous System; I. Introduction; II. Role of Molecular Chaperones in Protein Folding Quality Control; III. Regulation of Chaperone Expression: The Heat Shock Response; IV. Role of Molecular Chaperones in Neurodegenerative Diseases; V. Chaperone Hypotheses; VI. Therapeutic Avenues; References Chapter 6: Metabolic Biopsy of the BrainI. Phosphorus Magnetic Resonance Spectroscopy; II. The Phosphocreatine Shuttle Hypothesis; III. Magnetization Transfer Measurements of ATP and Phosphocreatine Synthesis; IV. Hydrogen (Proton) Spectroscopy; V. Carbon Spectroscopy; VI. MR Spectroscopic Measurements of Cerebral Lactate; VII. The Astrocyte-Neuron Lactate Shuttle Hypothesis; VIII. Cerebral Ammonia Metabolism; IX. Summary; References; Chapter 7: Gene Therapy Approaches in Neurology; I. Why Use Gene Transfer in the Development of Novel Therapies?; II. Gene Transfer Strategies III. Development of Neurological Gene TherapyIV. Conclusions-Future Developments; References; Chapter 8: Programmed Cell Death and Its Role in Neurological Disease; I. Introduction: Neurologists and Cell Death; II. Cell Death: History and Classification; III. Current Status of Programmed Cell Death Studies; IV. Trophic Factors and the Concept of Cellular Dependence; V. Apoptosis Induced by Unfolded, Misfolded, or Alternatively Folded Proteins; VI. Does Programmed Cell Death Play a Role in Neurodegeneration? VII. Are Programmed Cell Death Pathways Appropriate Therapeutic Targets in Neurodegeneration? |
| Record Nr. | UNINA-9910458636203321 |
Waxman Stephen G
|
||
| Burlington, MA, : Elsevier Academic Press, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Molecular neurology [[electronic resource] /] / Stephen Waxman
| Molecular neurology [[electronic resource] /] / Stephen Waxman |
| Autore | Waxman Stephen G |
| Pubbl/distr/stampa | Burlington, MA, : Elsevier Academic Press, c2007 |
| Descrizione fisica | 1 online resource (597 p.) |
| Disciplina |
573.84
616.8 |
| Altri autori (Persone) | WaxmanStephen G |
| Soggetto topico |
Molecular neurobiology
Molecular biology |
| ISBN |
1-281-03719-2
9786611037192 0-08-054618-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Molecular Neurology; Copyright Page; Contents; Contributor's List; Preface; Section I: Principles of Molecular Neurology; Chapter 1: Genetics as a Tool in Neurology; I. Introduction; II. Structure and Function of Genes and Chromosomes; III. Genetic Medicine; IV. The Neurogenetic Evaluation; V. Identification of Human Disease Genes; VI. Methods for Human Molecular Genetic Analysis; VII. Treatment of Genetic Diseases; References; Chapter 2: Neurology and Genomic Medicine; I. Introduction; II. Basic Concepts; III. The Human Genome Project (HGP) and Haplotype Mapping (HapMap) Project
IV. Family HistoryV. Genetic Mechanisms; VI. Pharmacogenetics; VII. Gene-Gene and Gene-Environment Interactions; VIII. Comparative Genomic Hybridization (CGH); IX. Mitochondria and the Mitochondrial Genome (mtDNA); X. Summary; References; Chapter 3: Mitochondrial Function and Dysfunction in the Nervous System; I. Introduction; II. Structure and Functions of Mitochondria; III. Mitochondria in Mechanisms of Neuronal Cell Death and Neurological Disease; IV. Roles of Mitochondrial Dysfunction in Common Neurodegenerative Diseases; V. Conclusions; References Cahpter 4: Neuronal Channels and ReceptorsI. Introduction; II. Nomenclature; III. Structure and Function; IV. Physiological Roles; V. Neurological Disorders Caused by Channelopathies; References; Chapter 5: Protein Misfolding, Chaperone Networks, and the Heat Shock Response in the Nervous System; I. Introduction; II. Role of Molecular Chaperones in Protein Folding Quality Control; III. Regulation of Chaperone Expression: The Heat Shock Response; IV. Role of Molecular Chaperones in Neurodegenerative Diseases; V. Chaperone Hypotheses; VI. Therapeutic Avenues; References Chapter 6: Metabolic Biopsy of the BrainI. Phosphorus Magnetic Resonance Spectroscopy; II. The Phosphocreatine Shuttle Hypothesis; III. Magnetization Transfer Measurements of ATP and Phosphocreatine Synthesis; IV. Hydrogen (Proton) Spectroscopy; V. Carbon Spectroscopy; VI. MR Spectroscopic Measurements of Cerebral Lactate; VII. The Astrocyte-Neuron Lactate Shuttle Hypothesis; VIII. Cerebral Ammonia Metabolism; IX. Summary; References; Chapter 7: Gene Therapy Approaches in Neurology; I. Why Use Gene Transfer in the Development of Novel Therapies?; II. Gene Transfer Strategies III. Development of Neurological Gene TherapyIV. Conclusions-Future Developments; References; Chapter 8: Programmed Cell Death and Its Role in Neurological Disease; I. Introduction: Neurologists and Cell Death; II. Cell Death: History and Classification; III. Current Status of Programmed Cell Death Studies; IV. Trophic Factors and the Concept of Cellular Dependence; V. Apoptosis Induced by Unfolded, Misfolded, or Alternatively Folded Proteins; VI. Does Programmed Cell Death Play a Role in Neurodegeneration? VII. Are Programmed Cell Death Pathways Appropriate Therapeutic Targets in Neurodegeneration? |
| Record Nr. | UNINA-9910784650603321 |
|
Waxman Stephen G
|
||
| Burlington, MA, : Elsevier Academic Press, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Molecular neurology / / Stephen Waxman
| Molecular neurology / / Stephen Waxman |
| Autore | Waxman Stephen G |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Burlington, MA, : Elsevier Academic Press, c2007 |
| Descrizione fisica | 1 online resource (597 p.) |
| Disciplina |
573.84
616.8 |
| Soggetto topico |
Molecular neurobiology
Molecular biology |
| ISBN |
1-281-03719-2
9786611037192 0-08-054618-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Molecular Neurology; Copyright Page; Contents; Contributor's List; Preface; Section I: Principles of Molecular Neurology; Chapter 1: Genetics as a Tool in Neurology; I. Introduction; II. Structure and Function of Genes and Chromosomes; III. Genetic Medicine; IV. The Neurogenetic Evaluation; V. Identification of Human Disease Genes; VI. Methods for Human Molecular Genetic Analysis; VII. Treatment of Genetic Diseases; References; Chapter 2: Neurology and Genomic Medicine; I. Introduction; II. Basic Concepts; III. The Human Genome Project (HGP) and Haplotype Mapping (HapMap) Project
IV. Family HistoryV. Genetic Mechanisms; VI. Pharmacogenetics; VII. Gene-Gene and Gene-Environment Interactions; VIII. Comparative Genomic Hybridization (CGH); IX. Mitochondria and the Mitochondrial Genome (mtDNA); X. Summary; References; Chapter 3: Mitochondrial Function and Dysfunction in the Nervous System; I. Introduction; II. Structure and Functions of Mitochondria; III. Mitochondria in Mechanisms of Neuronal Cell Death and Neurological Disease; IV. Roles of Mitochondrial Dysfunction in Common Neurodegenerative Diseases; V. Conclusions; References Cahpter 4: Neuronal Channels and ReceptorsI. Introduction; II. Nomenclature; III. Structure and Function; IV. Physiological Roles; V. Neurological Disorders Caused by Channelopathies; References; Chapter 5: Protein Misfolding, Chaperone Networks, and the Heat Shock Response in the Nervous System; I. Introduction; II. Role of Molecular Chaperones in Protein Folding Quality Control; III. Regulation of Chaperone Expression: The Heat Shock Response; IV. Role of Molecular Chaperones in Neurodegenerative Diseases; V. Chaperone Hypotheses; VI. Therapeutic Avenues; References Chapter 6: Metabolic Biopsy of the BrainI. Phosphorus Magnetic Resonance Spectroscopy; II. The Phosphocreatine Shuttle Hypothesis; III. Magnetization Transfer Measurements of ATP and Phosphocreatine Synthesis; IV. Hydrogen (Proton) Spectroscopy; V. Carbon Spectroscopy; VI. MR Spectroscopic Measurements of Cerebral Lactate; VII. The Astrocyte-Neuron Lactate Shuttle Hypothesis; VIII. Cerebral Ammonia Metabolism; IX. Summary; References; Chapter 7: Gene Therapy Approaches in Neurology; I. Why Use Gene Transfer in the Development of Novel Therapies?; II. Gene Transfer Strategies III. Development of Neurological Gene TherapyIV. Conclusions-Future Developments; References; Chapter 8: Programmed Cell Death and Its Role in Neurological Disease; I. Introduction: Neurologists and Cell Death; II. Cell Death: History and Classification; III. Current Status of Programmed Cell Death Studies; IV. Trophic Factors and the Concept of Cellular Dependence; V. Apoptosis Induced by Unfolded, Misfolded, or Alternatively Folded Proteins; VI. Does Programmed Cell Death Play a Role in Neurodegeneration? VII. Are Programmed Cell Death Pathways Appropriate Therapeutic Targets in Neurodegeneration? |
| Record Nr. | UNINA-9910820439703321 |
|
Waxman Stephen G
|
||
| Burlington, MA, : Elsevier Academic Press, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||