Autoimmune Disorders : Adjuvants and Other Risk Factors in Pathogenesis

• Autore: Watad Abdulla
• Pubblicazione: Newark : , : John Wiley & Sons, Incorporated, , 2024; ©2024
• Edizione: 1st ed.
• Descrizione fisica: 1 online resource (369 pages)
• Altri autori: BragazziNicola Luigi ShoenfeldYehuda
• Nota di contenuto: Cover -- Title Page -- Copyright Page -- Contents -- List of Contributors -- Introduction -- References -- 1 Hyperstimulation of the Immune System -- Background -- Biomaterials that are lined to hyperstimulation of the immune system (silicone, mesh and heavy metals) -- Hyperstimulation syndrome induced by silicone breast implants -- Hyperstimulation syndrome induced by mesh -- Hyperstimulation syndrome induced by metals -- Link among foreign bodies, chronic stimulation, and lymphoproliferative disorders -- Studies on silicone, metals, and the risk of lymphoma -- References -- 2 Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA): Genetics, Immunization, and Autoimmunity -- Introduction -- Genetic background -- Immunity -- Autoimmunity -- Conclusion -- References -- 3 Vaccine Adjuvants: History, Role, Mechanisms of Action, and Side Effects -- Introduction -- Materials and methods -- Etymology of adjuvants -- Classification of adjuvants -- Mineral salts -- Emulsions -- Bacterial- or microbial-derived adjuvants -- TLR agonists -- Lipid particles/liposomes -- Microparticles/nanoparticles -- Cytokine- and interleukin-based adjuvants -- Adjuvant delivery systems -- History of adjuvants -- Role and mechanisms of actions of adjuvants -- Safety and side effects -- Safety and side effects of aluminum-adjuvanted vaccines -- Safety and side effects of emulsion-adjuvanted vaccines -- Safety and side effects of novel adjuvants -- Overall synthesis of safety and side effects of adjuvanted vaccines -- Conclusions and future directions -- References -- 4 Commonly Used Food Additives Are Nutritional Adjuvants in ASIA Syndrome -- Introduction -- ASIA syndrome -- Increased usage of food additives in the processed food industries -- Gluten is a nutritional adjuvant -- Gluten side effects -- Gluten-depended autoimmunity. ; Gluten fulfills the diagnostic criteria of ASIA syndrome -- Microbial transglutaminase is a potential new adjuvant -- Microbial transglutaminase is a potential inducer of autoimmune disease -- Microbial transglutaminase fulfills the diagnostic criteria of ASIA syndrome -- Nanoparticle complexes are potential new adjuvants -- Nanoparticles fulfill the criteria of ASIA syndrome -- Food colorants are potential new adjuvants -- Food colorants fulfill the criteria of ASIA syndrome -- Emulsifiers are potential new adjuvants -- Emulsifiers fulfill the criteria of ASIA syndrome -- Conclusions -- Abbreviations -- Author contributions -- References -- 5 Silicone Implant Incompatibility Syndrome -- Highlights -- Introduction -- Silicone as an immunologic adjuvant -- Pathophysiological mechanisms of inflammatory/immunological disturbances related to SBI -- Silicone implant incompatibility syndrome -- Autoimmune diseases in patients with SIIS -- Effectivity of SBI explantation in improving symptoms and laboratory findings -- SIIS, who might be at risk? -- Conclusion -- Abbreviations -- References -- 6 Silicone Breast Implants (SBIs) and Autoimmune Dysautonomya -- References -- 7 Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA or Shoenfeld's Syndrome) Due to Polypropylene Mesh Implants -- Introduction -- Adverse events associated with mesh implants -- Systemic symptoms and signs of mesh-mediated systemic disease -- Laboratory and radiological findings and other diagnostic procedures in mesh-induced disease -- ASIA, autoimmune diseases, and lymphoma development -- ASIA: autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld's syndrome) -- Pathophysiology of ASIA after foreign body implantation -- Evidence that mesh can cause ASIA -- Exposure to mesh implants precedes the onset or worsening of symptoms. ; The appearance of "typical" clinical manifestations -- Removal of inciting agent induces improvement -- Biological plausibility of mesh implants as a cause of ASIA -- Approaches to causation -- Koch's postulates -- Bradford-Hill criteria -- Conclusion -- References -- 8 Vaccines, Vaccinosis, and Autoimmunity -- Vaccines and their epidemiological, clinical, societal, and economic impact -- Vaccines, vaccinosis, and autoimmunity -- Vaccines and immune system activation -- Autoimmune diseases: background and mechanisms -- Vaccine adjuvants: purpose and impact -- Adjuvants and autoimmunity: the body of currently available evidence -- Regulatory measures and ongoing research -- Conclusion -- References -- 9 Sustained Immune Activation in ASIA Syndrome - A Bridge to Lymphomagenesis -- Background -- Introduction -- Animal model as a proof of concept -- Autoimmunity and lymphoma: role of immune chronic stimulation in lymphoma development -- Vaccination and acute lymphoma development -- Foreign body reaction (FBR) and lymphoma -- Silicone versus aluminum compounds and lymphomagenesis association -- Lymphomagenesis in inflammatory diseases from a different perspective -- Conclusions and future goals -- References -- 10 Chronic Fatigue Syndrome -- Introduction -- The evolutionary history of "chronic fatigue syndrome" -- 1750, Febricula -- 1879, Neurocirculatory asthenia -- 1934, Atypical poliomyelitis -- 1948, Akureyri disease (Iceland disease) -- 1955, Royal Free disease -- 1955-1986, Myalgic encephalomyelitis -- 1984, Tapanui outbreak -- 1984, Chronic Epstein-Barr virus syndrome -- 1987, Chronic fatigue syndrome -- CFS syndrome through modern concepts -- Conclusion -- References -- 11 Autoantibodies and Autonomic Nervous System -- G-protein-coupled receptor antibodies: basic facts and historical perspective. ; Associations between anti-GPCR antibodies and clinical manifestations of dysautonomia -- The autoimmune concept for dysautonomia -- Potential treatment strategy of dysautonomia -- References -- 12 Postural Orthostatic Tachycardia Syndrome (POTS) as a Part of ASIA Syndrome -- Introduction -- POTS and autoantibodies -- POTS and chronic inflammation -- POTS and other autoimmune diseases -- POTS and small-fiber neuropathy (SFN) -- Targeting autoimmunity for POTS treatment -- POTS being one of the many arms of ASIA syndrome -- References -- 13 Role of the Small-fiber Neuropathy in the Pathogenesis of ASIA Syndrome -- Small-fiber neuropathy: definition and principles of diagnostics -- Etiology and pathogenesis -- Clinical manifestations -- Diagnostic methods -- Small-fiber neuropathy treatment -- SFN as part of ASIA syndrome -- Sarcoidosis -- Sjögren's syndrome -- Silicone implant incompatibility syndrome -- Conclusion -- References -- 14 Tattoo as a Possible Trigger for Autoimmune Syndrome Induced by Adjuvants -- Introduction -- Tattoo and its components -- Sjögren's syndrome and tattoo -- Sarcoidosis and tattoo -- Postural orthostatic tachycardia syndrome, ASIA syndrome, and tattoo -- Similarities between silicone incompatibility syndrome (SIS) and ASIA syndrome following tattoo -- Potential therapies for ASIA syndrome following tattoo -- Conclusion -- References -- 15 The Sick Building Syndrome as a Part of the Autoimmune (Autoinflammatory) Syndrome Induced by Adjuvant -- Introduction -- Manifestations of SBS -- Development of SBS: potential hazards and sources -- Conventional and green buildings -- Legal requirements and regulations -- SBS and Autoimmune (Autoinflammatory) Syndrome Induced by Adjuvants (ASIA) -- Conclusion -- References -- 16 Gulf War Syndrome (GWS) and ASIA Syndrome -- Introduction -- Prevalence of GWS. ; Heterogeneity of Clinical Manifestations -- Etiology and pathogenesis of GWS -- Environmental triggers associated with GWS -- The link between GWS and pesticides -- The link between GWS and nerve agents -- The link between GWS and pyridostigmine bromide (PB) -- The link between GWS and multiple vaccinations -- Genetic basis of individual variation in susceptibility to GWS -- Brain defects and central nervous system alterations in veterans with GWS -- Peripheral immune abnormalities associated with GWS -- Gut microbiome alterations in GWS -- GWS in relation to other multisymptom conditions -- GWS in relation to chronic fatigue syndrome (CFS) -- GWS in relation to fibromyalgia (FM) -- GWS in relation to multiple chemical sensitivity (MCS) -- Classification of GWS as part of the autoimmune/inflammatory syndrome induced by adjuvants (ASIA) -- Conclusion -- References -- 17 Vaccinations in Patients with Autoimmune Diseases -- Risk of infection in patients with AIRD -- Safety and efficacy of vaccinations in patients with AIRD -- Influenza vaccines -- Pneumococcal vaccine in AIRD patients -- Hepatitis B vaccine -- Quadrivalent HPV vaccine -- Tetanus and diphtheria vaccines -- References -- 18 Autoimmune Phenomena in Cancer Patients Treated with Immune Checkpoint Inhibitors -- Introduction -- Incidence and autoimmune irAEs -- Inflammatory arthritis -- Sicca syndrome/Sjögren's syndrome -- Myositis and neurological diseases -- Autoimmune diseases -- Vasculitis -- Systemic lupus erythematosus -- Sarcoidosis -- Organ-specific irAEs determined by specific ICI -- Management and treatment of autoimmune irAEs -- Summary -- References -- 19 Heavy Metals in Autoimmune Diseases: Too Much Noise in Autoimmunity -- Chapter highlights -- Introduction -- How metals affect the immune system -- Metals and systemic lupus erythematosus -- Nickel and SLE -- Aluminum and SLE. ; Cadmium and SLE.
• Titolo autorizzato: Autoimmune Disorders
• ISBN: 1-119-85842-9; 1-119-85843-7
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910877497303321
• Lo trovi qui: Univ. Federico II