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Biblioteca

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Gene Expression and Its Discontents : The Social Production of Chronic Disease / / by Rodrick Wallace, Deborah Wallace
Gene Expression and Its Discontents : The Social Production of Chronic Disease / / by Rodrick Wallace, Deborah Wallace
Autore Wallace Rodrick
Edizione [2nd ed. 2016.]
Pubbl/distr/stampa Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016
Descrizione fisica 1 online resource (XIII, 344 p. 52 illus.)
Disciplina 611.01816
599.935
Soggetto topico Human genetics
Epidemiology
Biochemistry
Bioinformatics
Public health
Human Genetics
Biochemistry, general
Computational Biology/Bioinformatics
Public Health
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Introduction -- 1. Toward new tools -- 2. Models of development -- 3. Groupoid symmetries -- 4. Epigenetic catalysis -- 5. Developmental disorders -- 6. An interim perspective -- 7. The obesity pandemic in the US -- 8. Coronary heart disease in the US. - 9. Cancer: a developmental perspective -- 10. Autoimmune disorders -- 11. Demoralization and obesity in Upper Manhattan -- 12. Death at an early age: AIDS and related mortality in New York City -- 13. Mental Disorders I: Western atomism and its culture-bound syndromes -- 14. Mental Disorders II: Psychopathology and sleep -- 15. Diabetes and Thyroid Cancer in Manhattan's Chinatown -- 16. Right-To-Work Laws and Alzheimer's Disease -- 17. Stress as an Environmental Exposure -- 18. Final Thoughts -- 19. Mathematical Appendix.
Record Nr. UNINA-9910155303003321
Wallace Rodrick  
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
A mathematical approach to multilevel, multiscale health interventions [[electronic resource] ] : pharmaceutical industry decline and policy response / / Rodrick Wallace, Deborah Wallace
A mathematical approach to multilevel, multiscale health interventions [[electronic resource] ] : pharmaceutical industry decline and policy response / / Rodrick Wallace, Deborah Wallace
Autore Wallace Rodrick
Pubbl/distr/stampa London, : Imperial College Press, 2013
Descrizione fisica 1 online resource (238 p.)
Disciplina 615.5/80151
Altri autori (Persone) WallaceDeborah
Soggetto topico Drug development
Drugs - Research
Drugs - Design - Mathematical models
Medical geography
Soggetto genere / forma Electronic books.
ISBN 1-299-46216-2
1-84816-997-3
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Preface; Contents; 1. BEYOND MAGIC BULLETS; 1.1 The Pharmaceutical Catastrophe; 1.2 A New Perspective; 1.3 Cognition as `Language'; 1.4 The Human Cognome; 2. EXPANDING THE THEORY; 2.1 No Free Lunch; 2.2 Multiple Broadcasts, Punctuated Detection; 2.3 Metabolic Constraints; 2.4 Environmental Signals; 3. DYNAMIC `REGRESSION' MODELS; 3.1 The Simplest Approach; 3.2 A Rate Distortion Reformulation; 3.3 Multiple Time Scales; 3.4 Incoming Information; 3.5 Pathologies; 3.6 Refining the Model; 4. AN EVOLUTIONARY EXCURSION; 4.1 Introduction; 4.2 Ecosystems as Information Sources; 4.3 Genetic Heritage
4.4 Gene Expression4.5 Interacting Information Sources; 4.6 Conclusions; 5. EXAMPLE: MENTAL DISORDERS; 5.1 Introduction; 5.2 Two Classes; 5.3 Global Broadcast Models; 5.4 Gene Expression; 5.5 Summary; 6. EXAMPLE: PROTEIN FOLDING; 6.1 Introduction; 6.2 Spontaneous Symmetry Breaking; 6.3 A Formal Approach; 6.4 The Energy Picture; 6.5 The Developmental Picture; 6.6 A Comprehensive Treatment; 6.7 Aging and Protein Folding; 6.8 Summary; 7. EXAMPLE: GLYCOME DETERMINANTS; 7.1 Introduction; 7.2 Stochastic Topology; 7.3 The Glycomic Conundrum; 7.4 Another Cognitive Paradigm
7.5 Regulating Glycan Determinants7.6 Glycan Spectra; 7.7 Summary; 8. EXAMPLE: GLYCAN/LECTIN LOGIC GATES; 8.1 Introduction; 8.2 The Critical Exponent; 8.3 Two Examples; 8.4 Information Catalysis; 8.5 A Tiling Symmetry Model; 8.6 Summary; 9. EXAMPLE: IDP LOGIC GATES; 9.1 Introduction; 9.2 Symbolic Dynamics of Molecular Switching; 9.3 Another Dual Information Source; 9.4 Information Catalysis; 9.5 Summary; 10. TREATMENT; 10.1 The Generalized Retina; 10.2 Therapeutic Efficacy; 10.3 Psychosocial Stress; 10.4 Flight, Fight, and Helplessness; 10.5 Institutions as Niche Construction
10.6 The Hall of Mirrors10.7 Side Effects Reconsidered; 11. HISTORY AND HEALTH; 11.1 Malaria and the Fulani; 11.2 The American Catastrophe; 12. BEYOND GLASPERLENSPIEL; 13. MATHEMATICAL APPENDIX; 13.1 The Tuning Theorem; 13.2 The Rate Distortion Theorem; 13.3 Stochastic Differential Equations; 13.4 Morse Theory; 13.5 Groupoids; 13.6 `Biological' Renormalization; 13.7 Large Deviations; Bibliography; Index
Record Nr. UNINA-9910452303303321
Wallace Rodrick  
London, : Imperial College Press, 2013
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
A mathematical approach to multilevel, multiscale health interventions : pharmaceutical industry decline and policy response / / Rodrick Wallace, Deborah Wallace, Columbia University, USA
A mathematical approach to multilevel, multiscale health interventions : pharmaceutical industry decline and policy response / / Rodrick Wallace, Deborah Wallace, Columbia University, USA
Autore Wallace Rodrick
Pubbl/distr/stampa London, : Imperial College Press, 2013
Descrizione fisica 1 online resource (xi, 225 pages)
Disciplina 615.5/80151
Collana Gale eBooks
Soggetto topico Drug development
Drugs - Research
Drugs - Design - Mathematical models
Medical geography
ISBN 1-299-46216-2
1-84816-997-3
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Preface; Contents; 1. BEYOND MAGIC BULLETS; 1.1 The Pharmaceutical Catastrophe; 1.2 A New Perspective; 1.3 Cognition as `Language'; 1.4 The Human Cognome; 2. EXPANDING THE THEORY; 2.1 No Free Lunch; 2.2 Multiple Broadcasts, Punctuated Detection; 2.3 Metabolic Constraints; 2.4 Environmental Signals; 3. DYNAMIC `REGRESSION' MODELS; 3.1 The Simplest Approach; 3.2 A Rate Distortion Reformulation; 3.3 Multiple Time Scales; 3.4 Incoming Information; 3.5 Pathologies; 3.6 Refining the Model; 4. AN EVOLUTIONARY EXCURSION; 4.1 Introduction; 4.2 Ecosystems as Information Sources; 4.3 Genetic Heritage
4.4 Gene Expression4.5 Interacting Information Sources; 4.6 Conclusions; 5. EXAMPLE: MENTAL DISORDERS; 5.1 Introduction; 5.2 Two Classes; 5.3 Global Broadcast Models; 5.4 Gene Expression; 5.5 Summary; 6. EXAMPLE: PROTEIN FOLDING; 6.1 Introduction; 6.2 Spontaneous Symmetry Breaking; 6.3 A Formal Approach; 6.4 The Energy Picture; 6.5 The Developmental Picture; 6.6 A Comprehensive Treatment; 6.7 Aging and Protein Folding; 6.8 Summary; 7. EXAMPLE: GLYCOME DETERMINANTS; 7.1 Introduction; 7.2 Stochastic Topology; 7.3 The Glycomic Conundrum; 7.4 Another Cognitive Paradigm
7.5 Regulating Glycan Determinants7.6 Glycan Spectra; 7.7 Summary; 8. EXAMPLE: GLYCAN/LECTIN LOGIC GATES; 8.1 Introduction; 8.2 The Critical Exponent; 8.3 Two Examples; 8.4 Information Catalysis; 8.5 A Tiling Symmetry Model; 8.6 Summary; 9. EXAMPLE: IDP LOGIC GATES; 9.1 Introduction; 9.2 Symbolic Dynamics of Molecular Switching; 9.3 Another Dual Information Source; 9.4 Information Catalysis; 9.5 Summary; 10. TREATMENT; 10.1 The Generalized Retina; 10.2 Therapeutic Efficacy; 10.3 Psychosocial Stress; 10.4 Flight, Fight, and Helplessness; 10.5 Institutions as Niche Construction
10.6 The Hall of Mirrors10.7 Side Effects Reconsidered; 11. HISTORY AND HEALTH; 11.1 Malaria and the Fulani; 11.2 The American Catastrophe; 12. BEYOND GLASPERLENSPIEL; 13. MATHEMATICAL APPENDIX; 13.1 The Tuning Theorem; 13.2 The Rate Distortion Theorem; 13.3 Stochastic Differential Equations; 13.4 Morse Theory; 13.5 Groupoids; 13.6 `Biological' Renormalization; 13.7 Large Deviations; Bibliography; Index
Record Nr. UNINA-9910779690703321
Wallace Rodrick  
London, : Imperial College Press, 2013
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
A mathematical approach to multilevel, multiscale health interventions : pharmaceutical industry decline and policy response / / Rodrick Wallace, Deborah Wallace, Columbia University, USA
A mathematical approach to multilevel, multiscale health interventions : pharmaceutical industry decline and policy response / / Rodrick Wallace, Deborah Wallace, Columbia University, USA
Autore Wallace Rodrick
Pubbl/distr/stampa London, : Imperial College Press, 2013
Descrizione fisica 1 online resource (xi, 225 pages)
Disciplina 615.5/80151
Collana Gale eBooks
Soggetto topico Drug development
Drugs - Research
Drugs - Design - Mathematical models
Medical geography
ISBN 1-299-46216-2
1-84816-997-3
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Preface; Contents; 1. BEYOND MAGIC BULLETS; 1.1 The Pharmaceutical Catastrophe; 1.2 A New Perspective; 1.3 Cognition as `Language'; 1.4 The Human Cognome; 2. EXPANDING THE THEORY; 2.1 No Free Lunch; 2.2 Multiple Broadcasts, Punctuated Detection; 2.3 Metabolic Constraints; 2.4 Environmental Signals; 3. DYNAMIC `REGRESSION' MODELS; 3.1 The Simplest Approach; 3.2 A Rate Distortion Reformulation; 3.3 Multiple Time Scales; 3.4 Incoming Information; 3.5 Pathologies; 3.6 Refining the Model; 4. AN EVOLUTIONARY EXCURSION; 4.1 Introduction; 4.2 Ecosystems as Information Sources; 4.3 Genetic Heritage
4.4 Gene Expression4.5 Interacting Information Sources; 4.6 Conclusions; 5. EXAMPLE: MENTAL DISORDERS; 5.1 Introduction; 5.2 Two Classes; 5.3 Global Broadcast Models; 5.4 Gene Expression; 5.5 Summary; 6. EXAMPLE: PROTEIN FOLDING; 6.1 Introduction; 6.2 Spontaneous Symmetry Breaking; 6.3 A Formal Approach; 6.4 The Energy Picture; 6.5 The Developmental Picture; 6.6 A Comprehensive Treatment; 6.7 Aging and Protein Folding; 6.8 Summary; 7. EXAMPLE: GLYCOME DETERMINANTS; 7.1 Introduction; 7.2 Stochastic Topology; 7.3 The Glycomic Conundrum; 7.4 Another Cognitive Paradigm
7.5 Regulating Glycan Determinants7.6 Glycan Spectra; 7.7 Summary; 8. EXAMPLE: GLYCAN/LECTIN LOGIC GATES; 8.1 Introduction; 8.2 The Critical Exponent; 8.3 Two Examples; 8.4 Information Catalysis; 8.5 A Tiling Symmetry Model; 8.6 Summary; 9. EXAMPLE: IDP LOGIC GATES; 9.1 Introduction; 9.2 Symbolic Dynamics of Molecular Switching; 9.3 Another Dual Information Source; 9.4 Information Catalysis; 9.5 Summary; 10. TREATMENT; 10.1 The Generalized Retina; 10.2 Therapeutic Efficacy; 10.3 Psychosocial Stress; 10.4 Flight, Fight, and Helplessness; 10.5 Institutions as Niche Construction
10.6 The Hall of Mirrors10.7 Side Effects Reconsidered; 11. HISTORY AND HEALTH; 11.1 Malaria and the Fulani; 11.2 The American Catastrophe; 12. BEYOND GLASPERLENSPIEL; 13. MATHEMATICAL APPENDIX; 13.1 The Tuning Theorem; 13.2 The Rate Distortion Theorem; 13.3 Stochastic Differential Equations; 13.4 Morse Theory; 13.5 Groupoids; 13.6 `Biological' Renormalization; 13.7 Large Deviations; Bibliography; Index
Record Nr. UNINA-9910813940903321
Wallace Rodrick  
London, : Imperial College Press, 2013
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui