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Aging of the genome [[electronic resource] ] : the dual role of DNA in life and death / / Jan Vijg
| Aging of the genome [[electronic resource] ] : the dual role of DNA in life and death / / Jan Vijg |
| Autore | Vijg Jan |
| Pubbl/distr/stampa | Oxford, : Oxford University Press, 2007 |
| Descrizione fisica | 1 online resource (385 p.) |
| Disciplina | 571.878 |
| Soggetto topico |
Aging - Genetic aspects
Genomes |
| Soggetto genere / forma | Electronic books. |
| ISBN |
9786611145255
1-281-14525-4 0-19-856922-X 0-19-152458-1 1-4294-6993-5 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Preface; 1 Introduction: the coming of age of the genome; 1.1 The age of biology; 1.2 From genetics to genomics; 1.3 A return to function; 1.4 The causes of aging: a random affair; 2 The logic of aging; 2.1 Aging genes; 2.2 Pleiotropy in aging; 2.3 Interrupting the pathways of aging; 2.4 Longevity-assurance genes; 2.5 Somatic damage and the aging genome; 3 Genome structure and function; 3.1 DNA primary structure; 3.2 Higher-order DNA structure; 3.3 Nuclear architecture; 3.4 Transcription regulation; 3.5 Conclusions; 4 Genome maintenance; 4.1 Why genome maintenance?
4.2 DNA-damage signaling and cellular responses4.3 DNA-repair mechanisms; 4.4 Genome maintenance and aging; 5 Genome instability and accerated aging; 5.1 Premature aging; 5.2 Validity of accelerated-aging phenotypes; 5.3 Genome maintenance and accelerated aging in mice; 5.4 Conclusions; 6 The aging genome; 6.1 DNA damage; 6.2 DNA-sequence changes; 6.3 Changes in DNA modification and conformation; 6.4 Summary and conclusions: a DNA damage report of aging; 7 From genome to phenome; 7.1 The causes of cancer; 7.2 Genome instability and tissue dysfunction 7.3 Testing the role of genome instability in aging8 A genomic limit to life?; 8.1 Aiming for immortality; 8.2 SENS, and does it make sense?; EPILOGUE; GLOSSARY; A; B; C; D; E; F; G; H; I; L; M; N; O; P; R; S; T; X; Y; Z; REFERENCES; INDEX; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; Q; R; S; T; U; V; W; X; Y; Z |
| Record Nr. | UNINA-9910465172503321 |
Vijg Jan
|
||
| Oxford, : Oxford University Press, 2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Aging of the genome [[electronic resource] ] : the dual role of DNA in life and death / / Jan Vijg
| Aging of the genome [[electronic resource] ] : the dual role of DNA in life and death / / Jan Vijg |
| Autore | Vijg Jan |
| Pubbl/distr/stampa | Oxford, : Oxford University Press, 2007 |
| Descrizione fisica | 1 online resource (385 p.) |
| Disciplina | 571.878 |
| Soggetto topico |
Aging - Genetic aspects
Genomes |
| ISBN |
9786611145255
1-281-14525-4 0-19-856922-X 0-19-152458-1 1-4294-6993-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Preface; 1 Introduction: the coming of age of the genome; 1.1 The age of biology; 1.2 From genetics to genomics; 1.3 A return to function; 1.4 The causes of aging: a random affair; 2 The logic of aging; 2.1 Aging genes; 2.2 Pleiotropy in aging; 2.3 Interrupting the pathways of aging; 2.4 Longevity-assurance genes; 2.5 Somatic damage and the aging genome; 3 Genome structure and function; 3.1 DNA primary structure; 3.2 Higher-order DNA structure; 3.3 Nuclear architecture; 3.4 Transcription regulation; 3.5 Conclusions; 4 Genome maintenance; 4.1 Why genome maintenance?
4.2 DNA-damage signaling and cellular responses4.3 DNA-repair mechanisms; 4.4 Genome maintenance and aging; 5 Genome instability and accerated aging; 5.1 Premature aging; 5.2 Validity of accelerated-aging phenotypes; 5.3 Genome maintenance and accelerated aging in mice; 5.4 Conclusions; 6 The aging genome; 6.1 DNA damage; 6.2 DNA-sequence changes; 6.3 Changes in DNA modification and conformation; 6.4 Summary and conclusions: a DNA damage report of aging; 7 From genome to phenome; 7.1 The causes of cancer; 7.2 Genome instability and tissue dysfunction 7.3 Testing the role of genome instability in aging8 A genomic limit to life?; 8.1 Aiming for immortality; 8.2 SENS, and does it make sense?; EPILOGUE; GLOSSARY; A; B; C; D; E; F; G; H; I; L; M; N; O; P; R; S; T; X; Y; Z; REFERENCES; INDEX; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; Q; R; S; T; U; V; W; X; Y; Z |
| Record Nr. | UNINA-9910792273803321 |
|
Vijg Jan
|
||
| Oxford, : Oxford University Press, 2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||