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Cell death [[electronic resource] /] / editors, Gerry Melino, David Vaux
| Cell death [[electronic resource] /] / editors, Gerry Melino, David Vaux |
| Pubbl/distr/stampa | Chichester, West Sussex ; ; Hoboken, NJ, : John Wiley & Sons, 2010 |
| Descrizione fisica | 1 online resource (317 p.) |
| Disciplina | 571.9/36 |
| Altri autori (Persone) |
MelinoGerry
VauxDavid |
| Soggetto topico |
Apoptosis
Cell death |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-282-54809-3
9786612548093 0-470-68657-X |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Cell Death; Copyright Page; Contents; Contributors; Preface; The Siren's Song: This Death That Makes Life Live; References; Further Reading; The Origin and Evolution of Programmed Cell Death; Introduction; Origins: From the Question 'When' to the Question 'How'; From Predator/Prey Coevolution to Symbioses: A 'Red Queen' Hypothesis in the Bacteria World; A Stable Evolutionary Strategy despite High Individual Costs; The 'Original Sin' Hypothesis: Self-destruction as an Unavoidable Consequence of Life; C. elegans Model: From Paradigm to Paradox; Walking Around the Evolutionary Bush
From the Origins of Programmed Cell Death to the Origins of Ageing'There is Grandeur in This View of Life...'; References; Further Reading; Cell Death in C. elegans; ced-3, ced-4, ced-9 and egl-1 are Conserved Genes Essential for Programmed Cell Death in C. elegans; Regulation of Cell Death during Somatic Development; Engulfment of Dying Cells; Germline Apoptosis; DNA Damage-induced Germline Apoptosis; Conclusion; References; Further Reading; Caspases and Cell Death; History and Classification; Structure and Active Site; Substrate Recognition and Mechanism of Action; Sequence of Action Substrates during ApoptosisInhibitors; Caspase Knockouts; Pathological Implications; Therapeutic Outlook; References; Further Reading; The Apoptosome: The Executioner of Mitochondria-mediated Apoptosis; Introduction; The Apoptosome Structure: Its Components and Its Assembly; Apaf1; Apoptosome assembly; Caspase-9; Cytochrome c; Modulation of the Apoptosome Formation; Apoptosome-like Complexes in Evolution. Is the Mitochondrial Pathway of Apoptosis Conserved?; Caenorhabditis elegans; Drosophila melanogaster; The Role of the Apoptosome in Mammalian Development; Caspase-9 knockout; Apaf1 knockout Cytochrome c deficiencyFinal Remarks; References; Further Reading; Caspases, Substrates and Sequential Activation; Introduction; Caspases Classification and Structure; Pathways That Lead to Caspase Activation; Extrinsic pathway; Granzyme B pathway; Intrinsic pathway; Effectors of demolition; Demolition Phase of Apoptosis; Detachment, rounding and blebbing; Nuclear fragmentation, DNA condensation and degradation; Undermining cell physiology; Immune Clearance and Immune Tolerance of Apoptotic Cells; Conclusions; Acknowledgements; References; Further Reading; Dismantling the Apoptotic Cell IntroductionCaspases: Regulators of the Apoptotic Process; Activation of the apoptotic caspases; Effect of caspase-mediated cleavage on target substrates - gain- or loss-of-function; Cleavage of caspase substrates leads to key morphological changes during apoptosis; Cytoskeletal events and membrane blebbing; Nuclear events; Changes in the Golgi apparatus; Caspases alter the transcriptional and translational machinery; Survival pathways are targeted during apoptosis; The apoptotic cell calls for its own disposal; Caspase-independent cell death; Concluding Remarks; References; Further Reading The BCL-2 Family Proteins - Key Regulators and Effectors of Apoptosis |
| Record Nr. | UNINA-9910459346203321 |
| Chichester, West Sussex ; ; Hoboken, NJ, : John Wiley & Sons, 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cell death [[electronic resource] /] / editors, Gerry Melino, David Vaux
| Cell death [[electronic resource] /] / editors, Gerry Melino, David Vaux |
| Pubbl/distr/stampa | Chichester, West Sussex ; ; Hoboken, NJ, : John Wiley & Sons, 2010 |
| Descrizione fisica | 1 online resource (317 p.) |
| Disciplina | 571.9/36 |
| Altri autori (Persone) |
MelinoGerry
VauxDavid |
| Soggetto topico |
Apoptosis
Cell death |
| ISBN |
1-282-54809-3
9786612548093 0-470-68657-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Cell Death; Copyright Page; Contents; Contributors; Preface; The Siren's Song: This Death That Makes Life Live; References; Further Reading; The Origin and Evolution of Programmed Cell Death; Introduction; Origins: From the Question 'When' to the Question 'How'; From Predator/Prey Coevolution to Symbioses: A 'Red Queen' Hypothesis in the Bacteria World; A Stable Evolutionary Strategy despite High Individual Costs; The 'Original Sin' Hypothesis: Self-destruction as an Unavoidable Consequence of Life; C. elegans Model: From Paradigm to Paradox; Walking Around the Evolutionary Bush
From the Origins of Programmed Cell Death to the Origins of Ageing'There is Grandeur in This View of Life...'; References; Further Reading; Cell Death in C. elegans; ced-3, ced-4, ced-9 and egl-1 are Conserved Genes Essential for Programmed Cell Death in C. elegans; Regulation of Cell Death during Somatic Development; Engulfment of Dying Cells; Germline Apoptosis; DNA Damage-induced Germline Apoptosis; Conclusion; References; Further Reading; Caspases and Cell Death; History and Classification; Structure and Active Site; Substrate Recognition and Mechanism of Action; Sequence of Action Substrates during ApoptosisInhibitors; Caspase Knockouts; Pathological Implications; Therapeutic Outlook; References; Further Reading; The Apoptosome: The Executioner of Mitochondria-mediated Apoptosis; Introduction; The Apoptosome Structure: Its Components and Its Assembly; Apaf1; Apoptosome assembly; Caspase-9; Cytochrome c; Modulation of the Apoptosome Formation; Apoptosome-like Complexes in Evolution. Is the Mitochondrial Pathway of Apoptosis Conserved?; Caenorhabditis elegans; Drosophila melanogaster; The Role of the Apoptosome in Mammalian Development; Caspase-9 knockout; Apaf1 knockout Cytochrome c deficiencyFinal Remarks; References; Further Reading; Caspases, Substrates and Sequential Activation; Introduction; Caspases Classification and Structure; Pathways That Lead to Caspase Activation; Extrinsic pathway; Granzyme B pathway; Intrinsic pathway; Effectors of demolition; Demolition Phase of Apoptosis; Detachment, rounding and blebbing; Nuclear fragmentation, DNA condensation and degradation; Undermining cell physiology; Immune Clearance and Immune Tolerance of Apoptotic Cells; Conclusions; Acknowledgements; References; Further Reading; Dismantling the Apoptotic Cell IntroductionCaspases: Regulators of the Apoptotic Process; Activation of the apoptotic caspases; Effect of caspase-mediated cleavage on target substrates - gain- or loss-of-function; Cleavage of caspase substrates leads to key morphological changes during apoptosis; Cytoskeletal events and membrane blebbing; Nuclear events; Changes in the Golgi apparatus; Caspases alter the transcriptional and translational machinery; Survival pathways are targeted during apoptosis; The apoptotic cell calls for its own disposal; Caspase-independent cell death; Concluding Remarks; References; Further Reading The BCL-2 Family Proteins - Key Regulators and Effectors of Apoptosis |
| Record Nr. | UNINA-9910792418603321 |
| Chichester, West Sussex ; ; Hoboken, NJ, : John Wiley & Sons, 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cell death [[electronic resource] /] / editors, Gerry Melino, David Vaux
| Cell death [[electronic resource] /] / editors, Gerry Melino, David Vaux |
| Pubbl/distr/stampa | Chichester, West Sussex ; ; Hoboken, NJ, : John Wiley & Sons, 2010 |
| Descrizione fisica | 1 online resource (317 p.) |
| Disciplina | 571.9/36 |
| Altri autori (Persone) |
MelinoGerry
VauxDavid |
| Soggetto topico |
Apoptosis
Cell death |
| ISBN |
1-282-54809-3
9786612548093 0-470-68657-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Cell Death; Copyright Page; Contents; Contributors; Preface; The Siren's Song: This Death That Makes Life Live; References; Further Reading; The Origin and Evolution of Programmed Cell Death; Introduction; Origins: From the Question 'When' to the Question 'How'; From Predator/Prey Coevolution to Symbioses: A 'Red Queen' Hypothesis in the Bacteria World; A Stable Evolutionary Strategy despite High Individual Costs; The 'Original Sin' Hypothesis: Self-destruction as an Unavoidable Consequence of Life; C. elegans Model: From Paradigm to Paradox; Walking Around the Evolutionary Bush
From the Origins of Programmed Cell Death to the Origins of Ageing'There is Grandeur in This View of Life...'; References; Further Reading; Cell Death in C. elegans; ced-3, ced-4, ced-9 and egl-1 are Conserved Genes Essential for Programmed Cell Death in C. elegans; Regulation of Cell Death during Somatic Development; Engulfment of Dying Cells; Germline Apoptosis; DNA Damage-induced Germline Apoptosis; Conclusion; References; Further Reading; Caspases and Cell Death; History and Classification; Structure and Active Site; Substrate Recognition and Mechanism of Action; Sequence of Action Substrates during ApoptosisInhibitors; Caspase Knockouts; Pathological Implications; Therapeutic Outlook; References; Further Reading; The Apoptosome: The Executioner of Mitochondria-mediated Apoptosis; Introduction; The Apoptosome Structure: Its Components and Its Assembly; Apaf1; Apoptosome assembly; Caspase-9; Cytochrome c; Modulation of the Apoptosome Formation; Apoptosome-like Complexes in Evolution. Is the Mitochondrial Pathway of Apoptosis Conserved?; Caenorhabditis elegans; Drosophila melanogaster; The Role of the Apoptosome in Mammalian Development; Caspase-9 knockout; Apaf1 knockout Cytochrome c deficiencyFinal Remarks; References; Further Reading; Caspases, Substrates and Sequential Activation; Introduction; Caspases Classification and Structure; Pathways That Lead to Caspase Activation; Extrinsic pathway; Granzyme B pathway; Intrinsic pathway; Effectors of demolition; Demolition Phase of Apoptosis; Detachment, rounding and blebbing; Nuclear fragmentation, DNA condensation and degradation; Undermining cell physiology; Immune Clearance and Immune Tolerance of Apoptotic Cells; Conclusions; Acknowledgements; References; Further Reading; Dismantling the Apoptotic Cell IntroductionCaspases: Regulators of the Apoptotic Process; Activation of the apoptotic caspases; Effect of caspase-mediated cleavage on target substrates - gain- or loss-of-function; Cleavage of caspase substrates leads to key morphological changes during apoptosis; Cytoskeletal events and membrane blebbing; Nuclear events; Changes in the Golgi apparatus; Caspases alter the transcriptional and translational machinery; Survival pathways are targeted during apoptosis; The apoptotic cell calls for its own disposal; Caspase-independent cell death; Concluding Remarks; References; Further Reading The BCL-2 Family Proteins - Key Regulators and Effectors of Apoptosis |
| Record Nr. | UNINA-9910821097203321 |
| Chichester, West Sussex ; ; Hoboken, NJ, : John Wiley & Sons, 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||