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miRNAs, Human Health and Diseases / / edited by Luis M. Vaschetto
| miRNAs, Human Health and Diseases / / edited by Luis M. Vaschetto |
| Autore | Vaschetto Luis M |
| Edizione | [1st ed. 2024.] |
| Pubbl/distr/stampa | Cham : , : Springer Nature Switzerland : , : Imprint : Springer, , 2024 |
| Descrizione fisica | 1 online resource (381 pages) |
| Disciplina | 572.865 |
| Collana | Epigenetics and Human Health |
| Soggetto topico |
Epigenetics
Genetics Molecular genetics Cancer - Genetic aspects Genetics and Genomics Molecular Genetics Cancer Genetics and Genomics |
| ISBN | 3-031-64788-2 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Chapter 1. MiRNomics: An Introduction to MicroRNA Biology -- Chapter 2. MicroRNA Databases -- Chapter 3. Bioinformatics Tools to Study the Role of miRNAs -- MicroRNAs as Promising Therapeutic Targets -- Chapter 4. MicroRNAs as Promising Therapeutic Targets -- Chapter 5. The Interplay Between MicroRNAs and Genetic Diseases -- Chapter 6. Circulating miRNAs as Biomarkers for Early Disease Diagnosis -- Chapter 7. miRNAs as Biomarkers for Neurodegenerative Diseases -- Chapter 8. MicroRNAs and Immune-Related Disorders -- Chapter 9. MicroRNAs and Cardiovascular Diseases -- Chapter 10. miRNAs in Aging -- Chapter 11. MicroRNAs in Viral Infection -- Chapter 12. Inter-Kingdom Signalling: Exploring the Relationships among Microorganisms and microRNAs in Human Health. |
| Record Nr. | UNINA-9910890193403321 |
Vaschetto Luis M
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| Cham : , : Springer Nature Switzerland : , : Imprint : Springer, , 2024 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular Mechanisms in Nutritional Epigenetics
| Molecular Mechanisms in Nutritional Epigenetics |
| Autore | Vaschetto Luis M |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Cham : , : Springer, , 2024 |
| Descrizione fisica | 1 online resource (300 pages) |
| Collana | Epigenetics and Human Health Series |
| ISBN | 3-031-54215-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Preface -- Contents -- About the Editor and Contributors -- About the Editor -- Contributors -- Chapter 1: A Brief Introduction to Diet and DNA Methylation -- 1.1 Introduction -- 1.2 DNA Methylation and Nutrients -- 1.3 Dietary Factors and Modulation of DNA Methylation -- 1.4 Phytochemicals and DNA Methylation -- 1.5 Conclusion -- References -- Chapter 2: Diet-Induced Histone Modifications: Implications for Human Health and Diseases -- 2.1 Introduction -- 2.1.1 Histone Modifications -- 2.1.2 Histone Acetylation -- 2.1.3 Histone Phosphorylation -- 2.1.4 Histone Methylation -- 2.2 Misregulated Histone Modifications in Cancers -- 2.3 Diet and Histone Modifications -- 2.3.1 Diet and Histone Methylation -- 2.3.2 Diet and Histone Acetylation -- 2.3.3 Diet and Histone Phosphorylation -- 2.4 Conclusions and Future Directions -- References -- Chapter 3: Non-Coding RNAs and Diet -- 3.1 Introduction -- 3.2 Types of Non-Coding RNAs -- 3.2.1 Long Non-Coding RNAs (lncRNAs) and Their Biogenesis -- 3.2.2 MicroRNAs and Their Biogenesis -- 3.2.3 Piwi-Interacting RNAs (piRNAs) and Their Biogenesis -- 3.2.4 Small-Interfering RNAs and Their Biogenesis -- 3.2.5 Circular RNAs and Their Biogenesis -- 3.3 Diet and Non-Coding RNAs -- 3.3.1 Long Non-Coding RNAs and Diet -- 3.3.2 MicroRNAs and Diet -- 3.3.3 Circular RNAs and Diet -- 3.3.4 Dietary Elements, ncRNA Targets, and Metabolic Disorders -- 3.4 Conclusion -- References -- Chapter 4: Epigenetics and Nutrition: Molecular Mechanisms and Tissue Adaptation in Developmental Programming -- 4.1 Introduction -- 4.2 Parental Nutrition and Programming of Fetal Development: Effects and Potential Mechanisms -- 4.3 Maternal Effects: Placenta Development and Function -- 4.4 Fetal Effects: Tissue Programming and Function -- 4.4.1 Liver Programming and Function -- 4.4.2 Muscle Programming and Function.
4.5 Concluding Remarks and Perspectives -- References -- Chapter 5: Nutrition and Epigenetic Modifications During Pregnancy -- 5.1 Introduction -- 5.2 Maternal Nutrition and Health -- 5.2.1 The Effects of Maternal Nutrition on Fetal Growth and Development -- 5.2.2 Long-Term Implications of Maternal Malnutrition and Overnutrition -- 5.3 Maternal Nutrition and Epigenetics -- 5.3.1 Understanding Epigenetics and Its Transgenerational Inheritance -- 5.3.2 Critical Periods of Vulnerability for Epigenetic Programming During Pregnancy -- 5.3.3 Pathways Linking Diet and Epigenetics -- 5.3.4 Animal Studies Investigating the Influence of Maternal Nutrition on Fetal Programming -- 5.3.5 Human Studies Examining Changes in Offspring Epigenome in Response to Maternal Nutrition -- 5.3.6 Long-Term Consequences of Altered Epigenetic Marks in Offspring -- 5.3.7 Potential for Interventions to Modify Epigenetic Marks and Improve Health Outcomes -- 5.4 Conclusion -- References -- Chapter 6: Nutrition, Epigenetics, and Stem Cells -- 6.1 Introduction -- 6.2 Epigenetics and Stem Cell Differentiation -- 6.3 Epigenetic Modifiers and Stem Cell Differentiation -- 6.3.1 DNA Methylation Inhibitors -- 6.3.2 Histone Deacetylase Inhibitors -- 6.3.3 The Combination of Both Modifier Classes -- 6.4 Nutrition, Epigenetics, Stem Cell Differentiation Axis -- 6.4.1 Examples of the Nutritional Constituents' Effect on Stem Cells Through Epigenetics -- 6.4.1.1 Curcumin -- 6.4.1.2 Fatty Acid-Rich Diets -- 6.4.1.3 Protein Low Diet -- 6.4.1.4 Ascorbic Acid -- 6.4.1.5 Choline-Rich Diet -- 6.4.1.6 Folic Acid Supplements -- 6.4.2 Nutritional Contaminants Effect on the Epigenetic, Stem Cell Differentiation Axis -- 6.4.2.1 Reactive Oxygen Species (ROS) -- 6.4.2.2 Bisphenol A -- 6.4.2.3 Pesticides -- 6.5 Microbiota-Induced Epigenetic Alteration -- 6.6 Knowledge Gaps -- 6.7 Conclusion -- References. Chapter 7: Nutritional Epigenetics and Gut Microbiome -- 7.1 Introduction to the Gut Microbiota -- 7.2 Composition of the Gut Microbiota -- 7.2.1 Bacterial and Non-Bacterial Microbes -- 7.2.1.1 Bacterial Community -- 7.2.1.2 Non-Bacterial Microbes -- 7.3 Development of the Gut Microbiota -- 7.4 Factors Affecting the Gut Microbiota -- 7.4.1 Diet and Nutrition -- 7.4.1.1 Carbohydrates -- 7.4.1.2 Fats -- 7.4.1.3 Protein -- 7.4.1.4 Vitamins -- 7.4.2 Antibiotics and Medications -- 7.4.3 Age -- 7.4.3.1 Physiological Changes -- 7.4.3.2 Lifestyle Influences -- 7.5 Functions of the Gut Microbiota -- 7.5.1 Nutrient Metabolism and Appetite Regulation -- 7.5.2 Immune System Interactions -- 7.5.3 Gut Barrier Function -- 7.5.4 Xenobiotic Metabolism -- 7.6 Microbiota and Long-Term Health/Disease -- 7.6.1 Metabolic Health -- 7.6.2 Gastrointestinal Disorders -- 7.6.3 Neurological and Mental Health -- 7.6.4 Immune Disorders -- 7.6.5 Other Disease Associations -- 7.6.6 Elderly Diseases -- 7.7 Gut Microbiome-Epigenome Crosstalk -- 7.7.1 Epigenetic Modifications -- 7.7.2 Role of the Microbiota and Its Metabolites in Epigenetic Processes -- 7.7.3 Other Mechanisms of Microbiota-Epigenetic Interactions -- 7.7.3.1 Immune System Interactions -- 7.7.3.2 Microbial DNA and RNA -- 7.7.3.3 Maternal-Fetal Microbiome Transfer -- 7.7.4 Evidence of Microbiota-Epigenetic-Environmental Interactions in Health and Disease -- 7.8 Therapeutic Strategies -- 7.8.1 Therapeutic Agents Enhance Gut Barrier Function by Regulating Host Metabolism -- 7.9 Conclusion -- References -- Chapter 8: Nutrition, Epigenetics, and Circadian Rhythms -- 8.1 Introduction -- 8.2 Molecular Regulation of the Biological Clock -- 8.3 Interaction Mechanisms Between the Biological Clock and Epigenetics -- 8.3.1 Histone Modification -- 8.3.2 DNA Methylation -- 8.3.3 Non-Coding RNA. 8.4 4Effect of Circadian Rhythms on Nutrient Metabolism -- 8.5 Nutrition, Circadian Rhythms, and Human Metabolic Diseases -- 8.6 Conclusion -- References -- Chapter 9: Exercise and Nutrition: Metabolic Partners in Epigenetic Regulation -- 9.1 Introduction -- 9.2 Methylation -- 9.2.1 Methyl Group Metabolism and Exercise -- 9.2.2 Mechanisms of Exercise-Induced Methylation -- 9.2.3 Effects of Dietary Factors on DNA Methylation -- 9.3 Demethylation -- 9.3.1 Mechanisms of Exercise-Induced Demethylation -- 9.3.2 Effects of Dietary Factors on DNA Hypomethylation -- 9.4 Acetylation -- 9.4.1 Mechanisms of Exercise-Induced Acetylation -- 9.4.2 Effects of Dietary Factors on Acetylation -- 9.5 Deacetylation -- 9.5.1 Mechanisms of Exercise-Induced Deacetylation -- 9.5.2 Effects of Dietary Factors on Deacetylation -- 9.5.3 Exercise-Induced SIRT1 and Circadian Regulation -- 9.5.4 Dietary Factors, Fat Tissue, Epigenetics, and Circadian Regulation -- 9.6 Conclusion -- References -- Chapter 10: Epigenetic Control and Obesity -- 10.1 Introduction -- 10.2 DNA Methylation and Obesity -- 10.3 Dietary Interventions on Weight Loss and Changes of DNA Methylation -- 10.4 miRNAs, lncRNAs, and circRNAs in Obesity -- 10.5 Conclusions -- References -- Chapter 11: Diet, Epigenetics, and Cardiovascular Disease -- 11.1 Introduction -- 11.2 Dietary Patterns -- 11.2.1 Mediterranean Diet -- 11.2.2 DASH Diet -- 11.2.3 Plant-Based Diet -- 11.2.4 Low-Carbohydrate Diet -- 11.3 Impact of Diet and Nutrients on CVD -- 11.3.1 Atherosclerosis -- 11.3.1.1 Lipids -- 11.3.1.2 Dietary Fiber -- 11.3.1.3 Gut Microbes -- 11.3.2 Heart Failure -- 11.3.2.1 Sodium Intake -- 11.3.2.2 Fatty Acids -- 11.3.2.3 Protein -- 11.3.2.4 Micronutrients -- 11.3.3 Hypertension -- 11.3.3.1 Sodium and Potassium Ions -- 11.3.3.2 Energy Intake -- 11.4 Epigenomic Regulation of Dietary Components -- 11.4.1 DNA Methylation. 11.4.2 Histone Modification -- 11.4.3 MicroRNA -- 11.5 Epigenetics of Dietary Modulation in Cardiovascular Health -- 11.5.1 DNA Methylation -- 11.5.2 Histone Modification -- 11.5.3 MicroRNA -- 11.6 Conclusion -- References -- Chapter 12: Epigenetic Pathways from Dietary Fat to Psychopathology -- 12.1 Introduction -- 12.2 Global Changes in DNA Methylation -- 12.3 Altered Histone Modification -- 12.4 RNA as an Epigenetic Modulator -- 12.5 Increased Stress Reactivity -- 12.6 Impaired Synaptic Plasticity and Neurogenesis -- 12.7 Leptin, FTO and RNA Methylation -- 12.8 Neurodegeneration and Alzheimer's Dementia -- 12.9 The Autism (ASD) Phenotype -- 12.10 Reward Processing -- 12.11 Sex Differences in Epigenetic Responses to an HFD -- 12.12 Good Fats: PUFAs, MUFAs and SCFAs -- 12.13 An Evolutionary Perspective -- 12.14 Discussion -- References. |
| Record Nr. | UNINA-9910864181003321 |
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Vaschetto Luis M
|
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| Cham : , : Springer, , 2024 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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