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Scleroderma : From Pathogenesis to Comprehensive Management / / edited by John Varga, Christopher P. Denton, Fredrick M. Wigley, Yannick Allanore, Masataka Kuwana
| Scleroderma : From Pathogenesis to Comprehensive Management / / edited by John Varga, Christopher P. Denton, Fredrick M. Wigley, Yannick Allanore, Masataka Kuwana |
| Edizione | [2nd ed. 2017.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017 |
| Descrizione fisica | 1 online resource (XXXV, 743 p. 191 illus., 174 illus. in color.) |
| Disciplina | 616.723 |
| Soggetto topico |
Rheumatology
Respiratory organs—Diseases Dermatology Pneumology/Respiratory System |
| ISBN | 3-319-31407-6 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Section I. Introduction -- Historical Perspective of Scleroderma -- Section II. Epidemiology, Genetics and Classification -- Epidemiology, Environmental and Infectious Risk Factors -- Genetic Factors -- Disease Subsets in Clinical Practice -- Evolving Concepts of Diagnosis and Classification -- Overlap Syndromes -- Juvenile Localized and Systemic Scleroderma -- Morphea (Localized Scleroderma) -- Scleroderma Mimics -- Systems Biology Approaches to Understanding the Pathogenesis of Systemic Sclerosis -- Section III: The Biological Basis of Systemic Sclerosis -- Introduction: The Etiopathogenesis of Systemic Sclerosis: An Integrated Overview -- Pathology of Systemic Sclerosis -- Inflammation and Immunity -- Autoantibodies as Markers and Possible Mediators of Scleroderma Pathogenesis -- The Clinical Aspects of Autoantibodies -- Mechanisms of Vascular Disease -- Biomarkers in Systemic Sclerosis -- Pathophysiology of Fibrosis in Systemic Sclerosis -- Overview of Animal Models -- Section IV. Cardiovascular Manifestations and Management -- Raynaud’s Phenomenon, Digital Ulcers, and Nailfold Capillaroscopy -- Renal Crisis and Other Renal Manifestations of Scleroderma -- Cardiac Involvement -- Section V. Pulmonary Manifestations and Management -- Overview of Lung Involvement: Diagnosis, Differential Diagnosis, and Monitoring -- Clinical Assessment of Lung Disease -- Treatment of Interstitial Lung Disease -- Pathogenesis of Pulmonary Arterial Hypertension -- Clinical Assessment of Pulmonary Hypertension -- The Management of Pulmonary Arterial Hypertension in the Setting of Systemic Sclerosis -- Section VI. Gastrointestinal Manifestations and Management -- Overview of Gastrointestinal Tract Involvement -- Upper Gastrointestinal Tract: Manifestations of Systemic Sclerosis -- Small and Large Intestinal Involvement and Nutritional Issues -- Section VII. Skin, Musculoskeletal and Other Complications -- Calcinosis -- Evaluation and Management of Skin Disease -- Assessment and Management of Progressive Skin Involvement in Diffuse Scleroderma -- Skeletal Muscle Involvement -- Tendons, Joints, and Bone -- Cancer in Systemic Sclerosis -- Overlooked Manifestations -- Pregnancy -- Section VIII: Management and Outcome Assessment -- Introduction to Section VIII: Management and Outcome Assessment -- Immunomodulatory, Immunoablative, and Biologic Therapies -- Investigative Approaches to Drug Therapy -- Drug Development and Regulatory Considerations for SSc Therapies -- Physical and Occupational Therapy -- Psychosocial Issues and Care for Patients with Systemic Sclerosis -- Clinical Trial Design in Systemic Sclerosis -- Measuring Disease Activity and Outcomes in Clinical Trials -- Innovative Approaches to Clinical Trials in Systemic Sclerosis -- Molecular Stratification by Gene Expression as a Paradigm for Precision Medicine in Systemic Sclerosis -- Section IX. Case Studies: Approach to Complex Clinical Problems -- Managing the Ischemic Finger in Scleroderma -- Scleroderma Renal Crisis -- Rapid Diffuse Skin Disease with Progressive Joint Contractures -- Management of the Scleroderma Patient with Pulmonary Arterial Hypertension Failing Initial Therapy -- Pseudo-obstruction with Malabsorption and Malnutrition -- Progressive Interstitial Lung Disease Non-Response to Cyclophosphamide -- Coping with the Disfigurement of Scleroderma: Facial, Skin, and Hand Changes -- Managing Complicated Digital Ulcers . |
| Record Nr. | UNINA-9910149482403321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Scleroderma : from pathogenesis to comprehensive management / / John Varga, Christopher P. Denton, Fredrick M. Wigley, editors
| Scleroderma : from pathogenesis to comprehensive management / / John Varga, Christopher P. Denton, Fredrick M. Wigley, editors |
| Pubbl/distr/stampa | New York, : Springer, 2012 |
| Descrizione fisica | 1 online resource (677 p.) |
| Disciplina | 616.544 |
| Altri autori (Persone) |
VargaJohn
DentonC. P (Christopher P.) WigleyFrederick M |
| Soggetto topico |
Scleroderma (Disease) - Pathogenesis
Scleroderma (Disease) - Treatment |
| ISBN |
1-280-39918-X
9786613577108 1-4419-5774-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | pt. 1. Introduction -- pt. 2. Epidemiology, genetics and classification -- pt. 3. Scleroderma in children -- pt. 4. Other fibrosing skin conditions -- pt. 5. Pathogenetic basis -- pt. 6. Cardiovascular manifestations and management -- pt. 7. Pulmonary manifestations and management -- pt. 8. Gastrointestinal manifestations and management -- pt. 9. Skin, musculoskeletal and other complications -- pt. 10. Disease-modifying strategies -- pt. 11. Outcome assessment. |
| Record Nr. | UNINA-9910698683703321 |
| New York, : Springer, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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