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Adult Stem Cells / / edited by Kursad Turksen
| Adult Stem Cells / / edited by Kursad Turksen |
| Edizione | [2nd ed. 2014.] |
| Pubbl/distr/stampa | New York, NY : , : Springer New York : , : Imprint : Humana, , 2014 |
| Descrizione fisica | 1 online resource (433 p.) |
| Disciplina | 571.8/35 |
| Collana | Stem Cell Biology and Regenerative Medicine |
| Soggetto topico |
Stem cells
Biotechnology Cytology Stem Cells Cell Biology |
| ISBN | 1-4614-9569-5 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Signaling Pathways Maintaining Stemness in Adult Hematopoietic Stem Cells -- The Adult Stem Cell Niche -- Adult Stem Cells: Adult Skeletal Muscle Stem Cells -- Adult Cardiac Stem Cells: Identity, Location and Potential -- Adult Pituitary Stem Cells -- Toward Translating Molecular Ear Development to Generate Hair Cells from Stem Cells -- Adult Human Corneal Epithelial Stem Cells -- Adult Stem Cells in Teeth -- Adult Mammary Stem Cells: Identity, Location and Functional Assays -- Adult Ovary Stem Cells -- Adult Prostate Stem Cells -- Adult Lung Stem Cells -- Adult Liver Stem Cells -- Lineage-committed Pancreatic Progenitors and Stem Cells -- Adult Stromal (Skeletal, Mesenchymal) Stem Cells -- Regeneration after Injury - Activation of Stem Cell Stress Response Pathways to Rapidly Repair Tissues -- Molecular and Endocrine Mechanisms Underlying the Stem Cell Theory of Aging. |
| Record Nr. | UNINA-9910298303903321 |
| New York, NY : , : Springer New York : , : Imprint : Humana, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Autophagy in Health and Disease : Potential Therapeutic Approaches / / edited by Kursad Turksen
| Autophagy in Health and Disease : Potential Therapeutic Approaches / / edited by Kursad Turksen |
| Edizione | [1st ed. 2018.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Humana, , 2018 |
| Descrizione fisica | 1 online resource (182 pages) |
| Disciplina | 571.936 |
| Collana | Stem Cell Biology and Regenerative Medicine |
| Soggetto topico |
Cell cycle
Cell physiology Pharmaceutical technology Metabolism - Disorders Cell Cycle Analysis Cell Physiology Pharmaceutical Sciences/Technology Metabolic Diseases |
| ISBN | 3-319-98146-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Autophagy and Stem cells -- Fine-Tuning the Stem Cell Fate by Autophagy -- Role of Autophagy in Aging of Hematopoietic Stem Cells and Their Niche: Relevance in Clinical Transplantations and Regenerative Medicine -- Forkhead box O (FoxO) Transcription Factors in Autophagy, Metabolic Health, and Tissue Homeostasis -- The Role of mTOR in Osteoclasts -- Apoptotic Cell Clearance in Gut Tissue-Role of Intestinal Regeneration -- Autophagic Regulation of Cardiomyocyte Survival and Heart Regeneration -- The Role of Autophagy in Mesenchymal Stem Cell-Based Suppression of Immune Response -- Emerging Connections: Presynaptic Autophagy in Brain Aging and Neurodegenerative Diseases -- Virus and Autophagy: Enemies or Allies -- Cancer Stem Cells and Autophagy: Present Knowledge and Future Perspectives. |
| Record Nr. | UNINA-9910298411803321 |
| Cham : , : Springer International Publishing : , : Imprint : Humana, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Autophagy in Stem Cell Maintenance and Differentiation / / edited by Bhupendra V. Shravage, Kursad Turksen
| Autophagy in Stem Cell Maintenance and Differentiation / / edited by Bhupendra V. Shravage, Kursad Turksen |
| Edizione | [1st ed. 2023.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2023 |
| Descrizione fisica | 1 online resource (290 pages) |
| Disciplina |
050
616.02774 |
| Collana | Stem Cell Biology and Regenerative Medicine |
| Soggetto topico |
Cancer
Stem cells Cytology Developmental biology Cancer Stem Cells Cell Biology Developmental Biology and Stem Cells |
| ISBN | 3-031-17362-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Assays for monitoring autophagy in stem cells -- Autophagy in Stem Cell Maintenance and Differentiation -- Autophagy in Embryonic stem cells and Neural stem cells -- Autophagy in Germline Stem Cells -- The role of autophagy in the regulation of hematopoietic stem cells -- Autophagy in Muscle Stem Cells -- Autophagy in Intestinal Stem Cells -- The autophagy lysosomal pathway: friend or foe in adult neural stem cells? -- Autophagy in Mesenchymal Stem Cell-based therapy -- Autophagic control of stem cells differentiation into osteogenic lineage- Implications in bone disorders -- Autophagy in Cancer Metastasis. |
| Record Nr. | UNINA-9910629289703321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2023 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Biology in Stem Cell Niche / / edited by Kursad Turksen
| Biology in Stem Cell Niche / / edited by Kursad Turksen |
| Edizione | [1st ed. 2015.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015 |
| Descrizione fisica | 1 online resource (239 p.) |
| Disciplina | 616.02774 |
| Collana | Stem Cell Biology and Regenerative Medicine |
| Soggetto topico |
Stem cells
Biomedical engineering Stem Cells Biomedical Engineering and Bioengineering |
| ISBN | 3-319-21702-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Preface; Contents; Editor and Contributors; 1 The Hematopoietic Stem Cell Niche: Cell-Cell Interactions and Quiescence; 1 Introduction; 2 Cell-Cell Interactions; 2.1 Endothelial Cells; 2.2 Mesenchymal-Derived Cells of the Hematopoietic Stem Cell Niche; 2.2.1 Chemokine Ligand 12 Expressing Cells; 2.2.2 Nestin Expressing Cells; 2.2.3 Osteoblasts; 2.2.4 Leptin-Receptor Expressing Cells; 2.2.5 CD146 Expressing Cells; 2.2.6 Bone Cartilage Stromal Progenitor Cells; 3 Other Niche Cells; 3.1 Megakaryocytes; 3.1.1 Non-myelinated Schwann Cells; 3.1.2 Monocytes/Macrophages
3.1.3 Sympathetic Nervous System4 Hematopoietic Stem Cell Niche Structure and Physiology; 4.1 Integrins; 4.2 Wnts; 4.3 Hypoxia; 4.4 Energetics; 5 Intrinsic Regulators of Cell Cycle; 6 Conclusions; Acknowledgments; References; 2 The Mammalian Limbal Stem Cell Niche: A Complex Interaction Between Cells, Growth Factors and Extracellular Matrix; 1 Introduction; 2 Defining the Limbus as the Residence Site for Corneal Stem Cells; 3 The Limbus: Its Structure and Composition; 3.1 Corneal Epithelial Stem Cells and Their Niche: Cells that Interact with the Limbal Stem Cell Reservoir 3.1.1 Epithelial Cells3.1.2 Melanocytes; 3.1.3 Langerhans' Cells; 3.1.4 Stromal Cells; 3.1.5 Corneal Innervation; 3.2 Corneal Epithelial Stem Cells and Their Niche: Basal Membrane and Extracellular Matrix Components; 3.3 Corneal Epithelial Stem Cells and Their Niche: Growth Factors and Cytokines; 4 The Niche as Regulator of Limbal Stem Cells; 5 Corneal Epithelial Stem Cells: Renewal and Wound Healing; 6 Limbal Stem Cells and Therapy; 7 Conclusion; Acknowledgements; References; 3 Emerging Engineering Strategies for Studying the Stem Cell Niche; 1 Introduction; 2 Stem Cells and Their Niches 3 Stem Cell-ECM Interactions3.1 Stem Cell Adhesion to Niche ECM via Integrins; 3.2 Cadherins, Another Class of Adhesion Receptors; 3.3 Molecular Sequestering of Growth Factors and Cytokines by ECM; 4 Seminal Engineering Strategies---Establishing a Foundation; 4.1 Micro/Nanofabrication Techniques for Generating Pre-Printed Topographies; 4.2 Micropatterning Techniques to Relate Stem Cell Shape to Behavior; 4.3 Soft Matter Hydrogel Systems with Predefined Characteristics; 5 Second Generation Engineering Strategies---Increased Complexity with a Focus on Spatiotemporal Control 5.1 Biomaterials with Tunable Properties5.2 Spatiotemporal Control over Topography; 5.3 Spatiotemporal Control over Matrix Stiffness; 5.4 Dynamic Control of Integrin-Based Focal Adhesions; 6 Dissecting Cell-Cell Interactions within the Stem Cell Niche; 7 Early Approaches for Studying Stem Cell-Niche Cell Interactions In Vitro; 7.1 Patterned Bulk Stem Cell Co-Cultures; 7.2 Patterned 3D Stem Cell Co-Cultures; 8 Shifting Focus to Single-Cell Resolution and Artificial Niches; 8.1 Microfluidic Approaches for Single-Cell Co-Cultures; 8.2 Artificial Stem Cell-Niche Cell Signaling Approaches 9 Conclusions and Future Directions |
| Record Nr. | UNINA-9910298266103321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Bioprinting in Regenerative Medicine / / edited by Kursad Turksen
| Bioprinting in Regenerative Medicine / / edited by Kursad Turksen |
| Edizione | [1st ed. 2015.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015 |
| Descrizione fisica | 1 online resource (148 p.) |
| Disciplina | 571.889 |
| Collana | Stem Cell Biology and Regenerative Medicine |
| Soggetto topico |
Regenerative medicine
Tissue engineering Stem cells Biomedical engineering Regenerative Medicine/Tissue Engineering Stem Cells Biomedical Engineering and Bioengineering |
| ISBN | 3-319-21386-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Preface; Contents; Contributors; About the Editor; Bioinks for Bioprinting; 1 Introduction; 1.1 Elements of 3D Bioprinting; 1.2 Bioinks-Gels and Solutions; 1.3 Materials Used as Bioinks in Bioprinting; 1.4 Additives to Bioinks to Influence Cellular Behavior; 1.5 Cells for Bioprinting; 1.6 Chemical and Photosensitive Cross Linking of Solutions and Gels; 1.7 Summary; References; 3D Bioprinting and 3D Imaging for Stem Cell Engineering; 1 Introduction; 2 Three-Dimensional Bio-Printing Techniques; 2.1 Inkjet-Based Printing; 2.2 Extrusion-Based Printing; 2.3 Laser Direct-Write
3 Bio-Printing for Stem Cell Engineering3.1 Stem Cell Niche; 3.2 Bioprinting Applications to Influence Stem Cell Signaling and Differentiation; 4 3D Imaging Techniques for Cell and Tissue Engineering Applications; 4.1 Biomedical Imaging Modalities; 4.2 Optical Imaging Techniques; 4.3 Conclusion; 5 Integration of Macro- and Micro-Printing, and Optical Imaging for Stem Cell and Tissue Engineering Applications; 5.1 Integration of Macro- and Micro-Printing; 5.2 Integration of Bioprinting and Optical Imaging; References; Bioprinting with Live Cells; 1 Introduction; 2 Bioprinting with Live Cells 2.1 2D Patterning and Cell-Sheet Technology2.2 Inkjet-Based Bioprinting; 2.3 Self-Assembly Based Bioprinting; 2.4 Extrusion-Based Bioprinting; 3 Conclusion and Discussion on Stem Cell Printing; References; Hydrogels for Cell Encapsulation and Bioprinting; 1 Introduction; 2 Hydrogels as Bio-Ink; 3 Hydrogels as Bio-Paper; 4 Properties of Bioprinting Hydrogels; 4.1 Viscosity; 4.2 Gelation Time; 4.3 Water Content and Swelling; 4.4 Degradation; 4.5 Mechanical Properties; 5 Conclusions; References; Three-Dimensional Bioprinting in Regenerative Medicine; 1 Introduction; 2 Cell Printing 3 Microvasculature Printing4 Muscle Printing; 5 Cartilage Printing; 6 Bone Printing; 7 The Future; References; Bioprinting of Dynamic Human Organs-on-Chips: Enabling Technologies for Rapid Drug Development and Personalized Medicine; 1 Clinical Need for Organs-on-Chips; 1.1 History of Drug Discovery and Development; 1.2 Tissue Culture Bioassays; 1.3 Animal Models; 1.4 Advent of Organs-on-Chips; 1.5 Current Challenges; 2 Bioprinting Design and Fabrication; 2.1 Design; 2.2 Fabrication; 3 Regulatory Pathway and Future Directions; 3.1 Regulatory Pathway 3.2 Future Directions and Concluding ThoughtsReferences; Index |
| Record Nr. | UNINA-9910298458003321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Cell biology and translational medicine . Volume 18. : tissue differentiation, repair in health and disease / / edited by Kursad Turksen
| Cell biology and translational medicine . Volume 18. : tissue differentiation, repair in health and disease / / edited by Kursad Turksen |
| Edizione | [1st ed. 2023.] |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer Nature Switzerland AG, , [2023] |
| Descrizione fisica | 1 online resource (210 pages) |
| Disciplina | 616.02774 |
| Collana | Cell Biology and Translational Medicine |
| Soggetto topico |
Stem cells
Tissue engineering Tissues - Differentiation |
| ISBN |
9783031284243
9783031284236 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Mitochondrial Permeability Transition in Stem Cells, Development, and Disease -- HSF1, Aging, and Neurodegeneration -- Pathophysiology of Spinal Cord Injury and Tissue Engineering Approach for Its Neuronal Regeneration: Current Status and Future Prospects -- Application of Biocompatible Scaffolds in Stem-Cell-Based Dental Tissue Engineering -- Therapeutic Perspectives for the Clinical Application of Umbilical Cord Hematopoietic and Mesenchymal Stem Cells: Overcoming Complications Arising After Allogeneic Hematopoietic Stem Cell Transplantation -- Advanced Nanotechnology Approaches as Emerging Tools in Cellular-Based Technologies -- Generation of a Beta-Cell Transplant Animal Model of Diabetes Using CRISPR Technology -- The Link Between Heat Shock Proteins, Renin-Angiotensin System, and the Coagulation Cascade in the Pathogenesis of the Coronavirus-19 Disease -- Aptamer-Based Tumor-Targeted Diagnosis and Drug Delivery -- Heat Shock Proteins: Central Players in Oncological and Immuno-Oncological Tracks. |
| Record Nr. | UNINA-9910683340703321 |
| Cham, Switzerland : , : Springer Nature Switzerland AG, , [2023] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Cell biology and translational medicine . Volume 19. : perspectives in diverse human diseases and their therapeutic options / / edited by Kursad Turksen
| Cell biology and translational medicine . Volume 19. : perspectives in diverse human diseases and their therapeutic options / / edited by Kursad Turksen |
| Edizione | [1st ed. 2023.] |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, Springer Nature Switzerland AG, , [2023] |
| Descrizione fisica | 1 online resource (196 pages) |
| Disciplina | 616.02774 |
| Collana | Cell Biology and Translational Medicine |
| Soggetto topico |
Diseases - Treatment - Technological innovations
Stem cells - Therapeutic use |
| ISBN |
9783031284205
9783031284199 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Monkeypox and Sexually Transmitted Diseases -- Clinical Manifestations of Monkeypox -- Laboratory Diagnosis for Monkeypox: Clinical Practice and Important Points to Be Recognized -- Regulatory Mechanisms of Muscle Mass: The Critical Role of Resistance Training in Children and Adolescent -- HSF1 and Its Role in Huntington's Disease Pathology -- Leveraging Tissue Engineering for Skin Cancer Models -- Application of Drug Repurposing-Based Precision Medicine Platform for Leukaemia Patient Treatment -- Stem Cell-Derived Extracellular Vesicles as a Potential Therapeutic Tool for Eye Diseases: From Benchtop to Bedside -- Cannabinoids as Prospective Anti-Cancer Drugs: Mechanism of Action in Healthy and Cancer Cells -- Direct Reprogramming of Somatic Cells into Induced β-Cells: An Overview. |
| Record Nr. | UNINA-9910683343903321 |
| Cham, Switzerland : , : Springer, Springer Nature Switzerland AG, , [2023] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cell biology and translational medicine . Volume 16 : stem cells in tissue regeneration, therapy and drug discovery / / edited by Kursad Turksen
| Cell biology and translational medicine . Volume 16 : stem cells in tissue regeneration, therapy and drug discovery / / edited by Kursad Turksen |
| Edizione | [1st ed. 2022.] |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2022] |
| Descrizione fisica | 1 online resource (VIII, 193 p. 29 illus., 19 illus. in color.) |
| Disciplina | 617.51 |
| Collana | Cell Biology and Translational Medicine |
| Soggetto topico | Regenerative medicine |
| ISBN | 3-031-10638-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Epithelial Stem Cells: Making, Shaping and Breaking the Niche -- Parathyroid Cell Differentiation from Progenitor Cells and Stem Cells: Development, Molecular Mechanism, Function, and Tissue Engineering -- Regenerative Medicine Application of Mesenchymal Stem -- Identification of Small Molecules That Enhance the Expansion of Mesenchymal Stem Cells Originating from Bone Marrow -- Human-Induced Pluripotent Stem Cell-Based Models for Studying Sex-Specific Differences in Neurodegenerative Diseases -- Current Status, Barriers, and Future Directions for Humanized Mouse Models to Evaluate Stem Cell-Based Islet Cell Transplant -- Mesenchymal Stem Cell Therapy for Osteoarthritis: Practice and Possible Promises -- The Historical Relationship Between Meis1 and Leukemia -- An Overview of Zebrafish Modeling Methods in Drug Discovery and Development -- Cellular Stress Responses in Oocytes: Molecular Changes and Clinical Implications. |
| Record Nr. | UNINA-9910733721703321 |
| Cham, Switzerland : , : Springer, , [2022] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cell biology and translational medicine . Volume 15 : stem cells in tissue differentiation, regulation and disease. / / edited by Kursad Turksen
| Cell biology and translational medicine . Volume 15 : stem cells in tissue differentiation, regulation and disease. / / edited by Kursad Turksen |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2022] |
| Descrizione fisica | 1 online resource (209 pages) |
| Disciplina | 605 |
| Collana | Advances in Experimental Medicine and Biology |
| Soggetto topico | Stem cells |
| Soggetto non controllato |
Biology
Science |
| ISBN | 3-031-02378-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910574079003321 |
| Cham, Switzerland : , : Springer, , [2022] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cell biology and translational medicine . Volume 17 : stem cells in tissue differentiation, regulation and disease / / edited by Kursad Turksen
| Cell biology and translational medicine . Volume 17 : stem cells in tissue differentiation, regulation and disease / / edited by Kursad Turksen |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2022] |
| Descrizione fisica | 1 online resource (249 pages) |
| Disciplina | 617.51 |
| Collana | Advances in Experimental Medicine and Biology |
| Soggetto topico | Regenerative medicine |
| ISBN |
9783031205149
9783031205132 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Preface -- Contents -- Endothelialization and Inflammatory Reactions After Intracardiac Device Implantation -- 1 Introduction -- 2 Intracardiac Devices -- 2.1 PFO Occluders -- 2.1.1 Amplatzer PFO Occluder -- 2.1.2 Gore Septal Occluder -- 2.1.3 Flex II PFO Occluder -- 2.2 ASD Occluders -- 2.2.1 Amplatzer Septal Occluder -- 2.2.2 Occlutech ASD Occluder -- 2.3 Left Atrial Appendage Occluders -- 2.3.1 Watchman Device -- 2.3.2 Amulet Occluder -- 2.4 Transcatheter Aortic Valve Implantation -- 2.4.1 Edwards SAPIEN 3/SAPIEN 3 Ultra -- 2.4.2 Medtronic Evolut R/Evolut PRO -- 2.5 Leadless Pacemakers -- 3 Common Device Components -- 3.1 Nitinol -- 3.2 Titanium -- 3.3 Tungsten -- 3.4 Gold -- 3.5 Steel -- 4 Cardiac Injury, Wound Healing, and Regeneration - A Brief Overview -- 4.1 Pro-inflammatory Phase -- 4.2 Cell Proliferation Phase -- 4.3 Endothelialization and Resolution of Inflammation -- 5 Discussion -- 6 Conclusion -- 7 Limitations -- References -- Articular Cartilage Regeneration in Veterinary Medicine -- 1 Cartilage and Its (In)Ability to Heal -- 2 Osteoarthritis in Companion Animals -- 3 Pain Management of OA -- 3.1 Conservative Treatment -- 3.2 Novel Pain Management Treatment Options -- 3.2.1 Platelet-Rich Plasma -- 3.2.2 Anti-nerve Growth Factor Monoclonal Antibodies Therapy -- 3.2.3 Mesenchymal Stem Cells/Medicinal Signaling Cells -- 4 Surgical Treatment of OA and Cartilage Defects -- 4.1 Conventional Treatment Options -- 4.2 Reparative Treatment Techniques -- 4.3 Regenerative Treatment Options -- 4.3.1 Osteochondral Transplantation -- 4.3.2 Autologous Chondrocyte Implantation -- 4.3.3 Matrix-Induced ACI (MACI) -- 5 Attempts to Improve Existing Regenerative Treatment Options with the Use of Mesenchymal Stem Cells -- 5.1 Chondrogenic Differentiation of MSCs -- 5.2 Hypertrophy Associated with Chondrogenic Differentiation of MSCs.
5.3 Attempts at Reduction of MSC Hypertrophy -- 5.3.1 Co-culture -- 5.3.2 PTHrP -- 5.3.3 Matrilin-3 -- 5.3.4 Hypoxia -- 5.4 Biomaterials for Mimicking Native Cartilage Tissue -- 5.4.1 The Influence of the 3D Structure on MSCs -- 5.4.2 Influence of Biomaterial Properties on MSCS -- 5.4.3 General Structure of Biomaterials for Cell Encapsulation -- 5.4.4 Natural Biomaterials to Promote MSC Chondrogenesis -- Collagen -- Hyaluronic Acid -- Silk Fibroin -- Decellularized Cartilage Matrix -- 5.4.5 Role of Mechanical Stimulation in Cartilage Regeneration -- 5.4.6 Importance of Biomaterial Architecture -- 6 Summary -- References -- Adult Stem Cell Therapy as Regenerative Medicine for End-Stage Liver Disease -- 1 End-Stage Liver Disease -- 2 Liver Development and Regeneration -- 3 Stem Cell Therapy -- 3.1 Mesenchymal Stem Cells -- 3.2 Hematopoietic Stem Cells -- 3.3 Endothelial Progenitor Cells -- 3.4 Fetal Human Hepatocytes -- 3.5 Hepatic Lineage Differentiation -- 4 Cell Reprogramming -- 4.1 Induced Pluripotent Stem Cells (iPSC) -- 4.2 Human Liver Organoids (HLO) -- 5 General Perspective -- References -- An Affordable Approach of Mesenchymal Stem Cell Therapy in Treating Perianal Fistula Treatment -- 1 Introduction -- 2 Pathophysiology of Perianal Fistula -- 3 Mechanism of Action of MSCs -- 3.1 Homing Ability -- 3.2 Anti-Inflammatory Mechanism -- 3.3 Cell Proliferation Stage -- 3.4 Re-epithelisation and Tissue Remodelling -- 4 A more Affordable MSC Therapy in Treating PF -- 4.1 Cell Source -- 4.2 Manufacturing Scales -- 4.3 Preconditioning of MSCs -- 4.4 Genetically Modified MSCs -- 4.4.1 Improving Migration -- 4.4.2 Reduced Premature/Replicative Senescence -- 4.4.3 Cost -- 4.5 Cell-Free Therapy -- 5 Remaining Challenges and Conclusion -- References -- Virus, Exosome, and MicroRNA: New Insights into Autophagy -- 1 Autophagy -- 2 MicroRNA and Autophagy. 2.1 Regulation of Autophagy by MicroRNAs -- 2.2 MiRNAs Interactions in Chemo-Induced Autophagy -- 3 Exosome and Autophagy -- 4 Inhibition or Stimulation of Autophagy by the Virus -- 5 Autophagy Supporting Viral Replication -- 6 Conclusion -- References -- Epitranscriptomics Changes the Play: m6A RNA Modifications in Apoptosis -- 1 Introduction -- 2 Apoptosis -- 3 m6A RNA Modification -- 3.1 Deposition of m6A Modification -- 3.2 Fates of m6A Methylated RNAs -- 4 m6A Modifications in Apoptosis -- References -- The Fingerprints of Biomedical Science in Internal Medicine -- 1 Introduction -- 2 Internal Medicine: Background and Present Status -- 2.1 Common Diagnostic Methods -- 2.2 Common Treatment Options -- 3 Biomedical Science: Subsets and Applications -- 3.1 Cellular and Molecular Biology -- 3.1.1 Biochemistry -- 3.1.2 Genetics -- 3.2 Bioinformatics -- 3.3 Bioengineering -- 3.4 Bionanotechnology -- 3.5 Microbiology -- 3.6 Embryology -- 3.7 Physiology -- 4 Molecular Diagnostics and Multi-Omics Approaches -- 4.1 Molecular Imaging -- 4.2 Single-Cell Multi-Omics Analysis -- 5 Advanced Preclinical Models -- 6 The Next Generation of Treatments -- 6.1 Cell-Based Therapies -- 6.2 Gene-Based Therapies -- 6.3 Regenerative Personalized Medicine -- 7 Conclusion and Future Perspectives -- References -- Mesenchymal Stem Cell-Derived Extracellular Vesicles: Progress and Remaining Hurdles in Developing Regulatory Compliant Qualit... -- 1 Introductions -- 2 Biological Characterization of MSC-EVs -- 2.1 Current Scenario on MSC-EV Characterization Assays -- 3 Quality Control Regulation for MSC-EVs -- 3.1 Establishing QC Assays for EV-Based Products -- 4 Remaining Challenges -- 5 Conclusion -- References -- Pharmacological Effects of Caffeic Acid and Its Derivatives in Cancer: New Targeted Compounds for the Mitochondria -- 1 Background -- 2 Mitochondria in Cancer Cells. 3 Antineoplastic Agents Targeting Mitochondrial Function -- 4 Polyphenols as Antitumoral Agents -- 5 Caffeic Acid and Its Derivatives with Antitumoral Action -- 6 Mitochondriotropic Derivatives of Caffeic Acid -- 7 Conclusion -- References -- Systematically Assessing Natural Compounds´ Wound Healing Potential with Spheroid and Scratch Assays -- 1 Introduction -- 2 Materials and Methods -- 2.1 Cells and Culture Conditions -- 2.2 Spheroid Formation for Compound Screening -- 2.3 Dissolving Natural Compounds: Spheroid Treatment -- 2.4 Cell Viability and Stains -- 2.5 Scratch Wounds -- 2.6 Imaging and Measurements -- 2.7 Histology -- 2.8 Statistics -- 3 Results -- 3.1 NIH 3T3 Spheroids Self-Assemble from Cell Sheets in the Absence of Extracellular Matrix -- 3.2 Manuka Honey Is a Spheroid-Supporting Compound -- 3.3 Manuka Honey Increases Cell Motility in Scratch Wound Assays -- 4 Discussion -- 4.1 Scaffold-Free Spheroids from NIH 3T3 Cells Form by Substrate-Specific Collective Cellular Processes from Cell Sheets -- 4.2 Using Spheroids and Scratch Wound Healing Assays to Screen Natural Compounds -- 4.3 Usefulness of Our Proposed Workflow -- References -- Index. |
| Record Nr. | UNINA-9910624305003321 |
| Cham, Switzerland : , : Springer, , [2022] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
