Info
- Utilizzare la checkbox di selezione a fianco di ciascun documento per attivare le funzionalità di stampa, invio email, download nei formati disponibili del (i) record.
Experimental glycoscience Glycochemistry [[electronic resource] /] / N. Taniguchi ... [et al.] (eds.)
| Experimental glycoscience Glycochemistry [[electronic resource] /] / N. Taniguchi ... [et al.] (eds.) |
| Edizione | [1st ed. 2008.] |
| Pubbl/distr/stampa | [Tokyo] ; ; New York, : Springer, c2008 |
| Descrizione fisica | 1 online resource (259 p.) |
| Disciplina | 572.565 |
| Altri autori (Persone) | TaniguchiNaoyuki <1942-> |
| Soggetto topico |
Glycoconjugates
Oligosaccharides |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-282-03839-7
9786612038396 4-431-77924-8 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Structural Analysis of Sugar Chains -- Chemical Liberation of N-linked Oligosaccharides from Glycoproteins -- Release of N-glycans by Enzymatic Methods -- Release of O-glycans by Chemical Methods -- Release of O-glycans by Enzymatic Methods -- Ceramidase and Related Enzymes -- Labeling of Oligosaccharides -- Chemical Labeling of Sialyloligo/polymer -- Separation of Oligosaccharides by 2D HPLC -- Analysis of Oligosaccharides by Capillary Electrophoresis -- Energy-Resolved Mass Spectrometry (ERMS) of Oligosaccharide -- LC/MS of N-Linked Oligosaccharides -- Convenient Structural Characterization of Intact Glycosphingolipids by MALDI-TOF Mass Spectrometry with Increased Laser Power and Cooling Gas Flow -- Structural Analyses of Glycoconjugates by NMR -- Sugar Chain Analysis by Enzymatic Digestion and 2D Mapping by HPLC -- Analysis of Binding Sites of Sugar Chains by Methylation Analysis -- Glycan Profiling -- Monoclonal Antibody as a Clue to Structural Analysis of Bioactive Functional Glycoconjugates -- Microsequencing of Functional Chondroitin Sulfate Oligosaccharides -- Structural Characterization of PA-oligosaccharide Isomers Derived from Glycosphingolipids by MALDI-TOF Mass Spectrometry -- Structural Analysis of Phospho-Glycosphingolipids in Lower Animals -- Structural Analysis of Polysialic Acid -- Milk Oligosaccharides: Structural Characterization and Future Aspects -- An XML Description of Carbohydrate Structures -- Construction of a Diagnostic Library for Glycans Using Multistage Tandem Mass Spectrometry (MS n ) -- A Method for Large-Scale Analysis for N-linked Glycoproteins by the Glycosylation Site-Specific Stable Isotope-Labeling and LC/MS Shotgun Technology -- Mass Spectrometry of Glycopeptides -- Development of MS Method for the Analysis of Sugar Peptide -- Calculations for Saccharides by the Use of MS Data -- Molecular Modeling of Oligosugar Structures -- Prediction of Sugar-Binding Sites on Proteins -- Frontal Affinity Chromatography: An Effective Analytical Tool for Protein-Sugar Interaction -- Analyses of Sugar-Protein Interactions by NMR -- Surface Plasmon Resonance and Sugar Chip Analysis for Sugar Chain-Protein Interactions -- Analysis of Interactions Between Carbohydrates and Proteins Using Capillary Affinity Electrophoresis -- Equilibrium Dialysis -- Interaction Assay of Oligosaccharide with Protein Using Fluorescence Polarization (FP) and Fluorescence Correlation Spectroscopy (FCS) -- Development of Neoglycoconjugate Probes and Detection of Lectins -- Chemical Synthesis of Sugar Chains -- Synthesis of Glycolipid and Its Application -- Chemo-Enzymatic Synthesis of Glycoconjugates -- Construction of O-Linked Glycopeptide Library Using Human Glycosyltransferases -- Alteration of N-Linked Oligosaccharides -- Stationary Solid-Phase Reaction (SSPR) for Oligosaccharide Synthesis -- Sugar Chain Synthesis by the Use of Cell Functions -- Glyco-Chemistry Cycle System Based on Glycosidases -- Endoglycosidases (Glycosaminoglycans) -- Oligosaccharide Synthesis Based on Combinatorial Chemistry and Labo Automation -- Endoglycosidases (Glycoproteins) -- Glycosaminoglycans -- Recent Advances in the Production of Mammalian-Type Sugar Chains in Yeast -- Solid-Phase Synthesis of Glycopeptides -- Efficient Synthesis of Oligosaccharides and Synthesis of Pathogen-Associated Molecular Patterns for Their Biofunctional Studies -- Sugar Polymers (Dendrimers and Pendant-Type Linear Polymers) -- Rapid Synthesis of Oligosaccharides: Resin Capture-Release Strategy. |
| Record Nr. | UNINA-9910454370803321 |
| [Tokyo] ; ; New York, : Springer, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Experimental glycoscience Glycochemistry [[electronic resource] /] / N. Taniguchi ... [et al.] (eds.)
| Experimental glycoscience Glycochemistry [[electronic resource] /] / N. Taniguchi ... [et al.] (eds.) |
| Edizione | [1st ed. 2008.] |
| Pubbl/distr/stampa | [Tokyo] ; ; New York, : Springer, c2008 |
| Descrizione fisica | 1 online resource (259 p.) |
| Disciplina | 572.565 |
| Altri autori (Persone) | TaniguchiNaoyuki <1942-> |
| Soggetto topico |
Glycoconjugates
Oligosaccharides |
| ISBN |
1-282-03839-7
9786612038396 4-431-77924-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Structural Analysis of Sugar Chains -- Chemical Liberation of N-linked Oligosaccharides from Glycoproteins -- Release of N-glycans by Enzymatic Methods -- Release of O-glycans by Chemical Methods -- Release of O-glycans by Enzymatic Methods -- Ceramidase and Related Enzymes -- Labeling of Oligosaccharides -- Chemical Labeling of Sialyloligo/polymer -- Separation of Oligosaccharides by 2D HPLC -- Analysis of Oligosaccharides by Capillary Electrophoresis -- Energy-Resolved Mass Spectrometry (ERMS) of Oligosaccharide -- LC/MS of N-Linked Oligosaccharides -- Convenient Structural Characterization of Intact Glycosphingolipids by MALDI-TOF Mass Spectrometry with Increased Laser Power and Cooling Gas Flow -- Structural Analyses of Glycoconjugates by NMR -- Sugar Chain Analysis by Enzymatic Digestion and 2D Mapping by HPLC -- Analysis of Binding Sites of Sugar Chains by Methylation Analysis -- Glycan Profiling -- Monoclonal Antibody as a Clue to Structural Analysis of Bioactive Functional Glycoconjugates -- Microsequencing of Functional Chondroitin Sulfate Oligosaccharides -- Structural Characterization of PA-oligosaccharide Isomers Derived from Glycosphingolipids by MALDI-TOF Mass Spectrometry -- Structural Analysis of Phospho-Glycosphingolipids in Lower Animals -- Structural Analysis of Polysialic Acid -- Milk Oligosaccharides: Structural Characterization and Future Aspects -- An XML Description of Carbohydrate Structures -- Construction of a Diagnostic Library for Glycans Using Multistage Tandem Mass Spectrometry (MS n ) -- A Method for Large-Scale Analysis for N-linked Glycoproteins by the Glycosylation Site-Specific Stable Isotope-Labeling and LC/MS Shotgun Technology -- Mass Spectrometry of Glycopeptides -- Development of MS Method for the Analysis of Sugar Peptide -- Calculations for Saccharides by the Use of MS Data -- Molecular Modeling of Oligosugar Structures -- Prediction of Sugar-Binding Sites on Proteins -- Frontal Affinity Chromatography: An Effective Analytical Tool for Protein-Sugar Interaction -- Analyses of Sugar-Protein Interactions by NMR -- Surface Plasmon Resonance and Sugar Chip Analysis for Sugar Chain-Protein Interactions -- Analysis of Interactions Between Carbohydrates and Proteins Using Capillary Affinity Electrophoresis -- Equilibrium Dialysis -- Interaction Assay of Oligosaccharide with Protein Using Fluorescence Polarization (FP) and Fluorescence Correlation Spectroscopy (FCS) -- Development of Neoglycoconjugate Probes and Detection of Lectins -- Chemical Synthesis of Sugar Chains -- Synthesis of Glycolipid and Its Application -- Chemo-Enzymatic Synthesis of Glycoconjugates -- Construction of O-Linked Glycopeptide Library Using Human Glycosyltransferases -- Alteration of N-Linked Oligosaccharides -- Stationary Solid-Phase Reaction (SSPR) for Oligosaccharide Synthesis -- Sugar Chain Synthesis by the Use of Cell Functions -- Glyco-Chemistry Cycle System Based on Glycosidases -- Endoglycosidases (Glycosaminoglycans) -- Oligosaccharide Synthesis Based on Combinatorial Chemistry and Labo Automation -- Endoglycosidases (Glycoproteins) -- Glycosaminoglycans -- Recent Advances in the Production of Mammalian-Type Sugar Chains in Yeast -- Solid-Phase Synthesis of Glycopeptides -- Efficient Synthesis of Oligosaccharides and Synthesis of Pathogen-Associated Molecular Patterns for Their Biofunctional Studies -- Sugar Polymers (Dendrimers and Pendant-Type Linear Polymers) -- Rapid Synthesis of Oligosaccharides: Resin Capture-Release Strategy. |
| Record Nr. | UNINA-9910782894103321 |
| [Tokyo] ; ; New York, : Springer, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Glycoscience : biology and medicine / / editors, Tamao Endo [et al.]
| Glycoscience : biology and medicine / / editors, Tamao Endo [et al.] |
| Pubbl/distr/stampa | Tokyo : , : Springer Japan : , : Imprint : Springer, , 2020 |
| Descrizione fisica | 1 online resource (Approx. 1200 pages, 540 illustrations, 240 illustrations in color) |
| Disciplina | 572 |
| Soggetto topico |
Biochemistry
Cytology Cancer - Research |
| ISBN | 4-431-54836-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | A. Analytical and Structural Approach - Technical Description for Analyzing Glycan Structures (Reviewed by Yoshiki Yamaguchi): Overview -- EMARS -- Development of glycan array -- Development of glycan array -- Development of glycan array -- Development of glycan array -- Automated programmable one-pot synthesis of glycans -- Lectin array -- Lectin-glycan interaction based on glycan array data -- Glycoform-specific protein staining by lectin and antibody -- Glycosaminoglycans analysis -- Mass analysis -- Mass analysis -- IGOT-lectin capture -- Membrane electrophoresis -- HPLC nucleotide-sugar analysis -- Capillary electrophoresis -- HPLC PA-sugar -- Congenital disorders of glycosylation, analytical aspect -- Quality control of pharmaceutical products and biosimilars -- NMR -- NMR -- STD-NMR -- Conformational analysis of glycans and glycoproteins -- Glycolipid LC-MS -- MALDI-MS -- MALDI-MS -- Sulfoglycolipids -- GAG array -- X-ray -- REMD simulation -- MD simulation and computational screening -- B. Glycoinformatics - New Approach for Informatics and Databases for Glycoscience (Reviewed by Kiyoko F. Aoki-Kinoshita): Informatics overview -- MIRAGE project -- RINGS -- JCGGDB -- UniCarb-DB -- CIRES -- GLYCOSCIENCES.de -- CSDB, Plant and Bacterial Carbohydrate Structure Database -- MonosaccharideDB -- GlycomeDB -- GlycoEpitope -- SugarBindDB -- GLYCAM -- CAZy -- 3D Lectines -- C. Chemoenzymatic Synthesis of Glycans - Chemical and Enzymatic Methods of Glycan Synthesis (Reviewed by Yasuhiro Kajihara and Peter Seeberger): Overview -- Chemical synthesis of glycans -- Chemical synthesis of glycans -- Chemical synthesis of glycans -- Synthesis of homogeneous glycoproteins -- Synthesis of homogeneous glycoproteins -- Synthesis of homogeneous glycoproteins -- Synthesis of homogeneous glycoproteins -- Synthesis of homogeneous glycoproteins -- Glycopeptide/glycoprotein synthesis -- Gangliosides synthesis -- Specific Glycosylation -- Furanoside chemistry -- Glycoside synthesis -- Carbohydrate Library Synthesis -- Development of sugar array -- Development of sugar array -- Development of sugar array -- Automated synthesis -- Automation in glycan synthesis -- GPI chemical synthesis -- Oligosialic acid synthesis -- Synthesis of sulfated glycans -- Synthesis of sulfated glycans -- Synthetic antitumor vaccines -- Synthetic carbohydrate antigens for HIV Vaccine Design -- Chemical approach in biology and disease -- Glycoenzyme inhibitors -- Glycoenzyme inhibitors -- Glycoenzymes in glycan analysis and synthesis -- Endo-enzymes -- Oxazoline derivatives -- Large-scale enzymatic synthesis of glycans with cofactor regeneration -- Large-scale enzymatic synthesis of glycans -- Chemoenzymatic synthesis -- Chemoenzymatic synthesis of heparins -- Chemoenzymatic synthesis of glycoproteins -- Multivalent glycan synthesis -- Biosynthesis of A and B blood group -- Glycosyltransferase structures -- Structural biology of oligosaccharyltransferase (OST) -- Chemoenzymatic synthesis of oligosaccharides and cancer and bacterial vaccines -- Neoglycoprotein and oligosaccharide synthesis -- Chemoenzymatic synthesis of glycoconjugates -- Synthesis of O-glycosylated proteins -- D. Imaging of Glycans - New Techniques for Imaging Glycans (Reviewed by Yasuhiro Kajihara and Chi-Huey Wong): Molecular probes for glycosylation: overview Imaging by Click Chemistry -- Imaging by Click Chemistry -- Imaging by Click Chemistry -- Chemical tools to detect Helicobacter pylori -- Enzymatic imaging -- PET imaging -- Glycoprotein imaging -- E. Neuroglycobiology - The Role of Glycans in Neurobiology and Neuroscience (Reviewed by Kenji Kadomatsu): Neuroglycobiology overview -- Neurochemistry and developmental neurobiology -- Glycans in neurobiology -- Glycosaminoglycans (GAGs) -- GAGs -- Polysialic acid -- Polysialic acid -- Glycolipids sialidase -- HNK-1 -- Ganglioside -- Single molecule imaging -- Glycolipid -- Heparan sulfate proteoglycans (HSPG) -- HSPG -- N-glycans and glial cells. |
| Record Nr. | UNINA-9910349267203321 |
| Tokyo : , : Springer Japan : , : Imprint : Springer, , 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Nitric oxide donors [[electronic resource] ] : for pharmaceutical and biological applications / / edited by Peng George Wang, Tingwei Bill Cai, Naoyuki Taniguchi
| Nitric oxide donors [[electronic resource] ] : for pharmaceutical and biological applications / / edited by Peng George Wang, Tingwei Bill Cai, Naoyuki Taniguchi |
| Pubbl/distr/stampa | Weinheim ; ; [Great Britain], : Wiley-VCH, c2005 |
| Descrizione fisica | 1 online resource (414 p.) |
| Disciplina | 572.54 |
| Altri autori (Persone) |
WangPeng George
CaiTingwai Bill TaniguchiNaoyuki <1942-> |
| Soggetto topico |
Nitric oxide
Nitric oxide - Physiological effect Drugs - Design Pharmaceutical chemistry |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-51948-7
9786610519484 3-527-60375-1 3-527-60384-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Nitric Oxide Donors; Contents; Preface; List of Contributors; Part 1 Chemistry of NO Donors; 1 NO and NO Donors; 1.1 Introduction to NO Biosynthesis and NO donors; 1.1.1 Nitric Oxide Synthases; 1.1.2 Chemistry of Reactive Nitrogen Species; 1.2 Classification of NO Donors; 1.3 New Classes of NO Donors under Development; 1.3.1 Nitroarene; 1.3.2 Hydroxamic Acids; 1.4 Development of NO-Drug Hybrid Molecules; 1.4.1 Nitrate Hybrid Molecules; 1.4.2 Furoxan Hybrid Molecules; 1.5 New Therapeutic Applications of NO Donors; 1.5.1 NO Donors against Cancer
1.5.1.1 Diazeniumdiolates (NONOates) as Promising Anticancer Drugs1.5.1.2 The Synergistic Effect of NO and Anticancer Drugs; 1.5.1.3 NO-NSAIDs as a New Generation of Anti-tumoral Agents; 1.5.1.4 Other NO Donors with Anticancer Activity; 1.5.2 NO against Virus; 1.5.2.1 HIV-1 Induces NO Production; 1.5.2.2 Antiviral and Proviral Activity of NO; 1.5.3 Inhibition of Bone Resorption; 1.5.4 Treatment of Diabetes; 1.5.5 Thromboresistant Polymeric Films; 1.5.6 Inhibition of Cysteine Proteases; 1.6 Conclusion; References; 2 Organic Nitrates and Nitrites; 2.1 Organic Nitrates 2.1.1 Direct Chemical Reaction between Organic Nitrates and Thiols2.1.2 Glutathione-S-transferase; 2.1.3 Cytochrome P-450-dependent Systems; 2.1.4 Membrane-bound Enzyme of Vascular Smooth Muscle Cells; 2.1.5 Xanthine Oxidoreductase; 2.1.6 Mitochondrial Aldehyde Dehydrogenase; 2.1.7 Tolerance; 2.2 Organic Nitrites; 2.3 Conclusions; References; 3 N-Nitroso Compounds; 3.1 Introduction; 3.2 N-Nitrosamines; 3.2.1 Synthesis of Nitrosamines; 3.2.2 Physical Properties and Reactions of N-Nitrosamines; 3.2.3 Structure-Activity Relationship of N-Nitrosamines; 3.2.4 Application of N-Nitrosamines 3.3 N-Hydroxy-N-nitrosoamines3.3.1 Biologically Active N-Hydroxy-N-nitrosamine Compounds; 3.3.2 Synthesis of N-Hydroxy-N-nitrosamines; 3.3.3 Properties of N-Hydroxy-N-nitrosamines; 3.3.4 Reactivity of N-Hydroxo-N-nitrosamines; 3.4 N-Nitrosimines; 3.4.1 Mechanism of Thermal Reaction of N-Nitrosoimine; 3.4.2 Properties of N-Nitrosoimines; 3.4.3 Synthesis of N-Nitrosoimines; 3.5 N-Diazeniumdiolates; 3.5.1 Mechanism of NO Release; 3.5.2 Synthesis of N-Diazeniumdiolates; 3.5.2.1 Ionic Diazeniumdiolates; 3.5.2.2 O-derivatized Diazeniumdiolates; 3.5.3 Reactions of N-Diazeniumdiolates 3.5.4 Clinical Applications3.5.4.1 Reversal of Cerebral Vasospasm; 3.5.4.2 Treatment of Impotency; 3.5.4.3 Nonthrombogenic Blood-contact Surfaces; 3.5.5 Future Directions; References; 4 The Role of S-Nitrosothiols in the Biological Milieu; 4.1 Structure and Cellular Reactivity of RSNOs; 4.1.1 RSNO Structure; 4.1.1.1 Enzymatic Consumption of RSNOs; 4.1.2 Formation of RSNOs in the Biological Milieu; 4.1.2.1 Nitrite Mediated; 4.1.2.2 NO Mediated; 4.1.2.3 NO Oxidation Products Mediated; 4.1.2.4 Metalloprotein Mediated; 4.1.2.5 Transnitrosation; 4.2 Postulated Physiological roles of RSNOs 4.2.1 Regulation of Blood Flow by HbSNO |
| Record Nr. | UNINA-9910144298603321 |
| Weinheim ; ; [Great Britain], : Wiley-VCH, c2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Nitric oxide donors [[electronic resource] ] : for pharmaceutical and biological applications / / edited by Peng George Wang, Tingwei Bill Cai, Naoyuki Taniguchi
| Nitric oxide donors [[electronic resource] ] : for pharmaceutical and biological applications / / edited by Peng George Wang, Tingwei Bill Cai, Naoyuki Taniguchi |
| Pubbl/distr/stampa | Weinheim ; ; [Great Britain], : Wiley-VCH, c2005 |
| Descrizione fisica | 1 online resource (414 p.) |
| Disciplina | 572.54 |
| Altri autori (Persone) |
WangPeng George
CaiTingwai Bill TaniguchiNaoyuki <1942-> |
| Soggetto topico |
Nitric oxide
Nitric oxide - Physiological effect Drugs - Design Pharmaceutical chemistry |
| ISBN |
1-280-51948-7
9786610519484 3-527-60375-1 3-527-60384-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Nitric Oxide Donors; Contents; Preface; List of Contributors; Part 1 Chemistry of NO Donors; 1 NO and NO Donors; 1.1 Introduction to NO Biosynthesis and NO donors; 1.1.1 Nitric Oxide Synthases; 1.1.2 Chemistry of Reactive Nitrogen Species; 1.2 Classification of NO Donors; 1.3 New Classes of NO Donors under Development; 1.3.1 Nitroarene; 1.3.2 Hydroxamic Acids; 1.4 Development of NO-Drug Hybrid Molecules; 1.4.1 Nitrate Hybrid Molecules; 1.4.2 Furoxan Hybrid Molecules; 1.5 New Therapeutic Applications of NO Donors; 1.5.1 NO Donors against Cancer
1.5.1.1 Diazeniumdiolates (NONOates) as Promising Anticancer Drugs1.5.1.2 The Synergistic Effect of NO and Anticancer Drugs; 1.5.1.3 NO-NSAIDs as a New Generation of Anti-tumoral Agents; 1.5.1.4 Other NO Donors with Anticancer Activity; 1.5.2 NO against Virus; 1.5.2.1 HIV-1 Induces NO Production; 1.5.2.2 Antiviral and Proviral Activity of NO; 1.5.3 Inhibition of Bone Resorption; 1.5.4 Treatment of Diabetes; 1.5.5 Thromboresistant Polymeric Films; 1.5.6 Inhibition of Cysteine Proteases; 1.6 Conclusion; References; 2 Organic Nitrates and Nitrites; 2.1 Organic Nitrates 2.1.1 Direct Chemical Reaction between Organic Nitrates and Thiols2.1.2 Glutathione-S-transferase; 2.1.3 Cytochrome P-450-dependent Systems; 2.1.4 Membrane-bound Enzyme of Vascular Smooth Muscle Cells; 2.1.5 Xanthine Oxidoreductase; 2.1.6 Mitochondrial Aldehyde Dehydrogenase; 2.1.7 Tolerance; 2.2 Organic Nitrites; 2.3 Conclusions; References; 3 N-Nitroso Compounds; 3.1 Introduction; 3.2 N-Nitrosamines; 3.2.1 Synthesis of Nitrosamines; 3.2.2 Physical Properties and Reactions of N-Nitrosamines; 3.2.3 Structure-Activity Relationship of N-Nitrosamines; 3.2.4 Application of N-Nitrosamines 3.3 N-Hydroxy-N-nitrosoamines3.3.1 Biologically Active N-Hydroxy-N-nitrosamine Compounds; 3.3.2 Synthesis of N-Hydroxy-N-nitrosamines; 3.3.3 Properties of N-Hydroxy-N-nitrosamines; 3.3.4 Reactivity of N-Hydroxo-N-nitrosamines; 3.4 N-Nitrosimines; 3.4.1 Mechanism of Thermal Reaction of N-Nitrosoimine; 3.4.2 Properties of N-Nitrosoimines; 3.4.3 Synthesis of N-Nitrosoimines; 3.5 N-Diazeniumdiolates; 3.5.1 Mechanism of NO Release; 3.5.2 Synthesis of N-Diazeniumdiolates; 3.5.2.1 Ionic Diazeniumdiolates; 3.5.2.2 O-derivatized Diazeniumdiolates; 3.5.3 Reactions of N-Diazeniumdiolates 3.5.4 Clinical Applications3.5.4.1 Reversal of Cerebral Vasospasm; 3.5.4.2 Treatment of Impotency; 3.5.4.3 Nonthrombogenic Blood-contact Surfaces; 3.5.5 Future Directions; References; 4 The Role of S-Nitrosothiols in the Biological Milieu; 4.1 Structure and Cellular Reactivity of RSNOs; 4.1.1 RSNO Structure; 4.1.1.1 Enzymatic Consumption of RSNOs; 4.1.2 Formation of RSNOs in the Biological Milieu; 4.1.2.1 Nitrite Mediated; 4.1.2.2 NO Mediated; 4.1.2.3 NO Oxidation Products Mediated; 4.1.2.4 Metalloprotein Mediated; 4.1.2.5 Transnitrosation; 4.2 Postulated Physiological roles of RSNOs 4.2.1 Regulation of Blood Flow by HbSNO |
| Record Nr. | UNINA-9910830161903321 |
| Weinheim ; ; [Great Britain], : Wiley-VCH, c2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Nitric oxide donors : for pharmaceutical and biological applications / / edited by Peng George Wang, Tingwei Bill Cai, Naoyuki Taniguchi
| Nitric oxide donors : for pharmaceutical and biological applications / / edited by Peng George Wang, Tingwei Bill Cai, Naoyuki Taniguchi |
| Pubbl/distr/stampa | Weinheim ; ; [Great Britain], : Wiley-VCH, c2005 |
| Descrizione fisica | 1 online resource (414 p.) |
| Disciplina | 572.54 |
| Altri autori (Persone) |
WangPeng George
CaiTingwai Bill TaniguchiNaoyuki <1942-> |
| Soggetto topico |
Nitric oxide
Nitric oxide - Physiological effect Drugs - Design Pharmaceutical chemistry |
| ISBN |
1-280-51948-7
9786610519484 3-527-60375-1 3-527-60384-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Nitric Oxide Donors; Contents; Preface; List of Contributors; Part 1 Chemistry of NO Donors; 1 NO and NO Donors; 1.1 Introduction to NO Biosynthesis and NO donors; 1.1.1 Nitric Oxide Synthases; 1.1.2 Chemistry of Reactive Nitrogen Species; 1.2 Classification of NO Donors; 1.3 New Classes of NO Donors under Development; 1.3.1 Nitroarene; 1.3.2 Hydroxamic Acids; 1.4 Development of NO-Drug Hybrid Molecules; 1.4.1 Nitrate Hybrid Molecules; 1.4.2 Furoxan Hybrid Molecules; 1.5 New Therapeutic Applications of NO Donors; 1.5.1 NO Donors against Cancer
1.5.1.1 Diazeniumdiolates (NONOates) as Promising Anticancer Drugs1.5.1.2 The Synergistic Effect of NO and Anticancer Drugs; 1.5.1.3 NO-NSAIDs as a New Generation of Anti-tumoral Agents; 1.5.1.4 Other NO Donors with Anticancer Activity; 1.5.2 NO against Virus; 1.5.2.1 HIV-1 Induces NO Production; 1.5.2.2 Antiviral and Proviral Activity of NO; 1.5.3 Inhibition of Bone Resorption; 1.5.4 Treatment of Diabetes; 1.5.5 Thromboresistant Polymeric Films; 1.5.6 Inhibition of Cysteine Proteases; 1.6 Conclusion; References; 2 Organic Nitrates and Nitrites; 2.1 Organic Nitrates 2.1.1 Direct Chemical Reaction between Organic Nitrates and Thiols2.1.2 Glutathione-S-transferase; 2.1.3 Cytochrome P-450-dependent Systems; 2.1.4 Membrane-bound Enzyme of Vascular Smooth Muscle Cells; 2.1.5 Xanthine Oxidoreductase; 2.1.6 Mitochondrial Aldehyde Dehydrogenase; 2.1.7 Tolerance; 2.2 Organic Nitrites; 2.3 Conclusions; References; 3 N-Nitroso Compounds; 3.1 Introduction; 3.2 N-Nitrosamines; 3.2.1 Synthesis of Nitrosamines; 3.2.2 Physical Properties and Reactions of N-Nitrosamines; 3.2.3 Structure-Activity Relationship of N-Nitrosamines; 3.2.4 Application of N-Nitrosamines 3.3 N-Hydroxy-N-nitrosoamines3.3.1 Biologically Active N-Hydroxy-N-nitrosamine Compounds; 3.3.2 Synthesis of N-Hydroxy-N-nitrosamines; 3.3.3 Properties of N-Hydroxy-N-nitrosamines; 3.3.4 Reactivity of N-Hydroxo-N-nitrosamines; 3.4 N-Nitrosimines; 3.4.1 Mechanism of Thermal Reaction of N-Nitrosoimine; 3.4.2 Properties of N-Nitrosoimines; 3.4.3 Synthesis of N-Nitrosoimines; 3.5 N-Diazeniumdiolates; 3.5.1 Mechanism of NO Release; 3.5.2 Synthesis of N-Diazeniumdiolates; 3.5.2.1 Ionic Diazeniumdiolates; 3.5.2.2 O-derivatized Diazeniumdiolates; 3.5.3 Reactions of N-Diazeniumdiolates 3.5.4 Clinical Applications3.5.4.1 Reversal of Cerebral Vasospasm; 3.5.4.2 Treatment of Impotency; 3.5.4.3 Nonthrombogenic Blood-contact Surfaces; 3.5.5 Future Directions; References; 4 The Role of S-Nitrosothiols in the Biological Milieu; 4.1 Structure and Cellular Reactivity of RSNOs; 4.1.1 RSNO Structure; 4.1.1.1 Enzymatic Consumption of RSNOs; 4.1.2 Formation of RSNOs in the Biological Milieu; 4.1.2.1 Nitrite Mediated; 4.1.2.2 NO Mediated; 4.1.2.3 NO Oxidation Products Mediated; 4.1.2.4 Metalloprotein Mediated; 4.1.2.5 Transnitrosation; 4.2 Postulated Physiological roles of RSNOs 4.2.1 Regulation of Blood Flow by HbSNO |
| Record Nr. | UNINA-9910876729103321 |
| Weinheim ; ; [Great Britain], : Wiley-VCH, c2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||