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The enzymes . Volume thirty eight Platelet-activating factor acetylhydrolases (PAF-AH) / / edited by Keizo Inoue, Diana M. Stafforini, Fuyuhiko Tamanoi ; contributors, Hiroyuki Arai [and eleven others]
The enzymes . Volume thirty eight Platelet-activating factor acetylhydrolases (PAF-AH) / / edited by Keizo Inoue, Diana M. Stafforini, Fuyuhiko Tamanoi ; contributors, Hiroyuki Arai [and eleven others]
Pubbl/distr/stampa Amsterdam, [Netherlands] : , : Academic Press, , 2015
Descrizione fisica 1 online resource (232 p.)
Disciplina 612.115
Collana Enzymes
Soggetto topico Platelet activating factor
Soggetto genere / forma Electronic books.
ISBN 0-12-803908-6
0-12-803946-9
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Front Cover; Platelet-Activating Factor Acetylhydrolases (PAF-AH); Copyright; Contents; Contributors; Preface; Chapter One: Overview of PAF-Degrading Enzymes; 1. Introduction; 2. Intracellular PAF-AH I; 2.1. Characteristics; 2.2. Brain Development; 2.3. Spermatogenesis; 2.4. Aβ Generation and Secretion; 2.5. Cancer Pathogenicity; 2.6. Protein Trafficking and Sorting; 2.7. Aspirin Metabolism; 3. Intracellular PAF-AH II; 3.1. Characteristics; 3.2. Protective Role Against Oxidative Stress; 3.3. Epidermal Morphogenesis; 3.4. Transacetylation from PAF to Other Lipid Mediators; 4. Plasma PAF-AH
4.1. Characteristics4.2. Involvement of Atherosclerosis; 4.3. Involvement in Asthma; 5. Conclusion; References; Chapter Two: Intracellular PAF-Acetylhydrolase Type I; 1. Introduction and History; 2. Identification of Intracellular PAF-AH, Isoform Ib; 3. Nomenclature of PAF-AH Ib Subunits; 4. Structure of PAF-AH Ib; 4.1. Structure of the Catalytic Subunits; 4.2. Structure of the Noncatalytic Subunit; 5. Physiological Roles of PAF-AH Ib; 5.1. Neuronal Development and Function; 5.2. Interaction Between PAF-AH Ib and the Reelin Signaling Pathway; 5.3. Spermatogenesis; 5.4. Cancer
5.5. Other Cellular Processes that Possibly Involve PAF-AH Ib6. Remaining Questions and Future Prospects; Acknowledgments; References; Chapter Three: Platelet-Activating Factor Acetylhydrolase and Brain Development; 1. Introduction; 2. Genetics of Human Lissencephaly and Recognition of the LIS1-Encoded Protein as PAFAH1B1; 3. Role of Pafah1b and Platelet-Activating Factor in Brain Development; 4. Coordination of Brain Platelet-Activating Factor Acetylhydrolase Signaling and Reelin Signaling in Mouse Brain
5. Roles of ""Brain"" Platelet-Activating Factor Acetylhydrolase in Testicular Development and Spermatogenesis6. Conclusions; References; Chapter Four: Intracellular Platelet-Activating Factor Acetylhydrolase, Type II: A Unique Cellular Phospholipase A2 That ...; 1. Introduction; 2. Structure of PAF-AH (II); 3. Substrate Specificity of PAF-AH (II); 4. Biological Roles of PAF-AH (II); 5. Regulation of PAF-AH (II); 6. Future Prospects; Acknowledgments; References; Chapter Five: Trafficking and Oligomeric Regulation of Platelet-Activating Factor Acetylhydrolase Type II; 1. Introduction
1.1. PAFAH Family1.2. Oxidative Stress; 1.3. PAFAH-II as a Transacetylase; 1.4. Homology Model of PAFAH-II; 2. Trafficking of PAFAH-II; 2.1. Previous Research; 2.2. Recent Discovery; 3. Oligomeric Regulation of PAFAH-II; 4. Conclusions and Future Work; Acknowledgment; References; Chapter Six: Plasma PAF-AH (PLA2G7): Biochemical Properties, Association with LDLs and HDLs, and Regulation of Expression; 1. Introduction and Perspectives; 2. Biochemical Properties of Plasma PAF-AH; 2.1. Generalities; 2.2. Substrate Specificity; 2.3. Susceptibility to Oxidation; 3. Association with Lipoproteins
3.1. PAF-AH and Lipoproteins
Record Nr. UNINA-9910460473103321
Amsterdam, [Netherlands] : , : Academic Press, , 2015
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
The enzymes . Volume thirty eight Platelet-activating factor acetylhydrolases (PAF-AH) / / edited by Keizo Inoue, Diana M. Stafforini, Fuyuhiko Tamanoi ; contributors, Hiroyuki Arai [and eleven others]
The enzymes . Volume thirty eight Platelet-activating factor acetylhydrolases (PAF-AH) / / edited by Keizo Inoue, Diana M. Stafforini, Fuyuhiko Tamanoi ; contributors, Hiroyuki Arai [and eleven others]
Pubbl/distr/stampa Amsterdam, [Netherlands] : , : Academic Press, , 2015
Descrizione fisica 1 online resource (232 p.)
Disciplina 612.115
Collana Enzymes
Soggetto topico Platelet activating factor
ISBN 0-12-803908-6
0-12-803946-9
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Front Cover; Platelet-Activating Factor Acetylhydrolases (PAF-AH); Copyright; Contents; Contributors; Preface; Chapter One: Overview of PAF-Degrading Enzymes; 1. Introduction; 2. Intracellular PAF-AH I; 2.1. Characteristics; 2.2. Brain Development; 2.3. Spermatogenesis; 2.4. Aβ Generation and Secretion; 2.5. Cancer Pathogenicity; 2.6. Protein Trafficking and Sorting; 2.7. Aspirin Metabolism; 3. Intracellular PAF-AH II; 3.1. Characteristics; 3.2. Protective Role Against Oxidative Stress; 3.3. Epidermal Morphogenesis; 3.4. Transacetylation from PAF to Other Lipid Mediators; 4. Plasma PAF-AH
4.1. Characteristics4.2. Involvement of Atherosclerosis; 4.3. Involvement in Asthma; 5. Conclusion; References; Chapter Two: Intracellular PAF-Acetylhydrolase Type I; 1. Introduction and History; 2. Identification of Intracellular PAF-AH, Isoform Ib; 3. Nomenclature of PAF-AH Ib Subunits; 4. Structure of PAF-AH Ib; 4.1. Structure of the Catalytic Subunits; 4.2. Structure of the Noncatalytic Subunit; 5. Physiological Roles of PAF-AH Ib; 5.1. Neuronal Development and Function; 5.2. Interaction Between PAF-AH Ib and the Reelin Signaling Pathway; 5.3. Spermatogenesis; 5.4. Cancer
5.5. Other Cellular Processes that Possibly Involve PAF-AH Ib6. Remaining Questions and Future Prospects; Acknowledgments; References; Chapter Three: Platelet-Activating Factor Acetylhydrolase and Brain Development; 1. Introduction; 2. Genetics of Human Lissencephaly and Recognition of the LIS1-Encoded Protein as PAFAH1B1; 3. Role of Pafah1b and Platelet-Activating Factor in Brain Development; 4. Coordination of Brain Platelet-Activating Factor Acetylhydrolase Signaling and Reelin Signaling in Mouse Brain
5. Roles of ""Brain"" Platelet-Activating Factor Acetylhydrolase in Testicular Development and Spermatogenesis6. Conclusions; References; Chapter Four: Intracellular Platelet-Activating Factor Acetylhydrolase, Type II: A Unique Cellular Phospholipase A2 That ...; 1. Introduction; 2. Structure of PAF-AH (II); 3. Substrate Specificity of PAF-AH (II); 4. Biological Roles of PAF-AH (II); 5. Regulation of PAF-AH (II); 6. Future Prospects; Acknowledgments; References; Chapter Five: Trafficking and Oligomeric Regulation of Platelet-Activating Factor Acetylhydrolase Type II; 1. Introduction
1.1. PAFAH Family1.2. Oxidative Stress; 1.3. PAFAH-II as a Transacetylase; 1.4. Homology Model of PAFAH-II; 2. Trafficking of PAFAH-II; 2.1. Previous Research; 2.2. Recent Discovery; 3. Oligomeric Regulation of PAFAH-II; 4. Conclusions and Future Work; Acknowledgment; References; Chapter Six: Plasma PAF-AH (PLA2G7): Biochemical Properties, Association with LDLs and HDLs, and Regulation of Expression; 1. Introduction and Perspectives; 2. Biochemical Properties of Plasma PAF-AH; 2.1. Generalities; 2.2. Substrate Specificity; 2.3. Susceptibility to Oxidation; 3. Association with Lipoproteins
3.1. PAF-AH and Lipoproteins
Record Nr. UNINA-9910797820303321
Amsterdam, [Netherlands] : , : Academic Press, , 2015
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
The enzymes . Volume thirty eight Platelet-activating factor acetylhydrolases (PAF-AH) / / edited by Keizo Inoue, Diana M. Stafforini, Fuyuhiko Tamanoi ; contributors, Hiroyuki Arai [and eleven others]
The enzymes . Volume thirty eight Platelet-activating factor acetylhydrolases (PAF-AH) / / edited by Keizo Inoue, Diana M. Stafforini, Fuyuhiko Tamanoi ; contributors, Hiroyuki Arai [and eleven others]
Pubbl/distr/stampa Amsterdam, [Netherlands] : , : Academic Press, , 2015
Descrizione fisica 1 online resource (232 p.)
Disciplina 612.115
Collana Enzymes
Soggetto topico Platelet activating factor
ISBN 0-12-803908-6
0-12-803946-9
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Front Cover; Platelet-Activating Factor Acetylhydrolases (PAF-AH); Copyright; Contents; Contributors; Preface; Chapter One: Overview of PAF-Degrading Enzymes; 1. Introduction; 2. Intracellular PAF-AH I; 2.1. Characteristics; 2.2. Brain Development; 2.3. Spermatogenesis; 2.4. Aβ Generation and Secretion; 2.5. Cancer Pathogenicity; 2.6. Protein Trafficking and Sorting; 2.7. Aspirin Metabolism; 3. Intracellular PAF-AH II; 3.1. Characteristics; 3.2. Protective Role Against Oxidative Stress; 3.3. Epidermal Morphogenesis; 3.4. Transacetylation from PAF to Other Lipid Mediators; 4. Plasma PAF-AH
4.1. Characteristics4.2. Involvement of Atherosclerosis; 4.3. Involvement in Asthma; 5. Conclusion; References; Chapter Two: Intracellular PAF-Acetylhydrolase Type I; 1. Introduction and History; 2. Identification of Intracellular PAF-AH, Isoform Ib; 3. Nomenclature of PAF-AH Ib Subunits; 4. Structure of PAF-AH Ib; 4.1. Structure of the Catalytic Subunits; 4.2. Structure of the Noncatalytic Subunit; 5. Physiological Roles of PAF-AH Ib; 5.1. Neuronal Development and Function; 5.2. Interaction Between PAF-AH Ib and the Reelin Signaling Pathway; 5.3. Spermatogenesis; 5.4. Cancer
5.5. Other Cellular Processes that Possibly Involve PAF-AH Ib6. Remaining Questions and Future Prospects; Acknowledgments; References; Chapter Three: Platelet-Activating Factor Acetylhydrolase and Brain Development; 1. Introduction; 2. Genetics of Human Lissencephaly and Recognition of the LIS1-Encoded Protein as PAFAH1B1; 3. Role of Pafah1b and Platelet-Activating Factor in Brain Development; 4. Coordination of Brain Platelet-Activating Factor Acetylhydrolase Signaling and Reelin Signaling in Mouse Brain
5. Roles of ""Brain"" Platelet-Activating Factor Acetylhydrolase in Testicular Development and Spermatogenesis6. Conclusions; References; Chapter Four: Intracellular Platelet-Activating Factor Acetylhydrolase, Type II: A Unique Cellular Phospholipase A2 That ...; 1. Introduction; 2. Structure of PAF-AH (II); 3. Substrate Specificity of PAF-AH (II); 4. Biological Roles of PAF-AH (II); 5. Regulation of PAF-AH (II); 6. Future Prospects; Acknowledgments; References; Chapter Five: Trafficking and Oligomeric Regulation of Platelet-Activating Factor Acetylhydrolase Type II; 1. Introduction
1.1. PAFAH Family1.2. Oxidative Stress; 1.3. PAFAH-II as a Transacetylase; 1.4. Homology Model of PAFAH-II; 2. Trafficking of PAFAH-II; 2.1. Previous Research; 2.2. Recent Discovery; 3. Oligomeric Regulation of PAFAH-II; 4. Conclusions and Future Work; Acknowledgment; References; Chapter Six: Plasma PAF-AH (PLA2G7): Biochemical Properties, Association with LDLs and HDLs, and Regulation of Expression; 1. Introduction and Perspectives; 2. Biochemical Properties of Plasma PAF-AH; 2.1. Generalities; 2.2. Substrate Specificity; 2.3. Susceptibility to Oxidation; 3. Association with Lipoproteins
3.1. PAF-AH and Lipoproteins
Record Nr. UNINA-9910806940703321
Amsterdam, [Netherlands] : , : Academic Press, , 2015
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Enzymes . Volume thirty-six Natural products and cancer signaling : isoprenoids, polyphenols and flavonoids / / edited by S. Zahra Bathaie, Fuyuhiko Tamanoi ; contributors, Javad Alizadeh [and twenty-nine others]
Enzymes . Volume thirty-six Natural products and cancer signaling : isoprenoids, polyphenols and flavonoids / / edited by S. Zahra Bathaie, Fuyuhiko Tamanoi ; contributors, Javad Alizadeh [and twenty-nine others]
Edizione [First edition.]
Pubbl/distr/stampa London, [England] : , : Academic Press, , 2014
Descrizione fisica 1 online resource (279 p.)
Disciplina 616.994061
Collana Enzymes
Soggetto topico Cancer - Alternative treatment
Cancer - Treatment
Soggetto genere / forma Electronic books.
ISBN 0-12-802527-1
0-12-802215-9
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Front Cover; The Enzymes: Natural Products and Cancer Signaling: Isoprenoids, Polyphenols and Flavonoids; Copyright; Contents; Contributors; Preface; Chapter One: Introduction; References; Chapter Two: Perillyl Alcohol (Monoterpene Alcohol), Limonene; 1. Introduction; 2. Perillyl Alcohol; 2.1. Perillyl Alcohol Mechanism of Action in Cancer Therapy and Pharmacokinetics; 2.2. Perillyl Alcohol Biosafety and Adverse Effects in Clinical Application and Clinical Trials; 3. Limonene; 3.1. Limonene Pharmacokinetics; 3.2. Limonene Anticancer Activity and Clinical Trials
3.3. Limonene Mechanisms of Action, Targets, and Clinical Applications3.4. Limonene Biosafety and Adverse Effects; 4. Concluding Remarks; Acknowledgment; References; Chapter Three: Ganoderic Acid and Lucidenic Acid (Triterpenoid); 1. Introduction; 2. Lucidenic Acids and Ganoderic Acids from Ganoderma Species; 2.1. The Sources of Lucidenic Acids and Ganoderic Acids; 2.2. The Biosynthesis of Ganoderic Acids; 2.3. Optimization of the Fermentation Process; 3. Biological Functions of Lucidenic Acids and Ganoderic Acids; 3.1. Cytotoxic and Apoptotic Effects; 3.2. Cell Cycle Arrest
3.3. Anti-invasive Effect3.4. Autophagy; 3.5. Anti-inflammatory Effect; 3.6. Antiosteoclastogenesis; 3.7. Antiasthma; 3.8. Antihepatitis B Activity; 4. Pharmacokinetics of Ganoderic Acids; 5. Conclusion; References; Chapter Four: Anticancer Effect and Molecular Targets of Saffron Carotenoids; 1. Introduction; 2. Anticancer Effect of Saffron and Its Carotenoids; 3. Comparing the Efficacy of Crocetin, Crocin, and Other Components; 4. Liposome Formulation of Saffron Compounds; 5. Effect of Crocetin and Crocin on Macromolecule Synthesis and Structure
5.1. Effect on DNA, RNA, and Protein Synthesis5.2. Protein Binding; 6. Effects on Cell Cycle, Apoptosis, and Signaling Pathways; 7. Role of Saffron Components on Chemoprevention; 8. Molecular Mechanisms Involved in the Protective Effect of Saffron Components against Various Damages in Different Tissues; 9. Antioxidant and Anti-inflammatory Effects of Saffron; 10. Safety; 11. Other Mechanisms; 12. Conclusions; References; Chapter Five: Zerumbone from Ginger (Monoterpenoid); 1. Introduction; 2. Characteristic Feature; 3. Target Pathways by Zerumbone; 3.1. Survival; 3.1.1. Caspase Family
3.1.2. Bcl Family3.1.3. c-FLIP; 3.1.4. G2/M Cell Cycle; 3.2. Proliferation; 3.2.1. Cyclin B1/CDK1; 3.2.2. Tumor Necrosis Factor; 3.3. Invasion; 3.4. Angiogenesis; 4. Nuclear Factor-Kappa B; 5. Future Perspectives; References; Chapter Six: Research Progress on Natural Triterpenoid Saponins in the Chemoprevention and Chemotherapy of Cancer; 1. Introduction; 2. Triterpenoid Saponins in the Prevention and Therapy of Cancers; 3. Anticancer Properties and Molecular Mechanisms of Triterpenoid Saponins; 3.1. Inhibition of Proliferation; 3.2. Induction of Apoptosis and Autophagy; 3.2.1. Apoptosis
3.2.2. Autophagy
Record Nr. UNINA-9910459571803321
London, [England] : , : Academic Press, , 2014
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Enzymes . Volume thirty-six Natural products and cancer signaling : isoprenoids, polyphenols and flavonoids / / edited by S. Zahra Bathaie, Fuyuhiko Tamanoi ; contributors, Javad Alizadeh [and twenty-nine others]
Enzymes . Volume thirty-six Natural products and cancer signaling : isoprenoids, polyphenols and flavonoids / / edited by S. Zahra Bathaie, Fuyuhiko Tamanoi ; contributors, Javad Alizadeh [and twenty-nine others]
Edizione [First edition.]
Pubbl/distr/stampa London, [England] : , : Academic Press, , 2014
Descrizione fisica 1 online resource (279 p.)
Disciplina 616.994061
Collana Enzymes
Soggetto topico Cancer - Alternative treatment
Cancer - Treatment
ISBN 0-12-802527-1
0-12-802215-9
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Front Cover; The Enzymes: Natural Products and Cancer Signaling: Isoprenoids, Polyphenols and Flavonoids; Copyright; Contents; Contributors; Preface; Chapter One: Introduction; References; Chapter Two: Perillyl Alcohol (Monoterpene Alcohol), Limonene; 1. Introduction; 2. Perillyl Alcohol; 2.1. Perillyl Alcohol Mechanism of Action in Cancer Therapy and Pharmacokinetics; 2.2. Perillyl Alcohol Biosafety and Adverse Effects in Clinical Application and Clinical Trials; 3. Limonene; 3.1. Limonene Pharmacokinetics; 3.2. Limonene Anticancer Activity and Clinical Trials
3.3. Limonene Mechanisms of Action, Targets, and Clinical Applications3.4. Limonene Biosafety and Adverse Effects; 4. Concluding Remarks; Acknowledgment; References; Chapter Three: Ganoderic Acid and Lucidenic Acid (Triterpenoid); 1. Introduction; 2. Lucidenic Acids and Ganoderic Acids from Ganoderma Species; 2.1. The Sources of Lucidenic Acids and Ganoderic Acids; 2.2. The Biosynthesis of Ganoderic Acids; 2.3. Optimization of the Fermentation Process; 3. Biological Functions of Lucidenic Acids and Ganoderic Acids; 3.1. Cytotoxic and Apoptotic Effects; 3.2. Cell Cycle Arrest
3.3. Anti-invasive Effect3.4. Autophagy; 3.5. Anti-inflammatory Effect; 3.6. Antiosteoclastogenesis; 3.7. Antiasthma; 3.8. Antihepatitis B Activity; 4. Pharmacokinetics of Ganoderic Acids; 5. Conclusion; References; Chapter Four: Anticancer Effect and Molecular Targets of Saffron Carotenoids; 1. Introduction; 2. Anticancer Effect of Saffron and Its Carotenoids; 3. Comparing the Efficacy of Crocetin, Crocin, and Other Components; 4. Liposome Formulation of Saffron Compounds; 5. Effect of Crocetin and Crocin on Macromolecule Synthesis and Structure
5.1. Effect on DNA, RNA, and Protein Synthesis5.2. Protein Binding; 6. Effects on Cell Cycle, Apoptosis, and Signaling Pathways; 7. Role of Saffron Components on Chemoprevention; 8. Molecular Mechanisms Involved in the Protective Effect of Saffron Components against Various Damages in Different Tissues; 9. Antioxidant and Anti-inflammatory Effects of Saffron; 10. Safety; 11. Other Mechanisms; 12. Conclusions; References; Chapter Five: Zerumbone from Ginger (Monoterpenoid); 1. Introduction; 2. Characteristic Feature; 3. Target Pathways by Zerumbone; 3.1. Survival; 3.1.1. Caspase Family
3.1.2. Bcl Family3.1.3. c-FLIP; 3.1.4. G2/M Cell Cycle; 3.2. Proliferation; 3.2.1. Cyclin B1/CDK1; 3.2.2. Tumor Necrosis Factor; 3.3. Invasion; 3.4. Angiogenesis; 4. Nuclear Factor-Kappa B; 5. Future Perspectives; References; Chapter Six: Research Progress on Natural Triterpenoid Saponins in the Chemoprevention and Chemotherapy of Cancer; 1. Introduction; 2. Triterpenoid Saponins in the Prevention and Therapy of Cancers; 3. Anticancer Properties and Molecular Mechanisms of Triterpenoid Saponins; 3.1. Inhibition of Proliferation; 3.2. Induction of Apoptosis and Autophagy; 3.2.1. Apoptosis
3.2.2. Autophagy
Record Nr. UNINA-9910787265603321
London, [England] : , : Academic Press, , 2014
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Enzymes . Volume thirty-six Natural products and cancer signaling : isoprenoids, polyphenols and flavonoids / / edited by S. Zahra Bathaie, Fuyuhiko Tamanoi ; contributors, Javad Alizadeh [and twenty-nine others]
Enzymes . Volume thirty-six Natural products and cancer signaling : isoprenoids, polyphenols and flavonoids / / edited by S. Zahra Bathaie, Fuyuhiko Tamanoi ; contributors, Javad Alizadeh [and twenty-nine others]
Edizione [First edition.]
Pubbl/distr/stampa London, [England] : , : Academic Press, , 2014
Descrizione fisica 1 online resource (279 p.)
Disciplina 616.994061
Collana Enzymes
Soggetto topico Cancer - Alternative treatment
Cancer - Treatment
ISBN 0-12-802527-1
0-12-802215-9
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Front Cover; The Enzymes: Natural Products and Cancer Signaling: Isoprenoids, Polyphenols and Flavonoids; Copyright; Contents; Contributors; Preface; Chapter One: Introduction; References; Chapter Two: Perillyl Alcohol (Monoterpene Alcohol), Limonene; 1. Introduction; 2. Perillyl Alcohol; 2.1. Perillyl Alcohol Mechanism of Action in Cancer Therapy and Pharmacokinetics; 2.2. Perillyl Alcohol Biosafety and Adverse Effects in Clinical Application and Clinical Trials; 3. Limonene; 3.1. Limonene Pharmacokinetics; 3.2. Limonene Anticancer Activity and Clinical Trials
3.3. Limonene Mechanisms of Action, Targets, and Clinical Applications3.4. Limonene Biosafety and Adverse Effects; 4. Concluding Remarks; Acknowledgment; References; Chapter Three: Ganoderic Acid and Lucidenic Acid (Triterpenoid); 1. Introduction; 2. Lucidenic Acids and Ganoderic Acids from Ganoderma Species; 2.1. The Sources of Lucidenic Acids and Ganoderic Acids; 2.2. The Biosynthesis of Ganoderic Acids; 2.3. Optimization of the Fermentation Process; 3. Biological Functions of Lucidenic Acids and Ganoderic Acids; 3.1. Cytotoxic and Apoptotic Effects; 3.2. Cell Cycle Arrest
3.3. Anti-invasive Effect3.4. Autophagy; 3.5. Anti-inflammatory Effect; 3.6. Antiosteoclastogenesis; 3.7. Antiasthma; 3.8. Antihepatitis B Activity; 4. Pharmacokinetics of Ganoderic Acids; 5. Conclusion; References; Chapter Four: Anticancer Effect and Molecular Targets of Saffron Carotenoids; 1. Introduction; 2. Anticancer Effect of Saffron and Its Carotenoids; 3. Comparing the Efficacy of Crocetin, Crocin, and Other Components; 4. Liposome Formulation of Saffron Compounds; 5. Effect of Crocetin and Crocin on Macromolecule Synthesis and Structure
5.1. Effect on DNA, RNA, and Protein Synthesis5.2. Protein Binding; 6. Effects on Cell Cycle, Apoptosis, and Signaling Pathways; 7. Role of Saffron Components on Chemoprevention; 8. Molecular Mechanisms Involved in the Protective Effect of Saffron Components against Various Damages in Different Tissues; 9. Antioxidant and Anti-inflammatory Effects of Saffron; 10. Safety; 11. Other Mechanisms; 12. Conclusions; References; Chapter Five: Zerumbone from Ginger (Monoterpenoid); 1. Introduction; 2. Characteristic Feature; 3. Target Pathways by Zerumbone; 3.1. Survival; 3.1.1. Caspase Family
3.1.2. Bcl Family3.1.3. c-FLIP; 3.1.4. G2/M Cell Cycle; 3.2. Proliferation; 3.2.1. Cyclin B1/CDK1; 3.2.2. Tumor Necrosis Factor; 3.3. Invasion; 3.4. Angiogenesis; 4. Nuclear Factor-Kappa B; 5. Future Perspectives; References; Chapter Six: Research Progress on Natural Triterpenoid Saponins in the Chemoprevention and Chemotherapy of Cancer; 1. Introduction; 2. Triterpenoid Saponins in the Prevention and Therapy of Cancers; 3. Anticancer Properties and Molecular Mechanisms of Triterpenoid Saponins; 3.1. Inhibition of Proliferation; 3.2. Induction of Apoptosis and Autophagy; 3.2.1. Apoptosis
3.2.2. Autophagy
Record Nr. UNINA-9910827756703321
London, [England] : , : Academic Press, , 2014
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Mechanism of the anticancer effect of phytochemicals / / edited by S. Zahra Bathaie, Department of Clinical Biochemistry, Tarbiat Modares University Tehran, Iran, Fuyuhiko Tamanoi, Department of Microbiology, Immunology and Molecular Genetics Jonsson Comprehensive Cancer Center Molecular Biology Institue University of California Los Angeles, California, USA
Mechanism of the anticancer effect of phytochemicals / / edited by S. Zahra Bathaie, Department of Clinical Biochemistry, Tarbiat Modares University Tehran, Iran, Fuyuhiko Tamanoi, Department of Microbiology, Immunology and Molecular Genetics Jonsson Comprehensive Cancer Center Molecular Biology Institue University of California Los Angeles, California, USA
Edizione [First edition.]
Pubbl/distr/stampa Waltham, MA : , : Elsevier Science, , 2015
Descrizione fisica 1 online resource (285 p.)
Disciplina 616.994061
Collana Enzymes
Soggetto topico Cancer - Chemoprevention
Cancer - Diet therapy
Phytochemicals - Therapeutic use
Soggetto genere / forma Electronic books.
ISBN 0-12-803877-2
0-12-803876-4
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Front Cover; Mechanism of the Anticancer Effect of Phytochemicals; Copyright; Contents; Contributors; Preface; Chapter One: How Phytochemicals Prevent Chemical Carcinogens and/or Suppress Tumor Growth?; 1. Introduction; 2. Phytochemicals Application in Chemoprevention Strategies; 2.1. Blocking Initiation/Reversing Promotion; 2.2. Activating Phase II Detoxifying Enzymes; 2.3. Prooxidant/Antioxidant Activities; 2.4. Protection Against Radiation; 2.5. Alteration in Signaling Pathways; 2.6. Effect on Cell-Cell Adhesion Machinery; 2.7. Induction of Epigenetic Changes
3. Phytochemicals Usage as Chemotherapeutic3.1. Inhibition of Enzymes; 3.1.1. Inhibition of Topoisomerases I or II; 3.1.2. Effect on Telomerase; 3.1.3. Other Enzymes; 3.2. Direct Binding to Biomacromolecules; 3.3. Epigenetic Alteration/Chromatin Modification; 3.3.1. Histone Modifications: Acetylation/Deacetylation and Methylation/Demethylation; 3.3.2. DNA Methylation Status; 3.4. RNA Modulation; 3.5. Autophagy and UPR68; 3.6. Apoptosis Induction; 3.7. Cell Cycle Arrest; 3.8. Inhibiting Angiogenesis; 3.9. Adjuvant/Combinatorial Therapy; 4. Summary; References
Chapter Two: Quercetin and Tryptanthrin: Two Broad Spectrum Anticancer Agents for Future Chemotherapeutic Interventions1. Introduction; 2. Quercetin; 2.1. Source; 2.2. Biosynthesis; 2.3. Structure and Antioxidative Property; 2.4. Properties; 2.4.1. Antioxidant Property; 2.4.2. Free Radical Scavenging Activity; 2.4.3. Nitric Oxide Inhibitory Action; 2.4.4. Inhibition of Xanthine Oxidase; 2.4.5. Interaction with Other Enzyme Systems; 2.5. Pharmacokinetics; 2.6. Role as an Anticancer Agent; 2.6.1. Cell Cycle Regulation; 2.6.2. Quercetinś Effect on Apoptosis
2.6.3. Inhibition of Pathways Involved in Tumor Growth and Invasiveness2.7. Quercetinś Role as an Anti-Inflammatory Agent; 2.8. Quercetinś Influence on p53; 2.9. Quercetinś Nontoxicity Against Normal Cells; 2.10. Quercetinś Action Against Chemical-Induced Tumor and Xenograft; 2.11. Synergism with Other Drugs; 2.12. Clinical Study; 3. Tryptanthrin; 3.1. Chemistry; 3.2. Source; 3.3. Medicinal Value; 3.4. Cytotoxic and Anticancer Properties of Tryptanthrin; 3.5. Structural Modification of Tryptanthrin for Increasing its Bioactivity
3.6. Tryptanthrin Prevents Development of Cancer by the Inhibition of Various Molecular Events3.6.1. Antioxidant Activity; 3.6.2. Anti-Inflammatory Activity; 3.7. Angiogenesis; 3.8. Toxicological Analysis; 4. Conclusion; Acknowledgement; References; Chapter Three: Potential Anticancer Properties and Mechanisms of Action of Withanolides; 1. Introduction; 2. Reactive Oxygen Species Signaling; 3. Cytoskeletal Organizing and Structural Proteins; 4. Proteasomal Inhibition; 5. Inhibition of Mitosis; 6. Transcription Factors; 7. Heat Shock Proteins; 8. Metabolic Enzymes; 9. Synergistic Action
References
Record Nr. UNINA-9910461754703321
Waltham, MA : , : Elsevier Science, , 2015
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Mechanism of the anticancer effect of phytochemicals / / edited by S. Zahra Bathaie, Department of Clinical Biochemistry, Tarbiat Modares University Tehran, Iran, Fuyuhiko Tamanoi, Department of Microbiology, Immunology and Molecular Genetics Jonsson Comprehensive Cancer Center Molecular Biology Institue University of California Los Angeles, California, USA
Mechanism of the anticancer effect of phytochemicals / / edited by S. Zahra Bathaie, Department of Clinical Biochemistry, Tarbiat Modares University Tehran, Iran, Fuyuhiko Tamanoi, Department of Microbiology, Immunology and Molecular Genetics Jonsson Comprehensive Cancer Center Molecular Biology Institue University of California Los Angeles, California, USA
Edizione [First edition.]
Pubbl/distr/stampa Waltham, MA : , : Elsevier Science, , 2015
Descrizione fisica 1 online resource (285 p.)
Disciplina 616.994061
Collana Enzymes
Soggetto topico Cancer - Chemoprevention
Cancer - Diet therapy
Phytochemicals - Therapeutic use
ISBN 0-12-803877-2
0-12-803876-4
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Front Cover; Mechanism of the Anticancer Effect of Phytochemicals; Copyright; Contents; Contributors; Preface; Chapter One: How Phytochemicals Prevent Chemical Carcinogens and/or Suppress Tumor Growth?; 1. Introduction; 2. Phytochemicals Application in Chemoprevention Strategies; 2.1. Blocking Initiation/Reversing Promotion; 2.2. Activating Phase II Detoxifying Enzymes; 2.3. Prooxidant/Antioxidant Activities; 2.4. Protection Against Radiation; 2.5. Alteration in Signaling Pathways; 2.6. Effect on Cell-Cell Adhesion Machinery; 2.7. Induction of Epigenetic Changes
3. Phytochemicals Usage as Chemotherapeutic3.1. Inhibition of Enzymes; 3.1.1. Inhibition of Topoisomerases I or II; 3.1.2. Effect on Telomerase; 3.1.3. Other Enzymes; 3.2. Direct Binding to Biomacromolecules; 3.3. Epigenetic Alteration/Chromatin Modification; 3.3.1. Histone Modifications: Acetylation/Deacetylation and Methylation/Demethylation; 3.3.2. DNA Methylation Status; 3.4. RNA Modulation; 3.5. Autophagy and UPR68; 3.6. Apoptosis Induction; 3.7. Cell Cycle Arrest; 3.8. Inhibiting Angiogenesis; 3.9. Adjuvant/Combinatorial Therapy; 4. Summary; References
Chapter Two: Quercetin and Tryptanthrin: Two Broad Spectrum Anticancer Agents for Future Chemotherapeutic Interventions1. Introduction; 2. Quercetin; 2.1. Source; 2.2. Biosynthesis; 2.3. Structure and Antioxidative Property; 2.4. Properties; 2.4.1. Antioxidant Property; 2.4.2. Free Radical Scavenging Activity; 2.4.3. Nitric Oxide Inhibitory Action; 2.4.4. Inhibition of Xanthine Oxidase; 2.4.5. Interaction with Other Enzyme Systems; 2.5. Pharmacokinetics; 2.6. Role as an Anticancer Agent; 2.6.1. Cell Cycle Regulation; 2.6.2. Quercetinś Effect on Apoptosis
2.6.3. Inhibition of Pathways Involved in Tumor Growth and Invasiveness2.7. Quercetinś Role as an Anti-Inflammatory Agent; 2.8. Quercetinś Influence on p53; 2.9. Quercetinś Nontoxicity Against Normal Cells; 2.10. Quercetinś Action Against Chemical-Induced Tumor and Xenograft; 2.11. Synergism with Other Drugs; 2.12. Clinical Study; 3. Tryptanthrin; 3.1. Chemistry; 3.2. Source; 3.3. Medicinal Value; 3.4. Cytotoxic and Anticancer Properties of Tryptanthrin; 3.5. Structural Modification of Tryptanthrin for Increasing its Bioactivity
3.6. Tryptanthrin Prevents Development of Cancer by the Inhibition of Various Molecular Events3.6.1. Antioxidant Activity; 3.6.2. Anti-Inflammatory Activity; 3.7. Angiogenesis; 3.8. Toxicological Analysis; 4. Conclusion; Acknowledgement; References; Chapter Three: Potential Anticancer Properties and Mechanisms of Action of Withanolides; 1. Introduction; 2. Reactive Oxygen Species Signaling; 3. Cytoskeletal Organizing and Structural Proteins; 4. Proteasomal Inhibition; 5. Inhibition of Mitosis; 6. Transcription Factors; 7. Heat Shock Proteins; 8. Metabolic Enzymes; 9. Synergistic Action
References
Record Nr. UNINA-9910797589003321
Waltham, MA : , : Elsevier Science, , 2015
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Mechanism of the anticancer effect of phytochemicals / / edited by S. Zahra Bathaie, Department of Clinical Biochemistry, Tarbiat Modares University Tehran, Iran, Fuyuhiko Tamanoi, Department of Microbiology, Immunology and Molecular Genetics Jonsson Comprehensive Cancer Center Molecular Biology Institue University of California Los Angeles, California, USA
Mechanism of the anticancer effect of phytochemicals / / edited by S. Zahra Bathaie, Department of Clinical Biochemistry, Tarbiat Modares University Tehran, Iran, Fuyuhiko Tamanoi, Department of Microbiology, Immunology and Molecular Genetics Jonsson Comprehensive Cancer Center Molecular Biology Institue University of California Los Angeles, California, USA
Edizione [First edition.]
Pubbl/distr/stampa Waltham, MA : , : Elsevier Science, , 2015
Descrizione fisica 1 online resource (285 p.)
Disciplina 616.994061
Collana Enzymes
Soggetto topico Cancer - Chemoprevention
Cancer - Diet therapy
Phytochemicals - Therapeutic use
ISBN 0-12-803877-2
0-12-803876-4
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Front Cover; Mechanism of the Anticancer Effect of Phytochemicals; Copyright; Contents; Contributors; Preface; Chapter One: How Phytochemicals Prevent Chemical Carcinogens and/or Suppress Tumor Growth?; 1. Introduction; 2. Phytochemicals Application in Chemoprevention Strategies; 2.1. Blocking Initiation/Reversing Promotion; 2.2. Activating Phase II Detoxifying Enzymes; 2.3. Prooxidant/Antioxidant Activities; 2.4. Protection Against Radiation; 2.5. Alteration in Signaling Pathways; 2.6. Effect on Cell-Cell Adhesion Machinery; 2.7. Induction of Epigenetic Changes
3. Phytochemicals Usage as Chemotherapeutic3.1. Inhibition of Enzymes; 3.1.1. Inhibition of Topoisomerases I or II; 3.1.2. Effect on Telomerase; 3.1.3. Other Enzymes; 3.2. Direct Binding to Biomacromolecules; 3.3. Epigenetic Alteration/Chromatin Modification; 3.3.1. Histone Modifications: Acetylation/Deacetylation and Methylation/Demethylation; 3.3.2. DNA Methylation Status; 3.4. RNA Modulation; 3.5. Autophagy and UPR68; 3.6. Apoptosis Induction; 3.7. Cell Cycle Arrest; 3.8. Inhibiting Angiogenesis; 3.9. Adjuvant/Combinatorial Therapy; 4. Summary; References
Chapter Two: Quercetin and Tryptanthrin: Two Broad Spectrum Anticancer Agents for Future Chemotherapeutic Interventions1. Introduction; 2. Quercetin; 2.1. Source; 2.2. Biosynthesis; 2.3. Structure and Antioxidative Property; 2.4. Properties; 2.4.1. Antioxidant Property; 2.4.2. Free Radical Scavenging Activity; 2.4.3. Nitric Oxide Inhibitory Action; 2.4.4. Inhibition of Xanthine Oxidase; 2.4.5. Interaction with Other Enzyme Systems; 2.5. Pharmacokinetics; 2.6. Role as an Anticancer Agent; 2.6.1. Cell Cycle Regulation; 2.6.2. Quercetinś Effect on Apoptosis
2.6.3. Inhibition of Pathways Involved in Tumor Growth and Invasiveness2.7. Quercetinś Role as an Anti-Inflammatory Agent; 2.8. Quercetinś Influence on p53; 2.9. Quercetinś Nontoxicity Against Normal Cells; 2.10. Quercetinś Action Against Chemical-Induced Tumor and Xenograft; 2.11. Synergism with Other Drugs; 2.12. Clinical Study; 3. Tryptanthrin; 3.1. Chemistry; 3.2. Source; 3.3. Medicinal Value; 3.4. Cytotoxic and Anticancer Properties of Tryptanthrin; 3.5. Structural Modification of Tryptanthrin for Increasing its Bioactivity
3.6. Tryptanthrin Prevents Development of Cancer by the Inhibition of Various Molecular Events3.6.1. Antioxidant Activity; 3.6.2. Anti-Inflammatory Activity; 3.7. Angiogenesis; 3.8. Toxicological Analysis; 4. Conclusion; Acknowledgement; References; Chapter Three: Potential Anticancer Properties and Mechanisms of Action of Withanolides; 1. Introduction; 2. Reactive Oxygen Species Signaling; 3. Cytoskeletal Organizing and Structural Proteins; 4. Proteasomal Inhibition; 5. Inhibition of Mitosis; 6. Transcription Factors; 7. Heat Shock Proteins; 8. Metabolic Enzymes; 9. Synergistic Action
References
Record Nr. UNINA-9910828715703321
Waltham, MA : , : Elsevier Science, , 2015
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui