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Erythropoietin [[electronic resource] ] : blood, brain and beyond / / Arthur J. Sytkowski
Erythropoietin [[electronic resource] ] : blood, brain and beyond / / Arthur J. Sytkowski
Autore Sytkowski Arthur J
Pubbl/distr/stampa Weinheim, : Wiley-VCH, 2004
Descrizione fisica 1 online resource (240 p.)
Disciplina 612.111
615.39
Soggetto topico Erythropoietin
Erythropoietin - Physiological effect
Erythropoietin - Therapeutic use
Soggetto genere / forma Electronic books.
ISBN 1-280-52052-3
9786610520527
3-527-60543-6
3-527-60238-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Erythropoietin; Preface; Contents; 1 Introduction and History; 1.1 Early Observations; 1.2 Carnot and Deflandre: A Humoral Factor that Stimulates Erythropoiesis; 1.3 Reissmann, Erslev, Jacobson and Stohlman: The Kidney as the Likely Source; 1.4 More Evidence for the Kidney . . . Erythrogenin?; 1.5 Early Assays for Erythropoietin; 1.6 Standardization: What is a "Unit" of Erythropoietin?; 1.7 References; 2 Developmental Biology of Erythropoiesis and Erythropoietin Production; 2.1 Introduction; 2.2 Yolk Sac Hematopoiesis; 2.2.1 The Role of Erythropoietin in Yolk Sac Erythropoiesis
2.2.2 Genes Essential to Primitive Erythropoiesis2.3 Fetal Liver and Bone Marrow (Definitive) Erythropoiesis; 2.4 Genes Essential for Definitive Erythropoiesis; 2.5 Erythropoietin Production; 2.6 References; 3 Regulation of the Erythropoietin Gene: A Paradigm for Hypoxia-dependent Genes; 3.1 The Structure of the Erythropoietin Gene; 3.2 Tissue-specific Expression; 3.3 Mechanism of Hypoxic Regulation - Identification of Transcription Factors and Other Regulatory Proteins; 3.3.1 Is the Oxygen Sensor a Heme Protein?
3.3.2 The 3 ́ Flanking Region of the Erythropoietin Gene Contains Important Regulatory Sequences3.3.3 Identification of the Hypoxia-inducible Factor - Hypoxia Regulates More Than the Erythropoietin Gene; 3.3.4 Other Interacting Proteins and the Regulation of HIF-1; 3.3.5 The von Hippel-Lindau Protein, Proline Hydroxylation and the Oxygen Sensor; 3.3.6 Modulation of HIF-1 Activity by Other Signals; 3.3.7 A Final Word on the Heme Protein Hypothesis; 3.4 References; 4 Physiology and Metabolism of Erythropoietin; 4.1 The Kidney as the Site of Production
4.2 The Liver as a Site of Erythropoietin Production4.3 Erythropoietin Produced in the Bone Marrow; 4.4 Metabolism and Clearance of Erythropoietin; 4.5 Erythropoietin and the Maternal/Fetal Circulation; 4.6 References; 5 Biochemistry and Protein Structure; 5.1 Naturally Occurring Epo; 5.1.1 Difficulties in Purifying the Hormone; 5.1.2 The Purification of Human Urinary Epo; 5.1.3 Biochemical Properties of Human Urinary Epo; 5.1.4 Some Biochemical Properties of Human Serum Epo; 5.2 Recombinant Human Epo; 5.2.1 Cloning the Human Epo Gene; 5.2.2 Glycosylation of Epo
5.2.3 Physicochemical Properties of Epo5.3 Structure-activity Relationships; 5.3.1 Antibody Studies; 5.3.2 Mutagenesis Studies; 5.4 The Tertiary Structure of Epo; 5.5 References; 6 Receptor Biology and Signal Transduction; 6.1 Receptor Biology; 6.1.1 Identification of the Erythropoietin Receptor; 6.1.2 The Erythropoietin Receptor Gene; 6.1.3 The Structure of the Erythropoietin Receptor: A Member of the Cytokine Receptor Superfamily; 6.1.4 The Extracellular Portion of the Erythropoietin Receptor; 6.1.5 The Cytoplasmic Portion of the Erythropoietin Receptor; 6.2 Signal Transduction Pathways
6.2.1 Phosphorylation of the Erythropoietin Receptor
Record Nr. UNINA-9910146241603321
Sytkowski Arthur J  
Weinheim, : Wiley-VCH, 2004
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Erythropoietin [[electronic resource] ] : blood, brain and beyond / / Arthur J. Sytkowski
Erythropoietin [[electronic resource] ] : blood, brain and beyond / / Arthur J. Sytkowski
Autore Sytkowski Arthur J
Pubbl/distr/stampa Weinheim, : Wiley-VCH, 2004
Descrizione fisica 1 online resource (240 p.)
Disciplina 612.111
615.39
Soggetto topico Erythropoietin
Erythropoietin - Physiological effect
Erythropoietin - Therapeutic use
ISBN 1-280-52052-3
9786610520527
3-527-60543-6
3-527-60238-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Erythropoietin; Preface; Contents; 1 Introduction and History; 1.1 Early Observations; 1.2 Carnot and Deflandre: A Humoral Factor that Stimulates Erythropoiesis; 1.3 Reissmann, Erslev, Jacobson and Stohlman: The Kidney as the Likely Source; 1.4 More Evidence for the Kidney . . . Erythrogenin?; 1.5 Early Assays for Erythropoietin; 1.6 Standardization: What is a "Unit" of Erythropoietin?; 1.7 References; 2 Developmental Biology of Erythropoiesis and Erythropoietin Production; 2.1 Introduction; 2.2 Yolk Sac Hematopoiesis; 2.2.1 The Role of Erythropoietin in Yolk Sac Erythropoiesis
2.2.2 Genes Essential to Primitive Erythropoiesis2.3 Fetal Liver and Bone Marrow (Definitive) Erythropoiesis; 2.4 Genes Essential for Definitive Erythropoiesis; 2.5 Erythropoietin Production; 2.6 References; 3 Regulation of the Erythropoietin Gene: A Paradigm for Hypoxia-dependent Genes; 3.1 The Structure of the Erythropoietin Gene; 3.2 Tissue-specific Expression; 3.3 Mechanism of Hypoxic Regulation - Identification of Transcription Factors and Other Regulatory Proteins; 3.3.1 Is the Oxygen Sensor a Heme Protein?
3.3.2 The 3 ́ Flanking Region of the Erythropoietin Gene Contains Important Regulatory Sequences3.3.3 Identification of the Hypoxia-inducible Factor - Hypoxia Regulates More Than the Erythropoietin Gene; 3.3.4 Other Interacting Proteins and the Regulation of HIF-1; 3.3.5 The von Hippel-Lindau Protein, Proline Hydroxylation and the Oxygen Sensor; 3.3.6 Modulation of HIF-1 Activity by Other Signals; 3.3.7 A Final Word on the Heme Protein Hypothesis; 3.4 References; 4 Physiology and Metabolism of Erythropoietin; 4.1 The Kidney as the Site of Production
4.2 The Liver as a Site of Erythropoietin Production4.3 Erythropoietin Produced in the Bone Marrow; 4.4 Metabolism and Clearance of Erythropoietin; 4.5 Erythropoietin and the Maternal/Fetal Circulation; 4.6 References; 5 Biochemistry and Protein Structure; 5.1 Naturally Occurring Epo; 5.1.1 Difficulties in Purifying the Hormone; 5.1.2 The Purification of Human Urinary Epo; 5.1.3 Biochemical Properties of Human Urinary Epo; 5.1.4 Some Biochemical Properties of Human Serum Epo; 5.2 Recombinant Human Epo; 5.2.1 Cloning the Human Epo Gene; 5.2.2 Glycosylation of Epo
5.2.3 Physicochemical Properties of Epo5.3 Structure-activity Relationships; 5.3.1 Antibody Studies; 5.3.2 Mutagenesis Studies; 5.4 The Tertiary Structure of Epo; 5.5 References; 6 Receptor Biology and Signal Transduction; 6.1 Receptor Biology; 6.1.1 Identification of the Erythropoietin Receptor; 6.1.2 The Erythropoietin Receptor Gene; 6.1.3 The Structure of the Erythropoietin Receptor: A Member of the Cytokine Receptor Superfamily; 6.1.4 The Extracellular Portion of the Erythropoietin Receptor; 6.1.5 The Cytoplasmic Portion of the Erythropoietin Receptor; 6.2 Signal Transduction Pathways
6.2.1 Phosphorylation of the Erythropoietin Receptor
Record Nr. UNINA-9910830768503321
Sytkowski Arthur J  
Weinheim, : Wiley-VCH, 2004
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Erythropoietin : blood, brain and beyond / / Arthur J. Sytkowski
Erythropoietin : blood, brain and beyond / / Arthur J. Sytkowski
Autore Sytkowski Arthur J
Pubbl/distr/stampa Weinheim, : Wiley-VCH, 2004
Descrizione fisica 1 online resource (240 p.)
Disciplina 612.111
615.39
Soggetto topico Erythropoietin
Erythropoietin - Physiological effect
Erythropoietin - Therapeutic use
ISBN 1-280-52052-3
9786610520527
3-527-60543-6
3-527-60238-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Erythropoietin; Preface; Contents; 1 Introduction and History; 1.1 Early Observations; 1.2 Carnot and Deflandre: A Humoral Factor that Stimulates Erythropoiesis; 1.3 Reissmann, Erslev, Jacobson and Stohlman: The Kidney as the Likely Source; 1.4 More Evidence for the Kidney . . . Erythrogenin?; 1.5 Early Assays for Erythropoietin; 1.6 Standardization: What is a "Unit" of Erythropoietin?; 1.7 References; 2 Developmental Biology of Erythropoiesis and Erythropoietin Production; 2.1 Introduction; 2.2 Yolk Sac Hematopoiesis; 2.2.1 The Role of Erythropoietin in Yolk Sac Erythropoiesis
2.2.2 Genes Essential to Primitive Erythropoiesis2.3 Fetal Liver and Bone Marrow (Definitive) Erythropoiesis; 2.4 Genes Essential for Definitive Erythropoiesis; 2.5 Erythropoietin Production; 2.6 References; 3 Regulation of the Erythropoietin Gene: A Paradigm for Hypoxia-dependent Genes; 3.1 The Structure of the Erythropoietin Gene; 3.2 Tissue-specific Expression; 3.3 Mechanism of Hypoxic Regulation - Identification of Transcription Factors and Other Regulatory Proteins; 3.3.1 Is the Oxygen Sensor a Heme Protein?
3.3.2 The 3 ́ Flanking Region of the Erythropoietin Gene Contains Important Regulatory Sequences3.3.3 Identification of the Hypoxia-inducible Factor - Hypoxia Regulates More Than the Erythropoietin Gene; 3.3.4 Other Interacting Proteins and the Regulation of HIF-1; 3.3.5 The von Hippel-Lindau Protein, Proline Hydroxylation and the Oxygen Sensor; 3.3.6 Modulation of HIF-1 Activity by Other Signals; 3.3.7 A Final Word on the Heme Protein Hypothesis; 3.4 References; 4 Physiology and Metabolism of Erythropoietin; 4.1 The Kidney as the Site of Production
4.2 The Liver as a Site of Erythropoietin Production4.3 Erythropoietin Produced in the Bone Marrow; 4.4 Metabolism and Clearance of Erythropoietin; 4.5 Erythropoietin and the Maternal/Fetal Circulation; 4.6 References; 5 Biochemistry and Protein Structure; 5.1 Naturally Occurring Epo; 5.1.1 Difficulties in Purifying the Hormone; 5.1.2 The Purification of Human Urinary Epo; 5.1.3 Biochemical Properties of Human Urinary Epo; 5.1.4 Some Biochemical Properties of Human Serum Epo; 5.2 Recombinant Human Epo; 5.2.1 Cloning the Human Epo Gene; 5.2.2 Glycosylation of Epo
5.2.3 Physicochemical Properties of Epo5.3 Structure-activity Relationships; 5.3.1 Antibody Studies; 5.3.2 Mutagenesis Studies; 5.4 The Tertiary Structure of Epo; 5.5 References; 6 Receptor Biology and Signal Transduction; 6.1 Receptor Biology; 6.1.1 Identification of the Erythropoietin Receptor; 6.1.2 The Erythropoietin Receptor Gene; 6.1.3 The Structure of the Erythropoietin Receptor: A Member of the Cytokine Receptor Superfamily; 6.1.4 The Extracellular Portion of the Erythropoietin Receptor; 6.1.5 The Cytoplasmic Portion of the Erythropoietin Receptor; 6.2 Signal Transduction Pathways
6.2.1 Phosphorylation of the Erythropoietin Receptor
Record Nr. UNINA-9910840911103321
Sytkowski Arthur J  
Weinheim, : Wiley-VCH, 2004
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui