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Ion Channels as Targets in Drug Discovery / / edited by Gary Stephens, Edward Stevens
| Ion Channels as Targets in Drug Discovery / / edited by Gary Stephens, Edward Stevens |
| Edizione | [1st ed. 2024.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2024 |
| Descrizione fisica | 1 online resource (IX, 537 p. 88 illus., 62 illus. in color.) |
| Disciplina | 612.8 |
| Collana | Biomedical and Life Sciences Series |
| Soggetto topico |
Neurosciences
Neurochemistry Pharmacology Neuroscience |
| ISBN | 3-031-52197-8 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Ion Channels as Targets in Drug Discovery: outlook and perspectives -- Conservation of ligand binding between voltage-gated sodium and T-type calcium channels -- The presynaptic α2δ protein family and their therapeutic potential -- Sodium channel in central hyperexcitability disease -- Therapeutic targeting of voltage-gated potassium channels -- The contribution of genetic sequencing information to the identification and functional characterisation of two pore domain (K2P) channels as viable therapeutic targets -- The voltage-gated potassium channel KV2.1 as a multicellular drug target -- Cystic fibrosis transmembrane conductance regulator (CFTR)-targeted therapeutics for cystic fibrosis -- Validation of TMEM16A modulation as a therapeutic approach for the treatment of cystic fibrosis – the discovery of novel TMEM16A potentiators -- Targeting acid-sensing ion channels in disease -- Transient Receptor Potential Canonical (TRPC) as a Therapeutic Drug Target -- Nicotinic receptors of the neuronal and non-neuronal cholinergic systems as therapeutic targets: Opportunities and limitations -- Purinergic P2X receptors as therapeutic targets -- Immune Cell Ion Channels as Therapeutic Targets -- Ion channel tools and therapeutics from venoms and toxins. |
| Record Nr. | UNINA-9910855396603321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2024 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Modulation of presynaptic calcium channels / / Gary Stephens, Sumiko Mochida, editors
| Modulation of presynaptic calcium channels / / Gary Stephens, Sumiko Mochida, editors |
| Edizione | [1st ed. 2013.] |
| Pubbl/distr/stampa | New York, : Springer, 2013 |
| Descrizione fisica | 1 online resource (365 p.) |
| Disciplina | 574.872 |
| Altri autori (Persone) |
StephensGary
MochidaSumiko |
| Soggetto topico |
Calcium channels
Calcium in the body |
| ISBN | 94-007-6334-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Spatial and temporal regulation of Ca2+ channels -- Neuronal functions of auxiliary calcium channel subunits.- Reciprocal regulation of neuronal calcium channels by synaptic proteins -- Molecular architecture of Ca2+ channel complexes organized by β subunits in presynaptic active zones -- Control of CaV2 calcium channels and neurosecretion by heterotrimeric G protein coupled receptors -- Regulation of CaV2 channels by small GTPases -- Protein interaction partners of Cav2.3 R-type voltage-gated calcium channels -- Voltage-gated calcium channel signaling to the nucleus -- Presynaptic Ca2+ influx and its modulation at auditory calyceal terminals -- Use of synthetic Ca2+ channel peptides to study presynaptic function -- Impact of a loss-of-function P/Q type Ca2+ channel mutation on excitatory synaptic control of cerebellar Purkinje neurons -- CaV2.1 (P/Q) voltage activated Ca2+ channels and synaptic transmission in genetic and autoimmune diseases -- Splicing and editing to customize CaV channel structures for optimal neural function -- Presynaptic calcium channels as drug targets for pain -- Sensory pathway modulation by calcium channel a2d1 subunit. |
| Record Nr. | UNINA-9910739415603321 |
| New York, : Springer, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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