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Chemistry of metalloproteins : problems and solutions in bioinorganic chemistry / / Joseph J. Stephanos, Anthony W. Addison
| Chemistry of metalloproteins : problems and solutions in bioinorganic chemistry / / Joseph J. Stephanos, Anthony W. Addison |
| Autore | Stephanos Joseph J. |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , 2014 |
| Descrizione fisica | 1 online resource (451 p.) |
| Disciplina | 572/.6076 |
| Collana | Wiley Series in Protein and Peptide Science |
| Soggetto topico | Metalloproteins |
| ISBN |
1-118-80152-0
1-118-80223-3 1-118-80149-0 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Chemistry of Metalloproteins: Problems and Solutions in Bioinorganic Chemistry; Contents; Preface; 1 Introduction; Proteins: Formation, Structures, and Metalloproteins; Organelles and Their Functions; Structure of DNA; Cell Growth and Division; Protein Synthesis; Common Natural α-Amino Acids; Peptide Chain Formation; Protein physiological functions; Structural Features of Proteins; Causes of Polypeptide Chain Folding; Metal Amino Acid Complexes; Comparison of P-O versus M-O Bond Scission Rates for Row 3 Elements; Redox Advantages: Sulfur versus Phosphorus; Bioenergetic Phosphate Derivatives
References2 Alkali and Alkaline Earth Cations; References; 3 Nonredox Metalloenzymes; Carboxypeptidases; What are the main functions of carboxypeptidases?; What are the main types of carboxypeptidases?; What are the requirements to stimulate carboxypeptidase-A and carboxypeptidase-B?; What are the main structural features of carboxypeptidase-A and carboxypeptidase-B?; How can Zn2+ be extracted from carboxypeptidase-A and carboxypeptidase-B?What are the consequences of metal ion removal?; What are the spectral consequences when Zn2+ is replaced by Co2+ in carboxypeptidases? Describe the role of Zn2+ in carboxypeptidase-A and carboxypeptidase-B.Design models to mimic the role of the metal ion in carboxypeptidase-A and carboxypeptidase-B.; Carbonic Anhydrase; What are the main functions of carbonic anhydrase?; Conversion of carbonic acid to CO2 and H2O is a spontaneous process. Why is carbonic anhydrase needed?; What are the main structural and chemical features of carbonic anhydrase?; Describe the role of the metal ion in carbonic anhydrase.; What are the possible mechanisms that describe the action of carbonic anhydrase? Design models for the carbonic anhydrase, and what do they reveal?Rate Constants; Alcohol Dehydrogenase; What is the catalytic role and the structural features of the alcohol dehydrogenases?; What is the sequence of events during the reaction of alcohol dehydrogenase?; A number of model systems have been investigated to study the influence of Zn2+ on the reactivity of the carbonyl; give an example.; References; 4 Copper Proteins; Introduction; Electronic Spectra of Copper Ions; What are the structural and spectral features of copper(II)-peptide complexes in the visible region? ESR Spectra of Copper IonsHow can ESR spectra be used as a ``spectral probe ́ ́ to study copper enzymes?; Define; How do the nuclear-spin of Cu2+ ion and the attached ligands affect the ESR signal? How can the hyperfine and superhyperfine splitting be used as a ``spectral probe ́ ́ for studying the copper enzymes?; How may the spectrochemical series and the stereochemistry affect g-values of Cu2+ ion and what is the significance of All-gll trend?; Copper Proteins Identify the significant roles of copper in the biological process, classify, give examples, and explain their functions and main chemical properties. |
| Record Nr. | UNINA-9910132185603321 |
Stephanos Joseph J.
|
||
| Hoboken, New Jersey : , : Wiley, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Chemistry of metalloproteins : problems and solutions in bioinorganic chemistry / / Joseph J. Stephanos, Anthony W. Addison
| Chemistry of metalloproteins : problems and solutions in bioinorganic chemistry / / Joseph J. Stephanos, Anthony W. Addison |
| Autore | Stephanos Joseph J. |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , 2014 |
| Descrizione fisica | 1 online resource (451 p.) |
| Disciplina | 572/.6076 |
| Collana | Wiley Series in Protein and Peptide Science |
| Soggetto topico | Metalloproteins |
| ISBN |
1-118-80152-0
1-118-80223-3 1-118-80149-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Chemistry of Metalloproteins: Problems and Solutions in Bioinorganic Chemistry; Contents; Preface; 1 Introduction; Proteins: Formation, Structures, and Metalloproteins; Organelles and Their Functions; Structure of DNA; Cell Growth and Division; Protein Synthesis; Common Natural α-Amino Acids; Peptide Chain Formation; Protein physiological functions; Structural Features of Proteins; Causes of Polypeptide Chain Folding; Metal Amino Acid Complexes; Comparison of P-O versus M-O Bond Scission Rates for Row 3 Elements; Redox Advantages: Sulfur versus Phosphorus; Bioenergetic Phosphate Derivatives
References2 Alkali and Alkaline Earth Cations; References; 3 Nonredox Metalloenzymes; Carboxypeptidases; What are the main functions of carboxypeptidases?; What are the main types of carboxypeptidases?; What are the requirements to stimulate carboxypeptidase-A and carboxypeptidase-B?; What are the main structural features of carboxypeptidase-A and carboxypeptidase-B?; How can Zn2+ be extracted from carboxypeptidase-A and carboxypeptidase-B?What are the consequences of metal ion removal?; What are the spectral consequences when Zn2+ is replaced by Co2+ in carboxypeptidases? Describe the role of Zn2+ in carboxypeptidase-A and carboxypeptidase-B.Design models to mimic the role of the metal ion in carboxypeptidase-A and carboxypeptidase-B.; Carbonic Anhydrase; What are the main functions of carbonic anhydrase?; Conversion of carbonic acid to CO2 and H2O is a spontaneous process. Why is carbonic anhydrase needed?; What are the main structural and chemical features of carbonic anhydrase?; Describe the role of the metal ion in carbonic anhydrase.; What are the possible mechanisms that describe the action of carbonic anhydrase? Design models for the carbonic anhydrase, and what do they reveal?Rate Constants; Alcohol Dehydrogenase; What is the catalytic role and the structural features of the alcohol dehydrogenases?; What is the sequence of events during the reaction of alcohol dehydrogenase?; A number of model systems have been investigated to study the influence of Zn2+ on the reactivity of the carbonyl; give an example.; References; 4 Copper Proteins; Introduction; Electronic Spectra of Copper Ions; What are the structural and spectral features of copper(II)-peptide complexes in the visible region? ESR Spectra of Copper IonsHow can ESR spectra be used as a ``spectral probe ́ ́ to study copper enzymes?; Define; How do the nuclear-spin of Cu2+ ion and the attached ligands affect the ESR signal? How can the hyperfine and superhyperfine splitting be used as a ``spectral probe ́ ́ for studying the copper enzymes?; How may the spectrochemical series and the stereochemistry affect g-values of Cu2+ ion and what is the significance of All-gll trend?; Copper Proteins Identify the significant roles of copper in the biological process, classify, give examples, and explain their functions and main chemical properties. |
| Record Nr. | UNINA-9910827658903321 |
|
Stephanos Joseph J.
|
||
| Hoboken, New Jersey : , : Wiley, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||