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The treatment of epilepsy / / edited by Simon Shorvon, Emilio Perucca, Jerome Engel, Jr. ; contributors, Patrick Adjei [and one hundred thirty others]
| The treatment of epilepsy / / edited by Simon Shorvon, Emilio Perucca, Jerome Engel, Jr. ; contributors, Patrick Adjei [and one hundred thirty others] |
| Edizione | [Fourth edition.] |
| Pubbl/distr/stampa | Chichester, England : , : Wiley Blackwell, , 2016 |
| Descrizione fisica | 1 online resource (2765 p.) |
| Disciplina | 617.481 |
| Soggetto topico |
Epilepsy - Surgery
Anticonvulsants - Therapeutic use Epilepsy - Chemotherapy |
| ISBN |
1-118-93697-3
1-118-93699-X 1-118-93698-1 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Title page; Copyright; List of Contributors; Preface to the Fourth Edition; Preface to the First Edition; Historical Introduction The Drug Treatment of Epilepsy from 1857 to 2015; Commentary; Acknowledgement; References; Section I Introduction; 1 Definition (Terminology) and Classification in Epilepsy: A Historical Survey and Current Formulation, with Special Reference to the ILAE; Definition; Classification; The future of classification schemes of epilepsy; Definition; Definition and classification - status epilepticus; Afterthought; Acknowledgement; References
2 Differential Diagnosis of EpilepsyIntroduction; General approach to the diagnosis of episodic disturbances; Syncope; Non-epileptic seizures; Panic disorder; Migraine; Sleep disorders; Vertigo; Movement disorders; Cerebral ischaemia; Endocrine and metabolic abnormalities; Transient global amnesia; References; 3 Mechanisms of Epileptogenesis; Membrane ion channels; Membrane ion channels as targets for antibodies in acquired autoimmune disorders; Network and system involvement in epileptogenesis; Epileptogenesis as a process; New targets for antiepileptic and antiepileptogenic strategies ConclusionsReferences; 4 Antiepileptic Drug Discovery; Characteristics of the ideal model system; The current era of AED discovery; Anticonvulsant Screening Program; Early identification of antiepileptic activity; MES, scPTZ and 6-Hz tests; Differentiation of anticonvulsant activity; Pharmacological profile and potential clinical utility; Pharmacoresistant seizure models; Therapeutic index and toxicity assessment; Aetiologically relevant model systems; Beyond the seizure; Antiepileptogenesis and disease modification (see also Chapter 8); Conclusions; Acknowledgement; References 5 Antiepileptic Drug DevelopmentIntroduction; Overview on clinical studies and trials for drug development; Opportunities for developing better antiseizure AEDs; Development of epilepsy drugs beyond suppressing seizures; Conclusions; Acknowledgements; References; 6 Mechanisms of Antiepileptic Drug Action; Main targets; Other targets; References; 7 Mechanisms of Drug Resistance and Tolerance; Introduction; The concept of drug resistance in epilepsy; Disease-related mechanisms of drug resistance in epilepsy; Drug-related mechanisms of drug resistance in epilepsy Pharmacogenetic mechanisms of drug resistance in epilepsyProof-of-concept of drug resistance hypotheses; Conclusions; References; 8 Epilepsy Biomarkers; Introduction; Need for biomarkers; Mechanisms of epilepsy; Potential biomarkers; Research to identify biomarkers; Acknowledgements; References; Section II Principles of Medical Management; 9 General Principles of Medical Management; Aims of treatment; When should treatment be started?; Initiation of treatment and dose optimization; Assessing clinical response; What next when the initial treatment fails? - monotherapy and combination therapy How long should treatment be continued? |
| Record Nr. | UNINA-9910131471703321 |
| Chichester, England : , : Wiley Blackwell, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The treatment of epilepsy / / edited by Simon D. Shorvon [and three others] ; foreword by Giuliano Avanzini
| The treatment of epilepsy / / edited by Simon D. Shorvon [and three others] ; foreword by Giuliano Avanzini |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Malden, Massachusetts : , : Blackwell Publishing, , 2004 |
| Descrizione fisica | 1 online resource (948 p.) |
| Disciplina | 616.85306 |
| Soggetto topico | Epilepsy - Treatment |
| ISBN |
0-470-75245-9
1-280-19934-2 9786610199341 0-470-75246-7 1-4051-2826-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
The Treatment of Epilepsy; Contents; Contributors; Foreword; Preface to the Second Edition; Preface to the First Edition; The Drug Treatment of Epilepsy Between 1938 and 1955, with Special Reference to the Journal of Epilepsia to the International League Against Epilepsy; SECTION 1: Introduction; 1 Definitions and Classification of Epilepsy; 2 Epidemiology and Prognosis of Epilepsy and its Treatment; 3 Sudden Death in Epilepsy; 4 Aetiology of Epilepsy; 5 Differential Diagnosis of Epilepsy; 6 Mechanisms of Epileptogenesis; 7 Mechanisms of Drug Resistance in Epilepsy
8 Antiepileptic Drug Discovery9 Mechanisms of Antiepileptic Drug Action; 10 Drug Interactions in Epilepsy; SECTION 2: Principles of Medical Treatment; 11 General Principles of Medical Treatment; 12 Management of Newly Diagnosed Epilepsy; 13 Management of Epilepsy in Remission; 14 Management of Epilepsy in Infants; 15 Management of Epilepsy in Children; 16 Management of Epilepsy in the Elderly Person; 17 Management of Epilepsy in People with Learning Disability; 18 Emergency Treatment of Seizures and Status Epilepticus; 19 Treatment of Epilepsy in General Medical Conditions 20 Treatment of Psychiatric Disorders in Epilepsy21 The Ketogenic Diet; 22 Complementary and Alternative Treatments in Epilepsy; 23 Reproductive Aspects of Epilepsy Treatment; 24 Genetic Counselling in Epilepsy; 25 Diagnosis and Treatment of Non-Epileptic Seizures; SECTION 3: Drugs Used in the Treatment of Epilepsy; 26 The Choice of Drugs andApproach to Drug Treatments in Partial Epilepsy; 27 Acetazolamide; 28 Carbamazepine; 29 Clobazam; 30 Clonazepam; 31 Short-Acting and Other Benzodiazepines; 32 Ethosuximide; 33 Felbamate; 34 Fosphenytoin; 35 Gabapentin; 36 Lamotrigine; 37 Levetiracetam 38 Oxcarbazepine39 Phenobarbital, Primidone and Other Barbiturates; 40 Phenytoin; 41 Piracetam; 42 Pregabalin; 43 Rufinamide; 44 Tiagabine; 45 Topiramate; 46 Valproate; 47 Vigabatrin; 48 Zonisamide; 49 Other Drugs More Rarely Used in the Treatment of Epilepsy; 50 Antiepileptic Drugs in Clinical Trials; SECTION 4: Presurgical Evaluation of Epilepsy and Epilepsy Surgery; 51 Introduction to Epilepsy Surgery and its Presurgical Assessment; 52 The Scalp EEG in Presurgical Evaluation of Epilepsy; 53 Invasive EEG in Presurgical Evaluation of Epilepsy; 54 MEG in Presurgical Evaluation of Epilepsy 55 MRI in Presurgical Evaluation of Epilepsy56 PET and SPECT in Presurgical Evaluation of Epilepsy; 57 New Physiological and Radiological Investigations in the Presurgical Evaluation of Epilepsy; Colour plates are found between pp. 670-671; 58 Psychological Testing in Presurgical Evaluation of Epilepsy; 59 The Role of Psychiatric Assessment in Presurgical Evaluation of Epilepsy; 60 Surgery of Hippocampal Sclerosis; 61 Resective Surgery of Neoplastic Lesions for Epilepsy; 62 Resective Surgery of Vascular and Infective Lesions for Epilepsy; 63 Surgery of Cortical Dysgenesis for Epilepsy 64 Surgery of Post-Traumatic Epilepsy |
| Record Nr. | UNISA-996213217903316 |
| Malden, Massachusetts : , : Blackwell Publishing, , 2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
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