Lipophilic Vitamins in Health and Disease

• Autore: Tappia Paramjit S
• Pubblicazione: Cham : , : Springer International Publishing AG, , 2024; ©2024
• Edizione: 1st ed.
• Descrizione fisica: 1 online resource (411 pages)
• Altri autori: ShahAnureet K DhallaNaranjan S
• Nota di contenuto: Intro -- Preface -- Contents -- Contributors -- Part I General Aspects of Lipophilic Vitamins -- 1 The Cardio-protective Effect of Fat-Soluble Vitamins on Anti-cancer Drug Induced Cardiotoxicity -- Introduction -- Chemotherapy Drugs Inducing Possible Mitochondrial Damage -- Disruption to the Sarcomere Structure -- Vitamin D3's Cytoprotective Effect Through Various Signaling Pathway -- Synergistic Effect of Pirfenidone and Vitamin D -- Safety Efficacy of High-Dose Vitamin D Supplementation -- Synergistic Effect of Eicosapentaenoic Acid and Vitamin E -- Synergistic Effect of Hesperidin and Vitamin E -- Vitamin E's Protective Effect on Cisplatin Induced Cardiotoxicity -- Conclusion and Discussion -- Strengths and Limitations -- References -- 2 Fat Soluble Vitamins in the Ocular, Cardiac, and Infectious Diseases: Myths and Misconceptions -- Fat Soluble Vitamins -- The Role of Fat-Soluble Vitamins in Eye Health and Disease -- The Role of Fat-Soluble Vitamins in Cardiovascular Diseases (CVD) -- More Concentrations on Vitamin D -- Myths and Misconceptions About Fat-Soluble Vitamins -- Conclusions -- References -- 3 The Effects of Lipophilic Vitamins on Women's Heart Health -- Cardiovascular Disease in Women -- The Beneficial Effect of Vitamins a and D on Women's Heart Health -- Vitamin E and Women's Heart Health -- Vitamin K and Women's Heart Health -- Clinical Studies and Epidemiological Evidence of the Effect of Lipophilic Vitamins on Women's Heart Health -- Potential Risks and Considerations -- References -- 4 Mitigation of Dementia and Alzheimer's Disease with Lipophilic Vitamins and Their Derivatives: Preclinical and Clinical Evidence -- Introduction -- Overview of Pre-clinical Studies -- Supportive Evidence from Clinical Studies -- Nanotechnological Interventions in Promoting the Systemic Delivery of Vitamins. ; Challenges and Opportunities in the Management of Neurodegenerative Diseases with Nanotechnology Delivery Systems -- References -- 5 Lipid-Soluble Vitamins: Their Roles in Cardiovascular Health and Diseases -- Introduction -- Vitamin A -- Overview -- Conversion of Carotenoids into Vitamin A -- Biochemical Reactions that Utilize Vitamin A -- Vitamin D -- Overview -- Biosynthesis of Vitamin D -- Biochemical Reactions -- Vitamin E -- Overview -- Biosynthesis -- Biochemical Reactions -- Vitamin K -- Overview -- Biosynthesis -- Biochemical Reactions and Cardiovascular Health -- Conclusion -- References -- 6 Interactions Between Gut Microbiota and Lipophilic Vitamins in Health and Disease -- Introduction -- Interactions of Fat-Soluble Vitamins with the Gut Microbiome to Maintain Physiological Homeostasis: Cellular and Molecular Insights -- Vitamin A -- Vitamin D -- Vitamin E -- Vitamin K -- Diseases Implicated for Gut Microbiome/lipophilic Vitamin Interaction Axis: A Pharmacological Overview -- Inflammatory Bowel Disease -- Neurological Complications -- Cancer Immunotherapy & -- Beyond -- Ageing -- Limitations in Current Understanding -- Future Perspectives -- Conclusion -- References -- Part II Vitamin E and Associated Metabolites in Health and Disease -- 7 The Potential Role of Tocotrienols Against Cardiovascular Diseases -- Introduction -- Structural and Chemical Differences Between Tocotrienol and Tocopherol Molecules that May Give Rise to Their Distinct Properties -- Dietary Sources -- Potential Role of Tocotrienols Against Cardiovascular Diseases: Inflammation and Immune Response -- Potential Role of Tocotrienols Against Cardiovascular Diseases: Cholesterol Metabolism and Homeostasis -- Concluding Remarks -- References -- 8 Recent Progress on the Skeletal Research of Tocotrienol -- Introduction -- Deposition of Tocotrienol in the Bone. ; Effects of Tocotrienol on Osteocytes and Wnt -- Effects of Tocotrienol on Mevalonate Pathway -- Effects of Tocotrienol on Bone in Humans -- Effects of Tocotrienol on Other Aspects of Bone Remodelling -- Research Gaps -- Conclusion -- References -- 9 Importance of Vitamin E and Its Metabolism for Health and Disease -- Introduction -- Metabolism of Vitamin E -- Diseases with Vitamin E Relevance -- Ataxia with Vitamin E Deficiency -- Cardiovascular Diseases -- Non-alcoholic Fatty Liver Disease -- Skin Health and Atopic Diseases -- Conclusions and Outlook -- References -- 10 Beneficial Effects of Vitamin E Combined with Antioxidants in Cardiovascular System Disorders: Experimental Evidence -- Introduction -- Metabolism and Functions of Vitamin E -- Vitamin E: Action in the Cell Membrane and Interaction with Intracellular Binding Proteins -- Vitamin E and Cardiovascular Function -- Beneficial Effects of Combined Treatment with Vitamin E and Other Antioxidants in the Cardiovascular System -- Conclusions -- References -- 11 Vitamin E for the Prevention and Treatment of Cardiovascular Disease -- Introduction -- Antioxidant Mechanism of Action of Vitamin E -- Vitamin E in Different Types of CVD -- Consideration for Other Classes of Vitamin E in CVD -- Role of Vitamin E in CVD in Diabetes -- Conclusion -- References -- 12 Vitamin E (Tocopherol): Implications in Cardiovascular Health and Neuroprotection -- Introduction -- Tocopherol Versus Tocotrienols -- Vitamin E as a Cofactor/Co-Enzyme in Various Metabolism -- Vitamin E-as an Antioxidant Property Against Lipid Peroxidation -- Scavenging Avenger of Vitamin E -- Vitamin E in Cell Membrane Protection -- Vitamin E in Primary Cardiac Prevention -- Vitamin E in Secondary RCT -- Vitamin E in Cardiac Muscle Recovery. ; Vitamin E-as a Neurodegenerative Agent and in Randomized Clinical Trials of Various Neurodegenerative Diseases -- Alzheimer's Diseases-Aging -- Pathogenesis of AD -- Proofs that Oxidative Damage Induced Damage of the Brain in AD Patients -- Vitamin-E Against AD -- Vitamin E in AD-Induced Animal Experimentation -- Clinical Trials with Vitamin E in AD Patients -- Neuroplasticity -- Parkinson's Disease -- Seizure's -- Purkinje Neurons Versus Vit-E -- Conclusion -- References -- Part III Functional Aspects of Vitamins A, D and K -- 13 Retinoids and the Vitamin a Receptor STRA6 in Health and Disease -- Introduction: The Importance of Vitamin a -- Vitamin a Metabolism -- Retinoid Signalling -- Retinoids in Cancer -- Retinoids in Development -- Retinoids in Skin -- STRA6 as the Receptor for RBP -- STRA6 in Disease (I): The Mathew Wood Syndrome -- STRA6 in Disease (II): Cancer -- STRA6 in Disease (III): Insulin Resistance -- Conclusions -- References -- 14 A Vitamin Treatment for Motor Neurone Disease -- Introduction -- Amyotrophic Lateral Sclerosis -- Retinoic Acid and the Retinoic Acid Receptor -- Retinoids as a Potential Therapeutic for Amyotrophic Lateral Sclerosis -- Conclusions -- References -- 15 Vitamin D and Its Role on Inflammation, Oxidative Stress and Cardiovascular Disease -- Introduction -- Vitamin D -- Biosynthesis -- Mechanism of Action -- Oxidative Stress, Inflammation and Cardiovascular Conditions -- Vitamin D, Inflammation and Oxidative Stress -- Vitamin D and Cardiovascular Risk -- Conclusion -- References -- 16 Vitamin D and Immune Function: Unraveling the Connections -- Introduction -- Vitamin D and Health -- Recommended Levels of Vitamin D -- Vitamin D and Immunity -- Vitamin D and Immune Cells -- Vitamin D and the Innate Immune System -- Vitamin D and the Adaptive Immune System. ; Vitamin D and Its Connection in Autoimmune Diseases and Immune-Related Disorders -- Type I Diabetes (TID) -- Psoriasis -- Multiple Sclerosis (MS) -- Rheumatoid Arthritis (RA) -- Systemic Lupus Erythematosus (SLE) -- Miscellaneous -- Conclusion -- Conflicts of Interest -- References -- 17 Maternal Vitamin D Levels During Gestation and Impact on Offspring's Risk of Non-communicable Diseases in Adulthood -- Background -- Why Vitamin D Matters? -- Vitamin D Level During Pregnancy and Infancy -- Vitamin D Effect on Fetal Growth and Neonatal Anthropomorphic Features -- Vitamin D Effect on Immune Response During Pregnancy -- Vitamin D Level During Adolescence -- Maternal Vitamin D Deficiency and Risk of Communicable Disease in Adulthood -- Vitamin D Metabolism During Pregnancy -- Vitamin D Supplementation During Gestation -- Fetal Programming and Vitamin D -- Conclusion -- References -- 18 Unveiling the Link of Vitamin D and Diverse Cardiovascular Disorders: Current Status and Future Prospective -- Introduction -- Vitamin D: Its Physiological Role and Deficiency -- Link Between Vitamin D and Various Cardiovascular Disorders -- Role of Vitamin D in Cardiomyopathy -- Role of Vitamin D in Pulmonary Arterial Hypertension -- Role of Vitamin D in Myocardial Infarction -- Role of Vitamin D in Cardiac Fibrosis and Remodeling -- Role of Vitamin D in Heart Failure -- Role of Vitamin D in Arrhythmias -- Role of Vitamin D in Endothelial Dysfunction -- Role of Vitamin D in Other Disorders -- Major Challenges and Future Directions -- Conclusion -- References -- 19 Environmental Pollution-Induced Vitamin D Deficiency and Its Impact on the Outcomes of Pregnancy -- Introduction -- Vitamin D -- Vitamin D Synthesis and Metabolism -- Vitamin D Metabolism in Pregnant Women -- Vitamin D and Calcium Metabolism in Pregnancy -- Physiological Effects Concerning Calcium and Phosphate. ; Environmental Pollution and Vitamin D Deficiency During Pregnancy.
• Titolo autorizzato: Lipophilic Vitamins in Health and Disease
• ISBN: 3-031-55489-2
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910857781403321
• Lo trovi qui: Univ. Federico II
• Serie: Advances in Biochemistry in Health and Disease Series