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Chemical modulators of protein misfolding and neurodegenerative disease / / Pierfausto Seneci
| Chemical modulators of protein misfolding and neurodegenerative disease / / Pierfausto Seneci |
| Autore | Seneci Pierfausto |
| Pubbl/distr/stampa | London, England : , : Academic Press, , 2015 |
| Descrizione fisica | 1 online resource (260 p.) |
| Disciplina | 616.8047 |
| Altri autori (Persone) | SeneciPierfausto <1960-> |
| Soggetto topico | Nervous system - Degeneration |
| ISBN | 0-12-801959-X |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Title Page; Copyright Page; Dedication; Contents; Abbreviations; Chapter 1 - Chemical Modulators of Protein Misfolding, Neurodegeneration and Tau; 1.1 - Tau-targeted compounds; 1.1.1 - Tau Kinase Inhibitors; 1.1.2 - Tau O-GlcNAcylation Enhancers; 1.1.3 - Microtubule (MT)-binding Compounds; 1.2 - Ab-targeted compounds; 1.2.1 - γ-Secretase Inhibitors (GSIs) and Modulators (GSMs); 1.2.2 - Multi-targeted Neuroprotective and Proneurogenic Compounds; References; Chapter 2 - Targeting the Protein Quality Control (PQC) Machinery; 2.1 - Molecular chaperones, pqc, and neurodegeneration
2.2 - Hsp272.3 - Hsp70; 2.3.1 - Hsp70 Inhibitors; 2.3.2 - Hsp70-BAG-1 Inhibitors; 2.4 - Hsp90; 2.4.1 - Hsp90 Inhibitors; 2.4.2 - Hsp90-Co-chaperone Complexes: Direct Inhibition; 2.4.3 - Hsp90-Co-chaperone Complexes: Indirect Inhibition; 2.5 - Recap; References; Chapter 3 - Targeting Proteasomal Degradation of Soluble, Misfolded Proteins; 3.1 - UPS-mediated degradation of misfolded proteins; 3.2 - CHIP; 3.3 - USP14; 3.4 - Recap; References; Chapter 4 - Targeting Unselective Autophagy of Cellular Aggregates; 4.1 - Macroautophagy mediated degradation of protein aggregates; 4.2 - mTORC1 4.3 - Small molecule enhancers of rapamycin (sMERs)4.4 - Recap; References; Chapter 5 - Targeting Selective Autophagy of Insoluble Protein Aggregates; 5.1 - Aggrephagy-mediated degradation of protein aggregates; 5.2 - p62; 5.3 - HDAC6; 5.4 - Recap; References; Chapter 6 - Targeting Assembly and Disassembly of Protein Aggregates; 6.1 - Disordered protein aggregates and ordered amyloid fibrils; 6.2 - Interfering with (neuro)toxic tau species in the aggregation process; 6.3 - Hsp110-driven disaggregation; 6.4 - Recap; References; Index |
| Record Nr. | UNINA-9910787447203321 |
Seneci Pierfausto
|
||
| London, England : , : Academic Press, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Chemical modulators of protein misfolding and neurodegenerative disease / / Pierfausto Seneci
| Chemical modulators of protein misfolding and neurodegenerative disease / / Pierfausto Seneci |
| Autore | Seneci Pierfausto |
| Pubbl/distr/stampa | London, England : , : Academic Press, , 2015 |
| Descrizione fisica | 1 online resource (260 p.) |
| Disciplina | 616.8047 |
| Altri autori (Persone) | SeneciPierfausto <1960-> |
| Soggetto topico | Nervous system - Degeneration |
| ISBN | 0-12-801959-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Title Page; Copyright Page; Dedication; Contents; Abbreviations; Chapter 1 - Chemical Modulators of Protein Misfolding, Neurodegeneration and Tau; 1.1 - Tau-targeted compounds; 1.1.1 - Tau Kinase Inhibitors; 1.1.2 - Tau O-GlcNAcylation Enhancers; 1.1.3 - Microtubule (MT)-binding Compounds; 1.2 - Ab-targeted compounds; 1.2.1 - γ-Secretase Inhibitors (GSIs) and Modulators (GSMs); 1.2.2 - Multi-targeted Neuroprotective and Proneurogenic Compounds; References; Chapter 2 - Targeting the Protein Quality Control (PQC) Machinery; 2.1 - Molecular chaperones, pqc, and neurodegeneration
2.2 - Hsp272.3 - Hsp70; 2.3.1 - Hsp70 Inhibitors; 2.3.2 - Hsp70-BAG-1 Inhibitors; 2.4 - Hsp90; 2.4.1 - Hsp90 Inhibitors; 2.4.2 - Hsp90-Co-chaperone Complexes: Direct Inhibition; 2.4.3 - Hsp90-Co-chaperone Complexes: Indirect Inhibition; 2.5 - Recap; References; Chapter 3 - Targeting Proteasomal Degradation of Soluble, Misfolded Proteins; 3.1 - UPS-mediated degradation of misfolded proteins; 3.2 - CHIP; 3.3 - USP14; 3.4 - Recap; References; Chapter 4 - Targeting Unselective Autophagy of Cellular Aggregates; 4.1 - Macroautophagy mediated degradation of protein aggregates; 4.2 - mTORC1 4.3 - Small molecule enhancers of rapamycin (sMERs)4.4 - Recap; References; Chapter 5 - Targeting Selective Autophagy of Insoluble Protein Aggregates; 5.1 - Aggrephagy-mediated degradation of protein aggregates; 5.2 - p62; 5.3 - HDAC6; 5.4 - Recap; References; Chapter 6 - Targeting Assembly and Disassembly of Protein Aggregates; 6.1 - Disordered protein aggregates and ordered amyloid fibrils; 6.2 - Interfering with (neuro)toxic tau species in the aggregation process; 6.3 - Hsp110-driven disaggregation; 6.4 - Recap; References; Index |
| Record Nr. | UNINA-9910807756203321 |
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Seneci Pierfausto
|
||
| London, England : , : Academic Press, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Chemical sciences in early drug discovery : medicinal chemistry 2.0 / / Pierfausto Seneci
| Chemical sciences in early drug discovery : medicinal chemistry 2.0 / / Pierfausto Seneci |
| Autore | Seneci Pierfausto |
| Pubbl/distr/stampa | Amsterdam, Netherlands : , : Elsevier, , 2018 |
| Descrizione fisica | 1 online resource (196 pages) |
| Disciplina | 540 |
| Soggetto topico | Chemistry |
| ISBN | 0-08-099928-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910583093703321 |
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Seneci Pierfausto
|
||
| Amsterdam, Netherlands : , : Elsevier, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||